CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HAI3_LEIBR

TriTrypDb:

LbrM.20.0670 , LBRM2903_200013600

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030689	Noc complex	3	1
GO:0030692	Noc4p-Nop14p complex	4	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HAI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAI3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0022613	ribonucleoprotein complex biogenesis	4	12
GO:0042254	ribosome biogenesis	5	12
GO:0044085	cellular component biogenesis	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.388
CLV_NRD_NRD_1	159	161	PF00675	0.531
CLV_NRD_NRD_1	321	323	PF00675	0.258
CLV_NRD_NRD_1	97	99	PF00675	0.429
CLV_PCSK_KEX2_1	159	161	PF00082	0.531
CLV_PCSK_KEX2_1	300	302	PF00082	0.308
CLV_PCSK_KEX2_1	99	101	PF00082	0.396
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.308
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.396
CLV_PCSK_PC7_1	95	101	PF00082	0.379
CLV_PCSK_SKI1_1	142	146	PF00082	0.539
CLV_PCSK_SKI1_1	322	326	PF00082	0.285
CLV_PCSK_SKI1_1	434	438	PF00082	0.334
CLV_PCSK_SKI1_1	62	66	PF00082	0.311
DEG_APCC_DBOX_1	273	281	PF00400	0.447
DEG_COP1_1	284	293	PF00400	0.472
DEG_MDM2_SWIB_1	182	190	PF02201	0.328
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DEG_SPOP_SBC_1	415	419	PF00917	0.598
DOC_CDC14_PxL_1	308	316	PF14671	0.458
DOC_CKS1_1	263	268	PF01111	0.458
DOC_CYCLIN_RxL_1	273	287	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.286
DOC_MAPK_DCC_7	403	413	PF00069	0.458
DOC_MAPK_gen_1	300	307	PF00069	0.472
DOC_MAPK_gen_1	98	109	PF00069	0.515
DOC_MAPK_MEF2A_6	403	411	PF00069	0.458
DOC_PP1_RVXF_1	130	136	PF00149	0.343
DOC_PP2B_LxvP_1	288	291	PF13499	0.458
DOC_PP2B_LxvP_1	307	310	PF13499	0.458
DOC_PP4_FxxP_1	316	319	PF00568	0.447
DOC_USP7_MATH_1	268	272	PF00917	0.369
DOC_USP7_MATH_1	303	307	PF00917	0.533
DOC_USP7_MATH_1	390	394	PF00917	0.469
DOC_USP7_MATH_1	415	419	PF00917	0.562
DOC_USP7_MATH_1	443	447	PF00917	0.657
DOC_WW_Pin1_4	262	267	PF00397	0.458
DOC_WW_Pin1_4	27	32	PF00397	0.587
DOC_WW_Pin1_4	36	41	PF00397	0.538
DOC_WW_Pin1_4	421	426	PF00397	0.605
DOC_WW_Pin1_4	47	52	PF00397	0.426
DOC_WW_Pin1_4	72	77	PF00397	0.616
LIG_14-3-3_CanoR_1	104	110	PF00244	0.510
LIG_AP2alpha_2	377	379	PF02296	0.458
LIG_APCC_ABBA_1	170	175	PF00400	0.274
LIG_Clathr_ClatBox_1	244	248	PF01394	0.315
LIG_CtBP_PxDLS_1	345	349	PF00389	0.371
LIG_eIF4E_1	275	281	PF01652	0.447
LIG_FHA_1	120	126	PF00498	0.440
LIG_FHA_1	165	171	PF00498	0.339
LIG_FHA_1	213	219	PF00498	0.290
LIG_FHA_1	367	373	PF00498	0.507
LIG_FHA_1	386	392	PF00498	0.533
LIG_FHA_1	435	441	PF00498	0.551
LIG_FHA_1	461	467	PF00498	0.634
LIG_FHA_2	15	21	PF00498	0.502
LIG_FHA_2	22	28	PF00498	0.510
LIG_FHA_2	392	398	PF00498	0.472
LIG_FHA_2	417	423	PF00498	0.586
LIG_FHA_2	47	53	PF00498	0.642
LIG_FHA_2	73	79	PF00498	0.582
LIG_LIR_Apic_2	313	319	PF02991	0.508
LIG_LIR_Apic_2	451	457	PF02991	0.596
LIG_LIR_Gen_1	114	125	PF02991	0.381
LIG_LIR_Gen_1	17	25	PF02991	0.492
LIG_LIR_Gen_1	258	269	PF02991	0.508
LIG_LIR_Nem_3	114	120	PF02991	0.381
LIG_LIR_Nem_3	17	21	PF02991	0.483
LIG_LIR_Nem_3	252	256	PF02991	0.450
LIG_LIR_Nem_3	258	264	PF02991	0.442
LIG_LIR_Nem_3	276	281	PF02991	0.350
LIG_LIR_Nem_3	313	318	PF02991	0.508
LIG_LIR_Nem_3	402	408	PF02991	0.523
LIG_LIR_Nem_3	429	435	PF02991	0.545
LIG_LIR_Nem_3	79	85	PF02991	0.479
LIG_NRBOX	259	265	PF00104	0.456
LIG_NRBOX	276	282	PF00104	0.406
LIG_PDZ_Class_2	463	468	PF00595	0.624
LIG_Pex14_1	82	86	PF04695	0.491
LIG_Pex14_2	182	186	PF04695	0.266
LIG_Pex14_2	316	320	PF04695	0.447
LIG_SH2_CRK	261	265	PF00017	0.456
LIG_SH2_CRK	432	436	PF00017	0.539
LIG_SH2_CRK	86	90	PF00017	0.570
LIG_SH2_NCK_1	454	458	PF00017	0.641
LIG_SH2_SRC	151	154	PF00017	0.302
LIG_SH2_STAP1	257	261	PF00017	0.508
LIG_SH2_STAP1	428	432	PF00017	0.557
LIG_SH2_STAT3	256	259	PF00017	0.458
LIG_SH2_STAT5	151	154	PF00017	0.317
LIG_SH2_STAT5	181	184	PF00017	0.196
LIG_SH2_STAT5	223	226	PF00017	0.307
LIG_SH2_STAT5	293	296	PF00017	0.447
LIG_SH2_STAT5	315	318	PF00017	0.447
LIG_SH3_3	206	212	PF00018	0.292
LIG_SH3_3	39	45	PF00018	0.656
LIG_SH3_3	404	410	PF00018	0.458
LIG_SUMO_SIM_par_1	167	175	PF11976	0.293
LIG_SUMO_SIM_par_1	215	222	PF11976	0.292
LIG_SUMO_SIM_par_1	232	238	PF11976	0.299
LIG_SUMO_SIM_par_1	243	248	PF11976	0.239
LIG_SUMO_SIM_par_1	279	284	PF11976	0.458
LIG_SUMO_SIM_par_1	409	414	PF11976	0.468
LIG_TYR_ITIM	84	89	PF00017	0.570
MOD_CDK_SPK_2	52	57	PF00069	0.615
MOD_CDK_SPxK_1	421	427	PF00069	0.620
MOD_CDK_SPxxK_3	36	43	PF00069	0.643
MOD_CK1_1	108	114	PF00069	0.399
MOD_CK1_1	154	160	PF00069	0.383
MOD_CK1_1	168	174	PF00069	0.202
MOD_CK1_1	235	241	PF00069	0.377
MOD_CK1_1	262	268	PF00069	0.493
MOD_CK1_1	284	290	PF00069	0.469
MOD_CK1_1	3	9	PF00069	0.535
MOD_CK1_1	414	420	PF00069	0.578
MOD_CK2_1	14	20	PF00069	0.461
MOD_CK2_1	21	27	PF00069	0.452
MOD_CK2_1	335	341	PF00069	0.458
MOD_CK2_1	391	397	PF00069	0.469
MOD_CK2_1	415	421	PF00069	0.555
MOD_CK2_1	47	53	PF00069	0.567
MOD_CK2_1	72	78	PF00069	0.593
MOD_GlcNHglycan	229	232	PF01048	0.312
MOD_GlcNHglycan	359	362	PF01048	0.313
MOD_GlcNHglycan	413	416	PF01048	0.330
MOD_GlcNHglycan	6	9	PF01048	0.377
MOD_GSK3_1	107	114	PF00069	0.463
MOD_GSK3_1	164	171	PF00069	0.328
MOD_GSK3_1	222	229	PF00069	0.317
MOD_GSK3_1	310	317	PF00069	0.536
MOD_GSK3_1	411	418	PF00069	0.529
MOD_GSK3_1	434	441	PF00069	0.543
MOD_GSK3_1	460	467	PF00069	0.651
MOD_N-GLC_1	154	159	PF02516	0.591
MOD_N-GLC_1	164	169	PF02516	0.588
MOD_N-GLC_1	391	396	PF02516	0.268
MOD_NEK2_1	119	124	PF00069	0.466
MOD_NEK2_1	164	169	PF00069	0.327
MOD_NEK2_1	281	286	PF00069	0.449
MOD_NEK2_1	314	319	PF00069	0.533
MOD_NEK2_1	366	371	PF00069	0.485
MOD_NEK2_1	391	396	PF00069	0.453
MOD_NEK2_1	411	416	PF00069	0.377
MOD_PK_1	205	211	PF00069	0.364
MOD_PKA_1	98	104	PF00069	0.667
MOD_PKA_2	336	342	PF00069	0.447
MOD_Plk_1	164	170	PF00069	0.413
MOD_Plk_1	281	287	PF00069	0.472
MOD_Plk_1	391	397	PF00069	0.487
MOD_Plk_1	428	434	PF00069	0.540
MOD_Plk_2-3	455	461	PF00069	0.641
MOD_Plk_4	108	114	PF00069	0.430
MOD_Plk_4	165	171	PF00069	0.334
MOD_Plk_4	205	211	PF00069	0.364
MOD_Plk_4	232	238	PF00069	0.194
MOD_Plk_4	259	265	PF00069	0.444
MOD_Plk_4	289	295	PF00069	0.456
MOD_Plk_4	303	309	PF00069	0.458
MOD_Plk_4	310	316	PF00069	0.489
MOD_Plk_4	391	397	PF00069	0.458
MOD_ProDKin_1	262	268	PF00069	0.458
MOD_ProDKin_1	27	33	PF00069	0.585
MOD_ProDKin_1	36	42	PF00069	0.545
MOD_ProDKin_1	421	427	PF00069	0.606
MOD_ProDKin_1	47	53	PF00069	0.425
MOD_ProDKin_1	72	78	PF00069	0.608
MOD_SUMO_for_1	138	141	PF00179	0.363
MOD_SUMO_rev_2	20	30	PF00179	0.576
MOD_SUMO_rev_2	417	425	PF00179	0.648
TRG_DiLeu_BaEn_1	276	281	PF01217	0.508
TRG_DiLeu_LyEn_5	276	281	PF01217	0.533
TRG_ENDOCYTIC_2	18	21	PF00928	0.487
TRG_ENDOCYTIC_2	181	184	PF00928	0.192
TRG_ENDOCYTIC_2	257	260	PF00928	0.447
TRG_ENDOCYTIC_2	261	264	PF00928	0.447
TRG_ENDOCYTIC_2	275	278	PF00928	0.447
TRG_ENDOCYTIC_2	315	318	PF00928	0.447
TRG_ENDOCYTIC_2	432	435	PF00928	0.537
TRG_ENDOCYTIC_2	86	89	PF00928	0.570
TRG_ER_diArg_1	272	275	PF00400	0.425
TRG_NLS_MonoExtC_3	97	102	PF00514	0.589
TRG_NLS_MonoExtN_4	95	102	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH0	Leptomonas seymouri	82%	100%
A0A0S4JK57	Bodo saltans	49%	100%
A0A1X0P9H6	Trypanosomatidae	60%	100%
A0A3S7X7L0	Leishmania donovani	92%	100%
A0A422N8P2	Trypanosoma rangeli	56%	100%
C9ZN09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AHS4	Leishmania infantum	91%	100%
E9B4P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F4IMH3	Arabidopsis thaliana	29%	81%
Q4Q3D2	Leishmania major	91%	100%
Q5I0I8	Rattus norvegicus	30%	91%
Q6NU91	Xenopus laevis	30%	89%
Q8BHY2	Mus musculus	30%	91%
V5BAB5	Trypanosoma cruzi	61%	100%