ACT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcription factor Pcc1, putative

Species:

Leishmania braziliensis

UniProt:

A4HAJ0_LEIBR

TriTrypDb:

LbrM.20.0740 , LBRM2903_200014300

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000408	EKC/KEOPS complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HAJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	83	85	PF00082	0.266
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.266
CLV_PCSK_SKI1_1	47	51	PF00082	0.292
DEG_SPOP_SBC_1	112	116	PF00917	0.484
DOC_PP1_RVXF_1	58	65	PF00149	0.466
DOC_PP2B_LxvP_1	32	35	PF13499	0.430
DOC_USP7_MATH_1	40	44	PF00917	0.445
DOC_USP7_MATH_1	5	9	PF00917	0.571
DOC_USP7_MATH_1	89	93	PF00917	0.466
LIG_14-3-3_CanoR_1	16	26	PF00244	0.424
LIG_Actin_WH2_2	71	89	PF00022	0.466
LIG_FHA_1	101	107	PF00498	0.466
LIG_FHA_1	54	60	PF00498	0.476
LIG_FHA_1	71	77	PF00498	0.420
LIG_FHA_2	114	120	PF00498	0.554
LIG_FHA_2	56	62	PF00498	0.468
LIG_PDZ_Class_1	120	125	PF00595	0.667
LIG_SH3_3	103	109	PF00018	0.557
LIG_SUMO_SIM_par_1	72	77	PF11976	0.448
LIG_UBA3_1	45	50	PF00899	0.389
MOD_CK1_1	70	76	PF00069	0.431
MOD_CK1_1	8	14	PF00069	0.546
MOD_CK2_1	55	61	PF00069	0.468
MOD_CK2_1	89	95	PF00069	0.402
MOD_GlcNHglycan	40	43	PF01048	0.266
MOD_GlcNHglycan	87	90	PF01048	0.266
MOD_GSK3_1	107	114	PF00069	0.543
MOD_GSK3_1	117	124	PF00069	0.619
MOD_GSK3_1	16	23	PF00069	0.520
MOD_GSK3_1	36	43	PF00069	0.514
MOD_GSK3_1	5	12	PF00069	0.583
MOD_GSK3_1	51	58	PF00069	0.430
MOD_GSK3_1	63	70	PF00069	0.403
MOD_GSK3_1	85	92	PF00069	0.434
MOD_NEK2_1	55	60	PF00069	0.448
MOD_PIKK_1	67	73	PF00454	0.466
MOD_PK_1	24	30	PF00069	0.343
MOD_PKA_2	9	15	PF00069	0.459
MOD_Plk_1	24	30	PF00069	0.510
MOD_Plk_4	40	46	PF00069	0.505
MOD_Plk_4	89	95	PF00069	0.519
TRG_DiLeu_BaEn_1	95	100	PF01217	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE2	Leptomonas seymouri	74%	100%
A0A3S7X7K3	Leishmania donovani	77%	100%
A0A422N8R9	Trypanosoma rangeli	42%	100%
A4IAL9	Leishmania infantum	77%	100%
E9B4Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3C4	Leishmania major	82%	100%