Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HAH4_LEIBR

TriTrypDb:

LbrM.20.0570 , LBRM2903_200012500

Length:

1031

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

A4HAH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	496	500	PF00656	0.547
CLV_C14_Caspase3-7	665	669	PF00656	0.453
CLV_C14_Caspase3-7	766	770	PF00656	0.372
CLV_NRD_NRD_1	1027	1029	PF00675	0.669
CLV_NRD_NRD_1	146	148	PF00675	0.556
CLV_NRD_NRD_1	230	232	PF00675	0.580
CLV_NRD_NRD_1	341	343	PF00675	0.482
CLV_NRD_NRD_1	387	389	PF00675	0.538
CLV_NRD_NRD_1	39	41	PF00675	0.608
CLV_NRD_NRD_1	406	408	PF00675	0.488
CLV_NRD_NRD_1	412	414	PF00675	0.459
CLV_NRD_NRD_1	441	443	PF00675	0.476
CLV_NRD_NRD_1	507	509	PF00675	0.756
CLV_PCSK_FUR_1	404	408	PF00082	0.490
CLV_PCSK_KEX2_1	1027	1029	PF00082	0.602
CLV_PCSK_KEX2_1	146	148	PF00082	0.556
CLV_PCSK_KEX2_1	339	341	PF00082	0.474
CLV_PCSK_KEX2_1	387	389	PF00082	0.538
CLV_PCSK_KEX2_1	39	41	PF00082	0.608
CLV_PCSK_KEX2_1	406	408	PF00082	0.488
CLV_PCSK_KEX2_1	412	414	PF00082	0.459
CLV_PCSK_KEX2_1	441	443	PF00082	0.474
CLV_PCSK_KEX2_1	507	509	PF00082	0.748
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.474
CLV_PCSK_PC7_1	437	443	PF00082	0.422
CLV_PCSK_SKI1_1	179	183	PF00082	0.591
CLV_PCSK_SKI1_1	317	321	PF00082	0.546
CLV_PCSK_SKI1_1	351	355	PF00082	0.491
CLV_PCSK_SKI1_1	360	364	PF00082	0.432
CLV_PCSK_SKI1_1	428	432	PF00082	0.525
CLV_PCSK_SKI1_1	442	446	PF00082	0.430
CLV_PCSK_SKI1_1	460	464	PF00082	0.523
CLV_PCSK_SKI1_1	508	512	PF00082	0.657
CLV_PCSK_SKI1_1	997	1001	PF00082	0.507
DEG_APCC_DBOX_1	350	358	PF00400	0.795
DEG_APCC_DBOX_1	42	50	PF00400	0.716
DEG_APCC_DBOX_1	587	595	PF00400	0.446
DEG_APCC_DBOX_1	815	823	PF00400	0.366
DEG_APCC_DBOX_1	840	848	PF00400	0.333
DEG_APCC_DBOX_1	932	940	PF00400	0.458
DEG_COP1_1	869	877	PF00400	0.458
DEG_Nend_UBRbox_4	1	3	PF02207	0.653
DEG_SPOP_SBC_1	125	129	PF00917	0.820
DEG_SPOP_SBC_1	253	257	PF00917	0.743
DEG_SPOP_SBC_1	3	7	PF00917	0.797
DOC_ANK_TNKS_1	145	152	PF00023	0.610
DOC_CDC14_PxL_1	951	959	PF14671	0.370
DOC_CKS1_1	485	490	PF01111	0.457
DOC_CKS1_1	926	931	PF01111	0.470
DOC_CYCLIN_RxL_1	697	706	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	725	731	PF00134	0.378
DOC_MAPK_DCC_7	418	427	PF00069	0.807
DOC_MAPK_gen_1	39	46	PF00069	0.795
DOC_MAPK_gen_1	441	447	PF00069	0.766
DOC_MAPK_gen_1	460	470	PF00069	0.466
DOC_MAPK_gen_1	976	986	PF00069	0.453
DOC_MAPK_MEF2A_6	418	427	PF00069	0.807
DOC_MAPK_MEF2A_6	460	468	PF00069	0.487
DOC_MAPK_MEF2A_6	880	889	PF00069	0.406
DOC_MAPK_MEF2A_6	979	988	PF00069	0.362
DOC_PP1_RVXF_1	138	145	PF00149	0.668
DOC_PP1_RVXF_1	971	978	PF00149	0.321
DOC_PP2B_LxvP_1	266	269	PF13499	0.734
DOC_PP2B_LxvP_1	389	392	PF13499	0.670
DOC_PP2B_LxvP_1	420	423	PF13499	0.722
DOC_PP2B_LxvP_1	725	728	PF13499	0.367
DOC_PP2B_LxvP_1	8	11	PF13499	0.640
DOC_PP4_FxxP_1	414	417	PF00568	0.686
DOC_USP7_MATH_1	11	15	PF00917	0.641
DOC_USP7_MATH_1	125	129	PF00917	0.692
DOC_USP7_MATH_1	158	162	PF00917	0.641
DOC_USP7_MATH_1	165	169	PF00917	0.651
DOC_USP7_MATH_1	346	350	PF00917	0.801
DOC_USP7_MATH_1	408	412	PF00917	0.824
DOC_USP7_MATH_1	639	643	PF00917	0.412
DOC_USP7_MATH_1	663	667	PF00917	0.384
DOC_USP7_MATH_1	771	775	PF00917	0.418
DOC_USP7_MATH_1	781	785	PF00917	0.361
DOC_WW_Pin1_4	163	168	PF00397	0.739
DOC_WW_Pin1_4	392	397	PF00397	0.682
DOC_WW_Pin1_4	484	489	PF00397	0.533
DOC_WW_Pin1_4	49	54	PF00397	0.689
DOC_WW_Pin1_4	869	874	PF00397	0.515
DOC_WW_Pin1_4	879	884	PF00397	0.521
DOC_WW_Pin1_4	925	930	PF00397	0.479
DOC_WW_Pin1_4	965	970	PF00397	0.392
LIG_14-3-3_CanoR_1	286	295	PF00244	0.757
LIG_14-3-3_CanoR_1	32	38	PF00244	0.658
LIG_14-3-3_CanoR_1	501	511	PF00244	0.516
LIG_14-3-3_CanoR_1	760	768	PF00244	0.389
LIG_14-3-3_CanoR_1	976	982	PF00244	0.420
LIG_14-3-3_CanoR_1	987	995	PF00244	0.323
LIG_Actin_WH2_2	617	635	PF00022	0.453
LIG_APCC_ABBA_1	325	330	PF00400	0.636
LIG_BRCT_BRCA1_1	165	169	PF00533	0.818
LIG_BRCT_BRCA1_1	410	414	PF00533	0.695
LIG_BRCT_BRCA1_1	984	988	PF00533	0.351
LIG_Clathr_ClatBox_1	785	789	PF01394	0.488
LIG_deltaCOP1_diTrp_1	436	443	PF00928	0.774
LIG_DLG_GKlike_1	953	960	PF00625	0.305
LIG_FHA_1	180	186	PF00498	0.785
LIG_FHA_1	197	203	PF00498	0.698
LIG_FHA_1	368	374	PF00498	0.625
LIG_FHA_1	393	399	PF00498	0.685
LIG_FHA_1	453	459	PF00498	0.649
LIG_FHA_1	542	548	PF00498	0.437
LIG_FHA_1	618	624	PF00498	0.386
LIG_FHA_1	694	700	PF00498	0.418
LIG_FHA_1	703	709	PF00498	0.376
LIG_FHA_1	823	829	PF00498	0.460
LIG_FHA_1	861	867	PF00498	0.450
LIG_FHA_1	880	886	PF00498	0.493
LIG_FHA_1	957	963	PF00498	0.330
LIG_FHA_1	981	987	PF00498	0.353
LIG_FHA_2	472	478	PF00498	0.306
LIG_FHA_2	718	724	PF00498	0.456
LIG_FHA_2	728	734	PF00498	0.340
LIG_FHA_2	966	972	PF00498	0.390
LIG_GBD_Chelix_1	547	555	PF00786	0.646
LIG_LIR_Apic_2	411	417	PF02991	0.834
LIG_LIR_Gen_1	1008	1017	PF02991	0.380
LIG_LIR_Gen_1	150	158	PF02991	0.762
LIG_LIR_Gen_1	474	483	PF02991	0.322
LIG_LIR_Gen_1	990	999	PF02991	0.380
LIG_LIR_Nem_3	1008	1012	PF02991	0.382
LIG_LIR_Nem_3	150	155	PF02991	0.753
LIG_LIR_Nem_3	474	478	PF02991	0.322
LIG_LIR_Nem_3	990	995	PF02991	0.378
LIG_MYND_3	954	958	PF01753	0.368
LIG_NRBOX	721	727	PF00104	0.375
LIG_Pex14_1	439	443	PF04695	0.775
LIG_Pex14_2	434	438	PF04695	0.774
LIG_Pex14_2	988	992	PF04695	0.372
LIG_SH2_CRK	275	279	PF00017	0.693
LIG_SH2_CRK	359	363	PF00017	0.788
LIG_SH2_CRK	678	682	PF00017	0.353
LIG_SH2_STAP1	1017	1021	PF00017	0.497
LIG_SH2_STAP1	678	682	PF00017	0.353
LIG_SH2_STAT3	323	326	PF00017	0.715
LIG_SH2_STAT3	718	721	PF00017	0.451
LIG_SH2_STAT5	1015	1018	PF00017	0.373
LIG_SH2_STAT5	323	326	PF00017	0.715
LIG_SH2_STAT5	429	432	PF00017	0.711
LIG_SH2_STAT5	718	721	PF00017	0.367
LIG_SH2_STAT5	731	734	PF00017	0.381
LIG_SH2_STAT5	745	748	PF00017	0.375
LIG_SH2_STAT5	941	944	PF00017	0.394
LIG_SH3_3	21	27	PF00018	0.634
LIG_SH3_3	393	399	PF00018	0.685
LIG_SH3_3	7	13	PF00018	0.791
LIG_SH3_3	923	929	PF00018	0.324
LIG_SH3_CIN85_PxpxPR_1	875	880	PF14604	0.457
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.726
LIG_SUMO_SIM_anti_2	620	625	PF11976	0.294
LIG_SUMO_SIM_anti_2	783	790	PF11976	0.343
LIG_SUMO_SIM_par_1	198	204	PF11976	0.725
LIG_SUMO_SIM_par_1	618	625	PF11976	0.450
LIG_SUMO_SIM_par_1	626	631	PF11976	0.358
LIG_SUMO_SIM_par_1	705	711	PF11976	0.325
LIG_SUMO_SIM_par_1	750	757	PF11976	0.476
LIG_SUMO_SIM_par_1	783	790	PF11976	0.486
LIG_SUMO_SIM_par_1	958	966	PF11976	0.381
LIG_TYR_ITIM	357	362	PF00017	0.709
LIG_WRC_WIRS_1	1006	1011	PF05994	0.463
LIG_WRC_WIRS_1	516	521	PF05994	0.397
MOD_CDK_SPK_2	392	397	PF00069	0.682
MOD_CDK_SPxxK_3	49	56	PF00069	0.684
MOD_CDK_SPxxK_3	879	886	PF00069	0.507
MOD_CK1_1	129	135	PF00069	0.726
MOD_CK1_1	160	166	PF00069	0.745
MOD_CK1_1	172	178	PF00069	0.829
MOD_CK1_1	254	260	PF00069	0.768
MOD_CK1_1	261	267	PF00069	0.673
MOD_CK1_1	615	621	PF00069	0.324
MOD_CK1_1	706	712	PF00069	0.388
MOD_CK1_1	762	768	PF00069	0.522
MOD_CK1_1	869	875	PF00069	0.549
MOD_CK1_1	897	903	PF00069	0.382
MOD_CK1_1	956	962	PF00069	0.412
MOD_CK1_1	980	986	PF00069	0.318
MOD_CK2_1	471	477	PF00069	0.306
MOD_CK2_1	490	496	PF00069	0.382
MOD_CK2_1	610	616	PF00069	0.499
MOD_CK2_1	717	723	PF00069	0.451
MOD_CK2_1	965	971	PF00069	0.391
MOD_GlcNHglycan	118	122	PF01048	0.627
MOD_GlcNHglycan	163	166	PF01048	0.510
MOD_GlcNHglycan	175	178	PF01048	0.576
MOD_GlcNHglycan	203	206	PF01048	0.530
MOD_GlcNHglycan	260	263	PF01048	0.546
MOD_GlcNHglycan	616	620	PF01048	0.672
MOD_GlcNHglycan	641	644	PF01048	0.562
MOD_GlcNHglycan	748	752	PF01048	0.657
MOD_GlcNHglycan	769	772	PF01048	0.618
MOD_GlcNHglycan	789	794	PF01048	0.674
MOD_GlcNHglycan	898	902	PF01048	0.562
MOD_GlcNHglycan	914	917	PF01048	0.588
MOD_GSK3_1	125	132	PF00069	0.813
MOD_GSK3_1	156	163	PF00069	0.685
MOD_GSK3_1	165	172	PF00069	0.764
MOD_GSK3_1	254	261	PF00069	0.727
MOD_GSK3_1	286	293	PF00069	0.806
MOD_GSK3_1	326	333	PF00069	0.632
MOD_GSK3_1	363	370	PF00069	0.778
MOD_GSK3_1	486	493	PF00069	0.531
MOD_GSK3_1	497	504	PF00069	0.553
MOD_GSK3_1	68	75	PF00069	0.800
MOD_GSK3_1	702	709	PF00069	0.382
MOD_GSK3_1	767	774	PF00069	0.370
MOD_GSK3_1	869	876	PF00069	0.561
MOD_GSK3_1	961	968	PF00069	0.358
MOD_LATS_1	426	432	PF00433	0.643
MOD_LATS_1	812	818	PF00433	0.376
MOD_N-GLC_1	169	174	PF02516	0.490
MOD_N-GLC_1	32	37	PF02516	0.608
MOD_N-GLC_1	399	404	PF02516	0.552
MOD_N-GLC_1	501	506	PF02516	0.788
MOD_N-GLC_1	845	850	PF02516	0.556
MOD_N-GLC_1	866	871	PF02516	0.681
MOD_N-GLC_1	99	104	PF02516	0.501
MOD_NEK2_1	169	174	PF00069	0.699
MOD_NEK2_1	382	387	PF00069	0.796
MOD_NEK2_1	515	520	PF00069	0.335
MOD_NEK2_1	534	539	PF00069	0.405
MOD_NEK2_1	626	631	PF00069	0.374
MOD_NEK2_1	702	707	PF00069	0.406
MOD_NEK2_1	822	827	PF00069	0.417
MOD_NEK2_1	828	833	PF00069	0.430
MOD_NEK2_1	845	850	PF00069	0.268
MOD_NEK2_1	866	871	PF00069	0.481
MOD_NEK2_1	937	942	PF00069	0.366
MOD_NEK2_1	975	980	PF00069	0.366
MOD_PIKK_1	126	132	PF00454	0.737
MOD_PIKK_1	245	251	PF00454	0.693
MOD_PIKK_1	330	336	PF00454	0.630
MOD_PIKK_1	375	381	PF00454	0.689
MOD_PIKK_1	399	405	PF00454	0.739
MOD_PIKK_1	579	585	PF00454	0.487
MOD_PIKK_1	68	74	PF00454	0.750
MOD_PIKK_1	685	691	PF00454	0.403
MOD_PIKK_1	717	723	PF00454	0.451
MOD_PIKK_1	845	851	PF00454	0.381
MOD_PKA_2	506	512	PF00069	0.497
MOD_PKA_2	759	765	PF00069	0.391
MOD_PKA_2	800	806	PF00069	0.546
MOD_PKA_2	975	981	PF00069	0.463
MOD_Plk_1	290	296	PF00069	0.707
MOD_Plk_1	3	9	PF00069	0.647
MOD_Plk_1	702	708	PF00069	0.317
MOD_Plk_1	747	753	PF00069	0.461
MOD_Plk_1	822	828	PF00069	0.454
MOD_Plk_1	90	96	PF00069	0.722
MOD_Plk_1	937	943	PF00069	0.372
MOD_Plk_1	99	105	PF00069	0.696
MOD_Plk_4	196	202	PF00069	0.636
MOD_Plk_4	261	267	PF00069	0.775
MOD_Plk_4	290	296	PF00069	0.843
MOD_Plk_4	318	324	PF00069	0.717
MOD_Plk_4	33	39	PF00069	0.764
MOD_Plk_4	471	477	PF00069	0.407
MOD_Plk_4	515	521	PF00069	0.328
MOD_Plk_4	550	556	PF00069	0.452
MOD_Plk_4	655	661	PF00069	0.387
MOD_Plk_4	703	709	PF00069	0.321
MOD_Plk_4	781	787	PF00069	0.322
MOD_Plk_4	956	962	PF00069	0.326
MOD_ProDKin_1	163	169	PF00069	0.739
MOD_ProDKin_1	392	398	PF00069	0.683
MOD_ProDKin_1	484	490	PF00069	0.537
MOD_ProDKin_1	49	55	PF00069	0.684
MOD_ProDKin_1	869	875	PF00069	0.514
MOD_ProDKin_1	879	885	PF00069	0.510
MOD_ProDKin_1	925	931	PF00069	0.474
MOD_ProDKin_1	965	971	PF00069	0.391
MOD_SUMO_rev_2	224	234	PF00179	0.753
MOD_SUMO_rev_2	309	319	PF00179	0.774
MOD_SUMO_rev_2	966	975	PF00179	0.475
TRG_DiLeu_BaEn_1	783	788	PF01217	0.331
TRG_DiLeu_BaEn_4	415	421	PF01217	0.649
TRG_ENDOCYTIC_2	1017	1020	PF00928	0.397
TRG_ENDOCYTIC_2	275	278	PF00928	0.747
TRG_ENDOCYTIC_2	359	362	PF00928	0.722
TRG_ENDOCYTIC_2	678	681	PF00928	0.352
TRG_ER_diArg_1	1026	1028	PF00400	0.392
TRG_ER_diArg_1	134	137	PF00400	0.695
TRG_ER_diArg_1	145	147	PF00400	0.717
TRG_ER_diArg_1	340	342	PF00400	0.724
TRG_ER_diArg_1	38	40	PF00400	0.809
TRG_ER_diArg_1	386	388	PF00400	0.734
TRG_ER_diArg_1	404	407	PF00400	0.592
TRG_ER_diArg_1	412	414	PF00400	0.649
TRG_ER_diArg_1	440	442	PF00400	0.675
TRG_NES_CRM1_1	930	943	PF08389	0.463
TRG_NLS_MonoCore_2	338	343	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	1014	1018	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	997	1001	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTI4	Leptomonas seymouri	48%	100%
A4I9N4	Leishmania infantum	73%	99%