EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania braziliensis

UniProt:

A4HAL6_LEIBR

TriTrypDb:

LbrM.20.1000 , LBRM2903_200017200

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAL6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.480
CLV_MEL_PAP_1	185	191	PF00089	0.362
DOC_MAPK_MEF2A_6	196	203	PF00069	0.399
DOC_PP1_RVXF_1	186	192	PF00149	0.362
DOC_USP7_MATH_1	171	175	PF00917	0.237
DOC_USP7_MATH_1	27	31	PF00917	0.611
DOC_USP7_MATH_1	54	58	PF00917	0.540
DOC_USP7_MATH_1	80	84	PF00917	0.621
DOC_USP7_UBL2_3	226	230	PF12436	0.561
DOC_WW_Pin1_4	121	126	PF00397	0.540
LIG_14-3-3_CanoR_1	213	217	PF00244	0.524
LIG_14-3-3_CanoR_1	7	15	PF00244	0.548
LIG_BRCT_BRCA1_1	8	12	PF00533	0.418
LIG_CaM_IQ_9	101	117	PF13499	0.592
LIG_deltaCOP1_diTrp_1	95	104	PF00928	0.533
LIG_FHA_2	135	141	PF00498	0.494
LIG_FHA_2	14	20	PF00498	0.559
LIG_LIR_Gen_1	156	166	PF02991	0.467
LIG_LIR_Gen_1	95	104	PF02991	0.533
LIG_LIR_Nem_3	103	107	PF02991	0.449
LIG_LIR_Nem_3	156	162	PF02991	0.584
LIG_LIR_Nem_3	164	169	PF02991	0.354
LIG_LIR_Nem_3	17	23	PF02991	0.515
LIG_LIR_Nem_3	217	222	PF02991	0.386
LIG_LIR_Nem_3	9	15	PF02991	0.553
LIG_LIR_Nem_3	95	101	PF02991	0.534
LIG_MLH1_MIPbox_1	8	12	PF16413	0.418
LIG_SH2_CRK	20	24	PF00017	0.591
LIG_SH2_GRB2like	84	87	PF00017	0.515
LIG_SH2_STAT5	142	145	PF00017	0.770
LIG_SH2_STAT5	176	179	PF00017	0.362
LIG_SH2_STAT5	84	87	PF00017	0.515
LIG_SH3_3	21	27	PF00018	0.602
LIG_SUMO_SIM_anti_2	197	205	PF11976	0.349
LIG_TRAF2_1	195	198	PF00917	0.362
LIG_WRC_WIRS_1	101	106	PF05994	0.527
MOD_CK1_1	28	34	PF00069	0.627
MOD_CK1_1	57	63	PF00069	0.578
MOD_CK2_1	13	19	PF00069	0.561
MOD_CK2_1	192	198	PF00069	0.449
MOD_CK2_1	57	63	PF00069	0.517
MOD_GlcNHglycan	126	129	PF01048	0.662
MOD_GlcNHglycan	25	30	PF01048	0.467
MOD_GlcNHglycan	37	40	PF01048	0.618
MOD_GlcNHglycan	44	47	PF01048	0.608
MOD_GlcNHglycan	52	55	PF01048	0.654
MOD_GlcNHglycan	56	59	PF01048	0.586
MOD_GlcNHglycan	71	74	PF01048	0.780
MOD_GlcNHglycan	77	80	PF01048	0.737
MOD_GlcNHglycan	8	11	PF01048	0.542
MOD_GSK3_1	130	137	PF00069	0.512
MOD_GSK3_1	50	57	PF00069	0.658
MOD_N-GLC_1	135	140	PF02516	0.620
MOD_N-GLC_1	85	90	PF02516	0.527
MOD_NEK2_1	100	105	PF00069	0.659
MOD_NEK2_1	107	112	PF00069	0.572
MOD_NEK2_1	143	148	PF00069	0.519
MOD_PIKK_1	143	149	PF00454	0.517
MOD_PKA_2	171	177	PF00069	0.237
MOD_PKA_2	212	218	PF00069	0.524
MOD_PKA_2	6	12	PF00069	0.544
MOD_Plk_1	135	141	PF00069	0.621
MOD_ProDKin_1	121	127	PF00069	0.541
TRG_DiLeu_BaEn_1	19	24	PF01217	0.586
TRG_DiLeu_BaEn_1	198	203	PF01217	0.362
TRG_ENDOCYTIC_2	20	23	PF00928	0.538
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7M0	Leishmania donovani	62%	92%
A4I9Q9	Leishmania infantum	62%	92%
E9B4S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	91%
Q4Q3A2	Leishmania major	63%	98%