Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAK4_LEIBR

TriTrypDb:

LbrM.20.0910 , LBRM2903_200015800

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HAK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.415
CLV_NRD_NRD_1	3	5	PF00675	0.409
CLV_NRD_NRD_1	35	37	PF00675	0.395
CLV_NRD_NRD_1	94	96	PF00675	0.553
CLV_PCSK_KEX2_1	11	13	PF00082	0.413
CLV_PCSK_KEX2_1	3	5	PF00082	0.408
CLV_PCSK_KEX2_1	35	37	PF00082	0.395
CLV_PCSK_KEX2_1	87	89	PF00082	0.555
CLV_PCSK_KEX2_1	94	96	PF00082	0.542
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.600
CLV_PCSK_SKI1_1	94	98	PF00082	0.583
DEG_APCC_DBOX_1	34	42	PF00400	0.583
DOC_CDC14_PxL_1	58	66	PF14671	0.351
DOC_MAPK_gen_1	35	43	PF00069	0.672
DOC_PP4_FxxP_1	59	62	PF00568	0.277
LIG_BRCT_BRCA1_1	55	59	PF00533	0.333
LIG_CSL_BTD_1	59	62	PF09270	0.277
LIG_FHA_2	104	110	PF00498	0.385
LIG_LIR_Apic_2	56	62	PF02991	0.356
LIG_LIR_Gen_1	48	57	PF02991	0.277
LIG_LIR_Gen_1	72	83	PF02991	0.353
LIG_LIR_Nem_3	48	52	PF02991	0.277
LIG_LIR_Nem_3	56	61	PF02991	0.277
LIG_LIR_Nem_3	72	78	PF02991	0.298
LIG_MLH1_MIPbox_1	55	59	PF16413	0.356
LIG_Pex14_1	53	57	PF04695	0.296
LIG_SH2_CRK	75	79	PF00017	0.359
LIG_SH2_STAP1	55	59	PF00017	0.277
LIG_SH2_STAT5	101	104	PF00017	0.402
LIG_SH2_STAT5	45	48	PF00017	0.277
LIG_SH3_3	23	29	PF00018	0.653
LIG_WRC_WIRS_1	70	75	PF05994	0.386
MOD_CK2_1	103	109	PF00069	0.390
MOD_CK2_1	27	33	PF00069	0.681
MOD_GSK3_1	27	34	PF00069	0.658
MOD_GSK3_1	99	106	PF00069	0.411
MOD_NEK2_1	108	113	PF00069	0.346
MOD_NEK2_1	20	25	PF00069	0.706
MOD_NEK2_1	31	36	PF00069	0.715
MOD_NEK2_1	97	102	PF00069	0.364
MOD_NEK2_2	53	58	PF00069	0.367
MOD_NEK2_2	6	11	PF00069	0.704
MOD_PIKK_1	99	105	PF00454	0.466
MOD_Plk_1	108	114	PF00069	0.365
MOD_Plk_1	97	103	PF00069	0.377
MOD_Plk_4	27	33	PF00069	0.649
MOD_Plk_4	39	45	PF00069	0.516
MOD_Plk_4	53	59	PF00069	0.298
MOD_Plk_4	69	75	PF00069	0.367
MOD_SUMO_rev_2	16	26	PF00179	0.653
MOD_SUMO_rev_2	86	93	PF00179	0.341
TRG_ENDOCYTIC_2	55	58	PF00928	0.280
TRG_ENDOCYTIC_2	75	78	PF00928	0.270
TRG_ER_diArg_1	10	12	PF00400	0.609
TRG_ER_diArg_1	2	4	PF00400	0.612
TRG_ER_diArg_1	93	95	PF00400	0.352
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JM59	Bodo saltans	53%	100%
A0A1X0PAL9	Trypanosomatidae	59%	100%
A0A3Q8IUG3	Leishmania donovani	97%	72%
A0A3R7MBG9	Trypanosoma rangeli	66%	100%
A4I9P8	Leishmania infantum	96%	72%
C6K3V2	Leptomonas seymouri	90%	100%
C9ZMZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B4R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	72%
Q4Q3B4	Leishmania major	96%	100%