Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAK8_LEIBR

TriTrypDb:

LbrM.20.0920 , LBRM2903_200015900

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.640
CLV_C14_Caspase3-7	410	414	PF00656	0.528
CLV_NRD_NRD_1	105	107	PF00675	0.843
CLV_NRD_NRD_1	144	146	PF00675	0.731
CLV_NRD_NRD_1	174	176	PF00675	0.760
CLV_NRD_NRD_1	265	267	PF00675	0.489
CLV_NRD_NRD_1	284	286	PF00675	0.698
CLV_NRD_NRD_1	496	498	PF00675	0.771
CLV_PCSK_FUR_1	142	146	PF00082	0.743
CLV_PCSK_KEX2_1	105	107	PF00082	0.773
CLV_PCSK_KEX2_1	144	146	PF00082	0.731
CLV_PCSK_KEX2_1	174	176	PF00082	0.751
CLV_PCSK_KEX2_1	202	204	PF00082	0.659
CLV_PCSK_KEX2_1	265	267	PF00082	0.489
CLV_PCSK_KEX2_1	284	286	PF00082	0.698
CLV_PCSK_KEX2_1	495	497	PF00082	0.789
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.563
CLV_PCSK_SKI1_1	108	112	PF00082	0.741
CLV_PCSK_SKI1_1	288	292	PF00082	0.480
CLV_PCSK_SKI1_1	75	79	PF00082	0.576
DEG_APCC_DBOX_1	20	28	PF00400	0.747
DEG_Nend_UBRbox_4	1	3	PF02207	0.490
DEG_SPOP_SBC_1	372	376	PF00917	0.612
DEG_SPOP_SBC_1	42	46	PF00917	0.834
DEG_SPOP_SBC_1	445	449	PF00917	0.522
DEG_SPOP_SBC_1	77	81	PF00917	0.830
DEG_SPOP_SBC_1	88	92	PF00917	0.636
DOC_CYCLIN_yCln2_LP_2	527	533	PF00134	0.492
DOC_MAPK_gen_1	21	29	PF00069	0.568
DOC_MAPK_gen_1	284	295	PF00069	0.480
DOC_MAPK_JIP1_4	218	224	PF00069	0.580
DOC_PP1_RVXF_1	263	270	PF00149	0.512
DOC_PP1_RVXF_1	356	362	PF00149	0.565
DOC_PP2B_LxvP_1	527	530	PF13499	0.493
DOC_USP7_MATH_1	121	125	PF00917	0.731
DOC_USP7_MATH_1	127	131	PF00917	0.662
DOC_USP7_MATH_1	227	231	PF00917	0.583
DOC_USP7_MATH_1	238	242	PF00917	0.623
DOC_USP7_MATH_1	255	259	PF00917	0.671
DOC_USP7_MATH_1	372	376	PF00917	0.514
DOC_USP7_MATH_1	396	400	PF00917	0.706
DOC_USP7_MATH_1	42	46	PF00917	0.692
DOC_USP7_MATH_1	445	449	PF00917	0.599
DOC_USP7_MATH_1	67	71	PF00917	0.595
DOC_USP7_MATH_1	77	81	PF00917	0.791
DOC_USP7_MATH_1	88	92	PF00917	0.636
DOC_WW_Pin1_4	130	135	PF00397	0.639
DOC_WW_Pin1_4	213	218	PF00397	0.725
DOC_WW_Pin1_4	225	230	PF00397	0.788
DOC_WW_Pin1_4	305	310	PF00397	0.630
DOC_WW_Pin1_4	451	456	PF00397	0.713
DOC_WW_Pin1_4	472	477	PF00397	0.789
DOC_WW_Pin1_4	485	490	PF00397	0.704
DOC_WW_Pin1_4	84	89	PF00397	0.686
LIG_14-3-3_CanoR_1	108	117	PF00244	0.739
LIG_14-3-3_CanoR_1	508	515	PF00244	0.504
LIG_Actin_WH2_2	10	27	PF00022	0.487
LIG_Actin_WH2_2	136	154	PF00022	0.531
LIG_deltaCOP1_diTrp_1	324	332	PF00928	0.487
LIG_EH_1	162	166	PF12763	0.568
LIG_FHA_1	202	208	PF00498	0.571
LIG_FHA_1	361	367	PF00498	0.519
LIG_FHA_1	374	380	PF00498	0.483
LIG_FHA_1	435	441	PF00498	0.667
LIG_FHA_1	49	55	PF00498	0.597
LIG_FHA_1	518	524	PF00498	0.567
LIG_FHA_1	543	549	PF00498	0.614
LIG_FHA_2	509	515	PF00498	0.619
LIG_FHA_2	545	551	PF00498	0.638
LIG_LIR_Apic_2	439	445	PF02991	0.512
LIG_LIR_Gen_1	287	298	PF02991	0.501
LIG_LIR_Gen_1	550	559	PF02991	0.482
LIG_LIR_Nem_3	323	329	PF02991	0.569
LIG_LIR_Nem_3	550	555	PF02991	0.472
LIG_PDZ_Class_2	554	559	PF00595	0.481
LIG_PTAP_UEV_1	228	233	PF05743	0.564
LIG_SH2_CRK	473	477	PF00017	0.539
LIG_SH2_NCK_1	442	446	PF00017	0.645
LIG_SH2_SRC	442	445	PF00017	0.505
LIG_SH2_STAP1	385	389	PF00017	0.333
LIG_SH2_STAT5	473	476	PF00017	0.754
LIG_SH3_3	221	227	PF00018	0.658
LIG_SH3_3	306	312	PF00018	0.546
LIG_SUMO_SIM_par_1	363	370	PF11976	0.444
LIG_TRAF2_1	345	348	PF00917	0.747
LIG_ULM_U2AF65_1	265	270	PF00076	0.488
MOD_CDC14_SPxK_1	492	495	PF00782	0.810
MOD_CDK_SPK_2	130	135	PF00069	0.582
MOD_CDK_SPK_2	213	218	PF00069	0.575
MOD_CDK_SPxK_1	489	495	PF00069	0.815
MOD_CDK_SPxxK_3	472	479	PF00069	0.701
MOD_CDK_SPxxK_3	489	496	PF00069	0.748
MOD_CK1_1	130	136	PF00069	0.745
MOD_CK1_1	186	192	PF00069	0.754
MOD_CK1_1	242	248	PF00069	0.660
MOD_CK1_1	249	255	PF00069	0.583
MOD_CK1_1	277	283	PF00069	0.557
MOD_CK1_1	328	334	PF00069	0.520
MOD_CK1_1	367	373	PF00069	0.398
MOD_CK1_1	399	405	PF00069	0.640
MOD_CK1_1	45	51	PF00069	0.724
MOD_CK1_1	465	471	PF00069	0.661
MOD_CK1_1	76	82	PF00069	0.830
MOD_CK1_1	83	89	PF00069	0.713
MOD_CK1_1	92	98	PF00069	0.561
MOD_CK2_1	445	451	PF00069	0.676
MOD_CK2_1	508	514	PF00069	0.630
MOD_CK2_1	544	550	PF00069	0.663
MOD_CMANNOS	361	364	PF00535	0.624
MOD_Cter_Amidation	263	266	PF01082	0.541
MOD_GlcNHglycan	123	126	PF01048	0.691
MOD_GlcNHglycan	129	132	PF01048	0.555
MOD_GlcNHglycan	192	195	PF01048	0.547
MOD_GlcNHglycan	229	232	PF01048	0.656
MOD_GlcNHglycan	241	244	PF01048	0.774
MOD_GlcNHglycan	248	251	PF01048	0.739
MOD_GlcNHglycan	257	260	PF01048	0.552
MOD_GlcNHglycan	262	265	PF01048	0.458
MOD_GlcNHglycan	350	353	PF01048	0.659
MOD_GlcNHglycan	396	399	PF01048	0.700
MOD_GlcNHglycan	401	404	PF01048	0.644
MOD_GlcNHglycan	410	413	PF01048	0.548
MOD_GlcNHglycan	468	471	PF01048	0.718
MOD_GlcNHglycan	476	479	PF01048	0.665
MOD_GlcNHglycan	485	488	PF01048	0.620
MOD_GlcNHglycan	523	526	PF01048	0.355
MOD_GlcNHglycan	75	78	PF01048	0.830
MOD_GSK3_1	123	130	PF00069	0.699
MOD_GSK3_1	175	182	PF00069	0.782
MOD_GSK3_1	186	193	PF00069	0.564
MOD_GSK3_1	209	216	PF00069	0.682
MOD_GSK3_1	238	245	PF00069	0.741
MOD_GSK3_1	27	34	PF00069	0.747
MOD_GSK3_1	274	281	PF00069	0.548
MOD_GSK3_1	360	367	PF00069	0.532
MOD_GSK3_1	41	48	PF00069	0.634
MOD_GSK3_1	445	452	PF00069	0.641
MOD_GSK3_1	456	463	PF00069	0.702
MOD_GSK3_1	485	492	PF00069	0.808
MOD_GSK3_1	517	524	PF00069	0.602
MOD_GSK3_1	73	80	PF00069	0.830
MOD_GSK3_1	83	90	PF00069	0.814
MOD_LATS_1	173	179	PF00433	0.590
MOD_N-GLC_1	49	54	PF02516	0.813
MOD_N-GLC_2	472	474	PF02516	0.801
MOD_NEK2_1	150	155	PF00069	0.652
MOD_NEK2_1	209	214	PF00069	0.581
MOD_NEK2_1	293	298	PF00069	0.528
MOD_NEK2_1	362	367	PF00069	0.618
MOD_NEK2_1	483	488	PF00069	0.570
MOD_NEK2_1	542	547	PF00069	0.577
MOD_NEK2_1	89	94	PF00069	0.699
MOD_PIKK_1	503	509	PF00454	0.758
MOD_PK_1	462	468	PF00069	0.538
MOD_PKA_1	202	208	PF00069	0.571
MOD_PKA_2	190	196	PF00069	0.662
MOD_PKA_2	202	208	PF00069	0.654
MOD_PKA_2	232	238	PF00069	0.576
MOD_PKB_1	106	114	PF00069	0.840
MOD_PKB_1	73	81	PF00069	0.577
MOD_Plk_1	372	378	PF00069	0.510
MOD_Plk_1	49	55	PF00069	0.815
MOD_Plk_2-3	544	550	PF00069	0.410
MOD_Plk_4	232	238	PF00069	0.576
MOD_Plk_4	373	379	PF00069	0.471
MOD_Plk_4	418	424	PF00069	0.334
MOD_Plk_4	436	442	PF00069	0.465
MOD_ProDKin_1	130	136	PF00069	0.640
MOD_ProDKin_1	213	219	PF00069	0.720
MOD_ProDKin_1	225	231	PF00069	0.786
MOD_ProDKin_1	305	311	PF00069	0.616
MOD_ProDKin_1	451	457	PF00069	0.713
MOD_ProDKin_1	472	478	PF00069	0.789
MOD_ProDKin_1	485	491	PF00069	0.704
MOD_ProDKin_1	84	90	PF00069	0.685
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.577
TRG_ER_diArg_1	105	108	PF00400	0.826
TRG_ER_diArg_1	142	145	PF00400	0.730
TRG_ER_diArg_1	20	23	PF00400	0.614
TRG_ER_diArg_1	265	268	PF00400	0.489
TRG_ER_diArg_1	283	285	PF00400	0.356
TRG_ER_diArg_1	495	497	PF00400	0.789
TRG_ER_diArg_1	537	540	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE77	Leishmania donovani	68%	81%
A4I9P9	Leishmania infantum	68%	81%
C6K3V3	Leptomonas seymouri	38%	82%
E9B4R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	82%
Q4Q3B3	Leishmania major	67%	100%