Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAH0_LEIBR

TriTrypDb:

LbrM.20.0530 , LBRM2903_200012000

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAH0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.790
CLV_C14_Caspase3-7	321	325	PF00656	0.387
CLV_C14_Caspase3-7	485	489	PF00656	0.623
CLV_NRD_NRD_1	139	141	PF00675	0.744
CLV_NRD_NRD_1	142	144	PF00675	0.745
CLV_NRD_NRD_1	287	289	PF00675	0.592
CLV_NRD_NRD_1	372	374	PF00675	0.666
CLV_NRD_NRD_1	432	434	PF00675	0.509
CLV_NRD_NRD_1	438	440	PF00675	0.506
CLV_NRD_NRD_1	789	791	PF00675	0.548
CLV_NRD_NRD_1	97	99	PF00675	0.804
CLV_PCSK_FUR_1	140	144	PF00082	0.773
CLV_PCSK_KEX2_1	139	141	PF00082	0.744
CLV_PCSK_KEX2_1	142	144	PF00082	0.745
CLV_PCSK_KEX2_1	269	271	PF00082	0.744
CLV_PCSK_KEX2_1	287	289	PF00082	0.676
CLV_PCSK_KEX2_1	372	374	PF00082	0.666
CLV_PCSK_KEX2_1	432	434	PF00082	0.524
CLV_PCSK_KEX2_1	438	440	PF00082	0.477
CLV_PCSK_KEX2_1	789	791	PF00082	0.548
CLV_PCSK_KEX2_1	798	800	PF00082	0.751
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.744
CLV_PCSK_PC1ET2_1	798	800	PF00082	0.751
CLV_PCSK_SKI1_1	198	202	PF00082	0.754
CLV_PCSK_SKI1_1	260	264	PF00082	0.681
CLV_PCSK_SKI1_1	343	347	PF00082	0.648
CLV_PCSK_SKI1_1	52	56	PF00082	0.573
CLV_PCSK_SKI1_1	611	615	PF00082	0.602
CLV_PCSK_SKI1_1	790	794	PF00082	0.698
DEG_APCC_DBOX_1	342	350	PF00400	0.645
DEG_APCC_DBOX_1	458	466	PF00400	0.658
DEG_SCF_FBW7_1	191	197	PF00400	0.623
DEG_SPOP_SBC_1	656	660	PF00917	0.624
DOC_ANK_TNKS_1	319	326	PF00023	0.641
DOC_CKS1_1	106	111	PF01111	0.785
DOC_CKS1_1	191	196	PF01111	0.625
DOC_CKS1_1	21	26	PF01111	0.600
DOC_MAPK_gen_1	139	149	PF00069	0.771
DOC_MAPK_gen_1	457	464	PF00069	0.514
DOC_MAPK_JIP1_4	143	149	PF00069	0.532
DOC_MAPK_MEF2A_6	140	149	PF00069	0.773
DOC_MAPK_MEF2A_6	307	316	PF00069	0.404
DOC_PP2B_LxvP_1	681	684	PF13499	0.593
DOC_PP2B_PxIxI_1	108	114	PF00149	0.829
DOC_PP4_FxxP_1	571	574	PF00568	0.603
DOC_USP7_MATH_1	112	116	PF00917	0.817
DOC_USP7_MATH_1	194	198	PF00917	0.615
DOC_USP7_MATH_1	236	240	PF00917	0.714
DOC_USP7_MATH_1	243	247	PF00917	0.662
DOC_USP7_MATH_1	477	481	PF00917	0.753
DOC_USP7_MATH_1	572	576	PF00917	0.794
DOC_USP7_MATH_1	583	587	PF00917	0.643
DOC_USP7_MATH_1	589	593	PF00917	0.617
DOC_USP7_MATH_1	623	627	PF00917	0.724
DOC_USP7_MATH_1	657	661	PF00917	0.696
DOC_USP7_MATH_1	664	668	PF00917	0.682
DOC_USP7_MATH_1	684	688	PF00917	0.515
DOC_USP7_MATH_1	708	712	PF00917	0.846
DOC_USP7_MATH_1	778	782	PF00917	0.548
DOC_USP7_MATH_1	8	12	PF00917	0.625
DOC_USP7_MATH_1	80	84	PF00917	0.689
DOC_WW_Pin1_4	105	110	PF00397	0.791
DOC_WW_Pin1_4	17	22	PF00397	0.706
DOC_WW_Pin1_4	190	195	PF00397	0.787
DOC_WW_Pin1_4	563	568	PF00397	0.805
DOC_WW_Pin1_4	574	579	PF00397	0.663
DOC_WW_Pin1_4	604	609	PF00397	0.854
DOC_WW_Pin1_4	636	641	PF00397	0.737
DOC_WW_Pin1_4	682	687	PF00397	0.664
DOC_WW_Pin1_4	720	725	PF00397	0.804
DOC_WW_Pin1_4	730	735	PF00397	0.581
DOC_WW_Pin1_4	84	89	PF00397	0.596
LIG_14-3-3_CanoR_1	142	148	PF00244	0.784
LIG_14-3-3_CanoR_1	198	204	PF00244	0.664
LIG_14-3-3_CanoR_1	545	555	PF00244	0.595
LIG_14-3-3_CanoR_1	611	619	PF00244	0.581
LIG_14-3-3_CanoR_1	678	682	PF00244	0.859
LIG_14-3-3_CanoR_1	692	698	PF00244	0.621
LIG_14-3-3_CanoR_1	718	724	PF00244	0.848
LIG_14-3-3_CanoR_1	779	785	PF00244	0.489
LIG_Actin_WH2_2	126	141	PF00022	0.718
LIG_Actin_WH2_2	25	40	PF00022	0.644
LIG_Actin_WH2_2	342	359	PF00022	0.642
LIG_BIR_II_1	1	5	PF00653	0.866
LIG_BRCT_BRCA1_1	836	840	PF00533	0.579
LIG_CAP-Gly_1	852	858	PF01302	0.816
LIG_Clathr_ClatBox_1	346	350	PF01394	0.643
LIG_Clathr_ClatBox_1	420	424	PF01394	0.655
LIG_CtBP_PxDLS_1	144	148	PF00389	0.535
LIG_deltaCOP1_diTrp_1	529	535	PF00928	0.453
LIG_FHA_1	106	112	PF00498	0.785
LIG_FHA_1	222	228	PF00498	0.755
LIG_FHA_1	29	35	PF00498	0.788
LIG_FHA_1	333	339	PF00498	0.635
LIG_FHA_1	400	406	PF00498	0.636
LIG_FHA_1	46	52	PF00498	0.425
LIG_FHA_1	730	736	PF00498	0.602
LIG_FHA_2	150	156	PF00498	0.780
LIG_FHA_2	230	236	PF00498	0.813
LIG_FHA_2	366	372	PF00498	0.405
LIG_FHA_2	512	518	PF00498	0.483
LIG_FHA_2	560	566	PF00498	0.602
LIG_FHA_2	657	663	PF00498	0.636
LIG_FHA_2	781	787	PF00498	0.444
LIG_LIR_Apic_2	468	474	PF02991	0.514
LIG_LIR_Apic_2	568	574	PF02991	0.603
LIG_LIR_Gen_1	305	316	PF02991	0.501
LIG_LIR_Nem_3	264	268	PF02991	0.561
LIG_LIR_Nem_3	305	311	PF02991	0.500
LIG_LIR_Nem_3	324	330	PF02991	0.601
LIG_NRBOX	62	68	PF00104	0.619
LIG_PDZ_Class_1	853	858	PF00595	0.567
LIG_Pex14_2	836	840	PF04695	0.826
LIG_REV1ctd_RIR_1	173	181	PF16727	0.534
LIG_REV1ctd_RIR_1	277	286	PF16727	0.721
LIG_SH2_CRK	471	475	PF00017	0.531
LIG_SH2_CRK	510	514	PF00017	0.744
LIG_SH2_GRB2like	747	750	PF00017	0.520
LIG_SH2_NCK_1	471	475	PF00017	0.547
LIG_SH2_STAP1	261	265	PF00017	0.689
LIG_SH2_STAP1	304	308	PF00017	0.497
LIG_SH2_STAT3	588	591	PF00017	0.634
LIG_SH2_STAT5	171	174	PF00017	0.772
LIG_SH3_3	103	109	PF00018	0.828
LIG_SH3_3	18	24	PF00018	0.610
LIG_SH3_3	500	506	PF00018	0.684
LIG_SH3_3	553	559	PF00018	0.636
LIG_SH3_3	634	640	PF00018	0.762
LIG_SH3_3	650	656	PF00018	0.707
LIG_SH3_3	680	686	PF00018	0.816
LIG_SH3_3	701	707	PF00018	0.733
LIG_SH3_3	721	727	PF00018	0.720
LIG_SH3_3	731	737	PF00018	0.805
LIG_SH3_3	82	88	PF00018	0.594
LIG_SUMO_SIM_par_1	30	36	PF11976	0.777
LIG_TRAF2_1	165	168	PF00917	0.780
LIG_TRAF2_1	391	394	PF00917	0.407
LIG_TRAF2_1	761	764	PF00917	0.677
MOD_CDC14_SPxK_1	195	198	PF00782	0.716
MOD_CDC14_SPxK_1	689	692	PF00782	0.604
MOD_CDK_SPK_2	636	641	PF00069	0.773
MOD_CDK_SPxK_1	192	198	PF00069	0.724
MOD_CDK_SPxK_1	563	569	PF00069	0.806
MOD_CDK_SPxK_1	686	692	PF00069	0.788
MOD_CDK_SPxxK_3	604	611	PF00069	0.613
MOD_CK1_1	115	121	PF00069	0.602
MOD_CK1_1	148	154	PF00069	0.704
MOD_CK1_1	199	205	PF00069	0.689
MOD_CK1_1	2	8	PF00069	0.851
MOD_CK1_1	229	235	PF00069	0.814
MOD_CK1_1	246	252	PF00069	0.436
MOD_CK1_1	576	582	PF00069	0.616
MOD_CK1_1	607	613	PF00069	0.749
MOD_CK1_1	635	641	PF00069	0.737
MOD_CK1_1	658	664	PF00069	0.695
MOD_CK1_1	667	673	PF00069	0.797
MOD_CK1_1	674	680	PF00069	0.674
MOD_CK1_1	711	717	PF00069	0.692
MOD_CK1_1	720	726	PF00069	0.685
MOD_CK1_1	839	845	PF00069	0.654
MOD_CK2_1	1	7	PF00069	0.707
MOD_CK2_1	149	155	PF00069	0.772
MOD_CK2_1	163	169	PF00069	0.560
MOD_CK2_1	216	222	PF00069	0.606
MOD_CK2_1	229	235	PF00069	0.654
MOD_CK2_1	280	286	PF00069	0.704
MOD_CK2_1	299	305	PF00069	0.662
MOD_CK2_1	30	36	PF00069	0.736
MOD_CK2_1	365	371	PF00069	0.405
MOD_CK2_1	388	394	PF00069	0.655
MOD_CK2_1	511	517	PF00069	0.486
MOD_CK2_1	559	565	PF00069	0.602
MOD_CK2_1	780	786	PF00069	0.447
MOD_CK2_1	839	845	PF00069	0.573
MOD_CK2_1	84	90	PF00069	0.847
MOD_Cter_Amidation	430	433	PF01082	0.415
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.615
MOD_GlcNHglycan	1	4	PF01048	0.659
MOD_GlcNHglycan	100	103	PF01048	0.832
MOD_GlcNHglycan	114	117	PF01048	0.529
MOD_GlcNHglycan	159	162	PF01048	0.762
MOD_GlcNHglycan	198	201	PF01048	0.532
MOD_GlcNHglycan	238	241	PF01048	0.684
MOD_GlcNHglycan	488	492	PF01048	0.604
MOD_GlcNHglycan	578	581	PF01048	0.667
MOD_GlcNHglycan	591	594	PF01048	0.558
MOD_GlcNHglycan	615	618	PF01048	0.656
MOD_GlcNHglycan	625	628	PF01048	0.681
MOD_GlcNHglycan	673	676	PF01048	0.691
MOD_GlcNHglycan	750	753	PF01048	0.648
MOD_GlcNHglycan	763	768	PF01048	0.569
MOD_GlcNHglycan	774	779	PF01048	0.500
MOD_GlcNHglycan	808	811	PF01048	0.587
MOD_GlcNHglycan	829	832	PF01048	0.804
MOD_GSK3_1	145	152	PF00069	0.648
MOD_GSK3_1	159	166	PF00069	0.671
MOD_GSK3_1	190	197	PF00069	0.736
MOD_GSK3_1	217	224	PF00069	0.532
MOD_GSK3_1	28	35	PF00069	0.661
MOD_GSK3_1	394	401	PF00069	0.405
MOD_GSK3_1	559	566	PF00069	0.649
MOD_GSK3_1	572	579	PF00069	0.576
MOD_GSK3_1	607	614	PF00069	0.785
MOD_GSK3_1	621	628	PF00069	0.639
MOD_GSK3_1	631	638	PF00069	0.677
MOD_GSK3_1	641	648	PF00069	0.616
MOD_GSK3_1	664	671	PF00069	0.755
MOD_GSK3_1	673	680	PF00069	0.689
MOD_GSK3_1	682	689	PF00069	0.550
MOD_GSK3_1	706	713	PF00069	0.697
MOD_GSK3_1	774	781	PF00069	0.549
MOD_GSK3_1	80	87	PF00069	0.837
MOD_GSK3_1	834	841	PF00069	0.621
MOD_LATS_1	482	488	PF00433	0.579
MOD_N-GLC_1	332	337	PF02516	0.641
MOD_N-GLC_1	469	474	PF02516	0.549
MOD_N-GLC_1	728	733	PF02516	0.606
MOD_N-GLC_1	748	753	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.707
MOD_NEK2_1	138	143	PF00069	0.668
MOD_NEK2_1	145	150	PF00069	0.592
MOD_NEK2_1	159	164	PF00069	0.787
MOD_NEK2_1	268	273	PF00069	0.734
MOD_NEK2_1	341	346	PF00069	0.567
MOD_NEK2_1	415	420	PF00069	0.592
MOD_NEK2_1	45	50	PF00069	0.621
MOD_NEK2_1	494	499	PF00069	0.728
MOD_NEK2_1	618	623	PF00069	0.644
MOD_NEK2_1	632	637	PF00069	0.589
MOD_NEK2_1	728	733	PF00069	0.644
MOD_NEK2_1	836	841	PF00069	0.662
MOD_NEK2_2	583	588	PF00069	0.616
MOD_PIKK_1	229	235	PF00454	0.817
MOD_PIKK_1	53	59	PF00454	0.654
MOD_PIKK_1	692	698	PF00454	0.609
MOD_PIKK_1	78	84	PF00454	0.829
MOD_PKA_1	269	275	PF00069	0.506
MOD_PKA_1	98	104	PF00069	0.593
MOD_PKA_2	138	144	PF00069	0.763
MOD_PKA_2	269	275	PF00069	0.506
MOD_PKA_2	374	380	PF00069	0.666
MOD_PKA_2	45	51	PF00069	0.735
MOD_PKA_2	677	683	PF00069	0.718
MOD_PKA_2	691	697	PF00069	0.622
MOD_PKA_2	717	723	PF00069	0.851
MOD_PKA_2	778	784	PF00069	0.606
MOD_PKB_1	461	469	PF00069	0.678
MOD_Plk_1	118	124	PF00069	0.763
MOD_Plk_1	341	347	PF00069	0.650
MOD_Plk_1	469	475	PF00069	0.531
MOD_Plk_1	487	493	PF00069	0.825
MOD_Plk_2-3	394	400	PF00069	0.654
MOD_Plk_4	145	151	PF00069	0.763
MOD_Plk_4	199	205	PF00069	0.753
MOD_Plk_4	583	589	PF00069	0.587
MOD_ProDKin_1	105	111	PF00069	0.792
MOD_ProDKin_1	17	23	PF00069	0.704
MOD_ProDKin_1	190	196	PF00069	0.784
MOD_ProDKin_1	563	569	PF00069	0.806
MOD_ProDKin_1	574	580	PF00069	0.662
MOD_ProDKin_1	604	610	PF00069	0.852
MOD_ProDKin_1	636	642	PF00069	0.737
MOD_ProDKin_1	682	688	PF00069	0.668
MOD_ProDKin_1	720	726	PF00069	0.804
MOD_ProDKin_1	730	736	PF00069	0.581
MOD_ProDKin_1	84	90	PF00069	0.600
MOD_SUMO_for_1	347	350	PF00179	0.639
MOD_SUMO_for_1	410	413	PF00179	0.532
MOD_SUMO_for_1	450	453	PF00179	0.652
MOD_SUMO_rev_2	47	56	PF00179	0.731
MOD_SUMO_rev_2	791	800	PF00179	0.722
MOD_SUMO_rev_2	96	101	PF00179	0.853
TRG_DiLeu_BaEn_1	342	347	PF01217	0.650
TRG_DiLeu_BaEn_2	275	281	PF01217	0.760
TRG_DiLeu_BaEn_4	167	173	PF01217	0.772
TRG_DiLeu_BaEn_4	453	459	PF01217	0.641
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.413
TRG_ENDOCYTIC_2	308	311	PF00928	0.506
TRG_ENDOCYTIC_2	327	330	PF00928	0.662
TRG_ENDOCYTIC_2	510	513	PF00928	0.748
TRG_ER_diArg_1	138	140	PF00400	0.736
TRG_ER_diArg_1	142	144	PF00400	0.729
TRG_ER_diArg_1	287	289	PF00400	0.676
TRG_ER_diArg_1	353	356	PF00400	0.638
TRG_ER_diArg_1	372	375	PF00400	0.354
TRG_ER_diArg_1	432	434	PF00400	0.665
TRG_ER_diArg_1	437	439	PF00400	0.576
TRG_ER_diArg_1	457	460	PF00400	0.319
TRG_ER_diArg_1	461	464	PF00400	0.561
TRG_NES_CRM1_1	336	350	PF08389	0.642
TRG_NES_CRM1_1	453	468	PF08389	0.658
TRG_NES_CRM1_1	53	65	PF08389	0.719
TRG_NLS_MonoExtC_3	797	803	PF00514	0.763
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7I5	Leishmania donovani	72%	100%
A4I9N0	Leishmania infantum	72%	100%
E9B4M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q3E7	Leishmania major	72%	98%