Elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor 1-beta

Species:

Leishmania braziliensis

UniProt:

A4HAJ3_LEIBR

TriTrypDb:

LbrM.20.0770 , LBRM2903_200014400

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 19
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005853	eukaryotic translation elongation factor 1 complex	2	21
GO:0032991	protein-containing complex	1	21
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HAJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAJ3

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0003746	translation elongation factor activity	4	21
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0045182	translation regulator activity	1	21
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21
GO:0005085	guanyl-nucleotide exchange factor activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.574
CLV_PCSK_KEX2_1	206	208	PF00082	0.515
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.515
CLV_PCSK_SKI1_1	102	106	PF00082	0.506
CLV_PCSK_SKI1_1	131	135	PF00082	0.507
CLV_PCSK_SKI1_1	206	210	PF00082	0.646
CLV_PCSK_SKI1_1	214	218	PF00082	0.587
DOC_CKS1_1	72	77	PF01111	0.509
DOC_CYCLIN_RxL_1	9	20	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	158	164	PF00134	0.692
DOC_MAPK_gen_1	269	277	PF00069	0.385
DOC_MAPK_MEF2A_6	152	160	PF00069	0.667
DOC_MAPK_MEF2A_6	32	40	PF00069	0.623
DOC_PIKK_1	113	121	PF02985	0.398
DOC_PP2B_LxvP_1	158	161	PF13499	0.690
DOC_PP2B_LxvP_1	16	19	PF13499	0.478
DOC_PP2B_LxvP_1	40	43	PF13499	0.512
DOC_PP4_FxxP_1	68	71	PF00568	0.481
DOC_USP7_MATH_1	222	226	PF00917	0.456
DOC_USP7_MATH_1	79	83	PF00917	0.712
DOC_USP7_UBL2_3	209	213	PF12436	0.628
DOC_USP7_UBL2_3	214	218	PF12436	0.599
DOC_USP7_UBL2_3	86	90	PF12436	0.552
DOC_WW_Pin1_4	14	19	PF00397	0.467
DOC_WW_Pin1_4	32	37	PF00397	0.511
DOC_WW_Pin1_4	5	10	PF00397	0.478
DOC_WW_Pin1_4	67	72	PF00397	0.705
LIG_14-3-3_CanoR_1	12	17	PF00244	0.474
LIG_14-3-3_CanoR_1	4	8	PF00244	0.482
LIG_14-3-3_CanoR_1	49	55	PF00244	0.512
LIG_APCC_ABBA_1	189	194	PF00400	0.635
LIG_BIR_II_1	1	5	PF00653	0.485
LIG_BRCT_BRCA1_1	224	228	PF00533	0.414
LIG_Clathr_ClatBox_1	274	278	PF01394	0.385
LIG_FHA_1	234	240	PF00498	0.388
LIG_FHA_1	35	41	PF00498	0.523
LIG_FHA_2	109	115	PF00498	0.591
LIG_FHA_2	136	142	PF00498	0.540
LIG_FHA_2	193	199	PF00498	0.634
LIG_LIR_Gen_1	8	18	PF02991	0.485
LIG_LIR_Nem_3	8	13	PF02991	0.487
LIG_NRBOX	117	123	PF00104	0.400
LIG_SH2_STAT5	139	142	PF00017	0.565
LIG_SUMO_SIM_anti_2	300	305	PF11976	0.276
LIG_SUMO_SIM_par_1	234	240	PF11976	0.423
LIG_SUMO_SIM_par_1	273	280	PF11976	0.385
LIG_TRAF2_1	195	198	PF00917	0.603
LIG_UBA3_1	226	231	PF00899	0.445
LIG_WW_3	41	45	PF00397	0.509
MOD_CDK_SPxxK_3	5	12	PF00069	0.481
MOD_CDK_SPxxK_3	71	78	PF00069	0.498
MOD_CK1_1	17	23	PF00069	0.542
MOD_CK1_1	3	9	PF00069	0.489
MOD_CK1_1	53	59	PF00069	0.480
MOD_CK1_1	70	76	PF00069	0.768
MOD_CK2_1	135	141	PF00069	0.535
MOD_CK2_1	192	198	PF00069	0.667
MOD_GlcNHglycan	282	285	PF01048	0.398
MOD_GSK3_1	32	39	PF00069	0.527
MOD_GSK3_1	66	73	PF00069	0.492
MOD_N-GLC_1	32	37	PF02516	0.514
MOD_NEK2_1	50	55	PF00069	0.563
MOD_NEK2_1	66	71	PF00069	0.477
MOD_NEK2_2	36	41	PF00069	0.581
MOD_NEK2_2	81	86	PF00069	0.469
MOD_PKA_2	3	9	PF00069	0.565
MOD_PKA_2	48	54	PF00069	0.509
MOD_Plk_1	233	239	PF00069	0.408
MOD_Plk_2-3	297	303	PF00069	0.433
MOD_Plk_4	125	131	PF00069	0.655
MOD_Plk_4	17	23	PF00069	0.536
MOD_Plk_4	222	228	PF00069	0.385
MOD_ProDKin_1	14	20	PF00069	0.467
MOD_ProDKin_1	32	38	PF00069	0.511
MOD_ProDKin_1	5	11	PF00069	0.479
MOD_ProDKin_1	67	73	PF00069	0.707
MOD_SUMO_for_1	294	297	PF00179	0.258
MOD_SUMO_rev_2	141	146	PF00179	0.587
MOD_SUMO_rev_2	198	208	PF00179	0.664
MOD_SUMO_rev_2	210	216	PF00179	0.549
MOD_SUMO_rev_2	224	232	PF00179	0.361
MOD_SUMO_rev_2	252	262	PF00179	0.411
MOD_SUMO_rev_2	278	283	PF00179	0.385
TRG_DiLeu_BaEn_4	198	204	PF01217	0.649
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.455
TRG_ER_diArg_1	54	57	PF00400	0.473
TRG_NLS_MonoExtC_3	213	218	PF00514	0.667
TRG_NLS_MonoExtN_4	213	218	PF00514	0.721
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W7	Leptomonas seymouri	61%	100%
A0A0N1HZF7	Leptomonas seymouri	72%	100%
A0A0S4JC29	Bodo saltans	53%	100%
A0A0S4JK70	Bodo saltans	61%	100%
A0A1X0PA37	Trypanosomatidae	71%	100%
A0A3Q8IVV7	Leishmania donovani	64%	100%
A0A3S5H7W1	Leishmania donovani	81%	100%
A0A422N8N9	Trypanosoma rangeli	71%	100%
A4HAJ1	Leishmania braziliensis	90%	100%
A4HAJ7	Leishmania braziliensis	92%	100%
A4HP03	Leishmania braziliensis	63%	100%
A4I9P1	Leishmania infantum	81%	100%
A4IDB2	Leishmania infantum	64%	100%
C9ZN03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	92%
E9ASR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9B4Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B4Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	96%
O74173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
O96827	Drosophila melanogaster	38%	100%
P12262	Artemia salina	39%	100%
P29522	Bombyx mori	37%	100%
P30151	Xenopus laevis	40%	100%
P34460	Caenorhabditis elegans	37%	100%
P34827	Trypanosoma cruzi	67%	100%
P78590	Candida albicans (strain WO-1)	31%	100%
Q40682	Oryza sativa subsp. japonica	31%	100%
Q4Q3C1	Leishmania major	80%	100%
Q66NE2	Leishmania major	64%	98%
Q69BZ7	Penicillium citrinum	33%	100%
Q6DET9	Xenopus tropicalis	36%	100%
Q84WM9	Arabidopsis thaliana	31%	100%
Q9GRF8	Dictyostelium discoideum	36%	100%