Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAI6_LEIBR

TriTrypDb:

LbrM.20.0700 , LBRM2903_200013900

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HAI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.709
CLV_NRD_NRD_1	7	9	PF00675	0.483
CLV_NRD_NRD_1	77	79	PF00675	0.371
CLV_PCSK_KEX2_1	7	9	PF00082	0.484
DEG_Nend_UBRbox_2	1	3	PF02207	0.647
DOC_MAPK_gen_1	83	92	PF00069	0.594
DOC_USP7_MATH_1	111	115	PF00917	0.617
DOC_USP7_MATH_1	160	164	PF00917	0.610
DOC_USP7_MATH_2	31	37	PF00917	0.624
DOC_WW_Pin1_4	27	32	PF00397	0.613
LIG_14-3-3_CanoR_1	112	120	PF00244	0.666
LIG_14-3-3_CanoR_1	138	148	PF00244	0.626
LIG_BRCT_BRCA1_1	31	35	PF00533	0.622
LIG_FHA_1	71	77	PF00498	0.628
LIG_FHA_2	51	57	PF00498	0.737
LIG_LIR_Apic_2	25	31	PF02991	0.618
LIG_LIR_Gen_1	103	113	PF02991	0.565
LIG_LIR_Gen_1	174	184	PF02991	0.549
LIG_LIR_Gen_1	23	31	PF02991	0.726
LIG_LIR_Nem_3	103	109	PF02991	0.638
LIG_LIR_Nem_3	174	179	PF02991	0.665
LIG_LIR_Nem_3	207	213	PF02991	0.388
LIG_LIR_Nem_3	23	29	PF02991	0.727
LIG_NRP_CendR_1	214	216	PF00754	0.775
LIG_Pex14_1	183	187	PF04695	0.411
LIG_Pex14_2	179	183	PF04695	0.400
LIG_SH2_CRK	26	30	PF00017	0.619
LIG_SH2_PTP2	28	31	PF00017	0.618
LIG_SH2_SRC	21	24	PF00017	0.613
LIG_SH2_STAP1	189	193	PF00017	0.513
LIG_SH2_STAT5	186	189	PF00017	0.448
LIG_SH2_STAT5	21	24	PF00017	0.613
LIG_SH2_STAT5	210	213	PF00017	0.497
LIG_SH2_STAT5	28	31	PF00017	0.598
LIG_SUMO_SIM_par_1	87	94	PF11976	0.573
MOD_CK1_1	119	125	PF00069	0.705
MOD_CK1_1	139	145	PF00069	0.722
MOD_CK1_1	163	169	PF00069	0.781
MOD_CK1_1	24	30	PF00069	0.643
MOD_CK1_1	50	56	PF00069	0.705
MOD_CK2_1	151	157	PF00069	0.709
MOD_CK2_1	168	174	PF00069	0.691
MOD_CK2_1	27	33	PF00069	0.640
MOD_CK2_1	90	96	PF00069	0.672
MOD_GlcNHglycan	138	141	PF01048	0.438
MOD_GlcNHglycan	144	147	PF01048	0.576
MOD_GlcNHglycan	162	165	PF01048	0.375
MOD_GlcNHglycan	193	196	PF01048	0.488
MOD_GSK3_1	111	118	PF00069	0.591
MOD_GSK3_1	136	143	PF00069	0.646
MOD_GSK3_1	29	36	PF00069	0.741
MOD_GSK3_1	40	47	PF00069	0.726
MOD_NEK2_1	144	149	PF00069	0.602
MOD_NEK2_1	191	196	PF00069	0.513
MOD_NEK2_1	40	45	PF00069	0.693
MOD_NEK2_1	72	77	PF00069	0.658
MOD_PIKK_1	111	117	PF00454	0.746
MOD_PK_1	55	61	PF00069	0.597
MOD_PKA_1	7	13	PF00069	0.622
MOD_PKA_2	111	117	PF00069	0.673
MOD_PKA_2	7	13	PF00069	0.622
MOD_Plk_1	24	30	PF00069	0.674
MOD_Plk_1	55	61	PF00069	0.656
MOD_Plk_4	24	30	PF00069	0.643
MOD_ProDKin_1	27	33	PF00069	0.613
TRG_DiLeu_BaEn_4	132	138	PF01217	0.826
TRG_ENDOCYTIC_2	181	184	PF00928	0.424
TRG_ENDOCYTIC_2	210	213	PF00928	0.411
TRG_ENDOCYTIC_2	26	29	PF00928	0.646
TRG_ER_diArg_1	213	216	PF00400	0.493
TRG_ER_diArg_1	6	8	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG5	Leptomonas seymouri	40%	91%
A0A3S7X7I7	Leishmania donovani	64%	100%
E9AHS7	Leishmania infantum	64%	100%
E9B4P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q3C9	Leishmania major	64%	98%