N2227 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Carnosine N-methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAL5_LEIBR

TriTrypDb:

LbrM.20.0990 , LBRM2903_200017100

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAL5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.469
CLV_NRD_NRD_1	108	110	PF00675	0.541
CLV_PCSK_KEX2_1	94	96	PF00082	0.509
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.509
CLV_PCSK_SKI1_1	116	120	PF00082	0.468
CLV_PCSK_SKI1_1	202	206	PF00082	0.305
CLV_PCSK_SKI1_1	240	244	PF00082	0.319
CLV_PCSK_SKI1_1	421	425	PF00082	0.245
CLV_PCSK_SKI1_1	429	433	PF00082	0.245
CLV_PCSK_SKI1_1	95	99	PF00082	0.510
DOC_CKS1_1	169	174	PF01111	0.382
DOC_CKS1_1	22	27	PF01111	0.734
DOC_MAPK_gen_1	215	225	PF00069	0.471
DOC_MAPK_MEF2A_6	116	123	PF00069	0.433
DOC_MAPK_MEF2A_6	218	225	PF00069	0.446
DOC_MAPK_MEF2A_6	232	239	PF00069	0.450
DOC_PP1_RVXF_1	398	404	PF00149	0.485
DOC_PP2B_LxvP_1	17	20	PF13499	0.505
DOC_PP2B_LxvP_1	361	364	PF13499	0.456
DOC_USP7_MATH_1	213	217	PF00917	0.508
DOC_USP7_UBL2_3	125	129	PF12436	0.431
DOC_WW_Pin1_4	168	173	PF00397	0.312
DOC_WW_Pin1_4	18	23	PF00397	0.502
DOC_WW_Pin1_4	42	47	PF00397	0.547
LIG_14-3-3_CanoR_1	232	236	PF00244	0.451
LIG_APCC_ABBA_1	272	277	PF00400	0.445
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_BRCT_BRCA1_1	137	141	PF00533	0.328
LIG_Clathr_ClatBox_1	118	122	PF01394	0.524
LIG_FHA_1	158	164	PF00498	0.454
LIG_FHA_1	277	283	PF00498	0.456
LIG_FHA_1	333	339	PF00498	0.531
LIG_FHA_2	137	143	PF00498	0.398
LIG_FHA_2	169	175	PF00498	0.322
LIG_FHA_2	440	446	PF00498	0.356
LIG_GBD_Chelix_1	397	405	PF00786	0.285
LIG_GSK3_LRP6_1	168	173	PF00069	0.382
LIG_LIR_Gen_1	138	147	PF02991	0.359
LIG_LIR_Gen_1	248	259	PF02991	0.445
LIG_LIR_Gen_1	287	297	PF02991	0.458
LIG_LIR_Gen_1	322	328	PF02991	0.445
LIG_LIR_Gen_1	335	344	PF02991	0.440
LIG_LIR_Gen_1	353	362	PF02991	0.314
LIG_LIR_Nem_3	106	111	PF02991	0.444
LIG_LIR_Nem_3	138	144	PF02991	0.394
LIG_LIR_Nem_3	149	155	PF02991	0.364
LIG_LIR_Nem_3	198	204	PF02991	0.452
LIG_LIR_Nem_3	248	254	PF02991	0.445
LIG_LIR_Nem_3	287	292	PF02991	0.476
LIG_LIR_Nem_3	312	316	PF02991	0.471
LIG_LIR_Nem_3	322	326	PF02991	0.414
LIG_LIR_Nem_3	335	339	PF02991	0.445
LIG_LIR_Nem_3	353	357	PF02991	0.314
LIG_MLH1_MIPbox_1	137	141	PF16413	0.328
LIG_PCNA_yPIPBox_3	420	429	PF02747	0.485
LIG_Pex14_2	152	156	PF04695	0.363
LIG_Pex14_2	185	189	PF04695	0.445
LIG_PTB_Apo_2	259	266	PF02174	0.531
LIG_Rb_LxCxE_1	128	149	PF01857	0.327
LIG_SH2_CRK	201	205	PF00017	0.485
LIG_SH2_CRK	251	255	PF00017	0.439
LIG_SH2_CRK	359	363	PF00017	0.456
LIG_SH2_GRB2like	416	419	PF00017	0.456
LIG_SH2_SRC	354	357	PF00017	0.373
LIG_SH2_SRC	61	64	PF00017	0.555
LIG_SH2_STAT3	38	41	PF00017	0.686
LIG_SH2_STAT3	93	96	PF00017	0.430
LIG_SH2_STAT5	130	133	PF00017	0.386
LIG_SH2_STAT5	259	262	PF00017	0.453
LIG_SH2_STAT5	354	357	PF00017	0.445
LIG_SH2_STAT5	416	419	PF00017	0.448
LIG_SH3_3	164	170	PF00018	0.429
LIG_SH3_3	19	25	PF00018	0.753
LIG_SH3_3	197	203	PF00018	0.450
LIG_SH3_3	220	226	PF00018	0.499
LIG_SH3_3	289	295	PF00018	0.456
LIG_SH3_3	40	46	PF00018	0.563
LIG_SH3_3	60	66	PF00018	0.494
LIG_SH3_3	68	74	PF00018	0.572
LIG_SUMO_SIM_anti_2	353	359	PF11976	0.456
LIG_TRAF2_1	147	150	PF00917	0.441
LIG_TYR_ITIM	352	357	PF00017	0.445
LIG_UBA3_1	118	125	PF00899	0.509
MOD_CK1_1	21	27	PF00069	0.505
MOD_CK1_1	276	282	PF00069	0.531
MOD_CK1_1	29	35	PF00069	0.633
MOD_CK1_1	49	55	PF00069	0.641
MOD_CK2_1	213	219	PF00069	0.490
MOD_CK2_1	387	393	PF00069	0.445
MOD_CK2_1	439	445	PF00069	0.347
MOD_GlcNHglycan	1	4	PF01048	0.745
MOD_GlcNHglycan	188	192	PF01048	0.245
MOD_GlcNHglycan	380	383	PF01048	0.309
MOD_GlcNHglycan	51	54	PF01048	0.610
MOD_GSK3_1	334	341	PF00069	0.510
MOD_GSK3_1	383	390	PF00069	0.453
MOD_GSK3_1	407	414	PF00069	0.531
MOD_GSK3_1	42	49	PF00069	0.690
MOD_GSK3_1	79	86	PF00069	0.367
MOD_N-GLC_1	136	141	PF02516	0.257
MOD_N-GLC_1	213	218	PF02516	0.239
MOD_N-GLC_1	29	34	PF02516	0.519
MOD_N-GLC_2	209	211	PF02516	0.169
MOD_NEK2_1	103	108	PF00069	0.512
MOD_NEK2_1	151	156	PF00069	0.432
MOD_NEK2_1	306	311	PF00069	0.369
MOD_NEK2_1	344	349	PF00069	0.450
MOD_NEK2_1	411	416	PF00069	0.445
MOD_NEK2_1	439	444	PF00069	0.348
MOD_NEK2_1	83	88	PF00069	0.345
MOD_PIKK_1	439	445	PF00454	0.347
MOD_PK_1	334	340	PF00069	0.550
MOD_PKA_2	103	109	PF00069	0.517
MOD_PKA_2	231	237	PF00069	0.488
MOD_PKA_2	306	312	PF00069	0.472
MOD_Plk_1	136	142	PF00069	0.325
MOD_Plk_1	247	253	PF00069	0.445
MOD_Plk_1	383	389	PF00069	0.468
MOD_Plk_1	412	418	PF00069	0.445
MOD_Plk_2-3	383	389	PF00069	0.469
MOD_Plk_4	136	142	PF00069	0.352
MOD_Plk_4	151	157	PF00069	0.422
MOD_Plk_4	158	164	PF00069	0.446
MOD_Plk_4	314	320	PF00069	0.445
MOD_Plk_4	407	413	PF00069	0.531
MOD_ProDKin_1	168	174	PF00069	0.312
MOD_ProDKin_1	18	24	PF00069	0.502
MOD_ProDKin_1	42	48	PF00069	0.544
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.445
TRG_ENDOCYTIC_2	201	204	PF00928	0.445
TRG_ENDOCYTIC_2	251	254	PF00928	0.439
TRG_ENDOCYTIC_2	354	357	PF00928	0.442
TRG_ENDOCYTIC_2	359	362	PF00928	0.437
TRG_ER_diLys_1	452	456	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M2	Leptomonas seymouri	86%	100%
A0A0S4IZ95	Bodo saltans	53%	100%
A0A1X0PA60	Trypanosomatidae	72%	100%
A0A3Q8IH25	Leishmania donovani	89%	100%
A0A3S5IQL4	Trypanosoma rangeli	74%	100%
A4I9R0	Leishmania infantum	89%	100%
C9ZMY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9B4S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
F1N9S8	Gallus gallus	37%	100%
P53934	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4Q3A3	Leishmania major	88%	100%
Q54ST2	Dictyostelium discoideum	36%	98%
Q5BJZ6	Rattus norvegicus	37%	100%
Q80UY1	Mus musculus	37%	100%
Q8N4J0	Homo sapiens	37%	100%
Q9Y7J3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
V5BEW2	Trypanosoma cruzi	68%	100%