Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAK1_LEIBR

TriTrypDb:

LbrM.20.0850 , LBRM2903_200015500

Length:

924

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.776
CLV_C14_Caspase3-7	282	286	PF00656	0.438
CLV_C14_Caspase3-7	810	814	PF00656	0.632
CLV_C14_Caspase3-7	893	897	PF00656	0.596
CLV_C14_Caspase3-7	911	915	PF00656	0.695
CLV_NRD_NRD_1	294	296	PF00675	0.540
CLV_NRD_NRD_1	432	434	PF00675	0.518
CLV_NRD_NRD_1	453	455	PF00675	0.623
CLV_NRD_NRD_1	744	746	PF00675	0.474
CLV_NRD_NRD_1	764	766	PF00675	0.258
CLV_NRD_NRD_1	868	870	PF00675	0.675
CLV_PCSK_KEX2_1	294	296	PF00082	0.540
CLV_PCSK_KEX2_1	432	434	PF00082	0.518
CLV_PCSK_KEX2_1	453	455	PF00082	0.521
CLV_PCSK_KEX2_1	743	745	PF00082	0.474
CLV_PCSK_KEX2_1	764	766	PF00082	0.588
CLV_PCSK_KEX2_1	868	870	PF00082	0.640
CLV_PCSK_KEX2_1	87	89	PF00082	0.350
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.482
CLV_PCSK_SKI1_1	267	271	PF00082	0.544
CLV_PCSK_SKI1_1	432	436	PF00082	0.534
CLV_PCSK_SKI1_1	523	527	PF00082	0.680
CLV_PCSK_SKI1_1	652	656	PF00082	0.450
CLV_PCSK_SKI1_1	701	705	PF00082	0.399
CLV_PCSK_SKI1_1	73	77	PF00082	0.530
CLV_PCSK_SKI1_1	745	749	PF00082	0.545
CLV_PCSK_SKI1_1	764	768	PF00082	0.319
DEG_APCC_DBOX_1	618	626	PF00400	0.322
DEG_APCC_KENBOX_2	546	550	PF00400	0.506
DOC_CKS1_1	232	237	PF01111	0.545
DOC_CKS1_1	572	577	PF01111	0.274
DOC_CYCLIN_RxL_1	246	256	PF00134	0.463
DOC_CYCLIN_RxL_1	43	54	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	883	889	PF00134	0.507
DOC_MAPK_gen_1	294	301	PF00069	0.606
DOC_MAPK_gen_1	701	709	PF00069	0.443
DOC_MAPK_MEF2A_6	584	592	PF00069	0.540
DOC_MAPK_MEF2A_6	701	709	PF00069	0.443
DOC_MAPK_MEF2A_6	899	907	PF00069	0.563
DOC_PP1_RVXF_1	360	366	PF00149	0.451
DOC_PP2B_LxvP_1	131	134	PF13499	0.419
DOC_PP2B_LxvP_1	203	206	PF13499	0.587
DOC_PP2B_LxvP_1	725	728	PF13499	0.588
DOC_PP4_FxxP_1	83	86	PF00568	0.567
DOC_USP7_MATH_1	134	138	PF00917	0.553
DOC_USP7_MATH_1	160	164	PF00917	0.690
DOC_USP7_MATH_1	28	32	PF00917	0.599
DOC_USP7_MATH_1	289	293	PF00917	0.427
DOC_USP7_MATH_1	327	331	PF00917	0.518
DOC_USP7_MATH_1	378	382	PF00917	0.737
DOC_USP7_MATH_1	603	607	PF00917	0.649
DOC_USP7_MATH_1	670	674	PF00917	0.433
DOC_USP7_MATH_1	697	701	PF00917	0.503
DOC_USP7_MATH_1	728	732	PF00917	0.566
DOC_USP7_MATH_1	8	12	PF00917	0.710
DOC_USP7_MATH_1	891	895	PF00917	0.679
DOC_USP7_UBL2_3	81	85	PF12436	0.496
DOC_WW_Pin1_4	21	26	PF00397	0.618
DOC_WW_Pin1_4	231	236	PF00397	0.551
DOC_WW_Pin1_4	319	324	PF00397	0.693
DOC_WW_Pin1_4	363	368	PF00397	0.505
DOC_WW_Pin1_4	38	43	PF00397	0.590
DOC_WW_Pin1_4	496	501	PF00397	0.718
DOC_WW_Pin1_4	571	576	PF00397	0.286
DOC_WW_Pin1_4	599	604	PF00397	0.616
DOC_WW_Pin1_4	885	890	PF00397	0.721
LIG_14-3-3_CanoR_1	188	195	PF00244	0.482
LIG_14-3-3_CanoR_1	288	294	PF00244	0.567
LIG_14-3-3_CanoR_1	328	336	PF00244	0.605
LIG_14-3-3_CanoR_1	342	347	PF00244	0.359
LIG_14-3-3_CanoR_1	419	428	PF00244	0.311
LIG_14-3-3_CanoR_1	523	528	PF00244	0.712
LIG_14-3-3_CanoR_1	538	543	PF00244	0.484
LIG_14-3-3_CanoR_1	599	603	PF00244	0.441
LIG_14-3-3_CanoR_1	619	623	PF00244	0.480
LIG_14-3-3_CanoR_1	745	755	PF00244	0.568
LIG_14-3-3_CanoR_1	764	770	PF00244	0.543
LIG_14-3-3_CanoR_1	822	827	PF00244	0.676
LIG_14-3-3_CanoR_1	833	839	PF00244	0.660
LIG_14-3-3_CanoR_1	868	872	PF00244	0.752
LIG_BRCT_BRCA1_1	12	16	PF00533	0.531
LIG_CSL_BTD_1	364	367	PF09270	0.575
LIG_CSL_BTD_1	572	575	PF09270	0.280
LIG_EH1_1	197	205	PF00400	0.567
LIG_eIF4E_1	198	204	PF01652	0.503
LIG_eIF4E_1	620	626	PF01652	0.313
LIG_eIF4E_1	755	761	PF01652	0.540
LIG_FHA_1	187	193	PF00498	0.453
LIG_FHA_1	199	205	PF00498	0.464
LIG_FHA_1	227	233	PF00498	0.454
LIG_FHA_1	264	270	PF00498	0.644
LIG_FHA_1	320	326	PF00498	0.633
LIG_FHA_1	380	386	PF00498	0.692
LIG_FHA_1	530	536	PF00498	0.509
LIG_FHA_1	572	578	PF00498	0.481
LIG_FHA_1	693	699	PF00498	0.459
LIG_FHA_1	834	840	PF00498	0.744
LIG_FHA_1	879	885	PF00498	0.684
LIG_FHA_1	92	98	PF00498	0.591
LIG_FHA_2	110	116	PF00498	0.380
LIG_FHA_2	213	219	PF00498	0.721
LIG_FHA_2	232	238	PF00498	0.552
LIG_FHA_2	280	286	PF00498	0.354
LIG_FHA_2	444	450	PF00498	0.480
LIG_FHA_2	543	549	PF00498	0.430
LIG_FHA_2	613	619	PF00498	0.612
LIG_FHA_2	766	772	PF00498	0.605
LIG_FHA_2	808	814	PF00498	0.645
LIG_FHA_2	94	100	PF00498	0.582
LIG_GBD_Chelix_1	244	252	PF00786	0.462
LIG_IRF3_LxIS_1	572	579	PF10401	0.356
LIG_LIR_Apic_2	642	648	PF02991	0.442
LIG_LIR_Apic_2	82	86	PF02991	0.514
LIG_LIR_Gen_1	591	600	PF02991	0.300
LIG_LIR_Gen_1	660	670	PF02991	0.427
LIG_LIR_Gen_1	713	722	PF02991	0.489
LIG_LIR_Gen_1	781	788	PF02991	0.524
LIG_LIR_Gen_1	870	878	PF02991	0.640
LIG_LIR_Nem_3	349	355	PF02991	0.423
LIG_LIR_Nem_3	591	596	PF02991	0.289
LIG_LIR_Nem_3	660	666	PF02991	0.394
LIG_LIR_Nem_3	713	717	PF02991	0.491
LIG_LIR_Nem_3	781	786	PF02991	0.524
LIG_LIR_Nem_3	870	875	PF02991	0.644
LIG_MYND_1	323	327	PF01753	0.447
LIG_NRBOX	530	536	PF00104	0.563
LIG_NRBOX	621	627	PF00104	0.556
LIG_NRBOX	756	762	PF00104	0.296
LIG_Pex14_2	779	783	PF04695	0.340
LIG_SH2_CRK	343	347	PF00017	0.558
LIG_SH2_CRK	408	412	PF00017	0.401
LIG_SH2_CRK	593	597	PF00017	0.288
LIG_SH2_CRK	663	667	PF00017	0.463
LIG_SH2_CRK	872	876	PF00017	0.471
LIG_SH2_NCK_1	872	876	PF00017	0.471
LIG_SH2_SRC	313	316	PF00017	0.515
LIG_SH2_STAP1	313	317	PF00017	0.513
LIG_SH2_STAP1	408	412	PF00017	0.434
LIG_SH2_STAP1	593	597	PF00017	0.443
LIG_SH2_STAP1	620	624	PF00017	0.330
LIG_SH2_STAP1	641	645	PF00017	0.519
LIG_SH2_STAP1	663	667	PF00017	0.517
LIG_SH2_STAP1	872	876	PF00017	0.471
LIG_SH2_STAT3	184	187	PF00017	0.570
LIG_SH2_STAT3	624	627	PF00017	0.413
LIG_SH2_STAT3	755	758	PF00017	0.542
LIG_SH2_STAT5	198	201	PF00017	0.503
LIG_SH2_STAT5	427	430	PF00017	0.413
LIG_SH2_STAT5	595	598	PF00017	0.312
LIG_SH2_STAT5	620	623	PF00017	0.442
LIG_SH2_STAT5	624	627	PF00017	0.365
LIG_SH2_STAT5	645	648	PF00017	0.434
LIG_SH2_STAT5	706	709	PF00017	0.422
LIG_SH2_STAT5	746	749	PF00017	0.482
LIG_SH2_STAT5	755	758	PF00017	0.369
LIG_SH2_STAT5	908	911	PF00017	0.648
LIG_SH3_3	229	235	PF00018	0.554
LIG_SH3_3	706	712	PF00018	0.563
LIG_SH3_3	883	889	PF00018	0.507
LIG_Sin3_3	298	305	PF02671	0.542
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.533
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.527
LIG_SUMO_SIM_anti_2	47	52	PF11976	0.553
LIG_SUMO_SIM_par_1	228	234	PF11976	0.466
LIG_SUMO_SIM_par_1	506	513	PF11976	0.638
LIG_SUMO_SIM_par_1	574	579	PF11976	0.483
LIG_SUMO_SIM_par_1	587	594	PF11976	0.489
LIG_TYR_ITIM	341	346	PF00017	0.610
LIG_TYR_ITIM	406	411	PF00017	0.481
LIG_TYR_ITIM	75	80	PF00017	0.565
LIG_TYR_ITSM	589	596	PF00017	0.285
LIG_TYR_ITSM	868	875	PF00017	0.479
LIG_UBA3_1	539	547	PF00899	0.476
MOD_CDK_SPK_2	231	236	PF00069	0.556
MOD_CDK_SPK_2	323	328	PF00069	0.446
MOD_CDK_SPxxK_3	885	892	PF00069	0.511
MOD_CK1_1	141	147	PF00069	0.602
MOD_CK1_1	158	164	PF00069	0.730
MOD_CK1_1	17	23	PF00069	0.679
MOD_CK1_1	190	196	PF00069	0.512
MOD_CK1_1	379	385	PF00069	0.706
MOD_CK1_1	49	55	PF00069	0.594
MOD_CK1_1	490	496	PF00069	0.725
MOD_CK1_1	503	509	PF00069	0.516
MOD_CK1_1	606	612	PF00069	0.653
MOD_CK1_1	800	806	PF00069	0.453
MOD_CK1_1	834	840	PF00069	0.583
MOD_CK1_1	890	896	PF00069	0.595
MOD_CK1_1	93	99	PF00069	0.589
MOD_CK2_1	109	115	PF00069	0.484
MOD_CK2_1	231	237	PF00069	0.548
MOD_CK2_1	308	314	PF00069	0.632
MOD_CK2_1	397	403	PF00069	0.588
MOD_CK2_1	443	449	PF00069	0.477
MOD_CK2_1	527	533	PF00069	0.369
MOD_CK2_1	542	548	PF00069	0.279
MOD_CK2_1	612	618	PF00069	0.587
MOD_CK2_1	871	877	PF00069	0.468
MOD_GlcNHglycan	124	127	PF01048	0.539
MOD_GlcNHglycan	17	20	PF01048	0.703
MOD_GlcNHglycan	175	178	PF01048	0.372
MOD_GlcNHglycan	181	184	PF01048	0.386
MOD_GlcNHglycan	218	222	PF01048	0.586
MOD_GlcNHglycan	30	33	PF01048	0.727
MOD_GlcNHglycan	314	318	PF01048	0.600
MOD_GlcNHglycan	36	39	PF01048	0.728
MOD_GlcNHglycan	372	375	PF01048	0.647
MOD_GlcNHglycan	386	389	PF01048	0.708
MOD_GlcNHglycan	394	397	PF01048	0.686
MOD_GlcNHglycan	459	462	PF01048	0.540
MOD_GlcNHglycan	512	515	PF01048	0.704
MOD_GlcNHglycan	520	523	PF01048	0.553
MOD_GlcNHglycan	578	581	PF01048	0.481
MOD_GlcNHglycan	605	608	PF01048	0.659
MOD_GlcNHglycan	609	612	PF01048	0.690
MOD_GlcNHglycan	748	751	PF01048	0.543
MOD_GlcNHglycan	833	836	PF01048	0.545
MOD_GlcNHglycan	889	892	PF01048	0.585
MOD_GlcNHglycan	893	896	PF01048	0.481
MOD_GSK3_1	10	17	PF00069	0.742
MOD_GSK3_1	134	141	PF00069	0.603
MOD_GSK3_1	158	165	PF00069	0.665
MOD_GSK3_1	179	186	PF00069	0.498
MOD_GSK3_1	190	197	PF00069	0.441
MOD_GSK3_1	212	219	PF00069	0.757
MOD_GSK3_1	300	307	PF00069	0.565
MOD_GSK3_1	313	320	PF00069	0.695
MOD_GSK3_1	323	330	PF00069	0.484
MOD_GSK3_1	34	41	PF00069	0.597
MOD_GSK3_1	376	383	PF00069	0.685
MOD_GSK3_1	384	391	PF00069	0.651
MOD_GSK3_1	487	494	PF00069	0.735
MOD_GSK3_1	496	503	PF00069	0.778
MOD_GSK3_1	523	530	PF00069	0.527
MOD_GSK3_1	538	545	PF00069	0.324
MOD_GSK3_1	599	606	PF00069	0.616
MOD_GSK3_1	609	616	PF00069	0.605
MOD_GSK3_1	760	767	PF00069	0.556
MOD_GSK3_1	807	814	PF00069	0.657
MOD_GSK3_1	818	825	PF00069	0.598
MOD_GSK3_1	834	841	PF00069	0.577
MOD_GSK3_1	867	874	PF00069	0.600
MOD_GSK3_1	887	894	PF00069	0.583
MOD_N-GLC_1	379	384	PF02516	0.655
MOD_N-GLC_1	518	523	PF02516	0.510
MOD_NEK2_1	109	114	PF00069	0.471
MOD_NEK2_1	138	143	PF00069	0.697
MOD_NEK2_1	149	154	PF00069	0.538
MOD_NEK2_1	15	20	PF00069	0.543
MOD_NEK2_1	370	375	PF00069	0.719
MOD_NEK2_1	411	416	PF00069	0.437
MOD_NEK2_1	487	492	PF00069	0.580
MOD_NEK2_1	501	506	PF00069	0.551
MOD_NEK2_1	542	547	PF00069	0.437
MOD_NEK2_1	576	581	PF00069	0.419
MOD_NEK2_1	625	630	PF00069	0.391
MOD_NEK2_1	63	68	PF00069	0.490
MOD_NEK2_1	661	666	PF00069	0.498
MOD_NEK2_1	687	692	PF00069	0.350
MOD_NEK2_1	760	765	PF00069	0.519
MOD_NEK2_1	818	823	PF00069	0.675
MOD_NEK2_1	831	836	PF00069	0.666
MOD_NEK2_1	871	876	PF00069	0.593
MOD_NEK2_1	878	883	PF00069	0.511
MOD_NEK2_1	90	95	PF00069	0.530
MOD_NEK2_1	916	921	PF00069	0.577
MOD_NEK2_2	127	132	PF00069	0.459
MOD_NEK2_2	289	294	PF00069	0.315
MOD_NEK2_2	867	872	PF00069	0.741
MOD_PIKK_1	183	189	PF00454	0.563
MOD_PIKK_1	198	204	PF00454	0.396
MOD_PIKK_1	459	465	PF00454	0.508
MOD_PIKK_1	501	507	PF00454	0.518
MOD_PIKK_1	563	569	PF00454	0.580
MOD_PIKK_1	68	74	PF00454	0.403
MOD_PK_1	822	828	PF00069	0.716
MOD_PKA_1	474	480	PF00069	0.521
MOD_PKA_1	764	770	PF00069	0.461
MOD_PKA_2	187	193	PF00069	0.499
MOD_PKA_2	327	333	PF00069	0.632
MOD_PKA_2	598	604	PF00069	0.363
MOD_PKA_2	61	67	PF00069	0.496
MOD_PKA_2	618	624	PF00069	0.259
MOD_PKA_2	764	770	PF00069	0.461
MOD_PKA_2	867	873	PF00069	0.749
MOD_PKA_2	891	897	PF00069	0.618
MOD_PKA_2	917	923	PF00069	0.726
MOD_Plk_1	149	155	PF00069	0.515
MOD_Plk_1	190	196	PF00069	0.496
MOD_Plk_1	240	246	PF00069	0.479
MOD_Plk_1	313	319	PF00069	0.510
MOD_Plk_1	46	52	PF00069	0.496
MOD_Plk_2-3	279	285	PF00069	0.393
MOD_Plk_2-3	618	624	PF00069	0.535
MOD_Plk_2-3	807	813	PF00069	0.673
MOD_Plk_4	240	246	PF00069	0.547
MOD_Plk_4	279	285	PF00069	0.393
MOD_Plk_4	46	52	PF00069	0.503
MOD_Plk_4	538	544	PF00069	0.510
MOD_Plk_4	588	594	PF00069	0.283
MOD_Plk_4	807	813	PF00069	0.647
MOD_Plk_4	834	840	PF00069	0.695
MOD_ProDKin_1	21	27	PF00069	0.619
MOD_ProDKin_1	231	237	PF00069	0.543
MOD_ProDKin_1	319	325	PF00069	0.684
MOD_ProDKin_1	363	369	PF00069	0.519
MOD_ProDKin_1	38	44	PF00069	0.579
MOD_ProDKin_1	496	502	PF00069	0.719
MOD_ProDKin_1	571	577	PF00069	0.283
MOD_ProDKin_1	599	605	PF00069	0.620
MOD_ProDKin_1	885	891	PF00069	0.717
MOD_SUMO_rev_2	688	693	PF00179	0.615
TRG_DiLeu_BaEn_1	430	435	PF01217	0.510
TRG_DiLeu_BaEn_2	709	715	PF01217	0.504
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.517
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.494
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.274
TRG_DiLeu_BaLyEn_6	698	703	PF01217	0.432
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.542
TRG_DiLeu_BaLyEn_6	771	776	PF01217	0.566
TRG_DiLeu_LyEn_5	430	435	PF01217	0.510
TRG_ENDOCYTIC_2	343	346	PF00928	0.629
TRG_ENDOCYTIC_2	408	411	PF00928	0.402
TRG_ENDOCYTIC_2	593	596	PF00928	0.289
TRG_ENDOCYTIC_2	663	666	PF00928	0.464
TRG_ENDOCYTIC_2	706	709	PF00928	0.455
TRG_ENDOCYTIC_2	77	80	PF00928	0.558
TRG_ENDOCYTIC_2	872	875	PF00928	0.474
TRG_ER_diArg_1	293	295	PF00400	0.583
TRG_ER_diArg_1	432	434	PF00400	0.518
TRG_ER_diArg_1	452	454	PF00400	0.433
TRG_ER_diArg_1	743	745	PF00400	0.475
TRG_ER_diArg_1	764	766	PF00400	0.538
TRG_ER_diArg_1	867	869	PF00400	0.698
TRG_NES_CRM1_1	773	789	PF08389	0.548
TRG_NES_CRM1_1	898	911	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	861	865	PF00026	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK2	Leptomonas seymouri	49%	91%
A0A3Q8IH15	Leishmania donovani	80%	99%
A0A3R7K529	Trypanosoma rangeli	33%	100%
A4I9P5	Leishmania infantum	80%	99%
C9ZMZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B4Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q3B7	Leishmania major	80%	99%