NmrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAI5_LEIBR

TriTrypDb:

LbrM.20.0690 , LBRM2903_200013800

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HAI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAI5

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016043	cellular component organization	3	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022607	cellular component assembly	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.357
CLV_C14_Caspase3-7	452	456	PF00656	0.539
CLV_NRD_NRD_1	112	114	PF00675	0.297
CLV_NRD_NRD_1	171	173	PF00675	0.602
CLV_NRD_NRD_1	267	269	PF00675	0.557
CLV_NRD_NRD_1	280	282	PF00675	0.476
CLV_NRD_NRD_1	306	308	PF00675	0.450
CLV_PCSK_KEX2_1	112	114	PF00082	0.300
CLV_PCSK_KEX2_1	158	160	PF00082	0.634
CLV_PCSK_KEX2_1	171	173	PF00082	0.554
CLV_PCSK_KEX2_1	267	269	PF00082	0.561
CLV_PCSK_KEX2_1	280	282	PF00082	0.476
CLV_PCSK_KEX2_1	306	308	PF00082	0.452
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.543
CLV_PCSK_SKI1_1	128	132	PF00082	0.453
CLV_PCSK_SKI1_1	159	163	PF00082	0.617
CLV_PCSK_SKI1_1	175	179	PF00082	0.416
DEG_APCC_DBOX_1	202	210	PF00400	0.440
DEG_APCC_DBOX_1	376	384	PF00400	0.377
DOC_CKS1_1	288	293	PF01111	0.272
DOC_CYCLIN_RxL_1	122	136	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.361
DOC_MAPK_gen_1	112	119	PF00069	0.277
DOC_MAPK_gen_1	126	134	PF00069	0.382
DOC_MAPK_gen_1	371	378	PF00069	0.471
DOC_MAPK_MEF2A_6	112	121	PF00069	0.277
DOC_MAPK_MEF2A_6	126	134	PF00069	0.382
DOC_PP1_RVXF_1	64	71	PF00149	0.564
DOC_PP2B_LxvP_1	130	133	PF13499	0.490
DOC_PP4_FxxP_1	4	7	PF00568	0.458
DOC_USP7_MATH_1	250	254	PF00917	0.569
DOC_USP7_MATH_1	352	356	PF00917	0.421
DOC_WW_Pin1_4	238	243	PF00397	0.662
DOC_WW_Pin1_4	255	260	PF00397	0.657
DOC_WW_Pin1_4	287	292	PF00397	0.427
DOC_WW_Pin1_4	297	302	PF00397	0.451
DOC_WW_Pin1_4	329	334	PF00397	0.468
DOC_WW_Pin1_4	371	376	PF00397	0.510
LIG_14-3-3_CanoR_1	112	118	PF00244	0.396
LIG_14-3-3_CanoR_1	141	150	PF00244	0.596
LIG_14-3-3_CanoR_1	183	189	PF00244	0.546
LIG_14-3-3_CanoR_1	203	207	PF00244	0.413
LIG_14-3-3_CanoR_1	224	229	PF00244	0.385
LIG_14-3-3_CanoR_1	377	381	PF00244	0.274
LIG_14-3-3_CanoR_1	382	389	PF00244	0.403
LIG_Actin_WH2_2	99	114	PF00022	0.342
LIG_APCC_ABBA_1	30	35	PF00400	0.556
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	226	230	PF00533	0.396
LIG_BRCT_BRCA1_1	456	460	PF00533	0.589
LIG_CSL_BTD_1	256	259	PF09270	0.531
LIG_DLG_GKlike_1	268	276	PF00625	0.292
LIG_eIF4E_1	303	309	PF01652	0.519
LIG_FHA_1	116	122	PF00498	0.172
LIG_FHA_1	160	166	PF00498	0.498
LIG_FHA_1	203	209	PF00498	0.439
LIG_FHA_1	339	345	PF00498	0.429
LIG_FHA_1	407	413	PF00498	0.640
LIG_FHA_1	97	103	PF00498	0.314
LIG_FHA_2	79	85	PF00498	0.565
LIG_Integrin_RGD_1	172	174	PF01839	0.403
LIG_LIR_Apic_2	2	7	PF02991	0.460
LIG_LIR_Apic_2	253	259	PF02991	0.546
LIG_LIR_Gen_1	146	156	PF02991	0.543
LIG_LIR_Gen_1	283	294	PF02991	0.462
LIG_LIR_Gen_1	457	466	PF02991	0.597
LIG_LIR_Nem_3	129	134	PF02991	0.531
LIG_LIR_Nem_3	146	152	PF02991	0.681
LIG_LIR_Nem_3	283	289	PF02991	0.452
LIG_LIR_Nem_3	385	391	PF02991	0.567
LIG_LIR_Nem_3	457	463	PF02991	0.575
LIG_LYPXL_yS_3	57	60	PF13949	0.593
LIG_SH2_CRK	149	153	PF00017	0.580
LIG_SH2_CRK	305	309	PF00017	0.464
LIG_SH2_STAT5	110	113	PF00017	0.393
LIG_SH2_STAT5	151	154	PF00017	0.484
LIG_SH2_STAT5	231	234	PF00017	0.407
LIG_SH2_STAT5	29	32	PF00017	0.544
LIG_SH2_STAT5	315	318	PF00017	0.387
LIG_SH2_STAT5	338	341	PF00017	0.470
LIG_SH2_STAT5	69	72	PF00017	0.532
LIG_SH2_STAT5	79	82	PF00017	0.403
LIG_SH3_3	285	291	PF00018	0.302
LIG_SH3_3	306	312	PF00018	0.398
LIG_SH3_3	4	10	PF00018	0.686
LIG_SH3_4	410	417	PF00018	0.405
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.300
LIG_SUMO_SIM_anti_2	205	210	PF11976	0.352
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.298
LIG_SUMO_SIM_par_1	116	125	PF11976	0.199
LIG_SUMO_SIM_par_1	204	210	PF11976	0.362
LIG_TRAF2_1	235	238	PF00917	0.541
LIG_TRAF2_2	411	416	PF00917	0.471
LIG_WRC_WIRS_1	269	274	PF05994	0.368
LIG_WRC_WIRS_1	388	393	PF05994	0.476
MOD_CDC14_SPxK_1	374	377	PF00782	0.517
MOD_CDK_SPxK_1	371	377	PF00069	0.501
MOD_CDK_SPxxK_3	238	245	PF00069	0.445
MOD_CDK_SPxxK_3	255	262	PF00069	0.389
MOD_CK1_1	258	264	PF00069	0.706
MOD_CK1_1	297	303	PF00069	0.440
MOD_CK2_1	387	393	PF00069	0.467
MOD_CK2_1	78	84	PF00069	0.604
MOD_CMANNOS	353	356	PF00535	0.592
MOD_CMANNOS	357	360	PF00535	0.604
MOD_Cter_Amidation	265	268	PF01082	0.532
MOD_GlcNHglycan	143	146	PF01048	0.461
MOD_GlcNHglycan	191	194	PF01048	0.627
MOD_GlcNHglycan	197	201	PF01048	0.672
MOD_GlcNHglycan	214	217	PF01048	0.305
MOD_GlcNHglycan	252	255	PF01048	0.674
MOD_GlcNHglycan	264	267	PF01048	0.489
MOD_GlcNHglycan	348	351	PF01048	0.578
MOD_GlcNHglycan	455	459	PF01048	0.546
MOD_GSK3_1	184	191	PF00069	0.557
MOD_GSK3_1	258	265	PF00069	0.650
MOD_GSK3_1	325	332	PF00069	0.497
MOD_GSK3_1	432	439	PF00069	0.492
MOD_GSK3_1	74	81	PF00069	0.425
MOD_N-GLC_1	141	146	PF02516	0.462
MOD_N-GLC_1	329	334	PF02516	0.384
MOD_NEK2_1	182	187	PF00069	0.449
MOD_NEK2_1	219	224	PF00069	0.474
MOD_NEK2_1	426	431	PF00069	0.437
MOD_NEK2_1	432	437	PF00069	0.490
MOD_NEK2_1	453	458	PF00069	0.393
MOD_NEK2_2	28	33	PF00069	0.605
MOD_PIKK_1	325	331	PF00454	0.570
MOD_PK_1	113	119	PF00069	0.335
MOD_PK_1	224	230	PF00069	0.412
MOD_PKA_2	121	127	PF00069	0.199
MOD_PKA_2	167	173	PF00069	0.514
MOD_PKA_2	182	188	PF00069	0.365
MOD_PKA_2	202	208	PF00069	0.415
MOD_PKA_2	294	300	PF00069	0.384
MOD_PKA_2	346	352	PF00069	0.557
MOD_PKA_2	376	382	PF00069	0.276
MOD_PKA_2	453	459	PF00069	0.388
MOD_PKB_1	139	147	PF00069	0.398
MOD_Plk_1	219	225	PF00069	0.481
MOD_Plk_1	322	328	PF00069	0.530
MOD_Plk_1	454	460	PF00069	0.402
MOD_Plk_4	115	121	PF00069	0.317
MOD_Plk_4	126	132	PF00069	0.371
MOD_Plk_4	224	230	PF00069	0.352
MOD_Plk_4	268	274	PF00069	0.345
MOD_Plk_4	322	328	PF00069	0.500
MOD_Plk_4	352	358	PF00069	0.405
MOD_Plk_4	432	438	PF00069	0.563
MOD_Plk_4	74	80	PF00069	0.414
MOD_Plk_4	91	97	PF00069	0.316
MOD_ProDKin_1	238	244	PF00069	0.667
MOD_ProDKin_1	255	261	PF00069	0.651
MOD_ProDKin_1	287	293	PF00069	0.429
MOD_ProDKin_1	297	303	PF00069	0.440
MOD_ProDKin_1	329	335	PF00069	0.467
MOD_ProDKin_1	371	377	PF00069	0.501
TRG_DiLeu_BaEn_1	91	96	PF01217	0.393
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.530
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.573
TRG_ENDOCYTIC_2	149	152	PF00928	0.652
TRG_ENDOCYTIC_2	29	32	PF00928	0.505
TRG_ENDOCYTIC_2	305	308	PF00928	0.456
TRG_ENDOCYTIC_2	57	60	PF00928	0.593
TRG_ER_diArg_1	111	113	PF00400	0.300
TRG_ER_diArg_1	17	20	PF00400	0.571
TRG_ER_diArg_1	267	269	PF00400	0.561
TRG_ER_diArg_1	280	282	PF00400	0.468
TRG_ER_diArg_1	305	307	PF00400	0.452
TRG_NES_CRM1_1	109	125	PF08389	0.208
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN2	Leptomonas seymouri	68%	98%
A0A0S4IVY0	Bodo saltans	25%	100%
A0A1X0P965	Trypanosomatidae	34%	100%
A0A3Q8IIA0	Leishmania donovani	80%	100%
E9AHS6	Leishmania infantum	80%	100%
E9B4P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q3D0	Leishmania major	78%	100%
V5BEX5	Trypanosoma cruzi	35%	100%