Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAM8_LEIBR

TriTrypDb:

LbrM.20.1130 , LBRM2903_200019800

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.427
CLV_C14_Caspase3-7	200	204	PF00656	0.444
CLV_NRD_NRD_1	250	252	PF00675	0.661
CLV_NRD_NRD_1	312	314	PF00675	0.614
CLV_NRD_NRD_1	328	330	PF00675	0.686
CLV_NRD_NRD_1	39	41	PF00675	0.532
CLV_PCSK_KEX2_1	250	252	PF00082	0.661
CLV_PCSK_KEX2_1	312	314	PF00082	0.614
CLV_PCSK_KEX2_1	328	330	PF00082	0.686
CLV_PCSK_KEX2_1	39	41	PF00082	0.532
CLV_PCSK_SKI1_1	333	337	PF00082	0.566
CLV_PCSK_SKI1_1	348	352	PF00082	0.273
CLV_PCSK_SKI1_1	380	384	PF00082	0.462
CLV_PCSK_SKI1_1	39	43	PF00082	0.535
DEG_APCC_DBOX_1	312	320	PF00400	0.604
DEG_APCC_DBOX_1	379	387	PF00400	0.505
DEG_APCC_DBOX_1	38	46	PF00400	0.545
DEG_SPOP_SBC_1	131	135	PF00917	0.594
DEG_SPOP_SBC_1	210	214	PF00917	0.561
DEG_SPOP_SBC_1	85	89	PF00917	0.562
DOC_CKS1_1	121	126	PF01111	0.599
DOC_CKS1_1	342	347	PF01111	0.495
DOC_CYCLIN_RxL_1	345	352	PF00134	0.599
DOC_CYCLIN_RxL_1	37	46	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.455
DOC_MAPK_gen_1	312	318	PF00069	0.606
DOC_MAPK_gen_1	328	336	PF00069	0.571
DOC_MAPK_gen_1	376	383	PF00069	0.572
DOC_MAPK_gen_1	39	45	PF00069	0.530
DOC_MAPK_HePTP_8	330	342	PF00069	0.670
DOC_MAPK_MEF2A_6	217	224	PF00069	0.610
DOC_MAPK_MEF2A_6	333	342	PF00069	0.520
DOC_PP4_FxxP_1	394	397	PF00568	0.499
DOC_USP7_MATH_1	112	116	PF00917	0.671
DOC_USP7_MATH_1	49	53	PF00917	0.733
DOC_USP7_MATH_1	60	64	PF00917	0.501
DOC_USP7_MATH_1	85	89	PF00917	0.668
DOC_USP7_MATH_1	95	99	PF00917	0.562
DOC_WW_Pin1_4	120	125	PF00397	0.736
DOC_WW_Pin1_4	288	293	PF00397	0.663
DOC_WW_Pin1_4	341	346	PF00397	0.506
DOC_WW_Pin1_4	81	86	PF00397	0.621
DOC_WW_Pin1_4	99	104	PF00397	0.810
LIG_14-3-3_CanoR_1	217	223	PF00244	0.514
LIG_14-3-3_CanoR_1	276	284	PF00244	0.626
LIG_14-3-3_CanoR_1	40	46	PF00244	0.529
LIG_Actin_WH2_2	270	288	PF00022	0.546
LIG_BRCT_BRCA1_1	220	224	PF00533	0.481
LIG_BRCT_BRCA1_1	351	355	PF00533	0.367
LIG_deltaCOP1_diTrp_1	5	11	PF00928	0.657
LIG_FHA_1	213	219	PF00498	0.697
LIG_FHA_1	280	286	PF00498	0.788
LIG_FHA_1	342	348	PF00498	0.402
LIG_FHA_2	223	229	PF00498	0.508
LIG_FHA_2	304	310	PF00498	0.450
LIG_FHA_2	356	362	PF00498	0.501
LIG_GBD_Chelix_1	346	354	PF00786	0.508
LIG_LIR_Gen_1	301	310	PF02991	0.412
LIG_LIR_Nem_3	139	145	PF02991	0.522
LIG_LIR_Nem_3	301	307	PF02991	0.424
LIG_LIR_Nem_3	349	354	PF02991	0.457
LIG_LIR_Nem_3	389	394	PF02991	0.580
LIG_LIR_Nem_3	5	10	PF02991	0.662
LIG_LIR_Nem_3	80	86	PF02991	0.609
LIG_MAD2	40	48	PF02301	0.642
LIG_NRBOX	181	187	PF00104	0.595
LIG_PCNA_yPIPBox_3	380	394	PF02747	0.511
LIG_Pex14_2	351	355	PF04695	0.514
LIG_Pex14_2	369	373	PF04695	0.499
LIG_PTB_Apo_2	44	51	PF02174	0.446
LIG_SH2_CRK	38	42	PF00017	0.553
LIG_SH2_STAP1	138	142	PF00017	0.631
LIG_SH2_STAP1	145	149	PF00017	0.609
LIG_SH2_STAP1	189	193	PF00017	0.614
LIG_SH2_STAT5	149	152	PF00017	0.698
LIG_SH3_1	116	122	PF00018	0.589
LIG_SH3_1	321	327	PF00018	0.527
LIG_SH3_2	324	329	PF14604	0.647
LIG_SH3_3	114	120	PF00018	0.705
LIG_SH3_3	321	327	PF00018	0.527
LIG_SH3_3	339	345	PF00018	0.628
LIG_SH3_3	45	51	PF00018	0.600
LIG_SH3_3	65	71	PF00018	0.584
LIG_SH3_3	75	81	PF00018	0.559
LIG_SUMO_SIM_par_1	41	46	PF11976	0.529
LIG_TRAF2_1	306	309	PF00917	0.570
LIG_TRAF2_2	75	80	PF00917	0.569
LIG_WW_2	119	122	PF00397	0.588
MOD_CDK_SPxxK_3	120	127	PF00069	0.599
MOD_CDK_SPxxK_3	341	348	PF00069	0.605
MOD_CK1_1	102	108	PF00069	0.712
MOD_CK1_1	111	117	PF00069	0.557
MOD_CK1_1	126	132	PF00069	0.846
MOD_CK1_1	134	140	PF00069	0.702
MOD_CK1_1	141	147	PF00069	0.688
MOD_CK1_1	148	154	PF00069	0.696
MOD_CK1_1	204	210	PF00069	0.744
MOD_CK1_1	212	218	PF00069	0.648
MOD_CK1_1	349	355	PF00069	0.508
MOD_CK1_1	63	69	PF00069	0.790
MOD_CK1_1	84	90	PF00069	0.633
MOD_CK2_1	222	228	PF00069	0.506
MOD_CK2_1	303	309	PF00069	0.457
MOD_CK2_1	355	361	PF00069	0.599
MOD_CK2_1	85	91	PF00069	0.671
MOD_GlcNHglycan	110	113	PF01048	0.673
MOD_GlcNHglycan	160	163	PF01048	0.724
MOD_GlcNHglycan	206	209	PF01048	0.772
MOD_GlcNHglycan	259	262	PF01048	0.619
MOD_GlcNHglycan	33	36	PF01048	0.607
MOD_GlcNHglycan	351	354	PF01048	0.377
MOD_GlcNHglycan	62	65	PF01048	0.837
MOD_GSK3_1	108	115	PF00069	0.636
MOD_GSK3_1	123	130	PF00069	0.741
MOD_GSK3_1	132	139	PF00069	0.696
MOD_GSK3_1	140	147	PF00069	0.681
MOD_GSK3_1	148	155	PF00069	0.653
MOD_GSK3_1	198	205	PF00069	0.549
MOD_GSK3_1	218	225	PF00069	0.444
MOD_GSK3_1	268	275	PF00069	0.618
MOD_GSK3_1	51	58	PF00069	0.754
MOD_GSK3_1	81	88	PF00069	0.806
MOD_GSK3_1	95	102	PF00069	0.578
MOD_LATS_1	125	131	PF00433	0.720
MOD_NEK2_1	211	216	PF00069	0.538
MOD_NEK2_1	346	351	PF00069	0.494
MOD_NEK2_1	355	360	PF00069	0.495
MOD_NEK2_1	386	391	PF00069	0.507
MOD_NEK2_1	43	48	PF00069	0.553
MOD_PIKK_1	250	256	PF00454	0.697
MOD_PIKK_1	95	101	PF00454	0.579
MOD_PK_1	127	133	PF00069	0.691
MOD_PKA_1	250	256	PF00069	0.697
MOD_PKA_2	126	132	PF00069	0.701
MOD_PKA_2	153	159	PF00069	0.628
MOD_PKA_2	201	207	PF00069	0.646
MOD_PKA_2	250	256	PF00069	0.608
MOD_PKA_2	268	274	PF00069	0.773
MOD_PKA_2	275	281	PF00069	0.514
MOD_Plk_1	127	133	PF00069	0.742
MOD_Plk_1	355	361	PF00069	0.599
MOD_Plk_2-3	238	244	PF00069	0.593
MOD_Plk_4	145	151	PF00069	0.579
MOD_Plk_4	173	179	PF00069	0.535
MOD_Plk_4	268	274	PF00069	0.539
MOD_Plk_4	346	352	PF00069	0.498
MOD_Plk_4	386	392	PF00069	0.466
MOD_ProDKin_1	120	126	PF00069	0.737
MOD_ProDKin_1	288	294	PF00069	0.662
MOD_ProDKin_1	341	347	PF00069	0.503
MOD_ProDKin_1	81	87	PF00069	0.622
MOD_ProDKin_1	99	105	PF00069	0.810
MOD_SUMO_rev_2	87	96	PF00179	0.800
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.394
TRG_ENDOCYTIC_2	38	41	PF00928	0.553
TRG_ER_diArg_1	249	251	PF00400	0.640
TRG_ER_diArg_1	312	314	PF00400	0.490
TRG_ER_diArg_1	327	329	PF00400	0.677
TRG_ER_diArg_1	38	40	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V9	Leptomonas seymouri	39%	67%
A0A3Q8II07	Leishmania donovani	68%	100%
A4I9S0	Leishmania infantum	68%	72%
E9B4T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q395	Leishmania major	68%	96%