Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of Unknown Function (DUF1042), putative

Species:

Leishmania braziliensis

UniProt:

A4HAN0_LEIBR

TriTrypDb:

LbrM.20.1150 , LBRM2903_200020000

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	11
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HAN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAN0

Function

Biological processes
Term	Name	Level	Count
GO:0033043	regulation of organelle organization	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.405
CLV_NRD_NRD_1	118	120	PF00675	0.413
CLV_NRD_NRD_1	78	80	PF00675	0.205
CLV_PCSK_FUR_1	25	29	PF00082	0.218
CLV_PCSK_KEX2_1	118	120	PF00082	0.413
CLV_PCSK_KEX2_1	166	168	PF00082	0.676
CLV_PCSK_KEX2_1	27	29	PF00082	0.205
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.588
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.205
CLV_PCSK_SKI1_1	236	240	PF00082	0.400
CLV_PCSK_SKI1_1	45	49	PF00082	0.261
CLV_Separin_Metazoa	242	246	PF03568	0.375
DOC_ANK_TNKS_1	31	38	PF00023	0.499
DOC_CYCLIN_RxL_1	76	84	PF00134	0.405
DOC_MAPK_FxFP_2	46	49	PF00069	0.418
DOC_MAPK_gen_1	103	112	PF00069	0.499
DOC_MAPK_gen_1	236	246	PF00069	0.351
DOC_MAPK_MEF2A_6	103	112	PF00069	0.459
DOC_PP1_RVXF_1	77	84	PF00149	0.405
DOC_PP4_FxxP_1	170	173	PF00568	0.444
DOC_PP4_FxxP_1	46	49	PF00568	0.418
DOC_PP4_FxxP_1	83	86	PF00568	0.418
DOC_USP7_MATH_1	137	141	PF00917	0.635
DOC_USP7_MATH_1	59	63	PF00917	0.405
DOC_USP7_UBL2_3	76	80	PF12436	0.499
LIG_Actin_WH2_2	98	113	PF00022	0.364
LIG_BIR_II_1	1	5	PF00653	0.496
LIG_BRCT_BRCA1_1	2	6	PF00533	0.468
LIG_FHA_1	227	233	PF00498	0.298
LIG_FHA_1	73	79	PF00498	0.347
LIG_FHA_2	115	121	PF00498	0.394
LIG_FHA_2	14	20	PF00498	0.419
LIG_FHA_2	220	226	PF00498	0.379
LIG_FHA_2	5	11	PF00498	0.397
LIG_Integrin_RGD_1	147	149	PF01839	0.478
LIG_LIR_Apic_2	169	173	PF02991	0.445
LIG_LIR_Gen_1	13	23	PF02991	0.242
LIG_LIR_Gen_1	68	78	PF02991	0.405
LIG_LIR_Nem_3	13	18	PF02991	0.242
LIG_LIR_Nem_3	68	73	PF02991	0.405
LIG_SH2_SRC	57	60	PF00017	0.461
LIG_SH2_STAT3	221	224	PF00017	0.492
LIG_SH2_STAT5	15	18	PF00017	0.405
LIG_SH2_STAT5	221	224	PF00017	0.492
LIG_SH2_STAT5	57	60	PF00017	0.411
LIG_SH2_STAT5	82	85	PF00017	0.499
LIG_SH3_3	168	174	PF00018	0.641
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.401
LIG_SUMO_SIM_par_1	228	235	PF11976	0.397
LIG_TRAF2_1	222	225	PF00917	0.486
LIG_TRAF2_1	86	89	PF00917	0.436
LIG_WW_3	173	177	PF00397	0.433
MOD_CK1_1	177	183	PF00069	0.683
MOD_CK2_1	219	225	PF00069	0.326
MOD_CK2_1	36	42	PF00069	0.499
MOD_GlcNHglycan	182	185	PF01048	0.564
MOD_GSK3_1	154	161	PF00069	0.604
MOD_GSK3_1	162	169	PF00069	0.603
MOD_GSK3_1	176	183	PF00069	0.671
MOD_NEK2_1	226	231	PF00069	0.366
MOD_PIKK_1	137	143	PF00454	0.581
MOD_PIKK_1	177	183	PF00454	0.616
MOD_PIKK_1	249	255	PF00454	0.287
MOD_PKA_1	166	172	PF00069	0.446
MOD_PKA_2	162	168	PF00069	0.743
MOD_PKA_2	226	232	PF00069	0.354
MOD_Plk_1	208	214	PF00069	0.448
MOD_Plk_1	219	225	PF00069	0.353
MOD_Plk_2-3	13	19	PF00069	0.373
MOD_Plk_2-3	36	42	PF00069	0.499
MOD_Plk_4	13	19	PF00069	0.373
MOD_Plk_4	166	172	PF00069	0.620
MOD_Plk_4	226	232	PF00069	0.283
MOD_SUMO_for_1	238	241	PF00179	0.387
MOD_SUMO_for_1	246	249	PF00179	0.355
MOD_SUMO_rev_2	242	252	PF00179	0.360
TRG_DiLeu_BaEn_3	88	94	PF01217	0.499
TRG_ENDOCYTIC_2	15	18	PF00928	0.405
TRG_ENDOCYTIC_2	82	85	PF00928	0.499
TRG_NES_CRM1_1	235	249	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.205

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G9	Leptomonas seymouri	65%	100%
A0A0S4JXH9	Bodo saltans	44%	100%
A0A1X0P9A7	Trypanosomatidae	51%	94%
A0A3S5H7W3	Leishmania donovani	77%	99%
A0A422NGQ0	Trypanosoma rangeli	51%	100%
A4I9S2	Leishmania infantum	76%	99%
C9ZMW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9B4T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q0IH24	Xenopus laevis	38%	100%
Q4Q393	Leishmania major	77%	100%
Q9Y4P9	Homo sapiens	37%	100%