Stc1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized conserved protein (DUF2039), putative

Species:

Leishmania braziliensis

UniProt:

A4HAH9_LEIBR

TriTrypDb:

LbrM.20.0630

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.351
CLV_C14_Caspase3-7	201	205	PF00656	0.542
CLV_NRD_NRD_1	169	171	PF00675	0.509
CLV_NRD_NRD_1	172	174	PF00675	0.519
CLV_NRD_NRD_1	189	191	PF00675	0.306
CLV_NRD_NRD_1	193	195	PF00675	0.458
CLV_NRD_NRD_1	48	50	PF00675	0.316
CLV_NRD_NRD_1	70	72	PF00675	0.360
CLV_PCSK_FUR_1	170	174	PF00082	0.567
CLV_PCSK_FUR_1	187	191	PF00082	0.316
CLV_PCSK_KEX2_1	171	173	PF00082	0.589
CLV_PCSK_KEX2_1	189	191	PF00082	0.297
CLV_PCSK_KEX2_1	2	4	PF00082	0.578
CLV_PCSK_KEX2_1	48	50	PF00082	0.311
CLV_PCSK_KEX2_1	70	72	PF00082	0.360
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.552
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.597
CLV_PCSK_PC7_1	185	191	PF00082	0.408
CLV_PCSK_SKI1_1	141	145	PF00082	0.440
CLV_PCSK_SKI1_1	190	194	PF00082	0.452
CLV_PCSK_SKI1_1	3	7	PF00082	0.590
DEG_APCC_DBOX_1	177	185	PF00400	0.573
DEG_Nend_UBRbox_1	1	4	PF02207	0.637
DOC_PP1_RVXF_1	34	41	PF00149	0.355
DOC_USP7_MATH_1	105	109	PF00917	0.631
DOC_USP7_MATH_1	200	204	PF00917	0.556
DOC_USP7_UBL2_3	2	6	PF12436	0.631
LIG_14-3-3_CanoR_1	189	197	PF00244	0.426
LIG_FHA_1	160	166	PF00498	0.528
LIG_FHA_2	181	187	PF00498	0.397
LIG_FHA_2	62	68	PF00498	0.410
LIG_LIR_Gen_1	139	148	PF02991	0.466
LIG_LIR_Nem_3	139	145	PF02991	0.439
LIG_LIR_Nem_3	59	63	PF02991	0.300
LIG_PDZ_Class_3	204	209	PF00595	0.587
LIG_Pex14_1	56	60	PF04695	0.300
LIG_SH2_CRK	84	88	PF00017	0.434
LIG_SH2_GRB2like	16	19	PF00017	0.360
LIG_SH2_STAT3	63	66	PF00017	0.434
LIG_SH2_STAT5	63	66	PF00017	0.303
LIG_TRAF2_1	64	67	PF00917	0.434
LIG_TYR_ITSM	138	145	PF00017	0.332
MOD_CK1_1	108	114	PF00069	0.693
MOD_CK1_1	180	186	PF00069	0.577
MOD_CK2_1	118	124	PF00069	0.634
MOD_CK2_1	146	152	PF00069	0.428
MOD_CK2_1	180	186	PF00069	0.577
MOD_CK2_1	61	67	PF00069	0.410
MOD_GlcNHglycan	110	113	PF01048	0.723
MOD_GlcNHglycan	204	207	PF01048	0.579
MOD_GlcNHglycan	6	9	PF01048	0.403
MOD_GSK3_1	118	125	PF00069	0.638
MOD_GSK3_1	155	162	PF00069	0.530
MOD_N-GLC_1	118	123	PF02516	0.655
MOD_N-GLC_1	17	22	PF02516	0.367
MOD_N-GLC_2	73	75	PF02516	0.300
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NEK2_1	17	22	PF00069	0.407
MOD_NEK2_1	40	45	PF00069	0.277
MOD_PKA_2	136	142	PF00069	0.531
MOD_PKA_2	155	161	PF00069	0.483
MOD_PKA_2	177	183	PF00069	0.525
MOD_PKA_2	188	194	PF00069	0.381
MOD_Plk_1	38	44	PF00069	0.197
MOD_Plk_2-3	122	128	PF00069	0.587
TRG_DiLeu_BaEn_4	152	158	PF01217	0.498
TRG_ENDOCYTIC_2	142	145	PF00928	0.425
TRG_ENDOCYTIC_2	84	87	PF00928	0.300
TRG_ER_diArg_1	169	172	PF00400	0.580
TRG_NLS_MonoCore_2	169	174	PF00514	0.346
TRG_NLS_MonoExtC_3	169	174	PF00514	0.346
TRG_NLS_MonoExtN_4	168	175	PF00514	0.344
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAJ2	Leptomonas seymouri	63%	100%
A0A0S4KI64	Bodo saltans	44%	92%
A0A1X0PAK0	Trypanosomatidae	40%	87%
A0A3S7X7J4	Leishmania donovani	77%	74%
A0A422MR74	Trypanosoma rangeli	41%	91%
A4IAN9	Leishmania infantum	77%	74%
C9ZN14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	73%
E9B4N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q3D7	Leishmania major	79%	100%
V5BJE2	Trypanosoma cruzi	39%	71%