SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAL8_LEIBR

TriTrypDb:

LbrM.20.1020 , LBRM2903_200017400

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAL8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.484
CLV_NRD_NRD_1	101	103	PF00675	0.472
CLV_NRD_NRD_1	164	166	PF00675	0.322
CLV_NRD_NRD_1	403	405	PF00675	0.297
CLV_NRD_NRD_1	485	487	PF00675	0.177
CLV_NRD_NRD_1	555	557	PF00675	0.486
CLV_NRD_NRD_1	61	63	PF00675	0.278
CLV_NRD_NRD_1	664	666	PF00675	0.415
CLV_NRD_NRD_1	78	80	PF00675	0.392
CLV_PCSK_KEX2_1	100	102	PF00082	0.569
CLV_PCSK_KEX2_1	164	166	PF00082	0.321
CLV_PCSK_KEX2_1	485	487	PF00082	0.177
CLV_PCSK_KEX2_1	555	557	PF00082	0.437
CLV_PCSK_KEX2_1	664	666	PF00082	0.415
CLV_PCSK_KEX2_1	78	80	PF00082	0.434
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.569
CLV_PCSK_SKI1_1	229	233	PF00082	0.495
CLV_PCSK_SKI1_1	290	294	PF00082	0.226
CLV_PCSK_SKI1_1	328	332	PF00082	0.380
CLV_PCSK_SKI1_1	408	412	PF00082	0.249
CLV_PCSK_SKI1_1	617	621	PF00082	0.417
CLV_PCSK_SKI1_1	641	645	PF00082	0.343
CLV_Separin_Metazoa	661	665	PF03568	0.418
DEG_APCC_DBOX_1	508	516	PF00400	0.405
DOC_CDC14_PxL_1	333	341	PF14671	0.534
DOC_CKS1_1	688	693	PF01111	0.559
DOC_MAPK_gen_1	164	174	PF00069	0.489
DOC_MAPK_gen_1	218	227	PF00069	0.343
DOC_MAPK_gen_1	229	239	PF00069	0.175
DOC_MAPK_gen_1	404	412	PF00069	0.500
DOC_MAPK_gen_1	60	70	PF00069	0.259
DOC_MAPK_gen_1	625	635	PF00069	0.294
DOC_MAPK_MEF2A_6	165	174	PF00069	0.491
DOC_MAPK_MEF2A_6	617	626	PF00069	0.305
DOC_MAPK_MEF2A_6	62	70	PF00069	0.252
DOC_MAPK_NFAT4_5	617	625	PF00069	0.304
DOC_PP1_RVXF_1	639	645	PF00149	0.376
DOC_PP4_FxxP_1	293	296	PF00568	0.474
DOC_PP4_FxxP_1	666	669	PF00568	0.375
DOC_USP7_MATH_1	429	433	PF00917	0.536
DOC_USP7_MATH_1	472	476	PF00917	0.474
DOC_USP7_MATH_2	649	655	PF00917	0.284
DOC_USP7_UBL2_3	607	611	PF12436	0.304
DOC_USP7_UBL2_3	90	94	PF12436	0.426
DOC_WW_Pin1_4	192	197	PF00397	0.458
DOC_WW_Pin1_4	248	253	PF00397	0.439
DOC_WW_Pin1_4	292	297	PF00397	0.474
DOC_WW_Pin1_4	342	347	PF00397	0.536
DOC_WW_Pin1_4	645	650	PF00397	0.409
DOC_WW_Pin1_4	684	689	PF00397	0.598
LIG_14-3-3_CanoR_1	131	135	PF00244	0.330
LIG_14-3-3_CanoR_1	502	506	PF00244	0.482
LIG_14-3-3_CanoR_1	511	516	PF00244	0.374
LIG_14-3-3_CanoR_1	62	70	PF00244	0.330
LIG_Actin_WH2_2	388	406	PF00022	0.454
LIG_Actin_WH2_2	670	687	PF00022	0.294
LIG_APCC_ABBAyCdc20_2	131	137	PF00400	0.450
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	131	135	PF00533	0.288
LIG_BRCT_BRCA1_1	288	292	PF00533	0.523
LIG_BRCT_BRCA1_1	63	67	PF00533	0.265
LIG_eIF4E_1	450	456	PF01652	0.497
LIG_FHA_1	110	116	PF00498	0.374
LIG_FHA_1	121	127	PF00498	0.377
LIG_FHA_1	257	263	PF00498	0.520
LIG_FHA_1	566	572	PF00498	0.410
LIG_FHA_2	350	356	PF00498	0.534
LIG_FHA_2	394	400	PF00498	0.534
LIG_FHA_2	512	518	PF00498	0.449
LIG_GBD_Chelix_1	480	488	PF00786	0.177
LIG_HCF-1_HBM_1	138	141	PF13415	0.417
LIG_LIR_Gen_1	250	257	PF02991	0.527
LIG_LIR_Gen_1	504	512	PF02991	0.427
LIG_LIR_Gen_1	573	581	PF02991	0.390
LIG_LIR_Gen_1	64	74	PF02991	0.384
LIG_LIR_Nem_3	250	256	PF02991	0.527
LIG_LIR_Nem_3	31	36	PF02991	0.512
LIG_LIR_Nem_3	494	500	PF02991	0.487
LIG_LIR_Nem_3	517	522	PF02991	0.460
LIG_LIR_Nem_3	573	577	PF02991	0.374
LIG_LIR_Nem_3	64	70	PF02991	0.381
LIG_LYPXL_S_1	32	36	PF13949	0.399
LIG_LYPXL_yS_3	33	36	PF13949	0.404
LIG_LYPXL_yS_3	336	339	PF13949	0.534
LIG_MYND_1	346	350	PF01753	0.474
LIG_NRBOX	123	129	PF00104	0.339
LIG_NRBOX	54	60	PF00104	0.535
LIG_Rb_LxCxE_1	110	133	PF01857	0.461
LIG_SH2_CRK	253	257	PF00017	0.527
LIG_SH2_CRK	327	331	PF00017	0.534
LIG_SH2_CRK	497	501	PF00017	0.530
LIG_SH2_GRB2like	111	114	PF00017	0.461
LIG_SH2_NCK_1	253	257	PF00017	0.534
LIG_SH2_PTP2	580	583	PF00017	0.465
LIG_SH2_SRC	141	144	PF00017	0.483
LIG_SH2_SRC	253	256	PF00017	0.490
LIG_SH2_SRC	574	577	PF00017	0.378
LIG_SH2_SRC	667	670	PF00017	0.348
LIG_SH2_SRC	679	682	PF00017	0.361
LIG_SH2_STAP1	253	257	PF00017	0.467
LIG_SH2_STAP1	563	567	PF00017	0.337
LIG_SH2_STAP1	574	578	PF00017	0.299
LIG_SH2_STAT3	268	271	PF00017	0.534
LIG_SH2_STAT3	306	309	PF00017	0.377
LIG_SH2_STAT5	111	114	PF00017	0.331
LIG_SH2_STAT5	268	271	PF00017	0.454
LIG_SH2_STAT5	391	394	PF00017	0.534
LIG_SH2_STAT5	544	547	PF00017	0.351
LIG_SH2_STAT5	580	583	PF00017	0.422
LIG_SH2_STAT5	603	606	PF00017	0.439
LIG_SH2_STAT5	679	682	PF00017	0.481
LIG_SH3_1	685	691	PF00018	0.523
LIG_SH3_3	529	535	PF00018	0.598
LIG_SH3_3	581	587	PF00018	0.381
LIG_SH3_3	685	691	PF00018	0.635
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.412
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.405
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.381
LIG_SUMO_SIM_par_1	235	240	PF11976	0.476
LIG_SUMO_SIM_par_1	259	267	PF11976	0.514
LIG_SUMO_SIM_par_1	567	573	PF11976	0.400
LIG_TRAF2_1	185	188	PF00917	0.530
LIG_TRAF2_1	38	41	PF00917	0.437
LIG_TYR_ITIM	325	330	PF00017	0.409
LIG_TYR_ITIM	495	500	PF00017	0.357
LIG_TYR_ITSM	249	256	PF00017	0.298
LIG_UBA3_1	55	63	PF00899	0.476
LIG_WRC_WIRS_1	465	470	PF05994	0.279
LIG_WW_3	215	219	PF00397	0.537
MOD_CDK_SPxxK_3	645	652	PF00069	0.398
MOD_CK1_1	240	246	PF00069	0.345
MOD_CK1_1	264	270	PF00069	0.409
MOD_CK1_1	501	507	PF00069	0.462
MOD_CK1_1	524	530	PF00069	0.485
MOD_CK2_1	182	188	PF00069	0.414
MOD_CK2_1	243	249	PF00069	0.311
MOD_CK2_1	393	399	PF00069	0.357
MOD_CK2_1	511	517	PF00069	0.325
MOD_CK2_1	645	651	PF00069	0.412
MOD_Cter_Amidation	553	556	PF01082	0.440
MOD_GlcNHglycan	228	232	PF01048	0.486
MOD_GlcNHglycan	28	31	PF01048	0.574
MOD_GlcNHglycan	341	345	PF01048	0.314
MOD_GlcNHglycan	425	428	PF01048	0.293
MOD_GlcNHglycan	80	83	PF01048	0.491
MOD_GSK3_1	1	8	PF00069	0.671
MOD_GSK3_1	182	189	PF00069	0.462
MOD_GSK3_1	22	29	PF00069	0.654
MOD_GSK3_1	360	367	PF00069	0.423
MOD_GSK3_1	417	424	PF00069	0.376
MOD_GSK3_1	425	432	PF00069	0.340
MOD_GSK3_1	680	687	PF00069	0.369
MOD_N-GLC_1	129	134	PF02516	0.360
MOD_N-GLC_1	430	435	PF02516	0.326
MOD_N-GLC_1	438	443	PF02516	0.458
MOD_NEK2_1	1	6	PF00069	0.677
MOD_NEK2_1	109	114	PF00069	0.354
MOD_NEK2_1	203	208	PF00069	0.471
MOD_NEK2_1	270	275	PF00069	0.279
MOD_NEK2_1	364	369	PF00069	0.438
MOD_NEK2_1	421	426	PF00069	0.483
MOD_NEK2_1	435	440	PF00069	0.303
MOD_NEK2_1	493	498	PF00069	0.423
MOD_NEK2_1	521	526	PF00069	0.375
MOD_NEK2_1	73	78	PF00069	0.390
MOD_OFUCOSY	269	275	PF10250	0.298
MOD_OFUCOSY	518	525	PF10250	0.370
MOD_PIKK_1	237	243	PF00454	0.455
MOD_PIKK_1	308	314	PF00454	0.409
MOD_PKA_1	78	84	PF00069	0.414
MOD_PKA_2	130	136	PF00069	0.323
MOD_PKA_2	271	277	PF00069	0.208
MOD_PKA_2	501	507	PF00069	0.472
MOD_PKA_2	61	67	PF00069	0.262
MOD_PKA_2	78	84	PF00069	0.372
MOD_PKB_1	509	517	PF00069	0.439
MOD_Plk_1	129	135	PF00069	0.354
MOD_Plk_1	430	436	PF00069	0.440
MOD_Plk_1	438	444	PF00069	0.244
MOD_Plk_1	491	497	PF00069	0.277
MOD_Plk_1	637	643	PF00069	0.395
MOD_Plk_1	680	686	PF00069	0.521
MOD_Plk_4	130	136	PF00069	0.329
MOD_Plk_4	154	160	PF00069	0.427
MOD_Plk_4	243	249	PF00069	0.295
MOD_Plk_4	258	264	PF00069	0.207
MOD_Plk_4	380	386	PF00069	0.301
MOD_Plk_4	430	436	PF00069	0.411
MOD_Plk_4	565	571	PF00069	0.371
MOD_Plk_4	668	674	PF00069	0.402
MOD_ProDKin_1	192	198	PF00069	0.457
MOD_ProDKin_1	248	254	PF00069	0.273
MOD_ProDKin_1	292	298	PF00069	0.326
MOD_ProDKin_1	342	348	PF00069	0.413
MOD_ProDKin_1	645	651	PF00069	0.404
MOD_ProDKin_1	684	690	PF00069	0.605
MOD_SUMO_rev_2	16	23	PF00179	0.724
MOD_SUMO_rev_2	618	626	PF00179	0.313
MOD_SUMO_rev_2	648	654	PF00179	0.382
TRG_DiLeu_BaEn_1	54	59	PF01217	0.399
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.423
TRG_ENDOCYTIC_2	253	256	PF00928	0.400
TRG_ENDOCYTIC_2	327	330	PF00928	0.409
TRG_ENDOCYTIC_2	33	36	PF00928	0.483
TRG_ENDOCYTIC_2	336	339	PF00928	0.409
TRG_ENDOCYTIC_2	465	468	PF00928	0.389
TRG_ENDOCYTIC_2	497	500	PF00928	0.375
TRG_ENDOCYTIC_2	519	522	PF00928	0.455
TRG_ENDOCYTIC_2	574	577	PF00928	0.378
TRG_ENDOCYTIC_2	603	606	PF00928	0.509
TRG_ER_diArg_1	164	167	PF00400	0.417
TRG_ER_diArg_1	217	220	PF00400	0.350
TRG_ER_diArg_1	484	486	PF00400	0.190
TRG_ER_diArg_1	508	511	PF00400	0.385
TRG_ER_diArg_1	555	557	PF00400	0.437
TRG_ER_diArg_1	663	665	PF00400	0.418
TRG_ER_diArg_1	78	80	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	555	560	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN8	Leptomonas seymouri	76%	99%
A0A0S4JQY2	Bodo saltans	41%	100%
A0A1X0P998	Trypanosomatidae	36%	100%
A0A3Q8IKU3	Leishmania donovani	87%	100%
A0A422N693	Trypanosoma rangeli	37%	100%
A4I9Q7	Leishmania infantum	87%	100%
C9ZMX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3A0	Leishmania major	88%	100%
V5BJB7	Trypanosoma cruzi	35%	100%