Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAN3_LEIBR

TriTrypDb:

LbrM.20.1180 , LBRM2903_200020500

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.634
CLV_NRD_NRD_1	311	313	PF00675	0.661
CLV_NRD_NRD_1	315	317	PF00675	0.612
CLV_PCSK_KEX2_1	311	313	PF00082	0.618
CLV_PCSK_KEX2_1	315	317	PF00082	0.622
CLV_PCSK_PC7_1	311	317	PF00082	0.536
CLV_PCSK_SKI1_1	184	188	PF00082	0.759
CLV_PCSK_SKI1_1	193	197	PF00082	0.632
CLV_PCSK_SKI1_1	24	28	PF00082	0.603
CLV_PCSK_SKI1_1	257	261	PF00082	0.730
CLV_PCSK_SKI1_1	47	51	PF00082	0.539
DEG_APCC_DBOX_1	183	191	PF00400	0.618
DEG_SCF_TRCP1_1	234	240	PF00400	0.517
DOC_CYCLIN_RxL_1	181	191	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.562
DOC_MAPK_DCC_7	184	192	PF00069	0.506
DOC_MAPK_MEF2A_6	78	86	PF00069	0.569
DOC_PP4_FxxP_1	68	71	PF00568	0.559
DOC_USP7_MATH_1	107	111	PF00917	0.544
DOC_USP7_MATH_1	134	138	PF00917	0.544
DOC_USP7_MATH_1	205	209	PF00917	0.665
DOC_USP7_MATH_1	42	46	PF00917	0.732
DOC_WW_Pin1_4	121	126	PF00397	0.550
DOC_WW_Pin1_4	13	18	PF00397	0.578
DOC_WW_Pin1_4	198	203	PF00397	0.598
DOC_WW_Pin1_4	211	216	PF00397	0.594
DOC_WW_Pin1_4	237	242	PF00397	0.487
DOC_WW_Pin1_4	38	43	PF00397	0.600
LIG_14-3-3_CanoR_1	287	296	PF00244	0.684
LIG_14-3-3_CanoR_1	321	330	PF00244	0.505
LIG_14-3-3_CanoR_1	47	52	PF00244	0.576
LIG_14-3-3_CanoR_1	7	13	PF00244	0.589
LIG_14-3-3_CterR_2	375	378	PF00244	0.626
LIG_Actin_WH2_2	179	195	PF00022	0.645
LIG_Actin_WH2_2	332	347	PF00022	0.501
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BRCT_BRCA1_1	123	127	PF00533	0.567
LIG_CtBP_PxDLS_1	189	193	PF00389	0.504
LIG_deltaCOP1_diTrp_1	272	275	PF00928	0.507
LIG_FHA_1	171	177	PF00498	0.672
LIG_FHA_1	238	244	PF00498	0.475
LIG_FHA_1	52	58	PF00498	0.592
LIG_FHA_1	71	77	PF00498	0.677
LIG_FHA_2	278	284	PF00498	0.548
LIG_FHA_2	349	355	PF00498	0.562
LIG_FHA_2	358	364	PF00498	0.583
LIG_FHA_2	38	44	PF00498	0.602
LIG_FHA_2	48	54	PF00498	0.510
LIG_FHA_2	83	89	PF00498	0.566
LIG_LIR_Apic_2	272	276	PF02991	0.516
LIG_LIR_Apic_2	65	71	PF02991	0.560
LIG_LIR_Gen_1	354	364	PF02991	0.535
LIG_LIR_Gen_1	95	105	PF02991	0.578
LIG_LIR_Nem_3	2	8	PF02991	0.632
LIG_LIR_Nem_3	272	278	PF02991	0.532
LIG_LIR_Nem_3	354	359	PF02991	0.539
LIG_LIR_Nem_3	95	101	PF02991	0.613
LIG_Pex14_2	34	38	PF04695	0.627
LIG_SH2_CRK	98	102	PF00017	0.576
LIG_SH3_3	173	179	PF00018	0.521
LIG_SH3_3	199	205	PF00018	0.609
LIG_SH3_3	327	333	PF00018	0.610
LIG_SH3_CIN85_PxpxPR_1	179	184	PF14604	0.503
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.615
LIG_TRFH_1	165	169	PF08558	0.528
LIG_TYR_ITSM	94	101	PF00017	0.450
LIG_WRC_WIRS_1	1	6	PF05994	0.564
LIG_WRC_WIRS_1	353	358	PF05994	0.546
LIG_WW_2	180	183	PF00397	0.501
MOD_CK1_1	121	127	PF00069	0.555
MOD_CK1_1	170	176	PF00069	0.592
MOD_CK1_1	201	207	PF00069	0.604
MOD_CK1_1	214	220	PF00069	0.600
MOD_CK1_1	322	328	PF00069	0.525
MOD_CK1_1	347	353	PF00069	0.523
MOD_CK1_1	37	43	PF00069	0.590
MOD_CK1_1	45	51	PF00069	0.620
MOD_CK2_1	107	113	PF00069	0.550
MOD_CK2_1	277	283	PF00069	0.536
MOD_CK2_1	348	354	PF00069	0.537
MOD_CK2_1	357	363	PF00069	0.536
MOD_CK2_1	47	53	PF00069	0.553
MOD_CK2_1	82	88	PF00069	0.570
MOD_GlcNHglycan	136	139	PF01048	0.672
MOD_GlcNHglycan	169	172	PF01048	0.570
MOD_GlcNHglycan	198	201	PF01048	0.721
MOD_GlcNHglycan	209	212	PF01048	0.729
MOD_GlcNHglycan	234	237	PF01048	0.525
MOD_GlcNHglycan	292	295	PF01048	0.615
MOD_GlcNHglycan	300	303	PF01048	0.618
MOD_GlcNHglycan	317	320	PF01048	0.501
MOD_GlcNHglycan	360	363	PF01048	0.534
MOD_GlcNHglycan	43	47	PF01048	0.680
MOD_GSK3_1	119	126	PF00069	0.556
MOD_GSK3_1	136	143	PF00069	0.567
MOD_GSK3_1	201	208	PF00069	0.625
MOD_GSK3_1	253	260	PF00069	0.516
MOD_GSK3_1	315	322	PF00069	0.612
MOD_GSK3_1	34	41	PF00069	0.604
MOD_GSK3_1	343	350	PF00069	0.542
MOD_GSK3_1	354	361	PF00069	0.573
MOD_GSK3_1	47	54	PF00069	0.546
MOD_GSK3_1	82	89	PF00069	0.569
MOD_N-GLC_1	119	124	PF02516	0.583
MOD_N-GLC_1	13	18	PF02516	0.627
MOD_N-GLC_1	140	145	PF02516	0.614
MOD_NEK2_1	119	124	PF00069	0.595
MOD_NEK2_1	248	253	PF00069	0.494
MOD_NEK2_1	295	300	PF00069	0.665
MOD_NEK2_1	344	349	PF00069	0.565
MOD_PIKK_1	107	113	PF00454	0.626
MOD_PIKK_1	126	132	PF00454	0.563
MOD_PIKK_1	203	209	PF00454	0.585
MOD_PIKK_1	287	293	PF00454	0.655
MOD_PIKK_1	70	76	PF00454	0.648
MOD_PKA_1	315	321	PF00069	0.521
MOD_PKA_2	278	284	PF00069	0.548
MOD_PKA_2	315	321	PF00069	0.521
MOD_PKA_2	86	92	PF00069	0.555
MOD_PKB_1	287	295	PF00069	0.531
MOD_Plk_1	140	146	PF00069	0.520
MOD_Plk_1	160	166	PF00069	0.521
MOD_Plk_1	257	263	PF00069	0.601
MOD_Plk_1	325	331	PF00069	0.630
MOD_Plk_4	140	146	PF00069	0.650
MOD_Plk_4	325	331	PF00069	0.630
MOD_ProDKin_1	121	127	PF00069	0.551
MOD_ProDKin_1	13	19	PF00069	0.581
MOD_ProDKin_1	198	204	PF00069	0.598
MOD_ProDKin_1	211	217	PF00069	0.594
MOD_ProDKin_1	237	243	PF00069	0.483
MOD_ProDKin_1	38	44	PF00069	0.599
TRG_DiLeu_BaEn_1	104	109	PF01217	0.556
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.530
TRG_ENDOCYTIC_2	98	101	PF00928	0.586
TRG_ER_diArg_1	286	289	PF00400	0.578
TRG_NES_CRM1_1	244	258	PF08389	0.404
TRG_NES_CRM1_1	74	88	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ1	Leptomonas seymouri	50%	78%
A0A3Q8IH36	Leishmania donovani	78%	98%
A4I9S5	Leishmania infantum	78%	98%
E9B4T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q390	Leishmania major	78%	100%