Putative enoyl-[acyl-carrier-protein] reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-[acyl-carrier-protein] reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAH1_LEIBR

TriTrypDb:

LbrM.20.0540 , LBRM2903_210020500

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HAH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAH1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004497	monooxygenase activity	3	8
GO:0016491	oxidoreductase activity	2	8
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	8
GO:0016703	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)	4	8
GO:0018580	nitronate monooxygenase activity	5	8
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.475
CLV_NRD_NRD_1	244	246	PF00675	0.299
CLV_NRD_NRD_1	57	59	PF00675	0.486
CLV_PCSK_FUR_1	264	268	PF00082	0.217
CLV_PCSK_KEX2_1	212	214	PF00082	0.286
CLV_PCSK_KEX2_1	244	246	PF00082	0.299
CLV_PCSK_KEX2_1	266	268	PF00082	0.241
CLV_PCSK_KEX2_1	57	59	PF00082	0.486
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.286
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.229
CLV_PCSK_SKI1_1	121	125	PF00082	0.308
CLV_PCSK_SKI1_1	160	164	PF00082	0.295
CLV_PCSK_SKI1_1	233	237	PF00082	0.328
CLV_PCSK_SKI1_1	267	271	PF00082	0.295
CLV_PCSK_SKI1_1	300	304	PF00082	0.286
CLV_PCSK_SKI1_1	60	64	PF00082	0.217
DEG_Kelch_Keap1_1	273	278	PF01344	0.194
DEG_Nend_UBRbox_3	1	3	PF02207	0.463
DOC_CYCLIN_RxL_1	227	238	PF00134	0.324
DOC_MAPK_gen_1	64	71	PF00069	0.397
DOC_MAPK_MEF2A_6	160	169	PF00069	0.295
DOC_MAPK_MEF2A_6	64	73	PF00069	0.307
DOC_PP1_RVXF_1	77	84	PF00149	0.194
DOC_SPAK_OSR1_1	197	201	PF12202	0.381
DOC_USP7_UBL2_3	121	125	PF12436	0.295
DOC_USP7_UBL2_3	253	257	PF12436	0.299
DOC_USP7_UBL2_3	262	266	PF12436	0.381
DOC_USP7_UBL2_3	60	64	PF12436	0.299
DOC_WW_Pin1_4	95	100	PF00397	0.295
LIG_14-3-3_CanoR_1	213	217	PF00244	0.229
LIG_14-3-3_CanoR_1	5	10	PF00244	0.295
LIG_BRCT_BRCA1_1	45	49	PF00533	0.281
LIG_CaM_IQ_9	189	204	PF13499	0.295
LIG_eIF4E_1	229	235	PF01652	0.229
LIG_FHA_1	101	107	PF00498	0.305
LIG_FHA_1	150	156	PF00498	0.295
LIG_FHA_1	230	236	PF00498	0.244
LIG_FHA_1	72	78	PF00498	0.229
LIG_FHA_2	285	291	PF00498	0.290
LIG_Integrin_isoDGR_2	145	147	PF01839	0.229
LIG_LIR_Gen_1	221	231	PF02991	0.295
LIG_LIR_Gen_1	46	56	PF02991	0.281
LIG_LIR_Nem_3	221	226	PF02991	0.309
LIG_LIR_Nem_3	46	52	PF02991	0.281
LIG_LYPXL_yS_3	14	17	PF13949	0.295
LIG_SH3_3	159	165	PF00018	0.299
LIG_SH3_3	9	15	PF00018	0.381
LIG_TRAF2_1	206	209	PF00917	0.286
LIG_TYR_ITIM	12	17	PF00017	0.295
MOD_CDK_SPK_2	95	100	PF00069	0.295
MOD_CK1_1	249	255	PF00069	0.295
MOD_CK1_1	31	37	PF00069	0.327
MOD_CK1_1	95	101	PF00069	0.304
MOD_CK2_1	202	208	PF00069	0.299
MOD_CK2_1	290	296	PF00069	0.234
MOD_GlcNHglycan	176	179	PF01048	0.295
MOD_GlcNHglycan	203	207	PF01048	0.295
MOD_GlcNHglycan	24	27	PF01048	0.461
MOD_GlcNHglycan	248	251	PF01048	0.295
MOD_GlcNHglycan	30	33	PF01048	0.240
MOD_GlcNHglycan	94	97	PF01048	0.295
MOD_GSK3_1	1	8	PF00069	0.412
MOD_GSK3_1	198	205	PF00069	0.295
MOD_GSK3_1	71	78	PF00069	0.240
MOD_GSK3_1	91	98	PF00069	0.298
MOD_N-GLC_1	69	74	PF02516	0.229
MOD_NEK2_1	1	6	PF00069	0.357
MOD_NEK2_1	246	251	PF00069	0.276
MOD_PIKK_1	100	106	PF00454	0.324
MOD_PIKK_1	198	204	PF00454	0.381
MOD_PKA_1	212	218	PF00069	0.357
MOD_PKA_1	244	250	PF00069	0.381
MOD_PKA_2	212	218	PF00069	0.357
MOD_PKA_2	244	250	PF00069	0.381
MOD_Plk_1	148	154	PF00069	0.295
MOD_Plk_1	69	75	PF00069	0.229
MOD_Plk_4	151	157	PF00069	0.191
MOD_Plk_4	219	225	PF00069	0.295
MOD_Plk_4	43	49	PF00069	0.229
MOD_ProDKin_1	95	101	PF00069	0.295
MOD_SUMO_for_1	124	127	PF00179	0.295
MOD_SUMO_rev_2	82	90	PF00179	0.295
TRG_DiLeu_BaEn_3	86	92	PF01217	0.381
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.295
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.217
TRG_ENDOCYTIC_2	14	17	PF00928	0.295
TRG_ER_diArg_1	244	246	PF00400	0.327
TRG_ER_diArg_1	305	308	PF00400	0.486
TRG_ER_diArg_1	56	58	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	233	238	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE9	Leptomonas seymouri	78%	100%
A0A3Q8IE60	Leishmania donovani	86%	100%
A4HBY5	Leishmania braziliensis	98%	100%
A4I9N1	Leishmania infantum	86%	100%
A5IR97	Staphylococcus aureus (strain JH9)	31%	89%
A6QFD2	Staphylococcus aureus (strain Newman)	31%	89%
A6U025	Staphylococcus aureus (strain JH1)	31%	89%
A8Z1H7	Staphylococcus aureus (strain USA300 / TCH1516)	31%	89%
B2TEK6	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	33%	87%
D0V3Y4	Pseudomonas sp.	33%	91%
E9B4N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O05413	Bacillus subtilis (strain 168)	30%	91%
O06179	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	85%
P71847	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	89%
Q01284	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	84%
Q0S7Q1	Rhodococcus jostii (strain RHA1)	30%	90%
Q2FIF3	Staphylococcus aureus (strain USA300)	31%	89%
Q2FZX9	Staphylococcus aureus (strain NCTC 8325 / PS 47)	31%	89%
Q49W60	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	33%	89%
Q4L4T4	Staphylococcus haemolyticus (strain JCSC1435)	30%	89%
Q4Q3E6	Leishmania major	85%	100%
Q5HHG4	Staphylococcus aureus (strain COL)	31%	89%
Q6GB05	Staphylococcus aureus (strain MSSA476)	31%	89%
Q6GIG7	Staphylococcus aureus (strain MRSA252)	31%	89%
Q8NXG7	Staphylococcus aureus (strain MW2)	31%	89%
Q99VF6	Staphylococcus aureus (strain N315)	31%	89%
Q9HWH9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	28%	90%
Q9I4V0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	33%	97%