Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAL4_LEIBR

TriTrypDb:

LbrM.20.0980 , LBRM2903_200017000

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.587
CLV_C14_Caspase3-7	294	298	PF00656	0.460
CLV_NRD_NRD_1	164	166	PF00675	0.539
CLV_NRD_NRD_1	254	256	PF00675	0.611
CLV_NRD_NRD_1	288	290	PF00675	0.626
CLV_NRD_NRD_1	387	389	PF00675	0.588
CLV_NRD_NRD_1	404	406	PF00675	0.759
CLV_PCSK_KEX2_1	164	166	PF00082	0.539
CLV_PCSK_KEX2_1	254	256	PF00082	0.609
CLV_PCSK_KEX2_1	287	289	PF00082	0.658
CLV_PCSK_KEX2_1	389	391	PF00082	0.610
CLV_PCSK_KEX2_1	406	408	PF00082	0.585
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.450
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.610
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.585
CLV_PCSK_SKI1_1	329	333	PF00082	0.542
CLV_PCSK_SKI1_1	451	455	PF00082	0.747
CLV_PCSK_SKI1_1	586	590	PF00082	0.534
CLV_PCSK_SKI1_1	605	609	PF00082	0.461
DEG_APCC_DBOX_1	585	593	PF00400	0.517
DEG_COP1_1	273	282	PF00400	0.424
DOC_ANK_TNKS_1	427	434	PF00023	0.592
DOC_CKS1_1	206	211	PF01111	0.706
DOC_MAPK_MEF2A_6	356	363	PF00069	0.520
DOC_PP2B_LxvP_1	6	9	PF13499	0.493
DOC_USP7_MATH_1	12	16	PF00917	0.633
DOC_USP7_MATH_1	189	193	PF00917	0.717
DOC_USP7_MATH_1	194	198	PF00917	0.756
DOC_USP7_MATH_1	280	284	PF00917	0.686
DOC_USP7_MATH_1	46	50	PF00917	0.568
DOC_USP7_MATH_1	539	543	PF00917	0.595
DOC_USP7_MATH_1	63	67	PF00917	0.749
DOC_WW_Pin1_4	205	210	PF00397	0.716
DOC_WW_Pin1_4	232	237	PF00397	0.705
DOC_WW_Pin1_4	278	283	PF00397	0.713
DOC_WW_Pin1_4	399	404	PF00397	0.703
DOC_WW_Pin1_4	437	442	PF00397	0.784
LIG_14-3-3_CanoR_1	158	162	PF00244	0.607
LIG_14-3-3_CanoR_1	213	219	PF00244	0.569
LIG_14-3-3_CanoR_1	264	274	PF00244	0.492
LIG_14-3-3_CanoR_1	409	419	PF00244	0.651
LIG_14-3-3_CanoR_1	460	466	PF00244	0.555
LIG_14-3-3_CanoR_1	502	510	PF00244	0.614
LIG_14-3-3_CanoR_1	586	596	PF00244	0.588
LIG_BRCT_BRCA1_1	539	543	PF00533	0.342
LIG_CaM_NSCaTE_8	85	92	PF13499	0.367
LIG_CtBP_PxDLS_1	111	115	PF00389	0.489
LIG_deltaCOP1_diTrp_1	155	161	PF00928	0.421
LIG_FHA_1	169	175	PF00498	0.654
LIG_FHA_1	201	207	PF00498	0.767
LIG_FHA_1	274	280	PF00498	0.564
LIG_FHA_1	36	42	PF00498	0.662
LIG_FHA_1	498	504	PF00498	0.597
LIG_FHA_1	70	76	PF00498	0.471
LIG_FHA_1	84	90	PF00498	0.511
LIG_FHA_2	18	24	PF00498	0.516
LIG_FHA_2	220	226	PF00498	0.781
LIG_FHA_2	305	311	PF00498	0.556
LIG_FHA_2	520	526	PF00498	0.633
LIG_FHA_2	536	542	PF00498	0.328
LIG_FHA_2	552	558	PF00498	0.529
LIG_FHA_2	579	585	PF00498	0.592
LIG_GBD_Chelix_1	252	260	PF00786	0.516
LIG_LIR_Apic_2	105	111	PF02991	0.747
LIG_LIR_Gen_1	333	344	PF02991	0.517
LIG_LIR_Gen_1	590	601	PF02991	0.555
LIG_LIR_Gen_1	606	616	PF02991	0.439
LIG_LIR_Gen_1	70	80	PF02991	0.465
LIG_LIR_Nem_3	54	60	PF02991	0.771
LIG_LIR_Nem_3	590	596	PF02991	0.585
LIG_LIR_Nem_3	606	611	PF02991	0.428
LIG_LIR_Nem_3	70	76	PF02991	0.462
LIG_LYPXL_yS_3	358	361	PF13949	0.531
LIG_PCNA_PIPBox_1	604	613	PF02747	0.581
LIG_PCNA_yPIPBox_3	600	611	PF02747	0.578
LIG_Pex14_1	157	161	PF04695	0.421
LIG_PTAP_UEV_1	8	13	PF05743	0.490
LIG_SH2_CRK	534	538	PF00017	0.464
LIG_SH2_PTP2	593	596	PF00017	0.363
LIG_SH2_SRC	492	495	PF00017	0.372
LIG_SH2_STAP1	573	577	PF00017	0.458
LIG_SH2_STAT3	601	604	PF00017	0.580
LIG_SH2_STAT5	306	309	PF00017	0.560
LIG_SH2_STAT5	336	339	PF00017	0.511
LIG_SH2_STAT5	378	381	PF00017	0.572
LIG_SH2_STAT5	40	43	PF00017	0.552
LIG_SH2_STAT5	492	495	PF00017	0.434
LIG_SH2_STAT5	593	596	PF00017	0.363
LIG_SH2_STAT5	610	613	PF00017	0.422
LIG_SH3_3	256	262	PF00018	0.507
LIG_SH3_3	276	282	PF00018	0.373
LIG_SH3_3	320	326	PF00018	0.603
LIG_SH3_3	435	441	PF00018	0.832
LIG_SH3_3	6	12	PF00018	0.562
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.501
LIG_TRAF2_1	223	226	PF00917	0.781
LIG_TRAF2_1	419	422	PF00917	0.663
LIG_TRAF2_1	522	525	PF00917	0.581
LIG_TRAF2_1	581	584	PF00917	0.593
MOD_CDK_SPxK_1	399	405	PF00069	0.574
MOD_CDK_SPxxK_3	399	406	PF00069	0.573
MOD_CK1_1	143	149	PF00069	0.704
MOD_CK1_1	183	189	PF00069	0.803
MOD_CK1_1	217	223	PF00069	0.720
MOD_CK1_1	231	237	PF00069	0.558
MOD_CK1_1	281	287	PF00069	0.724
MOD_CK1_1	296	302	PF00069	0.563
MOD_CK1_1	4	10	PF00069	0.637
MOD_CK1_1	410	416	PF00069	0.690
MOD_CK1_1	66	72	PF00069	0.574
MOD_CK2_1	219	225	PF00069	0.760
MOD_CK2_1	296	302	PF00069	0.734
MOD_CK2_1	417	423	PF00069	0.732
MOD_CK2_1	461	467	PF00069	0.604
MOD_CK2_1	519	525	PF00069	0.627
MOD_CK2_1	535	541	PF00069	0.327
MOD_CK2_1	551	557	PF00069	0.527
MOD_CK2_1	578	584	PF00069	0.594
MOD_GlcNHglycan	136	139	PF01048	0.628
MOD_GlcNHglycan	175	178	PF01048	0.758
MOD_GlcNHglycan	182	185	PF01048	0.832
MOD_GlcNHglycan	209	212	PF01048	0.574
MOD_GlcNHglycan	230	233	PF01048	0.651
MOD_GlcNHglycan	367	370	PF01048	0.534
MOD_GlcNHglycan	393	397	PF01048	0.752
MOD_GlcNHglycan	412	415	PF01048	0.504
MOD_GlcNHglycan	433	436	PF01048	0.737
MOD_GlcNHglycan	65	68	PF01048	0.612
MOD_GlcNHglycan	9	12	PF01048	0.586
MOD_GSK3_1	139	146	PF00069	0.793
MOD_GSK3_1	153	160	PF00069	0.597
MOD_GSK3_1	183	190	PF00069	0.777
MOD_GSK3_1	207	214	PF00069	0.724
MOD_GSK3_1	228	235	PF00069	0.583
MOD_GSK3_1	278	285	PF00069	0.650
MOD_GSK3_1	292	299	PF00069	0.409
MOD_GSK3_1	300	307	PF00069	0.416
MOD_GSK3_1	409	416	PF00069	0.612
MOD_GSK3_1	433	440	PF00069	0.753
MOD_GSK3_1	451	458	PF00069	0.707
MOD_GSK3_1	508	515	PF00069	0.557
MOD_GSK3_1	535	542	PF00069	0.338
MOD_GSK3_1	561	568	PF00069	0.385
MOD_GSK3_1	578	585	PF00069	0.505
MOD_GSK3_1	63	70	PF00069	0.494
MOD_N-GLC_2	62	64	PF02516	0.623
MOD_N-GLC_2	81	83	PF02516	0.425
MOD_NEK2_1	1	6	PF00069	0.718
MOD_NEK2_1	228	233	PF00069	0.607
MOD_NEK2_1	318	323	PF00069	0.640
MOD_NEK2_1	442	447	PF00069	0.724
MOD_NEK2_1	455	460	PF00069	0.651
MOD_NEK2_1	461	466	PF00069	0.514
MOD_NEK2_1	503	508	PF00069	0.625
MOD_NEK2_2	282	287	PF00069	0.471
MOD_NEK2_2	551	556	PF00069	0.344
MOD_PIKK_1	455	461	PF00454	0.594
MOD_PIKK_1	46	52	PF00454	0.500
MOD_PIKK_1	497	503	PF00454	0.652
MOD_PIKK_1	565	571	PF00454	0.522
MOD_PIKK_1	578	584	PF00454	0.422
MOD_PKA_2	143	149	PF00069	0.663
MOD_PKA_2	157	163	PF00069	0.487
MOD_PKA_2	194	200	PF00069	0.585
MOD_PKA_2	263	269	PF00069	0.547
MOD_PKA_2	481	487	PF00069	0.660
MOD_PKA_2	497	503	PF00069	0.598
MOD_PKA_2	551	557	PF00069	0.408
MOD_PKB_1	405	413	PF00069	0.762
MOD_Plk_1	238	244	PF00069	0.499
MOD_Plk_1	407	413	PF00069	0.622
MOD_Plk_1	53	59	PF00069	0.623
MOD_Plk_4	103	109	PF00069	0.501
MOD_Plk_4	157	163	PF00069	0.642
MOD_Plk_4	214	220	PF00069	0.704
MOD_Plk_4	539	545	PF00069	0.593
MOD_ProDKin_1	205	211	PF00069	0.712
MOD_ProDKin_1	232	238	PF00069	0.703
MOD_ProDKin_1	278	284	PF00069	0.710
MOD_ProDKin_1	399	405	PF00069	0.705
MOD_ProDKin_1	437	443	PF00069	0.784
MOD_SUMO_rev_2	540	548	PF00179	0.341
TRG_DiLeu_BaEn_4	225	231	PF01217	0.777
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.575
TRG_ENDOCYTIC_2	336	339	PF00928	0.458
TRG_ENDOCYTIC_2	358	361	PF00928	0.531
TRG_ENDOCYTIC_2	534	537	PF00928	0.461
TRG_ENDOCYTIC_2	593	596	PF00928	0.505
TRG_ENDOCYTIC_2	610	613	PF00928	0.457
TRG_ENDOCYTIC_2	73	76	PF00928	0.518
TRG_ER_diArg_1	253	255	PF00400	0.609
TRG_ER_diArg_1	288	290	PF00400	0.594
TRG_ER_diArg_1	326	329	PF00400	0.660
TRG_NES_CRM1_1	373	386	PF08389	0.582
TRG_NLS_MonoExtC_3	387	392	PF00514	0.611
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P311	Leptomonas seymouri	42%	98%
A0A3S7X7P4	Leishmania donovani	68%	100%
A4I9R1	Leishmania infantum	68%	100%
C9ZMY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B4S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q3A4	Leishmania major	70%	99%