Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAH3_LEIBR

TriTrypDb:

LbrM.20.0560 , LBRM2903_200012400

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	727	731	PF00656	0.550
CLV_NRD_NRD_1	191	193	PF00675	0.484
CLV_NRD_NRD_1	469	471	PF00675	0.652
CLV_NRD_NRD_1	536	538	PF00675	0.498
CLV_NRD_NRD_1	590	592	PF00675	0.606
CLV_NRD_NRD_1	761	763	PF00675	0.594
CLV_NRD_NRD_1	83	85	PF00675	0.537
CLV_PCSK_FUR_1	371	375	PF00082	0.637
CLV_PCSK_FUR_1	534	538	PF00082	0.554
CLV_PCSK_KEX2_1	130	132	PF00082	0.437
CLV_PCSK_KEX2_1	190	192	PF00082	0.469
CLV_PCSK_KEX2_1	373	375	PF00082	0.547
CLV_PCSK_KEX2_1	468	470	PF00082	0.669
CLV_PCSK_KEX2_1	536	538	PF00082	0.497
CLV_PCSK_KEX2_1	592	594	PF00082	0.738
CLV_PCSK_KEX2_1	761	763	PF00082	0.638
CLV_PCSK_KEX2_1	83	85	PF00082	0.505
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.430
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.635
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.738
CLV_PCSK_SKI1_1	201	205	PF00082	0.531
CLV_PCSK_SKI1_1	373	377	PF00082	0.597
CLV_PCSK_SKI1_1	394	398	PF00082	0.566
CLV_PCSK_SKI1_1	469	473	PF00082	0.710
CLV_PCSK_SKI1_1	476	480	PF00082	0.679
CLV_PCSK_SKI1_1	60	64	PF00082	0.487
CLV_PCSK_SKI1_1	714	718	PF00082	0.616
CLV_PCSK_SKI1_1	762	766	PF00082	0.467
CLV_PCSK_SKI1_1	772	776	PF00082	0.479
CLV_Separin_Metazoa	557	561	PF03568	0.467
CLV_Separin_Metazoa	568	572	PF03568	0.394
DEG_APCC_DBOX_1	373	381	PF00400	0.611
DEG_APCC_DBOX_1	618	626	PF00400	0.475
DEG_Nend_UBRbox_3	1	3	PF02207	0.596
DEG_SPOP_SBC_1	688	692	PF00917	0.543
DOC_CKS1_1	721	726	PF01111	0.469
DOC_CYCLIN_RxL_1	175	188	PF00134	0.465
DOC_CYCLIN_RxL_1	198	208	PF00134	0.474
DOC_CYCLIN_RxL_1	218	230	PF00134	0.323
DOC_CYCLIN_RxL_1	371	382	PF00134	0.615
DOC_MAPK_gen_1	371	380	PF00069	0.569
DOC_MAPK_gen_1	445	454	PF00069	0.533
DOC_MAPK_gen_1	534	543	PF00069	0.562
DOC_MAPK_gen_1	57	65	PF00069	0.465
DOC_MAPK_MEF2A_6	534	543	PF00069	0.508
DOC_MAPK_MEF2A_6	57	65	PF00069	0.539
DOC_PP4_FxxP_1	305	308	PF00568	0.634
DOC_USP7_MATH_1	232	236	PF00917	0.444
DOC_USP7_MATH_1	308	312	PF00917	0.684
DOC_USP7_MATH_1	321	325	PF00917	0.624
DOC_USP7_MATH_1	428	432	PF00917	0.588
DOC_USP7_MATH_1	606	610	PF00917	0.595
DOC_USP7_MATH_1	688	692	PF00917	0.585
DOC_USP7_MATH_1	736	740	PF00917	0.651
DOC_USP7_MATH_1	79	83	PF00917	0.642
DOC_USP7_MATH_2	511	517	PF00917	0.548
DOC_USP7_UBL2_3	159	163	PF12436	0.533
DOC_USP7_UBL2_3	422	426	PF12436	0.600
DOC_WW_Pin1_4	265	270	PF00397	0.733
DOC_WW_Pin1_4	278	283	PF00397	0.755
DOC_WW_Pin1_4	285	290	PF00397	0.757
DOC_WW_Pin1_4	431	436	PF00397	0.575
DOC_WW_Pin1_4	720	725	PF00397	0.465
LIG_14-3-3_CanoR_1	109	115	PF00244	0.519
LIG_14-3-3_CanoR_1	119	125	PF00244	0.578
LIG_14-3-3_CanoR_1	140	144	PF00244	0.418
LIG_14-3-3_CanoR_1	152	158	PF00244	0.541
LIG_14-3-3_CanoR_1	190	198	PF00244	0.439
LIG_14-3-3_CanoR_1	218	222	PF00244	0.476
LIG_14-3-3_CanoR_1	226	234	PF00244	0.451
LIG_14-3-3_CanoR_1	264	269	PF00244	0.746
LIG_14-3-3_CanoR_1	468	477	PF00244	0.558
LIG_14-3-3_CanoR_1	498	505	PF00244	0.604
LIG_14-3-3_CanoR_1	540	549	PF00244	0.520
LIG_14-3-3_CanoR_1	591	599	PF00244	0.503
LIG_14-3-3_CanoR_1	621	626	PF00244	0.494
LIG_14-3-3_CanoR_1	643	648	PF00244	0.502
LIG_14-3-3_CanoR_1	83	90	PF00244	0.446
LIG_Actin_RPEL_3	185	204	PF02755	0.327
LIG_Actin_WH2_2	757	774	PF00022	0.561
LIG_APCC_ABBA_1	552	557	PF00400	0.468
LIG_BRCT_BRCA1_1	243	247	PF00533	0.577
LIG_CaM_IQ_9	147	162	PF13499	0.467
LIG_Clathr_ClatBox_1	182	186	PF01394	0.442
LIG_Clathr_ClatBox_1	377	381	PF01394	0.595
LIG_Clathr_ClatBox_1	62	66	PF01394	0.520
LIG_FAT_LD_1	65	73	PF03623	0.533
LIG_FHA_1	131	137	PF00498	0.335
LIG_FHA_1	680	686	PF00498	0.498
LIG_FHA_1	704	710	PF00498	0.720
LIG_FHA_2	231	237	PF00498	0.616
LIG_FHA_2	329	335	PF00498	0.555
LIG_FHA_2	563	569	PF00498	0.489
LIG_FHA_2	596	602	PF00498	0.430
LIG_FHA_2	606	612	PF00498	0.369
LIG_FHA_2	725	731	PF00498	0.497
LIG_FHA_2	83	89	PF00498	0.611
LIG_HCF-1_HBM_1	403	406	PF13415	0.553
LIG_Integrin_isoDGR_2	352	354	PF01839	0.607
LIG_LIR_Apic_2	302	308	PF02991	0.636
LIG_LIR_Apic_2	403	409	PF02991	0.478
LIG_LIR_Apic_2	719	724	PF02991	0.547
LIG_LIR_Gen_1	244	253	PF02991	0.583
LIG_LIR_Gen_1	366	377	PF02991	0.629
LIG_LIR_Gen_1	646	655	PF02991	0.559
LIG_LIR_LC3C_4	24	28	PF02991	0.500
LIG_LIR_Nem_3	244	250	PF02991	0.493
LIG_LIR_Nem_3	335	341	PF02991	0.665
LIG_LIR_Nem_3	366	372	PF02991	0.628
LIG_LIR_Nem_3	431	436	PF02991	0.506
LIG_LIR_Nem_3	646	651	PF02991	0.560
LIG_LYPXL_yS_3	424	427	PF13949	0.515
LIG_PTB_Apo_2	418	425	PF02174	0.452
LIG_PTB_Phospho_1	418	424	PF10480	0.566
LIG_Rb_pABgroove_1	549	557	PF01858	0.473
LIG_SH2_CRK	338	342	PF00017	0.662
LIG_SH2_CRK	721	725	PF00017	0.468
LIG_SH2_NCK_1	577	581	PF00017	0.441
LIG_SH2_SRC	318	321	PF00017	0.560
LIG_SH2_STAP1	143	147	PF00017	0.472
LIG_SH2_STAP1	410	414	PF00017	0.524
LIG_SH2_STAP1	555	559	PF00017	0.400
LIG_SH2_STAT5	237	240	PF00017	0.458
LIG_SH2_STAT5	256	259	PF00017	0.571
LIG_SH3_1	422	428	PF00018	0.593
LIG_SH3_3	422	428	PF00018	0.593
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.552
LIG_SUMO_SIM_par_1	181	186	PF11976	0.441
LIG_SUMO_SIM_par_1	376	382	PF11976	0.500
LIG_SUMO_SIM_par_1	620	627	PF11976	0.364
LIG_TRAF2_1	519	522	PF00917	0.525
LIG_TRAF2_1	56	59	PF00917	0.378
LIG_TRAF2_1	705	708	PF00917	0.531
LIG_TRAF2_1	85	88	PF00917	0.556
LIG_UBA3_1	114	123	PF00899	0.510
LIG_UBA3_1	32	37	PF00899	0.477
LIG_UBA3_1	437	442	PF00899	0.498
MOD_CDC14_SPxK_1	288	291	PF00782	0.659
MOD_CDK_SPK_2	278	283	PF00069	0.619
MOD_CDK_SPK_2	720	725	PF00069	0.465
MOD_CDK_SPxK_1	285	291	PF00069	0.661
MOD_CDK_SPxxK_3	267	274	PF00069	0.716
MOD_CK1_1	194	200	PF00069	0.505
MOD_CK1_1	267	273	PF00069	0.799
MOD_CK1_1	277	283	PF00069	0.740
MOD_CK1_1	311	317	PF00069	0.636
MOD_CK1_1	324	330	PF00069	0.442
MOD_CK1_1	431	437	PF00069	0.555
MOD_CK1_1	494	500	PF00069	0.706
MOD_CK1_1	501	507	PF00069	0.593
MOD_CK1_1	545	551	PF00069	0.350
MOD_CK1_1	639	645	PF00069	0.480
MOD_CK1_1	646	652	PF00069	0.574
MOD_CK1_1	679	685	PF00069	0.694
MOD_CK1_1	686	692	PF00069	0.697
MOD_CK1_1	739	745	PF00069	0.498
MOD_CK1_1	82	88	PF00069	0.450
MOD_CK1_1	96	102	PF00069	0.335
MOD_CK2_1	138	144	PF00069	0.577
MOD_CK2_1	163	169	PF00069	0.432
MOD_CK2_1	328	334	PF00069	0.670
MOD_CK2_1	562	568	PF00069	0.485
MOD_CK2_1	583	589	PF00069	0.768
MOD_CK2_1	595	601	PF00069	0.513
MOD_CK2_1	605	611	PF00069	0.448
MOD_CK2_1	702	708	PF00069	0.573
MOD_CK2_1	82	88	PF00069	0.612
MOD_Cter_Amidation	188	191	PF01082	0.429
MOD_GlcNHglycan	186	190	PF01048	0.538
MOD_GlcNHglycan	314	317	PF01048	0.694
MOD_GlcNHglycan	323	326	PF01048	0.638
MOD_GlcNHglycan	391	394	PF01048	0.591
MOD_GlcNHglycan	578	581	PF01048	0.621
MOD_GlcNHglycan	608	611	PF01048	0.505
MOD_GlcNHglycan	686	689	PF01048	0.730
MOD_GlcNHglycan	738	741	PF01048	0.558
MOD_GSK3_1	138	145	PF00069	0.336
MOD_GSK3_1	226	233	PF00069	0.426
MOD_GSK3_1	263	270	PF00069	0.678
MOD_GSK3_1	274	281	PF00069	0.746
MOD_GSK3_1	308	315	PF00069	0.765
MOD_GSK3_1	324	331	PF00069	0.618
MOD_GSK3_1	476	483	PF00069	0.679
MOD_GSK3_1	490	497	PF00069	0.597
MOD_GSK3_1	541	548	PF00069	0.398
MOD_GSK3_1	591	598	PF00069	0.444
MOD_GSK3_1	639	646	PF00069	0.506
MOD_GSK3_1	675	682	PF00069	0.733
MOD_GSK3_1	683	690	PF00069	0.789
MOD_GSK3_1	699	706	PF00069	0.481
MOD_GSK3_1	720	727	PF00069	0.719
MOD_GSK3_1	736	743	PF00069	0.454
MOD_GSK3_1	762	769	PF00069	0.504
MOD_GSK3_1	93	100	PF00069	0.344
MOD_N-GLC_1	321	326	PF02516	0.683
MOD_N-GLC_1	367	372	PF02516	0.616
MOD_NEK2_1	150	155	PF00069	0.567
MOD_NEK2_1	185	190	PF00069	0.457
MOD_NEK2_1	257	262	PF00069	0.672
MOD_NEK2_1	541	546	PF00069	0.572
MOD_NEK2_1	576	581	PF00069	0.614
MOD_NEK2_1	749	754	PF00069	0.562
MOD_NEK2_1	779	784	PF00069	0.502
MOD_NEK2_2	595	600	PF00069	0.590
MOD_PIKK_1	161	167	PF00454	0.480
MOD_PIKK_1	462	468	PF00454	0.589
MOD_PIKK_1	542	548	PF00454	0.561
MOD_PIKK_1	762	768	PF00454	0.503
MOD_PK_1	621	627	PF00069	0.364
MOD_PKA_1	130	136	PF00069	0.336
MOD_PKA_1	191	197	PF00069	0.490
MOD_PKA_1	469	475	PF00069	0.618
MOD_PKA_1	591	597	PF00069	0.448
MOD_PKA_2	108	114	PF00069	0.523
MOD_PKA_2	118	124	PF00069	0.577
MOD_PKA_2	130	136	PF00069	0.534
MOD_PKA_2	139	145	PF00069	0.300
MOD_PKA_2	191	197	PF00069	0.461
MOD_PKA_2	217	223	PF00069	0.575
MOD_PKA_2	263	269	PF00069	0.708
MOD_PKA_2	277	283	PF00069	0.631
MOD_PKA_2	292	298	PF00069	0.462
MOD_PKA_2	469	475	PF00069	0.700
MOD_PKA_2	497	503	PF00069	0.685
MOD_PKA_2	583	589	PF00069	0.734
MOD_PKA_2	724	730	PF00069	0.506
MOD_PKA_2	779	785	PF00069	0.580
MOD_PKA_2	82	88	PF00069	0.571
MOD_PKA_2	93	99	PF00069	0.523
MOD_PKB_1	190	198	PF00069	0.467
MOD_PKB_1	262	270	PF00069	0.654
MOD_PKB_1	591	599	PF00069	0.555
MOD_PKB_1	619	627	PF00069	0.491
MOD_Plk_1	301	307	PF00069	0.642
MOD_Plk_1	367	373	PF00069	0.631
MOD_Plk_2-3	230	236	PF00069	0.424
MOD_Plk_2-3	301	307	PF00069	0.642
MOD_Plk_4	621	627	PF00069	0.458
MOD_Plk_4	643	649	PF00069	0.560
MOD_Plk_4	699	705	PF00069	0.594
MOD_Plk_4	749	755	PF00069	0.495
MOD_ProDKin_1	265	271	PF00069	0.731
MOD_ProDKin_1	278	284	PF00069	0.753
MOD_ProDKin_1	285	291	PF00069	0.758
MOD_ProDKin_1	431	437	PF00069	0.568
MOD_ProDKin_1	720	726	PF00069	0.467
MOD_SUMO_for_1	36	39	PF00179	0.484
MOD_SUMO_rev_2	138	147	PF00179	0.520
MOD_SUMO_rev_2	5	12	PF00179	0.523
MOD_SUMO_rev_2	53	62	PF00179	0.544
MOD_SUMO_rev_2	586	594	PF00179	0.663
TRG_DiLeu_BaEn_1	58	63	PF01217	0.541
TRG_DiLeu_BaEn_4	38	44	PF01217	0.491
TRG_DiLeu_BaEn_4	381	387	PF01217	0.596
TRG_DiLeu_BaEn_4	58	64	PF01217	0.539
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.441
TRG_ENDOCYTIC_2	338	341	PF00928	0.664
TRG_ENDOCYTIC_2	410	413	PF00928	0.471
TRG_ENDOCYTIC_2	424	427	PF00928	0.475
TRG_ENDOCYTIC_2	555	558	PF00928	0.406
TRG_ENDOCYTIC_2	648	651	PF00928	0.562
TRG_ER_diArg_1	190	192	PF00400	0.503
TRG_ER_diArg_1	451	454	PF00400	0.507
TRG_ER_diArg_1	468	470	PF00400	0.457
TRG_ER_diArg_1	534	537	PF00400	0.489
TRG_ER_diArg_1	760	762	PF00400	0.504
TRG_NLS_MonoExtN_4	371	377	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M8	Leptomonas seymouri	56%	77%
A0A3Q8IHX7	Leishmania donovani	84%	100%
A0A422N4B9	Trypanosoma rangeli	28%	89%
A4I9N3	Leishmania infantum	84%	100%
D0A1Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B4N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q3E4	Leishmania major	83%	99%
V5DIQ2	Trypanosoma cruzi	27%	92%