Putative ATP dependent DEAD-box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP dependent DEAD-box helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAM5_LEIBR

TriTrypDb:

LbrM.20.1100 , LBRM2903_200019100

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000313	organellar ribosome	6	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005761	mitochondrial ribosome	7	1
GO:0005840	ribosome	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAM5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004386	helicase activity	2	7
GO:0005488	binding	1	4
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0000166	nucleotide binding	3	3
GO:0003676	nucleic acid binding	3	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.780
CLV_C14_Caspase3-7	225	229	PF00656	0.641
CLV_NRD_NRD_1	13	15	PF00675	0.571
CLV_NRD_NRD_1	221	223	PF00675	0.612
CLV_NRD_NRD_1	326	328	PF00675	0.492
CLV_NRD_NRD_1	361	363	PF00675	0.456
CLV_NRD_NRD_1	365	367	PF00675	0.484
CLV_NRD_NRD_1	399	401	PF00675	0.337
CLV_NRD_NRD_1	539	541	PF00675	0.445
CLV_NRD_NRD_1	62	64	PF00675	0.561
CLV_NRD_NRD_1	686	688	PF00675	0.696
CLV_NRD_NRD_1	713	715	PF00675	0.479
CLV_PCSK_FUR_1	60	64	PF00082	0.622
CLV_PCSK_KEX2_1	13	15	PF00082	0.571
CLV_PCSK_KEX2_1	221	223	PF00082	0.564
CLV_PCSK_KEX2_1	326	328	PF00082	0.560
CLV_PCSK_KEX2_1	361	363	PF00082	0.433
CLV_PCSK_KEX2_1	365	367	PF00082	0.463
CLV_PCSK_KEX2_1	399	401	PF00082	0.351
CLV_PCSK_KEX2_1	538	540	PF00082	0.499
CLV_PCSK_KEX2_1	62	64	PF00082	0.587
CLV_PCSK_KEX2_1	623	625	PF00082	0.402
CLV_PCSK_KEX2_1	688	690	PF00082	0.674
CLV_PCSK_KEX2_1	713	715	PF00082	0.466
CLV_PCSK_KEX2_1	752	754	PF00082	0.497
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.402
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.699
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.504
CLV_PCSK_PC7_1	361	367	PF00082	0.525
CLV_PCSK_SKI1_1	110	114	PF00082	0.677
CLV_PCSK_SKI1_1	178	182	PF00082	0.555
CLV_PCSK_SKI1_1	198	202	PF00082	0.379
CLV_PCSK_SKI1_1	448	452	PF00082	0.392
CLV_PCSK_SKI1_1	46	50	PF00082	0.587
CLV_PCSK_SKI1_1	523	527	PF00082	0.518
CLV_PCSK_SKI1_1	565	569	PF00082	0.346
CLV_PCSK_SKI1_1	689	693	PF00082	0.571
CLV_PCSK_SKI1_1	85	89	PF00082	0.532
CLV_Separin_Metazoa	167	171	PF03568	0.508
CLV_Separin_Metazoa	420	424	PF03568	0.412
DEG_APCC_DBOX_1	537	545	PF00400	0.401
DEG_COP1_1	479	490	PF00400	0.401
DEG_MDM2_SWIB_1	560	568	PF02201	0.392
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.502
DOC_MAPK_gen_1	326	334	PF00069	0.481
DOC_MAPK_gen_1	502	512	PF00069	0.378
DOC_MAPK_gen_1	538	546	PF00069	0.353
DOC_MAPK_MEF2A_6	284	292	PF00069	0.357
DOC_MAPK_MEF2A_6	448	455	PF00069	0.375
DOC_MAPK_MEF2A_6	727	735	PF00069	0.460
DOC_MAPK_NFAT4_5	448	456	PF00069	0.372
DOC_MAPK_RevD_3	524	539	PF00069	0.416
DOC_PP1_RVXF_1	509	515	PF00149	0.363
DOC_PP1_RVXF_1	521	528	PF00149	0.368
DOC_PP2B_LxvP_1	239	242	PF13499	0.335
DOC_PP2B_LxvP_1	29	32	PF13499	0.491
DOC_PP2B_LxvP_1	526	529	PF13499	0.417
DOC_PP4_FxxP_1	692	695	PF00568	0.561
DOC_USP7_MATH_1	134	138	PF00917	0.733
DOC_USP7_MATH_1	171	175	PF00917	0.635
DOC_USP7_MATH_1	223	227	PF00917	0.649
DOC_USP7_MATH_1	242	246	PF00917	0.488
DOC_USP7_MATH_1	32	36	PF00917	0.741
DOC_USP7_MATH_1	454	458	PF00917	0.415
DOC_USP7_MATH_1	580	584	PF00917	0.365
DOC_USP7_UBL2_3	561	565	PF12436	0.549
DOC_USP7_UBL2_3	746	750	PF12436	0.544
DOC_WW_Pin1_4	137	142	PF00397	0.725
DOC_WW_Pin1_4	678	683	PF00397	0.487
DOC_WW_Pin1_4	90	95	PF00397	0.587
LIG_14-3-3_CanoR_1	132	141	PF00244	0.796
LIG_14-3-3_CanoR_1	14	23	PF00244	0.605
LIG_14-3-3_CanoR_1	150	157	PF00244	0.466
LIG_14-3-3_CanoR_1	365	373	PF00244	0.414
LIG_14-3-3_CanoR_1	505	509	PF00244	0.423
LIG_14-3-3_CanoR_1	672	678	PF00244	0.641
LIG_Actin_WH2_2	383	401	PF00022	0.382
LIG_AP2alpha_2	765	767	PF02296	0.661
LIG_BIR_III_4	228	232	PF00653	0.594
LIG_BRCT_BRCA1_1	160	164	PF00533	0.676
LIG_BRCT_BRCA1_1	341	345	PF00533	0.486
LIG_BRCT_BRCA1_1	571	575	PF00533	0.391
LIG_BRCT_BRCA1_1	582	586	PF00533	0.338
LIG_BRCT_BRCA1_1	632	636	PF00533	0.572
LIG_deltaCOP1_diTrp_1	339	345	PF00928	0.397
LIG_deltaCOP1_diTrp_1	563	566	PF00928	0.404
LIG_FHA_1	18	24	PF00498	0.626
LIG_FHA_1	213	219	PF00498	0.669
LIG_FHA_1	283	289	PF00498	0.368
LIG_FHA_1	31	37	PF00498	0.662
LIG_FHA_1	375	381	PF00498	0.417
LIG_FHA_1	477	483	PF00498	0.477
LIG_FHA_1	505	511	PF00498	0.426
LIG_FHA_1	52	58	PF00498	0.540
LIG_FHA_1	746	752	PF00498	0.468
LIG_FHA_2	179	185	PF00498	0.523
LIG_FHA_2	186	192	PF00498	0.510
LIG_FHA_2	346	352	PF00498	0.477
LIG_FHA_2	374	380	PF00498	0.333
LIG_LIR_Apic_2	690	695	PF02991	0.564
LIG_LIR_Gen_1	233	242	PF02991	0.456
LIG_LIR_Gen_1	24	32	PF02991	0.620
LIG_LIR_Gen_1	339	349	PF02991	0.364
LIG_LIR_Gen_1	391	398	PF02991	0.394
LIG_LIR_Gen_1	503	513	PF02991	0.373
LIG_LIR_Gen_1	563	574	PF02991	0.406
LIG_LIR_Gen_1	583	591	PF02991	0.331
LIG_LIR_Gen_1	592	600	PF02991	0.378
LIG_LIR_Gen_1	703	710	PF02991	0.525
LIG_LIR_Nem_3	233	237	PF02991	0.461
LIG_LIR_Nem_3	24	29	PF02991	0.587
LIG_LIR_Nem_3	248	254	PF02991	0.524
LIG_LIR_Nem_3	273	279	PF02991	0.408
LIG_LIR_Nem_3	339	344	PF02991	0.368
LIG_LIR_Nem_3	354	360	PF02991	0.379
LIG_LIR_Nem_3	391	395	PF02991	0.399
LIG_LIR_Nem_3	503	509	PF02991	0.355
LIG_LIR_Nem_3	563	569	PF02991	0.357
LIG_LIR_Nem_3	583	589	PF02991	0.330
LIG_LIR_Nem_3	592	597	PF02991	0.383
LIG_LIR_Nem_3	703	708	PF02991	0.545
LIG_LIR_Nem_3	89	95	PF02991	0.647
LIG_NRBOX	262	268	PF00104	0.398
LIG_PCNA_PIPBox_1	668	677	PF02747	0.550
LIG_Pex14_2	560	564	PF04695	0.425
LIG_REV1ctd_RIR_1	689	694	PF16727	0.588
LIG_SH2_CRK	251	255	PF00017	0.497
LIG_SH2_CRK	357	361	PF00017	0.336
LIG_SH2_CRK	705	709	PF00017	0.520
LIG_SH2_NCK_1	705	709	PF00017	0.520
LIG_SH2_NCK_1	92	96	PF00017	0.697
LIG_SH2_STAP1	341	345	PF00017	0.413
LIG_SH2_STAP1	675	679	PF00017	0.674
LIG_SH2_STAT3	356	359	PF00017	0.353
LIG_SH2_STAT3	675	678	PF00017	0.551
LIG_SH2_STAT5	15	18	PF00017	0.659
LIG_SH2_STAT5	397	400	PF00017	0.379
LIG_SH2_STAT5	402	405	PF00017	0.356
LIG_SH2_STAT5	508	511	PF00017	0.346
LIG_SH2_STAT5	614	617	PF00017	0.363
LIG_SH2_STAT5	675	678	PF00017	0.570
LIG_SH2_STAT5	705	708	PF00017	0.497
LIG_SH3_3	331	337	PF00018	0.404
LIG_SH3_3	408	414	PF00018	0.447
LIG_SH3_3	482	488	PF00018	0.461
LIG_SH3_3	574	580	PF00018	0.451
LIG_SH3_4	474	481	PF00018	0.612
LIG_SH3_4	746	753	PF00018	0.416
LIG_SH3_5	337	341	PF00018	0.532
LIG_TRAF2_1	78	81	PF00917	0.609
LIG_TRFH_1	663	667	PF08558	0.540
LIG_WRC_WIRS_1	494	499	PF05994	0.370
MOD_CK1_1	137	143	PF00069	0.715
MOD_CK1_1	174	180	PF00069	0.677
MOD_CK1_1	192	198	PF00069	0.470
MOD_CK1_1	213	219	PF00069	0.594
MOD_CK1_1	24	30	PF00069	0.607
MOD_CK1_1	282	288	PF00069	0.375
MOD_CK1_1	39	45	PF00069	0.555
MOD_CK1_1	593	599	PF00069	0.341
MOD_CK2_1	148	154	PF00069	0.679
MOD_CK2_1	185	191	PF00069	0.516
MOD_CK2_1	242	248	PF00069	0.418
MOD_CK2_1	345	351	PF00069	0.471
MOD_CK2_1	90	96	PF00069	0.595
MOD_GlcNHglycan	134	137	PF01048	0.782
MOD_GlcNHglycan	154	157	PF01048	0.438
MOD_GlcNHglycan	191	194	PF01048	0.556
MOD_GlcNHglycan	23	26	PF01048	0.588
MOD_GlcNHglycan	234	237	PF01048	0.445
MOD_GlcNHglycan	244	247	PF01048	0.430
MOD_GlcNHglycan	263	266	PF01048	0.304
MOD_GlcNHglycan	281	284	PF01048	0.375
MOD_GlcNHglycan	285	288	PF01048	0.346
MOD_GlcNHglycan	456	459	PF01048	0.346
MOD_GlcNHglycan	482	485	PF01048	0.539
MOD_GlcNHglycan	488	491	PF01048	0.484
MOD_GlcNHglycan	535	538	PF01048	0.311
MOD_GSK3_1	13	20	PF00069	0.538
MOD_GSK3_1	132	139	PF00069	0.687
MOD_GSK3_1	148	155	PF00069	0.528
MOD_GSK3_1	174	181	PF00069	0.589
MOD_GSK3_1	185	192	PF00069	0.493
MOD_GSK3_1	208	215	PF00069	0.608
MOD_GSK3_1	279	286	PF00069	0.424
MOD_GSK3_1	32	39	PF00069	0.642
MOD_GSK3_1	476	483	PF00069	0.492
MOD_GSK3_1	589	596	PF00069	0.452
MOD_GSK3_1	86	93	PF00069	0.540
MOD_LATS_1	717	723	PF00433	0.554
MOD_N-GLC_1	39	44	PF02516	0.676
MOD_NEK2_1	148	153	PF00069	0.550
MOD_NEK2_1	306	311	PF00069	0.407
MOD_NEK2_1	317	322	PF00069	0.381
MOD_NEK2_1	345	350	PF00069	0.434
MOD_NEK2_1	364	369	PF00069	0.367
MOD_NEK2_1	373	378	PF00069	0.385
MOD_NEK2_1	4	9	PF00069	0.660
MOD_NEK2_1	435	440	PF00069	0.372
MOD_NEK2_1	755	760	PF00069	0.517
MOD_NEK2_2	493	498	PF00069	0.362
MOD_PIKK_1	134	140	PF00454	0.722
MOD_PIKK_1	148	154	PF00454	0.786
MOD_PIKK_1	719	725	PF00454	0.557
MOD_PIKK_1	76	82	PF00454	0.677
MOD_PKA_1	13	19	PF00069	0.583
MOD_PKA_1	365	371	PF00069	0.512
MOD_PKA_2	13	19	PF00069	0.671
MOD_PKA_2	185	191	PF00069	0.589
MOD_PKA_2	21	27	PF00069	0.631
MOD_PKA_2	364	370	PF00069	0.525
MOD_PKA_2	504	510	PF00069	0.447
MOD_PKA_2	516	522	PF00069	0.382
MOD_PKA_2	654	660	PF00069	0.533
MOD_Plk_1	171	177	PF00069	0.609
MOD_Plk_1	339	345	PF00069	0.377
MOD_Plk_1	703	709	PF00069	0.533
MOD_Plk_2-3	158	164	PF00069	0.611
MOD_Plk_2-3	630	636	PF00069	0.526
MOD_Plk_4	118	124	PF00069	0.719
MOD_Plk_4	185	191	PF00069	0.528
MOD_Plk_4	214	220	PF00069	0.683
MOD_Plk_4	339	345	PF00069	0.431
MOD_Plk_4	352	358	PF00069	0.361
MOD_Plk_4	477	483	PF00069	0.492
MOD_Plk_4	593	599	PF00069	0.474
MOD_Plk_4	727	733	PF00069	0.547
MOD_ProDKin_1	137	143	PF00069	0.720
MOD_ProDKin_1	678	684	PF00069	0.488
MOD_ProDKin_1	90	96	PF00069	0.588
MOD_SUMO_rev_2	457	464	PF00179	0.499
MOD_SUMO_rev_2	553	562	PF00179	0.423
MOD_SUMO_rev_2	617	625	PF00179	0.451
TRG_DiLeu_BaEn_1	53	58	PF01217	0.580
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.559
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.319
TRG_ENDOCYTIC_2	251	254	PF00928	0.508
TRG_ENDOCYTIC_2	341	344	PF00928	0.460
TRG_ENDOCYTIC_2	357	360	PF00928	0.320
TRG_ENDOCYTIC_2	69	72	PF00928	0.602
TRG_ENDOCYTIC_2	705	708	PF00928	0.504
TRG_ENDOCYTIC_2	92	95	PF00928	0.650
TRG_ER_diArg_1	12	14	PF00400	0.564
TRG_ER_diArg_1	220	222	PF00400	0.667
TRG_ER_diArg_1	360	362	PF00400	0.455
TRG_ER_diArg_1	364	366	PF00400	0.462
TRG_ER_diArg_1	398	400	PF00400	0.340
TRG_ER_diArg_1	538	540	PF00400	0.514
TRG_ER_diArg_1	60	63	PF00400	0.636
TRG_ER_diArg_1	686	689	PF00400	0.578
TRG_ER_diArg_1	713	715	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	719	723	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC11	Leptomonas seymouri	71%	100%
A0A0S4IWL5	Bodo saltans	38%	87%
A0A1X0P9H1	Trypanosomatidae	56%	100%
A0A3R7MZ37	Trypanosoma rangeli	55%	100%
A0A3S7X7R6	Leishmania donovani	83%	100%
A4HAQ8	Leishmania braziliensis	86%	100%
C9ZMR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AHT4	Leishmania infantum	83%	100%
E9B4X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q347	Leishmania major	83%	100%
V5BT32	Trypanosoma cruzi	56%	100%