Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

Stage II sporulation protein E (SpoIIE), putative

Species:

Leishmania braziliensis

UniProt:

A4HAI2_LEIBR

TriTrypDb:

LbrM.20.0660 , LBRM2903_200013500

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAI2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0004722	protein serine/threonine phosphatase activity	4	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0017018	myosin phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.470
CLV_C14_Caspase3-7	46	50	PF00656	0.422
CLV_NRD_NRD_1	155	157	PF00675	0.290
CLV_PCSK_KEX2_1	155	157	PF00082	0.261
CLV_PCSK_KEX2_1	16	18	PF00082	0.595
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.595
CLV_PCSK_SKI1_1	16	20	PF00082	0.381
DEG_APCC_DBOX_1	1	9	PF00400	0.455
DEG_Nend_UBRbox_1	1	4	PF02207	0.412
DOC_MAPK_MEF2A_6	104	112	PF00069	0.457
DOC_PP4_FxxP_1	82	85	PF00568	0.409
DOC_USP7_MATH_1	12	16	PF00917	0.619
DOC_WW_Pin1_4	156	161	PF00397	0.434
LIG_14-3-3_CanoR_1	17	24	PF00244	0.316
LIG_14-3-3_CanoR_1	2	6	PF00244	0.364
LIG_Clathr_ClatBox_1	205	209	PF01394	0.562
LIG_FAT_LD_1	122	130	PF03623	0.504
LIG_FHA_1	179	185	PF00498	0.409
LIG_FHA_1	201	207	PF00498	0.444
LIG_FHA_2	44	50	PF00498	0.409
LIG_LIR_Apic_2	154	160	PF02991	0.422
LIG_LIR_Apic_2	81	85	PF02991	0.465
LIG_LIR_Gen_1	107	117	PF02991	0.457
LIG_LIR_Nem_3	107	112	PF02991	0.394
LIG_NRBOX	121	127	PF00104	0.504
LIG_SH2_STAT5	157	160	PF00017	0.473
LIG_SH2_STAT5	172	175	PF00017	0.364
LIG_SH2_STAT5	7	10	PF00017	0.506
LIG_SH3_1	86	92	PF00018	0.440
LIG_SH3_3	86	92	PF00018	0.422
LIG_SUMO_SIM_par_1	203	209	PF11976	0.346
LIG_SUMO_SIM_par_1	40	46	PF11976	0.400
LIG_UBA3_1	201	210	PF00899	0.472
MOD_CDK_SPxxK_3	156	163	PF00069	0.409
MOD_CK2_1	186	192	PF00069	0.465
MOD_CK2_1	91	97	PF00069	0.458
MOD_GlcNHglycan	104	107	PF01048	0.240
MOD_GlcNHglycan	93	96	PF01048	0.240
MOD_GSK3_1	12	19	PF00069	0.580
MOD_PKA_1	16	22	PF00069	0.311
MOD_PKA_2	1	7	PF00069	0.296
MOD_PKA_2	16	22	PF00069	0.315
MOD_PKA_2	170	176	PF00069	0.440
MOD_Plk_1	178	184	PF00069	0.409
MOD_Plk_4	43	49	PF00069	0.420
MOD_Plk_4	51	57	PF00069	0.410
MOD_ProDKin_1	156	162	PF00069	0.434
MOD_SUMO_for_1	99	102	PF00179	0.504
MOD_SUMO_rev_2	9	18	PF00179	0.325
TRG_DiLeu_BaEn_1	121	126	PF01217	0.504
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.598
TRG_DiLeu_LyEn_5	121	126	PF01217	0.504
TRG_ER_diArg_1	155	157	PF00400	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH92	Leptomonas seymouri	74%	75%
A0A0S4IN49	Bodo saltans	30%	66%
A0A1X0P973	Trypanosomatidae	56%	76%
A0A3Q8IUF7	Leishmania donovani	92%	100%
A0A3R7RFR7	Trypanosoma rangeli	53%	75%
B3P5D3	Drosophila erecta	35%	66%
B4HZE7	Drosophila sechellia	32%	67%
B4JYN1	Drosophila grimshawi	35%	68%
B4K616	Drosophila mojavensis	32%	67%
B4M5T5	Drosophila virilis	33%	67%
B4NBL6	Drosophila willistoni	29%	67%
B4R089	Drosophila simulans	32%	67%
C9ZN10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	75%
E9AHS3	Leishmania infantum	92%	100%
E9B4P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O64730	Arabidopsis thaliana	33%	70%
Q09189	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	70%
Q4Q3D3	Leishmania major	92%	100%
Q5U3N5	Danio rerio	37%	71%
Q6GR25	Xenopus laevis	36%	71%
Q6H7J3	Oryza sativa subsp. japonica	28%	67%
Q6NVE9	Mus musculus	35%	68%
Q8NI37	Homo sapiens	36%	69%
Q9VAH4	Drosophila melanogaster	35%	67%
V5AUW7	Trypanosoma cruzi	55%	75%