Elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor 1-beta

Species:

Leishmania braziliensis

UniProt:

A4HAJ1_LEIBR

TriTrypDb:

LbrM.20.0750 , LBRM2903_200014400

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 22

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005853	eukaryotic translation elongation factor 1 complex	2	19
GO:0032991	protein-containing complex	1	19
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HAJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAJ1

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	19
GO:0003746	translation elongation factor activity	4	19
GO:0005488	binding	1	19
GO:0008135	translation factor activity, RNA binding	3	19
GO:0045182	translation regulator activity	1	19
GO:0090079	translation regulator activity, nucleic acid binding	2	19
GO:0097159	organic cyclic compound binding	2	19
GO:1901363	heterocyclic compound binding	2	19
GO:0005085	guanyl-nucleotide exchange factor activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	27	29	PF00675	0.552
CLV_PCSK_KEX2_1	103	105	PF00082	0.476
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.476
CLV_PCSK_SKI1_1	103	107	PF00082	0.631
CLV_PCSK_SKI1_1	111	115	PF00082	0.555
CLV_PCSK_SKI1_1	15	19	PF00082	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.447
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.671
DOC_MAPK_gen_1	166	174	PF00069	0.364
DOC_MAPK_MEF2A_6	36	44	PF00069	0.659
DOC_PP2B_LxvP_1	42	45	PF13499	0.667
DOC_USP7_MATH_1	119	123	PF00917	0.446
DOC_USP7_UBL2_3	106	110	PF12436	0.608
DOC_USP7_UBL2_3	111	115	PF12436	0.573
LIG_APCC_ABBA_1	86	91	PF00400	0.615
LIG_BRCT_BRCA1_1	121	125	PF00533	0.380
LIG_Clathr_ClatBox_1	171	175	PF01394	0.364
LIG_FHA_1	131	137	PF00498	0.353
LIG_FHA_2	20	26	PF00498	0.532
LIG_FHA_2	90	96	PF00498	0.614
LIG_NRBOX	1	7	PF00104	0.465
LIG_SH2_STAT5	23	26	PF00017	0.618
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.236
LIG_SUMO_SIM_par_1	131	137	PF11976	0.369
LIG_SUMO_SIM_par_1	170	177	PF11976	0.364
LIG_TRAF2_1	92	95	PF00917	0.561
LIG_UBA3_1	123	128	PF00899	0.443
MOD_CK2_1	19	25	PF00069	0.521
MOD_CK2_1	89	95	PF00069	0.635
MOD_GlcNHglycan	179	182	PF01048	0.380
MOD_Plk_1	130	136	PF00069	0.373
MOD_Plk_2-3	194	200	PF00069	0.380
MOD_Plk_4	119	125	PF00069	0.364
MOD_Plk_4	9	15	PF00069	0.657
MOD_SUMO_rev_2	107	113	PF00179	0.515
MOD_SUMO_rev_2	121	129	PF00179	0.335
MOD_SUMO_rev_2	149	159	PF00179	0.378
MOD_SUMO_rev_2	175	180	PF00179	0.364
MOD_SUMO_rev_2	25	30	PF00179	0.566
MOD_SUMO_rev_2	95	105	PF00179	0.650
TRG_DiLeu_BaEn_4	95	101	PF01217	0.615
TRG_NLS_MonoExtC_3	110	115	PF00514	0.629
TRG_NLS_MonoExtN_4	110	115	PF00514	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W7	Leptomonas seymouri	61%	99%
A0A0N1HZF7	Leptomonas seymouri	74%	87%
A0A0S4JK70	Bodo saltans	63%	84%
A0A1X0PA37	Trypanosomatidae	67%	90%
A0A3Q8IVV7	Leishmania donovani	64%	98%
A0A3S5H7W1	Leishmania donovani	81%	86%
A0A422N8N9	Trypanosoma rangeli	68%	90%
A4HAJ3	Leishmania braziliensis	90%	67%
A4HAJ7	Leishmania braziliensis	100%	86%
A4HP03	Leishmania braziliensis	66%	99%
A4I9P1	Leishmania infantum	81%	86%
A4IDB2	Leishmania infantum	64%	98%
A5D989	Bos taurus	43%	74%
D0A2X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ASR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
E9B4Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	84%
O74173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	96%
O96827	Drosophila melanogaster	38%	93%
P12262	Artemia salina	50%	100%
P29522	Bombyx mori	38%	93%
P29692	Homo sapiens	46%	73%
P30151	Xenopus laevis	53%	91%
P34460	Caenorhabditis elegans	37%	97%
P34827	Trypanosoma cruzi	64%	93%
P57776	Mus musculus	46%	73%
Q4Q3C1	Leishmania major	81%	100%
Q4R3D4	Macaca fascicularis	46%	73%
Q66NE2	Leishmania major	61%	98%
Q68FR9	Rattus norvegicus	47%	73%
Q69BZ7	Penicillium citrinum	35%	90%