Putative 25 Kd elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

25 Kd elongation factor 1-beta, putative

Species:

Leishmania braziliensis

UniProt:

A4HAJ2_LEIBR

TriTrypDb:

LbrM.20.0760 , LBRM2903_200014500

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAJ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003746	translation elongation factor activity	4	5
GO:0005488	binding	1	5
GO:0008135	translation factor activity, RNA binding	3	5
GO:0045182	translation regulator activity	1	5
GO:0090079	translation regulator activity, nucleic acid binding	2	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.381
CLV_NRD_NRD_1	67	69	PF00675	0.560
LIG_14-3-3_CanoR_1	58	64	PF00244	0.467
LIG_FHA_2	19	25	PF00498	0.410
LIG_FHA_2	33	39	PF00498	0.363
LIG_FHA_2	62	68	PF00498	0.537
LIG_LIR_Gen_1	40	51	PF02991	0.534
LIG_LIR_Nem_3	40	46	PF02991	0.536
LIG_Pex14_2	42	46	PF04695	0.516
LIG_TRAF2_1	15	18	PF00917	0.446
LIG_WRC_WIRS_1	60	65	PF05994	0.524
MOD_CK2_1	59	65	PF00069	0.524
MOD_GSK3_1	59	66	PF00069	0.528
MOD_N-GLC_1	19	24	PF02516	0.388
MOD_Plk_1	19	25	PF00069	0.394
MOD_SUMO_rev_2	62	70	PF00179	0.549
TRG_ENDOCYTIC_2	43	46	PF00928	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYB6	Leptomonas seymouri	74%	100%
A0A3S7X7M1	Leishmania donovani	80%	100%
A4I9P0	Leishmania infantum	80%	100%
E9B4Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q3C2	Leishmania major	81%	100%