Dus domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrouridine synthase (Dus), putative

Species:

Leishmania braziliensis

UniProt:

A4HAN2_LEIBR

TriTrypDb:

LbrM.20.1170 , LBRM2903_200020300

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

A4HAN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAN2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0005488	binding	1	15
GO:0016491	oxidoreductase activity	2	15
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	15
GO:0017150	tRNA dihydrouridine synthase activity	5	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0050660	flavin adenine dinucleotide binding	4	15
GO:0097159	organic cyclic compound binding	2	15
GO:0106413	dihydrouridine synthase activity	4	15
GO:0140098	catalytic activity, acting on RNA	3	15
GO:0140101	catalytic activity, acting on a tRNA	4	15
GO:0140640	catalytic activity, acting on a nucleic acid	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.382
CLV_C14_Caspase3-7	422	426	PF00656	0.540
CLV_C14_Caspase3-7	86	90	PF00656	0.502
CLV_PCSK_SKI1_1	127	131	PF00082	0.238
CLV_PCSK_SKI1_1	298	302	PF00082	0.174
CLV_PCSK_SKI1_1	56	60	PF00082	0.575
DEG_APCC_DBOX_1	480	488	PF00400	0.410
DEG_Kelch_actinfilin_1	242	246	PF01344	0.403
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.434
DOC_MAPK_DCC_7	405	415	PF00069	0.369
DOC_MAPK_gen_1	314	324	PF00069	0.446
DOC_MAPK_MEF2A_6	317	326	PF00069	0.424
DOC_PP1_RVXF_1	409	416	PF00149	0.521
DOC_PP2B_LxvP_1	320	323	PF13499	0.488
DOC_PP2B_LxvP_1	416	419	PF13499	0.508
DOC_PP2B_LxvP_1	459	462	PF13499	0.479
DOC_USP7_MATH_1	177	181	PF00917	0.424
DOC_USP7_MATH_1	251	255	PF00917	0.381
DOC_USP7_MATH_1	288	292	PF00917	0.535
DOC_USP7_MATH_1	419	423	PF00917	0.442
DOC_USP7_MATH_1	99	103	PF00917	0.510
DOC_USP7_MATH_2	443	449	PF00917	0.300
DOC_USP7_UBL2_3	268	272	PF12436	0.543
DOC_WW_Pin1_4	152	157	PF00397	0.545
DOC_WW_Pin1_4	381	386	PF00397	0.552
DOC_WW_Pin1_4	405	410	PF00397	0.540
DOC_WW_Pin1_4	439	444	PF00397	0.520
DOC_WW_Pin1_4	474	479	PF00397	0.374
DOC_WW_Pin1_4	62	67	PF00397	0.712
LIG_14-3-3_CanoR_1	140	148	PF00244	0.551
LIG_14-3-3_CanoR_1	276	280	PF00244	0.447
LIG_14-3-3_CanoR_1	298	304	PF00244	0.558
LIG_14-3-3_CanoR_1	411	416	PF00244	0.563
LIG_14-3-3_CanoR_1	421	429	PF00244	0.475
LIG_14-3-3_CanoR_1	430	434	PF00244	0.518
LIG_14-3-3_CanoR_1	488	494	PF00244	0.386
LIG_Actin_WH2_2	260	278	PF00022	0.450
LIG_Actin_WH2_2	326	344	PF00022	0.529
LIG_APCC_ABBA_1	191	196	PF00400	0.446
LIG_APCC_ABBA_1	500	505	PF00400	0.293
LIG_BRCT_BRCA1_1	113	117	PF00533	0.279
LIG_BRCT_BRCA1_1	277	281	PF00533	0.434
LIG_BRCT_BRCA1_1	403	407	PF00533	0.510
LIG_FHA_1	142	148	PF00498	0.461
LIG_FHA_2	28	34	PF00498	0.384
LIG_FHA_2	333	339	PF00498	0.530
LIG_FHA_2	430	436	PF00498	0.605
LIG_FHA_2	440	446	PF00498	0.457
LIG_FHA_2	63	69	PF00498	0.557
LIG_LIR_Gen_1	291	300	PF02991	0.529
LIG_LIR_LC3C_4	169	174	PF02991	0.420
LIG_LIR_Nem_3	105	111	PF02991	0.377
LIG_LIR_Nem_3	162	166	PF02991	0.462
LIG_LIR_Nem_3	291	295	PF02991	0.529
LIG_LIR_Nem_3	404	410	PF02991	0.571
LIG_MYND_1	62	66	PF01753	0.482
LIG_Pex14_1	108	112	PF04695	0.477
LIG_Pex14_2	403	407	PF04695	0.510
LIG_SH2_CRK	112	116	PF00017	0.368
LIG_SH2_NCK_1	431	435	PF00017	0.491
LIG_SH2_PTP2	475	478	PF00017	0.356
LIG_SH2_SRC	503	506	PF00017	0.359
LIG_SH2_STAP1	143	147	PF00017	0.424
LIG_SH2_STAP1	47	51	PF00017	0.593
LIG_SH2_STAP1	8	12	PF00017	0.549
LIG_SH2_STAT5	112	115	PF00017	0.470
LIG_SH2_STAT5	143	146	PF00017	0.424
LIG_SH2_STAT5	194	197	PF00017	0.443
LIG_SH2_STAT5	431	434	PF00017	0.528
LIG_SH2_STAT5	475	478	PF00017	0.362
LIG_SH2_STAT5	503	506	PF00017	0.337
LIG_SH3_3	150	156	PF00018	0.552
LIG_SH3_3	20	26	PF00018	0.542
LIG_SH3_3	258	264	PF00018	0.450
LIG_SH3_3	388	394	PF00018	0.734
LIG_SH3_3	406	412	PF00018	0.530
LIG_SUMO_SIM_anti_2	489	496	PF11976	0.434
LIG_SUMO_SIM_par_1	483	489	PF11976	0.258
LIG_TRAF2_1	67	70	PF00917	0.533
MOD_CDC14_SPxK_1	408	411	PF00782	0.452
MOD_CDK_SPK_2	439	444	PF00069	0.480
MOD_CDK_SPxK_1	405	411	PF00069	0.451
MOD_CDK_SPxxK_3	152	159	PF00069	0.529
MOD_CDK_SPxxK_3	474	481	PF00069	0.327
MOD_CK1_1	102	108	PF00069	0.347
MOD_CK1_1	136	142	PF00069	0.380
MOD_CK1_1	291	297	PF00069	0.536
MOD_CK1_1	299	305	PF00069	0.543
MOD_CK1_1	363	369	PF00069	0.601
MOD_CK1_1	384	390	PF00069	0.498
MOD_CK1_1	489	495	PF00069	0.329
MOD_CK2_1	332	338	PF00069	0.530
MOD_CK2_1	376	382	PF00069	0.491
MOD_CK2_1	439	445	PF00069	0.539
MOD_CK2_1	474	480	PF00069	0.326
MOD_CK2_1	62	68	PF00069	0.556
MOD_GlcNHglycan	179	182	PF01048	0.249
MOD_GlcNHglycan	298	301	PF01048	0.246
MOD_GlcNHglycan	304	307	PF01048	0.271
MOD_GlcNHglycan	349	352	PF01048	0.241
MOD_GlcNHglycan	362	365	PF01048	0.289
MOD_GlcNHglycan	422	425	PF01048	0.403
MOD_GSK3_1	148	155	PF00069	0.441
MOD_GSK3_1	251	258	PF00069	0.459
MOD_GSK3_1	298	305	PF00069	0.456
MOD_GSK3_1	372	379	PF00069	0.527
MOD_GSK3_1	401	408	PF00069	0.580
MOD_GSK3_1	457	464	PF00069	0.377
MOD_GSK3_1	489	496	PF00069	0.340
MOD_LATS_1	296	302	PF00433	0.488
MOD_N-GLC_1	318	323	PF02516	0.383
MOD_N-GLC_1	41	46	PF02516	0.518
MOD_N-GLC_1	419	424	PF02516	0.444
MOD_N-GLC_1	489	494	PF02516	0.445
MOD_NEK2_1	111	116	PF00069	0.472
MOD_NEK2_1	228	233	PF00069	0.438
MOD_NEK2_1	244	249	PF00069	0.373
MOD_NEK2_1	360	365	PF00069	0.470
MOD_NEK2_1	376	381	PF00069	0.507
MOD_NEK2_1	429	434	PF00069	0.528
MOD_NEK2_1	436	441	PF00069	0.511
MOD_NEK2_1	486	491	PF00069	0.344
MOD_OFUCOSY	381	388	PF10250	0.412
MOD_OFUCOSY	96	103	PF10250	0.431
MOD_PIKK_1	299	305	PF00454	0.374
MOD_PIKK_1	83	89	PF00454	0.669
MOD_PKA_2	123	129	PF00069	0.447
MOD_PKA_2	275	281	PF00069	0.443
MOD_PKA_2	420	426	PF00069	0.441
MOD_PKA_2	429	435	PF00069	0.507
MOD_Plk_1	318	324	PF00069	0.450
MOD_Plk_1	372	378	PF00069	0.489
MOD_Plk_1	457	463	PF00069	0.270
MOD_Plk_1	47	53	PF00069	0.497
MOD_Plk_1	489	495	PF00069	0.373
MOD_Plk_4	148	154	PF00069	0.529
MOD_Plk_4	288	294	PF00069	0.535
MOD_Plk_4	372	378	PF00069	0.323
MOD_Plk_4	411	417	PF00069	0.585
MOD_Plk_4	489	495	PF00069	0.396
MOD_ProDKin_1	152	158	PF00069	0.545
MOD_ProDKin_1	381	387	PF00069	0.558
MOD_ProDKin_1	405	411	PF00069	0.542
MOD_ProDKin_1	439	445	PF00069	0.521
MOD_ProDKin_1	474	480	PF00069	0.369
MOD_ProDKin_1	62	68	PF00069	0.712
TRG_DiLeu_BaEn_1	186	191	PF01217	0.400
TRG_DiLeu_BaEn_1	311	316	PF01217	0.458
TRG_DiLeu_BaEn_1	480	485	PF01217	0.254
TRG_ENDOCYTIC_2	112	115	PF00928	0.323
TRG_ENDOCYTIC_2	143	146	PF00928	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT7	Leptomonas seymouri	59%	100%
A0A0S4JTG4	Bodo saltans	44%	100%
A0A1X0PAA8	Trypanosomatidae	44%	100%
A0A3Q8IJ00	Leishmania donovani	22%	100%
A0A3Q8IN46	Leishmania donovani	78%	100%
A0A3R7KZP3	Trypanosoma rangeli	44%	100%
A4HNQ5	Leishmania braziliensis	22%	100%
A4I9S4	Leishmania infantum	78%	100%
A4ICU0	Leishmania infantum	22%	100%
C9ZMV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B4T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q391	Leishmania major	79%	96%
V5DJT2	Trypanosoma cruzi	43%	100%