Putative importin beta-1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

importin beta-1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HAG4_LEIBR

TriTrypDb:

LbrM.20.0470 , LBRM2903_200010500

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HAG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAG4

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0019899	enzyme binding	3	11
GO:0031267	small GTPase binding	5	11
GO:0051020	GTPase binding	4	11
GO:0005048	signal sequence binding	4	1
GO:0008139	nuclear localization sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	772	776	PF00656	0.590
CLV_NRD_NRD_1	376	378	PF00675	0.532
CLV_NRD_NRD_1	583	585	PF00675	0.497
CLV_PCSK_KEX2_1	378	380	PF00082	0.542
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.542
CLV_PCSK_SKI1_1	296	300	PF00082	0.528
CLV_PCSK_SKI1_1	584	588	PF00082	0.413
CLV_PCSK_SKI1_1	644	648	PF00082	0.556
CLV_PCSK_SKI1_1	670	674	PF00082	0.455
CLV_PCSK_SKI1_1	695	699	PF00082	0.412
CLV_PCSK_SKI1_1	76	80	PF00082	0.392
CLV_PCSK_SKI1_1	829	833	PF00082	0.510
CLV_PCSK_SKI1_1	855	859	PF00082	0.632
DEG_APCC_DBOX_1	860	868	PF00400	0.576
DEG_ODPH_VHL_1	777	789	PF01847	0.451
DOC_CKS1_1	443	448	PF01111	0.541
DOC_MAPK_gen_1	377	386	PF00069	0.404
DOC_MAPK_gen_1	584	593	PF00069	0.393
DOC_MAPK_MEF2A_6	495	504	PF00069	0.560
DOC_MAPK_MEF2A_6	550	557	PF00069	0.385
DOC_PP4_FxxP_1	649	652	PF00568	0.599
DOC_USP7_MATH_1	14	18	PF00917	0.552
DOC_USP7_MATH_1	140	144	PF00917	0.519
DOC_USP7_MATH_1	243	247	PF00917	0.460
DOC_USP7_MATH_1	424	428	PF00917	0.435
DOC_USP7_MATH_1	619	623	PF00917	0.475
DOC_USP7_UBL2_3	854	858	PF12436	0.616
DOC_WW_Pin1_4	10	15	PF00397	0.398
DOC_WW_Pin1_4	101	106	PF00397	0.384
DOC_WW_Pin1_4	442	447	PF00397	0.491
LIG_14-3-3_CanoR_1	495	504	PF00244	0.307
LIG_14-3-3_CanoR_1	734	741	PF00244	0.548
LIG_Actin_WH2_2	402	419	PF00022	0.557
LIG_Actin_WH2_2	50	65	PF00022	0.392
LIG_Actin_WH2_2	830	848	PF00022	0.366
LIG_AP2alpha_1	438	442	PF02296	0.391
LIG_APCC_ABBA_1	590	595	PF00400	0.527
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BRCT_BRCA1_1	714	718	PF00533	0.562
LIG_FHA_1	175	181	PF00498	0.469
LIG_FHA_1	198	204	PF00498	0.412
LIG_FHA_1	268	274	PF00498	0.413
LIG_FHA_1	277	283	PF00498	0.407
LIG_FHA_1	3	9	PF00498	0.498
LIG_FHA_1	310	316	PF00498	0.482
LIG_FHA_1	321	327	PF00498	0.473
LIG_FHA_1	37	43	PF00498	0.478
LIG_FHA_1	443	449	PF00498	0.534
LIG_FHA_1	488	494	PF00498	0.476
LIG_FHA_1	681	687	PF00498	0.574
LIG_FHA_1	832	838	PF00498	0.384
LIG_FHA_2	255	261	PF00498	0.540
LIG_FHA_2	332	338	PF00498	0.561
LIG_FHA_2	517	523	PF00498	0.471
LIG_FHA_2	659	665	PF00498	0.330
LIG_FHA_2	687	693	PF00498	0.489
LIG_FHA_2	770	776	PF00498	0.585
LIG_FHA_2	847	853	PF00498	0.597
LIG_GBD_Chelix_1	112	120	PF00786	0.440
LIG_Integrin_RGD_1	742	744	PF01839	0.645
LIG_LIR_Gen_1	252	262	PF02991	0.421
LIG_LIR_Gen_1	365	375	PF02991	0.582
LIG_LIR_Gen_1	436	446	PF02991	0.425
LIG_LIR_Gen_1	494	505	PF02991	0.379
LIG_LIR_Gen_1	653	662	PF02991	0.312
LIG_LIR_Gen_1	683	693	PF02991	0.504
LIG_LIR_Gen_1	703	713	PF02991	0.206
LIG_LIR_Gen_1	760	769	PF02991	0.423
LIG_LIR_LC3C_4	498	502	PF02991	0.554
LIG_LIR_Nem_3	127	133	PF02991	0.485
LIG_LIR_Nem_3	252	258	PF02991	0.417
LIG_LIR_Nem_3	365	371	PF02991	0.571
LIG_LIR_Nem_3	436	441	PF02991	0.402
LIG_LIR_Nem_3	494	500	PF02991	0.404
LIG_LIR_Nem_3	588	593	PF02991	0.527
LIG_LIR_Nem_3	653	659	PF02991	0.542
LIG_LIR_Nem_3	683	688	PF02991	0.475
LIG_LIR_Nem_3	69	73	PF02991	0.415
LIG_LIR_Nem_3	703	708	PF02991	0.205
LIG_LIR_Nem_3	715	721	PF02991	0.369
LIG_LIR_Nem_3	760	765	PF02991	0.417
LIG_LIR_Nem_3	80	86	PF02991	0.316
LIG_MYND_1	723	727	PF01753	0.441
LIG_PCNA_yPIPBox_3	517	528	PF02747	0.477
LIG_PCNA_yPIPBox_3	838	846	PF02747	0.362
LIG_Pex14_2	438	442	PF04695	0.380
LIG_Pex14_2	701	705	PF04695	0.471
LIG_PTB_Apo_2	679	686	PF02174	0.535
LIG_PTB_Phospho_1	679	685	PF10480	0.528
LIG_SH2_CRK	255	259	PF00017	0.416
LIG_SH2_CRK	368	372	PF00017	0.530
LIG_SH2_CRK	656	660	PF00017	0.542
LIG_SH2_CRK	762	766	PF00017	0.375
LIG_SH2_GRB2like	368	371	PF00017	0.557
LIG_SH2_GRB2like	685	688	PF00017	0.573
LIG_SH2_NCK_1	368	372	PF00017	0.480
LIG_SH2_NCK_1	656	660	PF00017	0.316
LIG_SH2_NCK_1	762	766	PF00017	0.509
LIG_SH2_PTP2	685	688	PF00017	0.573
LIG_SH2_SRC	368	371	PF00017	0.583
LIG_SH2_STAP1	497	501	PF00017	0.301
LIG_SH2_STAP1	656	660	PF00017	0.316
LIG_SH2_STAT3	310	313	PF00017	0.501
LIG_SH2_STAT3	539	542	PF00017	0.589
LIG_SH2_STAT3	611	614	PF00017	0.563
LIG_SH2_STAT5	158	161	PF00017	0.458
LIG_SH2_STAT5	209	212	PF00017	0.545
LIG_SH2_STAT5	222	225	PF00017	0.420
LIG_SH2_STAT5	261	264	PF00017	0.415
LIG_SH2_STAT5	415	418	PF00017	0.430
LIG_SH2_STAT5	539	542	PF00017	0.471
LIG_SH2_STAT5	611	614	PF00017	0.528
LIG_SH2_STAT5	634	637	PF00017	0.409
LIG_SH2_STAT5	645	648	PF00017	0.325
LIG_SH2_STAT5	685	688	PF00017	0.505
LIG_SH2_STAT5	750	753	PF00017	0.412
LIG_SH3_1	717	723	PF00018	0.444
LIG_SH3_3	352	358	PF00018	0.525
LIG_SH3_3	389	395	PF00018	0.315
LIG_SH3_3	717	723	PF00018	0.444
LIG_SH3_3	816	822	PF00018	0.561
LIG_SUMO_SIM_anti_2	498	505	PF11976	0.529
LIG_SUMO_SIM_par_1	316	323	PF11976	0.292
LIG_SUMO_SIM_par_1	603	608	PF11976	0.577
LIG_TRAF2_1	396	399	PF00917	0.560
LIG_TRAF2_1	483	486	PF00917	0.512
LIG_TRAF2_1	519	522	PF00917	0.509
LIG_TRAF2_1	78	81	PF00917	0.505
LIG_TYR_ITIM	253	258	PF00017	0.494
LIG_UBA3_1	133	142	PF00899	0.334
LIG_UBA3_1	412	420	PF00899	0.326
LIG_WRC_WIRS_1	34	39	PF05994	0.478
LIG_WRC_WIRS_1	784	789	PF05994	0.498
LIG_WRPW_2	718	721	PF00400	0.560
MOD_CDC14_SPxK_1	104	107	PF00782	0.504
MOD_CDK_SPxK_1	101	107	PF00069	0.392
MOD_CK1_1	700	706	PF00069	0.522
MOD_CK1_1	760	766	PF00069	0.420
MOD_CK1_1	847	853	PF00069	0.622
MOD_CK2_1	140	146	PF00069	0.519
MOD_CK2_1	173	179	PF00069	0.567
MOD_CK2_1	187	193	PF00069	0.450
MOD_CK2_1	287	293	PF00069	0.382
MOD_CK2_1	347	353	PF00069	0.500
MOD_CK2_1	516	522	PF00069	0.455
MOD_CK2_1	558	564	PF00069	0.562
MOD_CK2_1	66	72	PF00069	0.459
MOD_CK2_1	686	692	PF00069	0.497
MOD_CK2_1	793	799	PF00069	0.501
MOD_CK2_1	845	851	PF00069	0.660
MOD_GlcNHglycan	126	129	PF01048	0.570
MOD_GlcNHglycan	142	145	PF01048	0.441
MOD_GlcNHglycan	181	184	PF01048	0.357
MOD_GlcNHglycan	189	192	PF01048	0.329
MOD_GlcNHglycan	197	200	PF01048	0.521
MOD_GlcNHglycan	425	429	PF01048	0.439
MOD_GlcNHglycan	536	539	PF01048	0.611
MOD_GlcNHglycan	561	564	PF01048	0.617
MOD_GlcNHglycan	579	582	PF01048	0.486
MOD_GlcNHglycan	606	610	PF01048	0.484
MOD_GlcNHglycan	813	816	PF01048	0.433
MOD_GSK3_1	10	17	PF00069	0.415
MOD_GSK3_1	116	123	PF00069	0.240
MOD_GSK3_1	175	182	PF00069	0.527
MOD_GSK3_1	29	36	PF00069	0.478
MOD_GSK3_1	304	311	PF00069	0.538
MOD_GSK3_1	338	345	PF00069	0.485
MOD_GSK3_1	487	494	PF00069	0.453
MOD_GSK3_1	516	523	PF00069	0.451
MOD_GSK3_1	615	622	PF00069	0.305
MOD_GSK3_1	757	764	PF00069	0.395
MOD_GSK3_1	846	853	PF00069	0.551
MOD_GSK3_1	97	104	PF00069	0.414
MOD_N-GLC_1	2	7	PF02516	0.630
MOD_N-GLC_1	308	313	PF02516	0.547
MOD_N-GLC_1	338	343	PF02516	0.441
MOD_N-GLC_1	371	376	PF02516	0.587
MOD_N-GLC_1	686	691	PF02516	0.576
MOD_N-GLC_1	793	798	PF02516	0.400
MOD_N-GLC_1	817	822	PF02516	0.380
MOD_N-GLC_2	232	234	PF02516	0.338
MOD_N-GLC_2	533	535	PF02516	0.470
MOD_NEK2_1	197	202	PF00069	0.523
MOD_NEK2_1	253	258	PF00069	0.425
MOD_NEK2_1	287	292	PF00069	0.374
MOD_NEK2_1	304	309	PF00069	0.564
MOD_NEK2_1	347	352	PF00069	0.370
MOD_NEK2_1	37	42	PF00069	0.443
MOD_NEK2_1	516	521	PF00069	0.448
MOD_NEK2_1	558	563	PF00069	0.592
MOD_NEK2_1	57	62	PF00069	0.378
MOD_NEK2_1	594	599	PF00069	0.497
MOD_NEK2_1	665	670	PF00069	0.441
MOD_NEK2_1	697	702	PF00069	0.410
MOD_NEK2_1	754	759	PF00069	0.388
MOD_NEK2_1	761	766	PF00069	0.386
MOD_NEK2_1	798	803	PF00069	0.491
MOD_NEK2_1	845	850	PF00069	0.623
MOD_NEK2_2	233	238	PF00069	0.341
MOD_OFUCOSY	699	704	PF10250	0.505
MOD_PIKK_1	309	315	PF00454	0.326
MOD_PIKK_1	320	326	PF00454	0.427
MOD_PIKK_1	763	769	PF00454	0.481
MOD_PIKK_1	798	804	PF00454	0.543
MOD_PK_1	379	385	PF00069	0.528
MOD_PKA_2	416	422	PF00069	0.525
MOD_PKA_2	733	739	PF00069	0.559
MOD_PKA_2	845	851	PF00069	0.407
MOD_PKB_1	377	385	PF00069	0.536
MOD_Plk_1	276	282	PF00069	0.440
MOD_Plk_1	338	344	PF00069	0.422
MOD_Plk_1	379	385	PF00069	0.528
MOD_Plk_1	424	430	PF00069	0.500
MOD_Plk_1	491	497	PF00069	0.429
MOD_Plk_1	594	600	PF00069	0.553
MOD_Plk_1	663	669	PF00069	0.404
MOD_Plk_1	798	804	PF00069	0.515
MOD_Plk_2-3	331	337	PF00069	0.561
MOD_Plk_4	313	319	PF00069	0.421
MOD_Plk_4	33	39	PF00069	0.449
MOD_Plk_4	379	385	PF00069	0.528
MOD_Plk_4	553	559	PF00069	0.514
MOD_Plk_4	567	573	PF00069	0.280
MOD_Plk_4	57	63	PF00069	0.392
MOD_Plk_4	680	686	PF00069	0.416
MOD_Plk_4	697	703	PF00069	0.273
MOD_Plk_4	757	763	PF00069	0.407
MOD_ProDKin_1	10	16	PF00069	0.403
MOD_ProDKin_1	101	107	PF00069	0.384
MOD_ProDKin_1	442	448	PF00069	0.488
MOD_SUMO_for_1	94	97	PF00179	0.429
MOD_SUMO_rev_2	190	198	PF00179	0.546
MOD_SUMO_rev_2	414	422	PF00179	0.334
MOD_SUMO_rev_2	44	52	PF00179	0.374
MOD_SUMO_rev_2	509	519	PF00179	0.567
MOD_SUMO_rev_2	692	700	PF00179	0.483
MOD_SUMO_rev_2	821	831	PF00179	0.384
TRG_DiLeu_BaEn_1	129	134	PF01217	0.463
TRG_DiLeu_BaEn_4	277	283	PF01217	0.422
TRG_ENDOCYTIC_2	255	258	PF00928	0.394
TRG_ENDOCYTIC_2	368	371	PF00928	0.452
TRG_ENDOCYTIC_2	497	500	PF00928	0.469
TRG_ENDOCYTIC_2	656	659	PF00928	0.534
TRG_ENDOCYTIC_2	685	688	PF00928	0.511
TRG_ENDOCYTIC_2	762	765	PF00928	0.375
TRG_ER_diArg_1	237	240	PF00400	0.394
TRG_ER_diArg_1	376	379	PF00400	0.554
TRG_NES_CRM1_1	589	603	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB22	Leptomonas seymouri	77%	100%
A0A0S4J2L0	Bodo saltans	48%	100%
A0A1X0P8K4	Trypanosomatidae	53%	100%
A0A3Q8IUD8	Leishmania donovani	89%	100%
A0A3R7LLX8	Trypanosoma rangeli	51%	100%
A4I9L9	Leishmania infantum	88%	100%
D0A1Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B4L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O00410	Homo sapiens	21%	79%
O13864	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O18388	Drosophila melanogaster	27%	98%
P52296	Rattus norvegicus	28%	99%
P52297	Xenopus laevis	28%	99%
P70168	Mus musculus	29%	99%
Q06142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q14974	Homo sapiens	29%	99%
Q3SYU7	Bos taurus	21%	97%
Q4Q3F9	Leishmania major	88%	100%
Q8BFY9	Mus musculus	21%	97%
Q8BKC5	Mus musculus	21%	79%
Q8H0U4	Arabidopsis thaliana	21%	98%
Q92973	Homo sapiens	21%	97%
Q9FJD4	Arabidopsis thaliana	30%	100%
V5BHR5	Trypanosoma cruzi	48%	100%