ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAK0_LEIBR

TriTrypDb:

LbrM.20.0840 , LBRM2903_200015400

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.581
CLV_NRD_NRD_1	109	111	PF00675	0.473
CLV_NRD_NRD_1	333	335	PF00675	0.641
CLV_NRD_NRD_1	387	389	PF00675	0.578
CLV_NRD_NRD_1	416	418	PF00675	0.557
CLV_PCSK_FUR_1	385	389	PF00082	0.479
CLV_PCSK_FUR_1	76	80	PF00082	0.350
CLV_PCSK_KEX2_1	109	111	PF00082	0.417
CLV_PCSK_KEX2_1	333	335	PF00082	0.641
CLV_PCSK_KEX2_1	385	387	PF00082	0.496
CLV_PCSK_KEX2_1	415	417	PF00082	0.556
CLV_PCSK_KEX2_1	425	427	PF00082	0.647
CLV_PCSK_KEX2_1	446	448	PF00082	0.531
CLV_PCSK_KEX2_1	534	536	PF00082	0.525
CLV_PCSK_KEX2_1	78	80	PF00082	0.474
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.523
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.531
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.525
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.354
CLV_PCSK_PC7_1	421	427	PF00082	0.509
CLV_PCSK_SKI1_1	125	129	PF00082	0.418
CLV_PCSK_SKI1_1	40	44	PF00082	0.527
CLV_PCSK_SKI1_1	531	535	PF00082	0.591
CLV_PCSK_SKI1_1	87	91	PF00082	0.612
DEG_SPOP_SBC_1	28	32	PF00917	0.548
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.606
DOC_MAPK_JIP1_4	61	67	PF00069	0.402
DOC_PP1_RVXF_1	98	104	PF00149	0.406
DOC_PP4_FxxP_1	7	10	PF00568	0.492
DOC_USP7_MATH_1	10	14	PF00917	0.625
DOC_USP7_MATH_1	149	153	PF00917	0.478
DOC_USP7_MATH_1	19	23	PF00917	0.490
DOC_USP7_MATH_1	236	240	PF00917	0.623
DOC_USP7_MATH_1	27	31	PF00917	0.571
DOC_USP7_MATH_1	302	306	PF00917	0.527
DOC_USP7_UBL2_3	424	428	PF12436	0.568
DOC_WW_Pin1_4	140	145	PF00397	0.574
DOC_WW_Pin1_4	239	244	PF00397	0.601
DOC_WW_Pin1_4	287	292	PF00397	0.636
DOC_WW_Pin1_4	387	392	PF00397	0.472
DOC_WW_Pin1_4	507	512	PF00397	0.532
DOC_WW_Pin1_4	534	539	PF00397	0.524
LIG_14-3-3_CanoR_1	138	143	PF00244	0.493
LIG_14-3-3_CanoR_1	196	204	PF00244	0.492
LIG_14-3-3_CanoR_1	334	340	PF00244	0.611
LIG_14-3-3_CanoR_1	64	68	PF00244	0.400
LIG_14-3-3_CanoR_1	9	18	PF00244	0.513
LIG_Actin_WH2_2	517	533	PF00022	0.585
LIG_deltaCOP1_diTrp_1	395	399	PF00928	0.642
LIG_FHA_1	132	138	PF00498	0.418
LIG_FHA_1	344	350	PF00498	0.513
LIG_FHA_1	37	43	PF00498	0.483
LIG_FHA_1	432	438	PF00498	0.521
LIG_FHA_1	461	467	PF00498	0.643
LIG_FHA_2	190	196	PF00498	0.491
LIG_FHA_2	228	234	PF00498	0.613
LIG_FHA_2	455	461	PF00498	0.647
LIG_LIR_Apic_2	15	21	PF02991	0.497
LIG_LIR_Apic_2	353	358	PF02991	0.577
LIG_LIR_Apic_2	4	10	PF02991	0.575
LIG_LIR_Apic_2	92	98	PF02991	0.403
LIG_LIR_Gen_1	130	139	PF02991	0.310
LIG_LIR_Nem_3	130	136	PF02991	0.296
LIG_LIR_Nem_3	155	159	PF02991	0.475
LIG_LIR_Nem_3	405	411	PF02991	0.493
LIG_PCNA_yPIPBox_3	401	415	PF02747	0.541
LIG_SH2_CRK	18	22	PF00017	0.553
LIG_SH2_NCK_1	18	22	PF00017	0.594
LIG_SH2_NCK_1	355	359	PF00017	0.578
LIG_SH2_SRC	411	414	PF00017	0.494
LIG_SH2_STAT3	311	314	PF00017	0.545
LIG_SH2_STAT5	142	145	PF00017	0.624
LIG_SH2_STAT5	275	278	PF00017	0.564
LIG_SH2_STAT5	411	414	PF00017	0.536
LIG_SH3_1	417	423	PF00018	0.573
LIG_SH3_2	420	425	PF14604	0.567
LIG_SH3_3	417	423	PF00018	0.573
LIG_SH3_3	509	515	PF00018	0.637
LIG_TRAF2_1	441	444	PF00917	0.609
LIG_TRAF2_1	458	461	PF00917	0.753
LIG_TRAF2_1	467	470	PF00917	0.657
LIG_UBA3_1	153	160	PF00899	0.478
LIG_UBA3_1	523	531	PF00899	0.574
LIG_WW_3	363	367	PF00397	0.528
MOD_CDK_SPxK_1	140	146	PF00069	0.577
MOD_CDK_SPxK_1	534	540	PF00069	0.526
MOD_CK1_1	152	158	PF00069	0.467
MOD_CK1_1	219	225	PF00069	0.518
MOD_CK1_1	239	245	PF00069	0.556
MOD_CK1_1	30	36	PF00069	0.765
MOD_CK1_1	390	396	PF00069	0.491
MOD_CK2_1	227	233	PF00069	0.604
MOD_CK2_1	432	438	PF00069	0.521
MOD_CK2_1	454	460	PF00069	0.537
MOD_CMANNOS	380	383	PF00535	0.413
MOD_CMANNOS	396	399	PF00535	0.501
MOD_Cter_Amidation	444	447	PF01082	0.529
MOD_GlcNHglycan	14	17	PF01048	0.607
MOD_GlcNHglycan	181	184	PF01048	0.554
MOD_GlcNHglycan	287	290	PF01048	0.502
MOD_GlcNHglycan	297	300	PF01048	0.550
MOD_GlcNHglycan	392	395	PF01048	0.537
MOD_GlcNHglycan	434	437	PF01048	0.668
MOD_GlcNHglycan	516	519	PF01048	0.591
MOD_GlcNHglycan	527	530	PF01048	0.486
MOD_GSK3_1	127	134	PF00069	0.325
MOD_GSK3_1	138	145	PF00069	0.513
MOD_GSK3_1	239	246	PF00069	0.571
MOD_GSK3_1	29	36	PF00069	0.578
MOD_N-GLC_1	302	307	PF02516	0.522
MOD_N-GLC_1	68	73	PF02516	0.435
MOD_NEK2_1	127	132	PF00069	0.265
MOD_NEK2_1	407	412	PF00069	0.455
MOD_NEK2_2	343	348	PF00069	0.524
MOD_OFUCOSY	256	262	PF10250	0.432
MOD_PIKK_1	89	95	PF00454	0.436
MOD_PKA_1	424	430	PF00069	0.522
MOD_PKA_2	195	201	PF00069	0.531
MOD_PKA_2	216	222	PF00069	0.512
MOD_PKA_2	295	301	PF00069	0.580
MOD_PKA_2	329	335	PF00069	0.566
MOD_PKA_2	63	69	PF00069	0.414
MOD_Plk_1	460	466	PF00069	0.536
MOD_Plk_1	68	74	PF00069	0.470
MOD_Plk_2-3	438	444	PF00069	0.642
MOD_Plk_4	149	155	PF00069	0.472
MOD_Plk_4	21	27	PF00069	0.595
MOD_Plk_4	461	467	PF00069	0.532
MOD_ProDKin_1	140	146	PF00069	0.578
MOD_ProDKin_1	239	245	PF00069	0.590
MOD_ProDKin_1	287	293	PF00069	0.638
MOD_ProDKin_1	387	393	PF00069	0.479
MOD_ProDKin_1	507	513	PF00069	0.531
MOD_ProDKin_1	534	540	PF00069	0.526
MOD_SUMO_rev_2	432	442	PF00179	0.685
TRG_DiLeu_BaEn_1	461	466	PF01217	0.535
TRG_ER_diArg_1	137	140	PF00400	0.502
TRG_ER_diArg_1	333	336	PF00400	0.529
TRG_ER_diArg_1	384	387	PF00400	0.501
TRG_ER_diArg_1	415	417	PF00400	0.548
TRG_NLS_Bipartite_1	415	429	PF00514	0.536
TRG_NLS_MonoExtC_3	423	428	PF00514	0.586
TRG_NLS_MonoExtN_4	421	428	PF00514	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A7	Leptomonas seymouri	53%	100%
A0A3S7X7L7	Leishmania donovani	75%	98%
A4I9P4	Leishmania infantum	74%	98%
E9B4Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%
Q4Q3B8	Leishmania major	76%	100%
V5BJD3	Trypanosoma cruzi	48%	100%