Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAI4_LEIBR

TriTrypDb:

LbrM.20.0680 , LBRM2903_200013700

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.252
CLV_NRD_NRD_1	221	223	PF00675	0.437
CLV_NRD_NRD_1	499	501	PF00675	0.564
CLV_NRD_NRD_1	73	75	PF00675	0.442
CLV_PCSK_FUR_1	73	77	PF00082	0.437
CLV_PCSK_KEX2_1	223	225	PF00082	0.458
CLV_PCSK_KEX2_1	73	75	PF00082	0.466
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.539
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.470
CLV_PCSK_SKI1_1	168	172	PF00082	0.387
CLV_PCSK_SKI1_1	291	295	PF00082	0.327
CLV_PCSK_SKI1_1	37	41	PF00082	0.561
CLV_PCSK_SKI1_1	377	381	PF00082	0.398
CLV_PCSK_SKI1_1	384	388	PF00082	0.398
CLV_PCSK_SKI1_1	477	481	PF00082	0.479
CLV_PCSK_SKI1_1	75	79	PF00082	0.431
DEG_APCC_DBOX_1	376	384	PF00400	0.431
DEG_Nend_Nbox_1	1	3	PF02207	0.515
DEG_SCF_FBW7_1	28	35	PF00400	0.452
DOC_CKS1_1	29	34	PF01111	0.455
DOC_CYCLIN_RxL_1	286	298	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.443
DOC_MAPK_FxFP_2	113	116	PF00069	0.406
DOC_MAPK_gen_1	222	231	PF00069	0.455
DOC_PP1_RVXF_1	435	441	PF00149	0.393
DOC_PP1_SILK_1	90	95	PF00149	0.492
DOC_PP2B_LxvP_1	321	324	PF13499	0.427
DOC_PP2B_LxvP_1	357	360	PF13499	0.443
DOC_PP2B_LxvP_1	40	43	PF13499	0.334
DOC_PP4_FxxP_1	113	116	PF00568	0.406
DOC_PP4_FxxP_1	262	265	PF00568	0.306
DOC_USP7_MATH_1	32	36	PF00917	0.612
DOC_USP7_MATH_1	368	372	PF00917	0.477
DOC_USP7_MATH_1	495	499	PF00917	0.509
DOC_USP7_UBL2_3	54	58	PF12436	0.551
DOC_WW_Pin1_4	118	123	PF00397	0.466
DOC_WW_Pin1_4	206	211	PF00397	0.529
DOC_WW_Pin1_4	241	246	PF00397	0.460
DOC_WW_Pin1_4	275	280	PF00397	0.496
DOC_WW_Pin1_4	28	33	PF00397	0.633
LIG_14-3-3_CanoR_1	168	177	PF00244	0.299
LIG_14-3-3_CanoR_1	248	255	PF00244	0.545
LIG_14-3-3_CanoR_1	3	10	PF00244	0.654
LIG_14-3-3_CanoR_1	401	407	PF00244	0.548
LIG_14-3-3_CanoR_1	475	480	PF00244	0.511
LIG_14-3-3_CanoR_1	74	80	PF00244	0.434
LIG_Actin_WH2_2	153	170	PF00022	0.377
LIG_APCC_ABBA_1	484	489	PF00400	0.418
LIG_APCC_ABBA_1	64	69	PF00400	0.415
LIG_BRCT_BRCA1_1	148	152	PF00533	0.390
LIG_deltaCOP1_diTrp_1	68	79	PF00928	0.423
LIG_EH_1	257	261	PF12763	0.370
LIG_eIF4E_1	289	295	PF01652	0.330
LIG_FHA_1	139	145	PF00498	0.469
LIG_FHA_1	203	209	PF00498	0.522
LIG_FHA_1	481	487	PF00498	0.562
LIG_FHA_2	196	202	PF00498	0.607
LIG_FHA_2	296	302	PF00498	0.401
LIG_LIR_Apic_2	111	116	PF02991	0.389
LIG_LIR_Gen_1	105	114	PF02991	0.373
LIG_LIR_Gen_1	172	182	PF02991	0.340
LIG_LIR_Gen_1	419	428	PF02991	0.349
LIG_LIR_Nem_3	105	109	PF02991	0.365
LIG_LIR_Nem_3	149	155	PF02991	0.366
LIG_LIR_Nem_3	172	177	PF02991	0.350
LIG_LIR_Nem_3	419	425	PF02991	0.343
LIG_LIR_Nem_3	433	439	PF02991	0.381
LIG_LYPXL_SIV_4	417	425	PF13949	0.429
LIG_PCNA_PIPBox_1	145	154	PF02747	0.489
LIG_PCNA_yPIPBox_3	460	468	PF02747	0.531
LIG_Pex14_2	260	264	PF04695	0.355
LIG_Pex14_2	436	440	PF04695	0.500
LIG_SH2_CRK	106	110	PF00017	0.362
LIG_SH2_CRK	418	422	PF00017	0.344
LIG_SH2_GRB2like	439	442	PF00017	0.245
LIG_SH2_NCK_1	106	110	PF00017	0.362
LIG_SH2_NCK_1	189	193	PF00017	0.453
LIG_SH2_NCK_1	418	422	PF00017	0.321
LIG_SH2_SRC	189	192	PF00017	0.441
LIG_SH2_STAP1	289	293	PF00017	0.318
LIG_SH2_STAP1	418	422	PF00017	0.344
LIG_SH2_STAP1	62	66	PF00017	0.430
LIG_SH2_STAT5	106	109	PF00017	0.335
LIG_SH2_STAT5	185	188	PF00017	0.439
LIG_SH2_STAT5	274	277	PF00017	0.576
LIG_SH2_STAT5	418	421	PF00017	0.339
LIG_SH2_STAT5	422	425	PF00017	0.341
LIG_SH3_3	121	127	PF00018	0.438
LIG_SH3_3	26	32	PF00018	0.641
LIG_SH3_3	326	332	PF00018	0.338
LIG_TYR_ITIM	416	421	PF00017	0.346
LIG_UBA3_1	379	384	PF00899	0.414
LIG_WRC_WIRS_1	364	369	PF05994	0.447
MOD_CDK_SPxK_1	275	281	PF00069	0.480
MOD_CDK_SPxK_1	28	34	PF00069	0.451
MOD_CDK_SPxxK_3	241	248	PF00069	0.458
MOD_CK2_1	136	142	PF00069	0.432
MOD_GlcNHglycan	18	21	PF01048	0.525
MOD_GlcNHglycan	22	25	PF01048	0.599
MOD_GlcNHglycan	337	340	PF01048	0.275
MOD_GlcNHglycan	34	37	PF01048	0.487
MOD_GlcNHglycan	4	7	PF01048	0.638
MOD_GSK3_1	156	163	PF00069	0.466
MOD_GSK3_1	16	23	PF00069	0.510
MOD_GSK3_1	202	209	PF00069	0.566
MOD_GSK3_1	28	35	PF00069	0.460
MOD_GSK3_1	351	358	PF00069	0.390
MOD_GSK3_1	475	482	PF00069	0.562
MOD_GSK3_1	52	59	PF00069	0.508
MOD_N-GLC_1	137	142	PF02516	0.468
MOD_NEK2_1	156	161	PF00069	0.464
MOD_NEK2_1	2	7	PF00069	0.631
MOD_NEK2_1	204	209	PF00069	0.541
MOD_NEK2_1	295	300	PF00069	0.390
MOD_NEK2_1	351	356	PF00069	0.373
MOD_NEK2_1	416	421	PF00069	0.354
MOD_NEK2_1	479	484	PF00069	0.482
MOD_NEK2_1	87	92	PF00069	0.516
MOD_NEK2_2	284	289	PF00069	0.364
MOD_PIKK_1	195	201	PF00454	0.573
MOD_PIKK_1	387	393	PF00454	0.509
MOD_PK_1	88	94	PF00069	0.424
MOD_PKA_1	75	81	PF00069	0.458
MOD_PKA_2	2	8	PF00069	0.480
MOD_PKA_2	247	253	PF00069	0.549
MOD_PKA_2	306	312	PF00069	0.616
MOD_PKA_2	335	341	PF00069	0.380
MOD_PKA_2	368	374	PF00069	0.459
MOD_PKA_2	400	406	PF00069	0.557
MOD_PKA_2	75	81	PF00069	0.427
MOD_PKA_2	87	93	PF00069	0.411
MOD_Plk_1	104	110	PF00069	0.373
MOD_Plk_1	369	375	PF00069	0.487
MOD_Plk_1	56	62	PF00069	0.562
MOD_Plk_1	68	74	PF00069	0.517
MOD_Plk_2-3	225	231	PF00069	0.472
MOD_Plk_4	104	110	PF00069	0.316
MOD_Plk_4	289	295	PF00069	0.345
MOD_Plk_4	416	422	PF00069	0.346
MOD_Plk_4	475	481	PF00069	0.504
MOD_Plk_4	88	94	PF00069	0.397
MOD_ProDKin_1	118	124	PF00069	0.466
MOD_ProDKin_1	206	212	PF00069	0.521
MOD_ProDKin_1	241	247	PF00069	0.454
MOD_ProDKin_1	275	281	PF00069	0.489
MOD_ProDKin_1	28	34	PF00069	0.635
MOD_SUMO_for_1	373	376	PF00179	0.443
MOD_SUMO_rev_2	197	205	PF00179	0.660
MOD_SUMO_rev_2	376	386	PF00179	0.422
MOD_SUMO_rev_2	47	56	PF00179	0.462
MOD_SUMO_rev_2	498	503	PF00179	0.555
MOD_SUMO_rev_2	57	66	PF00179	0.438
TRG_DiLeu_BaEn_1	459	464	PF01217	0.449
TRG_DiLeu_BaEn_2	235	241	PF01217	0.385
TRG_DiLeu_BaEn_2	380	386	PF01217	0.418
TRG_DiLeu_BaEn_4	381	387	PF01217	0.426
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.355
TRG_ENDOCYTIC_2	106	109	PF00928	0.356
TRG_ENDOCYTIC_2	189	192	PF00928	0.468
TRG_ENDOCYTIC_2	418	421	PF00928	0.343
TRG_ENDOCYTIC_2	422	425	PF00928	0.345
TRG_ENDOCYTIC_2	428	431	PF00928	0.378
TRG_ENDOCYTIC_2	67	70	PF00928	0.421
TRG_ER_diArg_1	221	224	PF00400	0.440
TRG_ER_diArg_1	72	74	PF00400	0.466
TRG_ER_diArg_1	93	96	PF00400	0.402
TRG_NLS_MonoExtN_4	73	78	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA50	Leptomonas seymouri	86%	100%
A0A0N1PBN6	Leptomonas seymouri	27%	73%
A0A0S4ISW7	Bodo saltans	28%	68%
A0A0S4JJ07	Bodo saltans	69%	100%
A0A1X0NY35	Trypanosomatidae	26%	72%
A0A1X0P990	Trypanosomatidae	70%	100%
A0A3Q8IE69	Leishmania donovani	93%	100%
A0A3R7MZ34	Trypanosoma rangeli	27%	74%
A0A3R7N7Y7	Trypanosoma rangeli	72%	100%
C9ZN08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
C9ZVC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	73%
E9AHS5	Leishmania infantum	93%	100%
E9AWF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	74%
E9B4P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3D1	Leishmania major	93%	100%
Q4QB18	Leishmania major	26%	73%
V5BJD7	Trypanosoma cruzi	73%	100%