Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HAG2_LEIBR

TriTrypDb:

LbrM.20.0450 , LBRM2903_200010300

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0005730	nucleolus	5	5

Expansion

Sequence features

A4HAG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAG2

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.586
CLV_NRD_NRD_1	275	277	PF00675	0.407
CLV_NRD_NRD_1	294	296	PF00675	0.707
CLV_NRD_NRD_1	411	413	PF00675	0.530
CLV_NRD_NRD_1	513	515	PF00675	0.732
CLV_PCSK_KEX2_1	107	109	PF00082	0.586
CLV_PCSK_KEX2_1	275	277	PF00082	0.407
CLV_PCSK_KEX2_1	294	296	PF00082	0.707
CLV_PCSK_SKI1_1	155	159	PF00082	0.351
CLV_PCSK_SKI1_1	373	377	PF00082	0.330
CLV_PCSK_SKI1_1	434	438	PF00082	0.514
CLV_PCSK_SKI1_1	498	502	PF00082	0.521
CLV_PCSK_SKI1_1	541	545	PF00082	0.509
CLV_PCSK_SKI1_1	668	672	PF00082	0.385
DEG_SCF_FBW7_1	280	286	PF00400	0.481
DEG_SPOP_SBC_1	185	189	PF00917	0.579
DEG_SPOP_SBC_1	208	212	PF00917	0.498
DOC_CKS1_1	280	285	PF01111	0.479
DOC_CYCLIN_yClb5_NLxxxL_5	647	655	PF00134	0.476
DOC_MAPK_gen_1	233	242	PF00069	0.334
DOC_MAPK_MEF2A_6	233	242	PF00069	0.317
DOC_MAPK_MEF2A_6	505	512	PF00069	0.522
DOC_PP1_RVXF_1	134	141	PF00149	0.396
DOC_PP1_RVXF_1	410	417	PF00149	0.567
DOC_PP2B_LxvP_1	101	104	PF13499	0.554
DOC_PP2B_LxvP_1	701	704	PF13499	0.461
DOC_PP4_FxxP_1	11	14	PF00568	0.447
DOC_PP4_FxxP_1	183	186	PF00568	0.390
DOC_USP7_MATH_1	165	169	PF00917	0.619
DOC_USP7_MATH_1	184	188	PF00917	0.410
DOC_USP7_MATH_1	204	208	PF00917	0.402
DOC_USP7_MATH_1	281	285	PF00917	0.558
DOC_USP7_MATH_1	352	356	PF00917	0.513
DOC_USP7_MATH_1	448	452	PF00917	0.555
DOC_USP7_MATH_1	457	461	PF00917	0.712
DOC_USP7_MATH_1	491	495	PF00917	0.605
DOC_USP7_MATH_1	499	503	PF00917	0.544
DOC_USP7_MATH_1	535	539	PF00917	0.546
DOC_USP7_MATH_1	570	574	PF00917	0.601
DOC_USP7_MATH_1	654	658	PF00917	0.495
DOC_WW_Pin1_4	279	284	PF00397	0.514
DOC_WW_Pin1_4	287	292	PF00397	0.538
DOC_WW_Pin1_4	37	42	PF00397	0.542
DOC_WW_Pin1_4	406	411	PF00397	0.664
DOC_WW_Pin1_4	453	458	PF00397	0.659
DOC_WW_Pin1_4	517	522	PF00397	0.645
DOC_WW_Pin1_4	81	86	PF00397	0.508
LIG_14-3-3_CanoR_1	107	115	PF00244	0.604
LIG_14-3-3_CanoR_1	245	249	PF00244	0.391
LIG_14-3-3_CanoR_1	275	281	PF00244	0.522
LIG_14-3-3_CanoR_1	294	300	PF00244	0.689
LIG_14-3-3_CanoR_1	357	365	PF00244	0.427
LIG_14-3-3_CanoR_1	434	442	PF00244	0.574
LIG_14-3-3_CanoR_1	679	687	PF00244	0.497
LIG_Actin_WH2_2	655	670	PF00022	0.360
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BIR_III_4	264	268	PF00653	0.498
LIG_BRCT_BRCA1_1	210	214	PF00533	0.498
LIG_BRCT_BRCA1_1	249	253	PF00533	0.461
LIG_BRCT_BRCA1_1	31	35	PF00533	0.502
LIG_BRCT_BRCA1_1	354	358	PF00533	0.502
LIG_CSL_BTD_1	101	104	PF09270	0.513
LIG_eIF4E_1	560	566	PF01652	0.496
LIG_EVH1_2	521	525	PF00568	0.534
LIG_FHA_1	110	116	PF00498	0.687
LIG_FHA_1	200	206	PF00498	0.502
LIG_FHA_1	329	335	PF00498	0.616
LIG_FHA_1	372	378	PF00498	0.502
LIG_FHA_1	394	400	PF00498	0.489
LIG_FHA_1	594	600	PF00498	0.624
LIG_LIR_Apic_2	182	186	PF02991	0.380
LIG_LIR_Gen_1	212	219	PF02991	0.498
LIG_LIR_Gen_1	632	643	PF02991	0.488
LIG_LIR_Gen_1	96	104	PF02991	0.461
LIG_LIR_Nem_3	2	6	PF02991	0.577
LIG_LIR_Nem_3	211	217	PF02991	0.498
LIG_LIR_Nem_3	632	638	PF02991	0.490
LIG_LIR_Nem_3	92	98	PF02991	0.475
LIG_MLH1_MIPbox_1	211	215	PF16413	0.498
LIG_MYND_1	37	41	PF01753	0.498
LIG_Pex14_1	160	164	PF04695	0.443
LIG_Pex14_2	179	183	PF04695	0.401
LIG_Rb_pABgroove_1	236	244	PF01858	0.420
LIG_SH2_CRK	343	347	PF00017	0.293
LIG_SH2_CRK	635	639	PF00017	0.485
LIG_SH2_PTP2	98	101	PF00017	0.502
LIG_SH2_STAP1	687	691	PF00017	0.471
LIG_SH2_STAT5	147	150	PF00017	0.348
LIG_SH2_STAT5	209	212	PF00017	0.501
LIG_SH2_STAT5	217	220	PF00017	0.503
LIG_SH2_STAT5	258	261	PF00017	0.493
LIG_SH2_STAT5	341	344	PF00017	0.372
LIG_SH2_STAT5	564	567	PF00017	0.627
LIG_SH2_STAT5	98	101	PF00017	0.525
LIG_SH3_3	11	17	PF00018	0.441
LIG_SH3_3	40	46	PF00018	0.498
LIG_SH3_3	503	509	PF00018	0.507
LIG_SH3_3	518	524	PF00018	0.548
LIG_SUMO_SIM_par_1	201	207	PF11976	0.502
LIG_TRAF2_1	619	622	PF00917	0.510
LIG_WRC_WIRS_1	180	185	PF05994	0.469
LIG_WW_2	506	509	PF00397	0.526
MOD_CDK_SPK_2	453	458	PF00069	0.598
MOD_CDK_SPK_2	81	86	PF00069	0.498
MOD_CDK_SPxK_1	406	412	PF00069	0.493
MOD_CDK_SPxxK_3	287	294	PF00069	0.483
MOD_CDK_SPxxK_3	406	413	PF00069	0.560
MOD_CK1_1	207	213	PF00069	0.539
MOD_CK1_1	247	253	PF00069	0.506
MOD_CK1_1	279	285	PF00069	0.609
MOD_CK1_1	427	433	PF00069	0.511
MOD_CK1_1	451	457	PF00069	0.620
MOD_CK1_1	464	470	PF00069	0.732
MOD_CK1_1	593	599	PF00069	0.577
MOD_CK1_1	612	618	PF00069	0.483
MOD_CK1_1	657	663	PF00069	0.354
MOD_CK2_1	388	394	PF00069	0.605
MOD_CK2_1	517	523	PF00069	0.623
MOD_CK2_1	716	722	PF00069	0.513
MOD_GlcNHglycan	206	209	PF01048	0.307
MOD_GlcNHglycan	219	222	PF01048	0.264
MOD_GlcNHglycan	261	264	PF01048	0.276
MOD_GlcNHglycan	265	268	PF01048	0.302
MOD_GlcNHglycan	3	6	PF01048	0.645
MOD_GlcNHglycan	324	327	PF01048	0.305
MOD_GlcNHglycan	379	382	PF01048	0.372
MOD_GlcNHglycan	416	419	PF01048	0.662
MOD_GlcNHglycan	450	453	PF01048	0.596
MOD_GlcNHglycan	459	462	PF01048	0.724
MOD_GlcNHglycan	463	466	PF01048	0.765
MOD_GlcNHglycan	476	479	PF01048	0.669
MOD_GlcNHglycan	49	52	PF01048	0.263
MOD_GlcNHglycan	537	540	PF01048	0.529
MOD_GlcNHglycan	572	575	PF01048	0.574
MOD_GlcNHglycan	592	595	PF01048	0.808
MOD_GlcNHglycan	611	614	PF01048	0.552
MOD_GlcNHglycan	709	712	PF01048	0.587
MOD_GlcNHglycan	91	94	PF01048	0.302
MOD_GSK3_1	103	110	PF00069	0.509
MOD_GSK3_1	204	211	PF00069	0.532
MOD_GSK3_1	259	266	PF00069	0.538
MOD_GSK3_1	275	282	PF00069	0.626
MOD_GSK3_1	283	290	PF00069	0.574
MOD_GSK3_1	35	42	PF00069	0.468
MOD_GSK3_1	352	359	PF00069	0.461
MOD_GSK3_1	388	395	PF00069	0.606
MOD_GSK3_1	423	430	PF00069	0.576
MOD_GSK3_1	453	460	PF00069	0.636
MOD_GSK3_1	551	558	PF00069	0.738
MOD_GSK3_1	589	596	PF00069	0.612
MOD_GSK3_1	608	615	PF00069	0.481
MOD_GSK3_1	657	664	PF00069	0.446
MOD_GSK3_1	673	680	PF00069	0.452
MOD_GSK3_1	707	714	PF00069	0.541
MOD_N-GLC_1	327	332	PF02516	0.298
MOD_N-GLC_1	434	439	PF02516	0.517
MOD_N-GLC_1	491	496	PF02516	0.630
MOD_N-GLC_1	578	583	PF02516	0.540
MOD_N-GLC_1	609	614	PF02516	0.456
MOD_N-GLC_1	711	716	PF02516	0.482
MOD_N-GLC_2	124	126	PF02516	0.501
MOD_NEK2_1	1	6	PF00069	0.579
MOD_NEK2_1	179	184	PF00069	0.469
MOD_NEK2_1	342	347	PF00069	0.359
MOD_NEK2_1	423	428	PF00069	0.544
MOD_NEK2_1	543	548	PF00069	0.505
MOD_NEK2_1	565	570	PF00069	0.625
MOD_NEK2_1	716	721	PF00069	0.510
MOD_NEK2_1	89	94	PF00069	0.473
MOD_NEK2_2	244	249	PF00069	0.328
MOD_NEK2_2	352	357	PF00069	0.450
MOD_NEK2_2	595	600	PF00069	0.603
MOD_PIKK_1	165	171	PF00454	0.559
MOD_PIKK_1	427	433	PF00454	0.604
MOD_PIKK_1	434	440	PF00454	0.536
MOD_PIKK_1	459	465	PF00454	0.677
MOD_PIKK_1	661	667	PF00454	0.366
MOD_PIKK_1	679	685	PF00454	0.370
MOD_PK_1	544	550	PF00069	0.501
MOD_PKA_1	107	113	PF00069	0.590
MOD_PKA_1	275	281	PF00069	0.474
MOD_PKA_1	294	300	PF00069	0.683
MOD_PKA_2	106	112	PF00069	0.537
MOD_PKA_2	122	128	PF00069	0.496
MOD_PKA_2	15	21	PF00069	0.457
MOD_PKA_2	244	250	PF00069	0.483
MOD_PKA_2	275	281	PF00069	0.573
MOD_PKA_2	294	300	PF00069	0.358
MOD_PKA_2	356	362	PF00069	0.427
MOD_PKA_2	448	454	PF00069	0.533
MOD_PKB_1	677	685	PF00069	0.379
MOD_Plk_1	153	159	PF00069	0.404
MOD_Plk_1	371	377	PF00069	0.502
MOD_Plk_1	393	399	PF00069	0.523
MOD_Plk_1	491	497	PF00069	0.593
MOD_Plk_1	544	550	PF00069	0.690
MOD_Plk_1	551	557	PF00069	0.593
MOD_Plk_1	578	584	PF00069	0.542
MOD_Plk_1	711	717	PF00069	0.485
MOD_Plk_4	210	216	PF00069	0.498
MOD_Plk_4	295	301	PF00069	0.540
MOD_Plk_4	371	377	PF00069	0.502
MOD_Plk_4	508	514	PF00069	0.538
MOD_Plk_4	544	550	PF00069	0.569
MOD_Plk_4	657	663	PF00069	0.378
MOD_ProDKin_1	279	285	PF00069	0.516
MOD_ProDKin_1	287	293	PF00069	0.536
MOD_ProDKin_1	37	43	PF00069	0.542
MOD_ProDKin_1	406	412	PF00069	0.666
MOD_ProDKin_1	453	459	PF00069	0.660
MOD_ProDKin_1	517	523	PF00069	0.647
MOD_ProDKin_1	81	87	PF00069	0.508
MOD_SUMO_rev_2	330	340	PF00179	0.498
MOD_SUMO_rev_2	528	538	PF00179	0.584
MOD_SUMO_rev_2	688	697	PF00179	0.467
TRG_DiLeu_BaEn_1	624	629	PF01217	0.506
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.498
TRG_ENDOCYTIC_2	343	346	PF00928	0.348
TRG_ENDOCYTIC_2	635	638	PF00928	0.488
TRG_ENDOCYTIC_2	98	101	PF00928	0.528
TRG_ER_diArg_1	274	276	PF00400	0.355
TRG_ER_diArg_1	293	295	PF00400	0.735
TRG_ER_diArg_1	678	681	PF00400	0.388
TRG_NES_CRM1_1	693	707	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY0	Leptomonas seymouri	41%	100%
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3Q8IKN8	Leishmania donovani	77%	100%
A0A3R7NL29	Trypanosoma rangeli	35%	98%
A4HDT7	Leishmania braziliensis	24%	100%
A4I135	Leishmania infantum	24%	100%
A4I9L7	Leishmania infantum	76%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B4L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q3G1	Leishmania major	76%	100%
Q4QAA4	Leishmania major	24%	100%