Putative ubiquitin-conjugating enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme E2, putative

Species:

Leishmania braziliensis

UniProt:

A4HAM6_LEIBR

TriTrypDb:

LbrM.20.1110 , LBRM2903_200025000

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAM6

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016874	ligase activity	2	4
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.369
CLV_PCSK_KEX2_1	7	9	PF00082	0.369
CLV_PCSK_SKI1_1	121	125	PF00082	0.341
CLV_PCSK_SKI1_1	83	87	PF00082	0.287
DOC_CKS1_1	111	116	PF01111	0.357
DOC_MAPK_gen_1	4	13	PF00069	0.373
DOC_PP4_FxxP_1	68	71	PF00568	0.246
DOC_PP4_FxxP_1	77	80	PF00568	0.287
DOC_USP7_MATH_1	161	165	PF00917	0.459
DOC_USP7_MATH_1	54	58	PF00917	0.287
DOC_WW_Pin1_4	110	115	PF00397	0.357
DOC_WW_Pin1_4	145	150	PF00397	0.357
LIG_14-3-3_CanoR_1	22	30	PF00244	0.355
LIG_14-3-3_CanoR_1	83	92	PF00244	0.246
LIG_BIR_II_1	1	5	PF00653	0.428
LIG_FHA_1	110	116	PF00498	0.357
LIG_FHA_1	130	136	PF00498	0.315
LIG_FHA_1	61	67	PF00498	0.287
LIG_FHA_2	145	151	PF00498	0.316
LIG_FHA_2	60	66	PF00498	0.357
LIG_LIR_Apic_2	65	71	PF02991	0.312
LIG_LIR_Apic_2	74	80	PF02991	0.270
LIG_LIR_Gen_1	12	20	PF02991	0.376
LIG_LIR_Gen_1	132	141	PF02991	0.302
LIG_LIR_Gen_1	62	71	PF02991	0.291
LIG_LIR_Nem_3	12	16	PF02991	0.365
LIG_LIR_Nem_3	129	133	PF02991	0.306
LIG_LIR_Nem_3	62	67	PF02991	0.333
LIG_MAD2	83	91	PF02301	0.287
LIG_SH2_CRK	133	137	PF00017	0.357
LIG_SH2_CRK	64	68	PF00017	0.287
LIG_SH2_STAP1	64	68	PF00017	0.287
LIG_SH3_3	108	114	PF00018	0.287
LIG_SH3_3	48	54	PF00018	0.287
LIG_SH3_3	73	79	PF00018	0.287
LIG_SH3_5	71	75	PF00018	0.246
LIG_TRAF2_1	148	151	PF00917	0.287
MOD_CK1_1	145	151	PF00069	0.246
MOD_CK1_1	2	8	PF00069	0.546
MOD_CK1_1	21	27	PF00069	0.340
MOD_CK2_1	144	150	PF00069	0.316
MOD_GlcNHglycan	1	4	PF01048	0.448
MOD_GlcNHglycan	40	43	PF01048	0.378
MOD_GSK3_1	109	116	PF00069	0.248
MOD_GSK3_1	159	166	PF00069	0.499
MOD_GSK3_1	18	25	PF00069	0.492
MOD_NEK2_1	144	149	PF00069	0.294
MOD_NEK2_2	23	28	PF00069	0.357
MOD_NEK2_2	54	59	PF00069	0.287
MOD_PKA_2	159	165	PF00069	0.468
MOD_PKA_2	21	27	PF00069	0.388
MOD_Plk_4	54	60	PF00069	0.287
MOD_ProDKin_1	110	116	PF00069	0.357
MOD_ProDKin_1	145	151	PF00069	0.357
MOD_SUMO_rev_2	107	112	PF00179	0.328
TRG_ENDOCYTIC_2	133	136	PF00928	0.357
TRG_ENDOCYTIC_2	64	67	PF00928	0.287
TRG_ER_diArg_1	47	50	PF00400	0.412
TRG_ER_diArg_1	6	8	PF00400	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA94	Leptomonas seymouri	54%	100%
A0A0S4JGV6	Bodo saltans	25%	100%
A0A0S4JK56	Bodo saltans	27%	100%
A0A1X0NT81	Trypanosomatidae	26%	79%
A0A1X0NW06	Trypanosomatidae	28%	100%
A0A3Q8II37	Leishmania donovani	83%	100%
A0A422MW82	Trypanosoma rangeli	29%	100%
A0A422NDI3	Trypanosoma rangeli	27%	78%
A0A422NWQ7	Trypanosoma rangeli	28%	100%
A3KN22	Bos taurus	29%	91%
A4I9W7	Leishmania infantum	83%	100%
C9ZJA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	67%
C9ZMR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZW85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B4Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O14933	Homo sapiens	24%	100%
O74196	Colletotrichum gloeosporioides	32%	100%
O74201	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	93%
P06104	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	97%
P0CS16	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	98%
P0CS17	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	98%
P23566	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P25153	Drosophila melanogaster	25%	100%
P25865	Arabidopsis thaliana	26%	100%
P25866	Triticum aestivum	26%	100%
P35130	Medicago sativa	26%	100%
P42745	Arabidopsis thaliana	26%	100%
P42746	Arabidopsis thaliana	26%	100%
P43102	Candida albicans	29%	100%
P49427	Homo sapiens	29%	70%
P49459	Homo sapiens	26%	100%
P52478	Caenorhabditis elegans	25%	86%
P52487	Drosophila melanogaster	30%	100%
P52493	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
P61081	Homo sapiens	29%	91%
P61082	Mus musculus	29%	91%
P63146	Homo sapiens	26%	100%
P63147	Mus musculus	26%	100%
P63148	Oryctolagus cuniculus	26%	100%
P63149	Rattus norvegicus	26%	100%
P78717	Fusarium solani	25%	100%
Q29503	Oryctolagus cuniculus	29%	70%
Q32P99	Bos taurus	26%	100%
Q4PFA5	Ustilago maydis (strain 521 / FGSC 9021)	25%	90%
Q4Q346	Leishmania major	80%	100%
Q4WLA7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54XS6	Dictyostelium discoideum	26%	100%
Q553F3	Dictyostelium discoideum	25%	100%
Q58FS2	Trichoderma harzianum	26%	100%
Q5UQC9	Acanthamoeba polyphaga mimivirus	21%	100%
Q6BU36	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	99%
Q6C093	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q6C9W0	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	93%
Q6CUD9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q6DCZ9	Xenopus laevis	30%	91%
Q6FR76	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	99%
Q6P8D9	Xenopus tropicalis	30%	91%
Q6ZWZ2	Mus musculus	29%	70%
Q712K3	Homo sapiens	29%	70%
Q75EB8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	98%
Q8CFI2	Mus musculus	29%	71%
Q8L7T3	Arabidopsis thaliana	29%	92%
Q8LGF7	Arabidopsis thaliana	28%	100%
Q95044	Spisula solidissima	27%	94%
Q96UP5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q9LJZ5	Arabidopsis thaliana	29%	92%
Q9VSF3	Drosophila melanogaster	26%	92%
Q9VTY6	Drosophila melanogaster	30%	93%
Q9Z255	Mus musculus	26%	100%
V5BVS1	Trypanosoma cruzi	26%	74%
V5BYE2	Trypanosoma cruzi	26%	100%