Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar attachment zone protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAH8_LEIBR

TriTrypDb:

LbrM.20.0610 , LBRM2903_200013100

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0031514	motile cilium	5	1

Expansion

Sequence features

A4HAH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAH8

Function

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.602
CLV_C14_Caspase3-7	412	416	PF00656	0.736
CLV_NRD_NRD_1	122	124	PF00675	0.551
CLV_NRD_NRD_1	167	169	PF00675	0.615
CLV_NRD_NRD_1	424	426	PF00675	0.687
CLV_NRD_NRD_1	565	567	PF00675	0.679
CLV_NRD_NRD_1	809	811	PF00675	0.648
CLV_NRD_NRD_1	93	95	PF00675	0.532
CLV_PCSK_FUR_1	397	401	PF00082	0.694
CLV_PCSK_FUR_1	528	532	PF00082	0.652
CLV_PCSK_KEX2_1	166	168	PF00082	0.439
CLV_PCSK_KEX2_1	236	238	PF00082	0.587
CLV_PCSK_KEX2_1	316	318	PF00082	0.494
CLV_PCSK_KEX2_1	399	401	PF00082	0.564
CLV_PCSK_KEX2_1	423	425	PF00082	0.641
CLV_PCSK_KEX2_1	530	532	PF00082	0.546
CLV_PCSK_KEX2_1	811	813	PF00082	0.458
CLV_PCSK_KEX2_1	93	95	PF00082	0.532
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.612
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.494
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.564
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.548
CLV_PCSK_PC1ET2_1	811	813	PF00082	0.458
CLV_PCSK_PC7_1	807	813	PF00082	0.454
CLV_PCSK_SKI1_1	123	127	PF00082	0.551
CLV_PCSK_SKI1_1	168	172	PF00082	0.415
CLV_PCSK_SKI1_1	258	262	PF00082	0.492
CLV_PCSK_SKI1_1	360	364	PF00082	0.618
CLV_PCSK_SKI1_1	38	42	PF00082	0.587
CLV_PCSK_SKI1_1	61	65	PF00082	0.532
CLV_PCSK_SKI1_1	672	676	PF00082	0.475
CLV_PCSK_SKI1_1	728	732	PF00082	0.457
CLV_PCSK_SKI1_1	817	821	PF00082	0.638
DEG_APCC_DBOX_1	110	118	PF00400	0.419
DEG_APCC_DBOX_1	167	175	PF00400	0.401
DEG_APCC_DBOX_1	727	735	PF00400	0.458
DEG_APCC_DBOX_1	85	93	PF00400	0.601
DEG_APCC_KENBOX_2	755	759	PF00400	0.658
DEG_MDM2_SWIB_1	801	809	PF02201	0.654
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DOC_CKS1_1	559	564	PF01111	0.604
DOC_MAPK_gen_1	672	680	PF00069	0.664
DOC_MAPK_gen_1	737	744	PF00069	0.454
DOC_MAPK_MEF2A_6	283	292	PF00069	0.460
DOC_USP7_MATH_1	440	444	PF00917	0.773
DOC_USP7_MATH_1	446	450	PF00917	0.639
DOC_USP7_MATH_1	537	541	PF00917	0.579
DOC_USP7_MATH_1	562	566	PF00917	0.606
DOC_USP7_UBL2_3	199	203	PF12436	0.652
DOC_USP7_UBL2_3	312	316	PF12436	0.436
DOC_WW_Pin1_4	129	134	PF00397	0.619
DOC_WW_Pin1_4	206	211	PF00397	0.532
DOC_WW_Pin1_4	294	299	PF00397	0.510
DOC_WW_Pin1_4	432	437	PF00397	0.642
DOC_WW_Pin1_4	558	563	PF00397	0.638
DOC_WW_Pin1_4	587	592	PF00397	0.556
LIG_14-3-3_CanoR_1	123	131	PF00244	0.628
LIG_14-3-3_CanoR_1	283	287	PF00244	0.618
LIG_14-3-3_CanoR_1	351	361	PF00244	0.457
LIG_14-3-3_CanoR_1	385	391	PF00244	0.536
LIG_14-3-3_CanoR_1	407	411	PF00244	0.579
LIG_14-3-3_CanoR_1	423	432	PF00244	0.550
LIG_14-3-3_CanoR_1	538	542	PF00244	0.662
LIG_14-3-3_CanoR_1	74	79	PF00244	0.424
LIG_Actin_WH2_2	110	125	PF00022	0.620
LIG_Actin_WH2_2	357	375	PF00022	0.419
LIG_CSK_EPIYA_1	458	462	PF00017	0.710
LIG_FHA_1	218	224	PF00498	0.464
LIG_FHA_1	269	275	PF00498	0.719
LIG_FHA_1	282	288	PF00498	0.470
LIG_FHA_1	42	48	PF00498	0.577
LIG_FHA_1	491	497	PF00498	0.470
LIG_FHA_1	498	504	PF00498	0.418
LIG_FHA_1	584	590	PF00498	0.653
LIG_FHA_1	673	679	PF00498	0.506
LIG_FHA_1	781	787	PF00498	0.717
LIG_FHA_1	788	794	PF00498	0.650
LIG_FHA_2	149	155	PF00498	0.601
LIG_FHA_2	271	277	PF00498	0.552
LIG_FHA_2	309	315	PF00498	0.610
LIG_FHA_2	323	329	PF00498	0.437
LIG_FHA_2	34	40	PF00498	0.539
LIG_FHA_2	353	359	PF00498	0.609
LIG_FHA_2	407	413	PF00498	0.589
LIG_FHA_2	462	468	PF00498	0.724
LIG_FHA_2	601	607	PF00498	0.572
LIG_GBD_Chelix_1	656	664	PF00786	0.453
LIG_Integrin_isoDGR_2	72	74	PF01839	0.574
LIG_LIR_Apic_2	780	785	PF02991	0.607
LIG_LIR_Gen_1	157	165	PF02991	0.455
LIG_LIR_Gen_1	41	47	PF02991	0.573
LIG_LIR_Gen_1	631	639	PF02991	0.452
LIG_LIR_Gen_1	704	713	PF02991	0.489
LIG_LIR_Gen_1	77	85	PF02991	0.411
LIG_LIR_Gen_1	794	801	PF02991	0.628
LIG_LIR_Gen_1	802	813	PF02991	0.612
LIG_LIR_Nem_3	157	161	PF02991	0.462
LIG_LIR_Nem_3	41	46	PF02991	0.580
LIG_LIR_Nem_3	704	709	PF02991	0.491
LIG_LIR_Nem_3	794	800	PF02991	0.639
LIG_LIR_Nem_3	802	808	PF02991	0.617
LIG_LYPXL_SIV_4	224	232	PF13949	0.577
LIG_PCNA_PIPBox_1	17	26	PF02747	0.390
LIG_PCNA_PIPBox_1	177	186	PF02747	0.417
LIG_PCNA_yPIPBox_3	14	24	PF02747	0.393
LIG_Pex14_2	797	801	PF04695	0.544
LIG_Pex14_2	840	844	PF04695	0.498
LIG_SH2_CRK	21	25	PF00017	0.448
LIG_SH2_CRK	229	233	PF00017	0.612
LIG_SH2_CRK	43	47	PF00017	0.571
LIG_SH2_CRK	559	563	PF00017	0.605
LIG_SH2_CRK	706	710	PF00017	0.442
LIG_SH2_NCK_1	559	563	PF00017	0.605
LIG_SH2_PTP2	5	8	PF00017	0.590
LIG_SH2_SRC	23	26	PF00017	0.578
LIG_SH2_SRC	5	8	PF00017	0.668
LIG_SH2_STAP1	229	233	PF00017	0.418
LIG_SH2_STAP1	344	348	PF00017	0.533
LIG_SH2_STAP1	353	357	PF00017	0.496
LIG_SH2_STAP1	43	47	PF00017	0.571
LIG_SH2_STAP1	461	465	PF00017	0.734
LIG_SH2_STAP1	706	710	PF00017	0.636
LIG_SH2_STAT5	23	26	PF00017	0.578
LIG_SH2_STAT5	367	370	PF00017	0.408
LIG_SH2_STAT5	43	46	PF00017	0.579
LIG_SH2_STAT5	5	8	PF00017	0.558
LIG_SH3_3	285	291	PF00018	0.606
LIG_SH3_3	292	298	PF00018	0.492
LIG_SH3_3	3	9	PF00018	0.519
LIG_SH3_3	585	591	PF00018	0.722
LIG_SUMO_SIM_par_1	297	303	PF11976	0.429
LIG_TRAF2_1	110	113	PF00917	0.411
LIG_TRAF2_1	389	392	PF00917	0.565
LIG_TRAF2_1	603	606	PF00917	0.671
LIG_TRAF2_2	578	583	PF00917	0.589
LIG_TYR_ITIM	19	24	PF00017	0.531
LIG_TYR_ITSM	39	46	PF00017	0.430
LIG_UBA3_1	81	88	PF00899	0.561
LIG_WRC_WIRS_1	278	283	PF05994	0.615
MOD_CK1_1	186	192	PF00069	0.608
MOD_CK1_1	268	274	PF00069	0.708
MOD_CK1_1	297	303	PF00069	0.429
MOD_CK2_1	148	154	PF00069	0.593
MOD_CK2_1	270	276	PF00069	0.712
MOD_CK2_1	308	314	PF00069	0.607
MOD_CK2_1	322	328	PF00069	0.430
MOD_CK2_1	33	39	PF00069	0.532
MOD_CK2_1	352	358	PF00069	0.608
MOD_CK2_1	386	392	PF00069	0.675
MOD_CK2_1	406	412	PF00069	0.461
MOD_CK2_1	461	467	PF00069	0.724
MOD_CK2_1	600	606	PF00069	0.581
MOD_CK2_1	634	640	PF00069	0.466
MOD_CK2_1	662	668	PF00069	0.539
MOD_Cter_Amidation	670	673	PF01082	0.465
MOD_GlcNHglycan	185	188	PF01048	0.630
MOD_GlcNHglycan	292	295	PF01048	0.537
MOD_GlcNHglycan	369	372	PF01048	0.539
MOD_GlcNHglycan	664	667	PF01048	0.460
MOD_GSK3_1	186	193	PF00069	0.621
MOD_GSK3_1	26	33	PF00069	0.475
MOD_GSK3_1	264	271	PF00069	0.546
MOD_GSK3_1	277	284	PF00069	0.372
MOD_GSK3_1	286	293	PF00069	0.436
MOD_GSK3_1	558	565	PF00069	0.789
MOD_GSK3_1	583	590	PF00069	0.762
MOD_GSK3_1	787	794	PF00069	0.603
MOD_GSK3_1	88	95	PF00069	0.611
MOD_N-GLC_1	268	273	PF02516	0.549
MOD_N-GLC_1	440	445	PF02516	0.649
MOD_N-GLC_1	562	567	PF02516	0.604
MOD_N-GLC_2	826	828	PF02516	0.670
MOD_NEK2_1	281	286	PF00069	0.610
MOD_NEK2_1	333	338	PF00069	0.630
MOD_NEK2_1	386	391	PF00069	0.672
MOD_NEK2_1	662	667	PF00069	0.503
MOD_NEK2_1	720	725	PF00069	0.439
MOD_NEK2_1	821	826	PF00069	0.452
MOD_PIKK_1	434	440	PF00454	0.836
MOD_PIKK_1	787	793	PF00454	0.574
MOD_PK_1	88	94	PF00069	0.608
MOD_PKA_1	123	129	PF00069	0.630
MOD_PKA_1	423	429	PF00069	0.645
MOD_PKA_1	672	678	PF00069	0.474
MOD_PKA_2	282	288	PF00069	0.611
MOD_PKA_2	406	412	PF00069	0.593
MOD_PKA_2	423	429	PF00069	0.546
MOD_PKA_2	497	503	PF00069	0.475
MOD_PKA_2	537	543	PF00069	0.662
MOD_PKA_2	795	801	PF00069	0.699
MOD_PKA_2	92	98	PF00069	0.620
MOD_PKB_1	423	431	PF00069	0.646
MOD_Plk_1	41	47	PF00069	0.581
MOD_Plk_2-3	415	421	PF00069	0.623
MOD_Plk_2-3	490	496	PF00069	0.468
MOD_Plk_4	227	233	PF00069	0.404
MOD_Plk_4	282	288	PF00069	0.611
MOD_ProDKin_1	129	135	PF00069	0.609
MOD_ProDKin_1	206	212	PF00069	0.524
MOD_ProDKin_1	294	300	PF00069	0.521
MOD_ProDKin_1	432	438	PF00069	0.644
MOD_ProDKin_1	558	564	PF00069	0.638
MOD_ProDKin_1	587	593	PF00069	0.551
MOD_SUMO_for_1	262	265	PF00179	0.625
MOD_SUMO_for_1	519	522	PF00179	0.539
MOD_SUMO_for_1	701	704	PF00179	0.439
MOD_SUMO_rev_2	313	318	PF00179	0.597
MOD_SUMO_rev_2	466	470	PF00179	0.705
MOD_SUMO_rev_2	502	508	PF00179	0.629
MOD_SUMO_rev_2	521	527	PF00179	0.359
TRG_DiLeu_BaEn_1	359	364	PF01217	0.425
TRG_DiLeu_BaEn_1	705	710	PF01217	0.633
TRG_DiLeu_BaEn_1	715	720	PF01217	0.481
TRG_DiLeu_BaEn_2	357	363	PF01217	0.420
TRG_ENDOCYTIC_2	21	24	PF00928	0.439
TRG_ENDOCYTIC_2	229	232	PF00928	0.606
TRG_ENDOCYTIC_2	43	46	PF00928	0.579
TRG_ENDOCYTIC_2	633	636	PF00928	0.482
TRG_ENDOCYTIC_2	706	709	PF00928	0.637
TRG_ENDOCYTIC_2	78	81	PF00928	0.623
TRG_ER_diArg_1	165	168	PF00400	0.418
TRG_ER_diArg_1	423	425	PF00400	0.641
TRG_ER_diArg_1	647	650	PF00400	0.491
TRG_ER_diArg_1	809	812	PF00400	0.678
TRG_ER_diArg_1	92	94	PF00400	0.523
TRG_NES_CRM1_1	690	705	PF08389	0.483
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7W0	Leishmania donovani	75%	100%
A4I9N8	Leishmania infantum	77%	66%
Q4Q3D9	Leishmania major	77%	66%