Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAI1_LEIBR

TriTrypDb:

LbrM.20.0650 , LBRM2903_200013400

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAI1

PDB structure(s): 7ane_y

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004784	superoxide dismutase activity	2	4
GO:0005488	binding	1	4
GO:0016209	antioxidant activity	1	4
GO:0016491	oxidoreductase activity	2	4
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	3	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.585
CLV_C14_Caspase3-7	464	468	PF00656	0.419
CLV_C14_Caspase3-7	473	477	PF00656	0.435
CLV_NRD_NRD_1	301	303	PF00675	0.619
CLV_PCSK_KEX2_1	22	24	PF00082	0.490
CLV_PCSK_KEX2_1	301	303	PF00082	0.475
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.424
CLV_PCSK_SKI1_1	11	15	PF00082	0.423
CLV_PCSK_SKI1_1	125	129	PF00082	0.369
DEG_APCC_DBOX_1	10	18	PF00400	0.481
DEG_Nend_UBRbox_1	1	4	PF02207	0.333
DEG_SPOP_SBC_1	353	357	PF00917	0.616
DEG_SPOP_SBC_1	384	388	PF00917	0.693
DOC_CYCLIN_RxL_1	122	132	PF00134	0.343
DOC_CYCLIN_RxL_1	57	65	PF00134	0.376
DOC_MAPK_DCC_7	11	19	PF00069	0.441
DOC_MAPK_FxFP_2	454	457	PF00069	0.531
DOC_MAPK_gen_1	245	255	PF00069	0.453
DOC_MAPK_gen_1	60	66	PF00069	0.553
DOC_MAPK_MEF2A_6	11	19	PF00069	0.456
DOC_MAPK_MEF2A_6	248	257	PF00069	0.418
DOC_MAPK_RevD_3	8	23	PF00069	0.317
DOC_PP2B_LxvP_1	177	180	PF13499	0.456
DOC_PP4_FxxP_1	454	457	PF00568	0.531
DOC_USP7_MATH_1	208	212	PF00917	0.517
DOC_USP7_MATH_1	259	263	PF00917	0.291
DOC_USP7_MATH_1	325	329	PF00917	0.547
DOC_USP7_MATH_1	353	357	PF00917	0.753
DOC_USP7_MATH_1	389	393	PF00917	0.593
DOC_USP7_MATH_1	44	48	PF00917	0.525
DOC_WW_Pin1_4	151	156	PF00397	0.515
DOC_WW_Pin1_4	160	165	PF00397	0.471
DOC_WW_Pin1_4	229	234	PF00397	0.582
DOC_WW_Pin1_4	337	342	PF00397	0.679
DOC_WW_Pin1_4	385	390	PF00397	0.560
LIG_14-3-3_CanoR_1	256	264	PF00244	0.464
LIG_14-3-3_CanoR_1	330	337	PF00244	0.466
LIG_14-3-3_CanoR_1	470	475	PF00244	0.406
LIG_Actin_WH2_2	303	319	PF00022	0.571
LIG_BRCT_BRCA1_1	333	337	PF00533	0.628
LIG_BRCT_BRCA1_1	90	94	PF00533	0.297
LIG_EH1_1	28	36	PF00400	0.489
LIG_FHA_1	22	28	PF00498	0.682
LIG_FHA_1	324	330	PF00498	0.556
LIG_FHA_1	347	353	PF00498	0.647
LIG_FHA_1	36	42	PF00498	0.442
LIG_FHA_1	437	443	PF00498	0.505
LIG_FHA_1	458	464	PF00498	0.402
LIG_FHA_2	239	245	PF00498	0.679
LIG_FHA_2	401	407	PF00498	0.549
LIG_FHA_2	450	456	PF00498	0.435
LIG_FHA_2	471	477	PF00498	0.409
LIG_LIR_Apic_2	451	457	PF02991	0.403
LIG_LIR_Nem_3	132	138	PF02991	0.401
LIG_LIR_Nem_3	91	97	PF02991	0.450
LIG_PCNA_yPIPBox_3	422	430	PF02747	0.345
LIG_Pex14_1	417	421	PF04695	0.398
LIG_Pex14_2	94	98	PF04695	0.435
LIG_SH2_CRK	135	139	PF00017	0.418
LIG_SH2_SRC	474	477	PF00017	0.569
LIG_SH2_STAT3	97	100	PF00017	0.262
LIG_SH2_STAT5	40	43	PF00017	0.355
LIG_SH2_STAT5	88	91	PF00017	0.436
LIG_SH2_STAT5	97	100	PF00017	0.473
LIG_SH3_3	12	18	PF00018	0.287
LIG_SH3_3	158	164	PF00018	0.490
LIG_SH3_3	372	378	PF00018	0.647
LIG_TRAF2_2	391	396	PF00917	0.524
LIG_TRFH_1	188	192	PF08558	0.344
LIG_UBA3_1	13	22	PF00899	0.450
LIG_UBA3_1	176	183	PF00899	0.352
MOD_CDC14_SPxK_1	154	157	PF00782	0.484
MOD_CDK_SPK_2	229	234	PF00069	0.529
MOD_CDK_SPxK_1	151	157	PF00069	0.507
MOD_CK1_1	134	140	PF00069	0.463
MOD_CK1_1	30	36	PF00069	0.466
MOD_CK1_1	333	339	PF00069	0.637
MOD_CK1_1	340	346	PF00069	0.608
MOD_CK1_1	90	96	PF00069	0.371
MOD_CK2_1	164	170	PF00069	0.630
MOD_CK2_1	238	244	PF00069	0.685
MOD_CK2_1	286	292	PF00069	0.482
MOD_CK2_1	400	406	PF00069	0.602
MOD_CK2_1	449	455	PF00069	0.405
MOD_CK2_1	475	481	PF00069	0.441
MOD_Cter_Amidation	20	23	PF01082	0.560
MOD_GlcNHglycan	138	141	PF01048	0.351
MOD_GlcNHglycan	166	169	PF01048	0.652
MOD_GlcNHglycan	210	213	PF01048	0.544
MOD_GlcNHglycan	248	251	PF01048	0.655
MOD_GlcNHglycan	257	260	PF01048	0.561
MOD_GlcNHglycan	261	264	PF01048	0.556
MOD_GlcNHglycan	282	285	PF01048	0.447
MOD_GlcNHglycan	318	321	PF01048	0.516
MOD_GlcNHglycan	342	345	PF01048	0.713
MOD_GlcNHglycan	356	359	PF01048	0.491
MOD_GlcNHglycan	378	381	PF01048	0.741
MOD_GlcNHglycan	46	49	PF01048	0.635
MOD_GSK3_1	143	150	PF00069	0.572
MOD_GSK3_1	160	167	PF00069	0.312
MOD_GSK3_1	17	24	PF00069	0.661
MOD_GSK3_1	255	262	PF00069	0.560
MOD_GSK3_1	276	283	PF00069	0.346
MOD_GSK3_1	287	294	PF00069	0.434
MOD_GSK3_1	30	37	PF00069	0.319
MOD_GSK3_1	325	332	PF00069	0.540
MOD_GSK3_1	333	340	PF00069	0.585
MOD_GSK3_1	343	350	PF00069	0.460
MOD_GSK3_1	366	373	PF00069	0.703
MOD_GSK3_1	376	383	PF00069	0.732
MOD_GSK3_1	385	392	PF00069	0.698
MOD_GSK3_1	396	403	PF00069	0.477
MOD_GSK3_1	40	47	PF00069	0.434
MOD_GSK3_1	436	443	PF00069	0.523
MOD_LATS_1	107	113	PF00433	0.469
MOD_N-GLC_1	196	201	PF02516	0.349
MOD_N-GLC_1	424	429	PF02516	0.581
MOD_N-GLC_1	457	462	PF02516	0.418
MOD_N-GLC_1	49	54	PF02516	0.531
MOD_NEK2_1	141	146	PF00069	0.464
MOD_NEK2_1	147	152	PF00069	0.466
MOD_NEK2_1	276	281	PF00069	0.364
MOD_NEK2_1	316	321	PF00069	0.505
MOD_NEK2_1	34	39	PF00069	0.474
MOD_NEK2_1	347	352	PF00069	0.640
MOD_NEK2_1	354	359	PF00069	0.579
MOD_NEK2_1	370	375	PF00069	0.455
MOD_NEK2_1	442	447	PF00069	0.400
MOD_NEK2_2	325	330	PF00069	0.427
MOD_PIKK_1	276	282	PF00454	0.321
MOD_PIKK_1	291	297	PF00454	0.411
MOD_PIKK_1	311	317	PF00454	0.558
MOD_PIKK_1	389	395	PF00454	0.694
MOD_PKA_2	255	261	PF00069	0.372
MOD_PKA_2	329	335	PF00069	0.515
MOD_PKA_2	469	475	PF00069	0.364
MOD_PKB_1	109	117	PF00069	0.445
MOD_Plk_1	109	115	PF00069	0.449
MOD_Plk_1	131	137	PF00069	0.496
MOD_Plk_1	366	372	PF00069	0.664
MOD_Plk_1	457	463	PF00069	0.414
MOD_Plk_4	172	178	PF00069	0.349
MOD_Plk_4	248	254	PF00069	0.596
MOD_Plk_4	30	36	PF00069	0.470
MOD_Plk_4	442	448	PF00069	0.492
MOD_Plk_4	449	455	PF00069	0.366
MOD_Plk_4	458	464	PF00069	0.343
MOD_Plk_4	62	68	PF00069	0.361
MOD_ProDKin_1	151	157	PF00069	0.507
MOD_ProDKin_1	160	166	PF00069	0.487
MOD_ProDKin_1	229	235	PF00069	0.586
MOD_ProDKin_1	337	343	PF00069	0.679
MOD_ProDKin_1	385	391	PF00069	0.556
MOD_SUMO_for_1	358	361	PF00179	0.608
MOD_SUMO_rev_2	93	103	PF00179	0.460
TRG_DiLeu_BaEn_1	9	14	PF01217	0.344
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.368
TRG_ENDOCYTIC_2	135	138	PF00928	0.411
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P312	Leptomonas seymouri	49%	95%
A0A1X0PA30	Trypanosomatidae	39%	100%
A0A3Q8IHA9	Leishmania donovani	80%	100%
A0A3R7K8T3	Trypanosoma rangeli	36%	100%
A4IAP2	Leishmania infantum	80%	100%
C9ZN11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B4P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q3D4	Leishmania major	81%	100%
V5DAY1	Trypanosoma cruzi	36%	100%