Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HAF9_LEIBR

TriTrypDb:

LbrM.20.0420 , LBRM2903_200010100

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.578
CLV_C14_Caspase3-7	683	687	PF00656	0.809
CLV_C14_Caspase3-7	924	928	PF00656	0.723
CLV_NRD_NRD_1	114	116	PF00675	0.817
CLV_NRD_NRD_1	419	421	PF00675	0.762
CLV_NRD_NRD_1	697	699	PF00675	0.826
CLV_NRD_NRD_1	738	740	PF00675	0.820
CLV_NRD_NRD_1	770	772	PF00675	0.562
CLV_NRD_NRD_1	824	826	PF00675	0.728
CLV_NRD_NRD_1	939	941	PF00675	0.626
CLV_NRD_NRD_1	944	946	PF00675	0.648
CLV_PCSK_KEX2_1	114	116	PF00082	0.817
CLV_PCSK_KEX2_1	419	421	PF00082	0.762
CLV_PCSK_KEX2_1	511	513	PF00082	0.678
CLV_PCSK_KEX2_1	696	698	PF00082	0.812
CLV_PCSK_KEX2_1	725	727	PF00082	0.684
CLV_PCSK_KEX2_1	737	739	PF00082	0.769
CLV_PCSK_KEX2_1	770	772	PF00082	0.562
CLV_PCSK_KEX2_1	824	826	PF00082	0.743
CLV_PCSK_KEX2_1	939	941	PF00082	0.626
CLV_PCSK_KEX2_1	944	946	PF00082	0.648
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.738
CLV_PCSK_PC1ET2_1	725	727	PF00082	0.639
CLV_PCSK_PC7_1	940	946	PF00082	0.483
CLV_PCSK_SKI1_1	38	42	PF00082	0.692
CLV_PCSK_SKI1_1	486	490	PF00082	0.597
CLV_PCSK_SKI1_1	520	524	PF00082	0.543
CLV_PCSK_SKI1_1	849	853	PF00082	0.735
CLV_Separin_Metazoa	530	534	PF03568	0.437
DEG_APCC_DBOX_1	37	45	PF00400	0.582
DEG_APCC_KENBOX_2	140	144	PF00400	0.831
DEG_SCF_FBW7_1	25	31	PF00400	0.688
DEG_SCF_FBW7_1	321	328	PF00400	0.628
DEG_SCF_FBW7_1	336	341	PF00400	0.748
DEG_SPOP_SBC_1	434	438	PF00917	0.601
DEG_SPOP_SBC_1	793	797	PF00917	0.564
DOC_CKS1_1	25	30	PF01111	0.687
DOC_CKS1_1	322	327	PF01111	0.564
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.585
DOC_MAPK_gen_1	275	283	PF00069	0.556
DOC_MAPK_gen_1	696	703	PF00069	0.579
DOC_MAPK_MEF2A_6	275	283	PF00069	0.556
DOC_PP2B_LxvP_1	57	60	PF13499	0.559
DOC_PP2B_LxvP_1	775	778	PF13499	0.567
DOC_PP4_FxxP_1	22	25	PF00568	0.797
DOC_PP4_FxxP_1	350	353	PF00568	0.821
DOC_PP4_FxxP_1	646	649	PF00568	0.554
DOC_PP4_MxPP_1	351	354	PF00568	0.776
DOC_USP7_MATH_1	125	129	PF00917	0.586
DOC_USP7_MATH_1	2	6	PF00917	0.737
DOC_USP7_MATH_1	200	204	PF00917	0.688
DOC_USP7_MATH_1	210	214	PF00917	0.820
DOC_USP7_MATH_1	228	232	PF00917	0.650
DOC_USP7_MATH_1	250	254	PF00917	0.622
DOC_USP7_MATH_1	256	260	PF00917	0.733
DOC_USP7_MATH_1	299	303	PF00917	0.724
DOC_USP7_MATH_1	325	329	PF00917	0.654
DOC_USP7_MATH_1	338	342	PF00917	0.734
DOC_USP7_MATH_1	346	350	PF00917	0.680
DOC_USP7_MATH_1	430	434	PF00917	0.706
DOC_USP7_MATH_1	435	439	PF00917	0.713
DOC_USP7_MATH_1	467	471	PF00917	0.525
DOC_USP7_MATH_1	500	504	PF00917	0.713
DOC_USP7_MATH_1	516	520	PF00917	0.712
DOC_USP7_MATH_1	60	64	PF00917	0.651
DOC_USP7_MATH_1	804	808	PF00917	0.686
DOC_USP7_MATH_1	892	896	PF00917	0.620
DOC_USP7_MATH_2	447	453	PF00917	0.584
DOC_USP7_UBL2_3	523	527	PF12436	0.642
DOC_USP7_UBL2_3	664	668	PF12436	0.692
DOC_WW_Pin1_4	196	201	PF00397	0.619
DOC_WW_Pin1_4	21	26	PF00397	0.619
DOC_WW_Pin1_4	28	33	PF00397	0.679
DOC_WW_Pin1_4	295	300	PF00397	0.830
DOC_WW_Pin1_4	321	326	PF00397	0.725
DOC_WW_Pin1_4	334	339	PF00397	0.804
DOC_WW_Pin1_4	428	433	PF00397	0.638
DOC_WW_Pin1_4	596	601	PF00397	0.617
DOC_WW_Pin1_4	624	629	PF00397	0.650
DOC_WW_Pin1_4	708	713	PF00397	0.735
DOC_WW_Pin1_4	787	792	PF00397	0.722
DOC_WW_Pin1_4	823	828	PF00397	0.825
LIG_14-3-3_CanoR_1	252	260	PF00244	0.573
LIG_14-3-3_CanoR_1	286	292	PF00244	0.679
LIG_14-3-3_CanoR_1	347	351	PF00244	0.710
LIG_14-3-3_CanoR_1	419	424	PF00244	0.730
LIG_14-3-3_CanoR_1	46	53	PF00244	0.566
LIG_14-3-3_CanoR_1	512	516	PF00244	0.529
LIG_14-3-3_CanoR_1	533	538	PF00244	0.439
LIG_14-3-3_CanoR_1	575	581	PF00244	0.752
LIG_14-3-3_CanoR_1	666	674	PF00244	0.709
LIG_14-3-3_CanoR_1	696	702	PF00244	0.649
LIG_14-3-3_CanoR_1	730	735	PF00244	0.830
LIG_14-3-3_CanoR_1	770	778	PF00244	0.708
LIG_14-3-3_CanoR_1	856	865	PF00244	0.775
LIG_14-3-3_CanoR_1	902	908	PF00244	0.539
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BIR_III_4	686	690	PF00653	0.595
LIG_BRCT_BRCA1_1	233	237	PF00533	0.692
LIG_BRCT_BRCA1_1	503	507	PF00533	0.709
LIG_BRCT_BRCA1_1	63	67	PF00533	0.559
LIG_BRCT_BRCA1_1	639	643	PF00533	0.719
LIG_CaM_IQ_9	932	947	PF13499	0.641
LIG_CtBP_PxDLS_1	353	357	PF00389	0.578
LIG_CtBP_PxDLS_1	466	470	PF00389	0.515
LIG_deltaCOP1_diTrp_1	635	643	PF00928	0.717
LIG_FHA_1	10	16	PF00498	0.520
LIG_FHA_1	160	166	PF00498	0.624
LIG_FHA_1	21	27	PF00498	0.503
LIG_FHA_1	287	293	PF00498	0.597
LIG_FHA_1	328	334	PF00498	0.617
LIG_FHA_1	391	397	PF00498	0.819
LIG_FHA_1	592	598	PF00498	0.801
LIG_FHA_1	688	694	PF00498	0.594
LIG_FHA_1	781	787	PF00498	0.650
LIG_FHA_1	860	866	PF00498	0.535
LIG_FHA_2	329	335	PF00498	0.576
LIG_FHA_2	71	77	PF00498	0.610
LIG_FHA_2	818	824	PF00498	0.588
LIG_Integrin_isoDGR_2	401	403	PF01839	0.817
LIG_LIR_Apic_2	19	25	PF02991	0.793
LIG_LIR_Apic_2	348	353	PF02991	0.809
LIG_LIR_Apic_2	645	649	PF02991	0.556
LIG_LIR_Gen_1	640	650	PF02991	0.560
LIG_LIR_Nem_3	190	195	PF02991	0.556
LIG_LIR_Nem_3	504	510	PF02991	0.713
LIG_LIR_Nem_3	640	646	PF02991	0.566
LIG_NRP_CendR_1	944	947	PF00754	0.656
LIG_PCNA_yPIPBox_3	86	100	PF02747	0.555
LIG_RPA_C_Fungi	661	673	PF08784	0.550
LIG_SH2_CRK	481	485	PF00017	0.496
LIG_SH2_STAT3	781	784	PF00017	0.558
LIG_SH2_STAT5	193	196	PF00017	0.569
LIG_SH3_3	162	168	PF00018	0.731
LIG_SH3_3	22	28	PF00018	0.735
LIG_SH3_3	441	447	PF00018	0.570
LIG_SH3_3	489	495	PF00018	0.679
LIG_SH3_3	594	600	PF00018	0.545
LIG_SH3_3	729	735	PF00018	0.797
LIG_SH3_3	782	788	PF00018	0.643
LIG_SH3_3	82	88	PF00018	0.809
LIG_SUMO_SIM_anti_2	314	319	PF11976	0.605
LIG_SUMO_SIM_anti_2	817	823	PF11976	0.587
LIG_TRAF2_2	494	499	PF00917	0.665
LIG_WRC_WIRS_1	473	478	PF05994	0.691
LIG_WRC_WIRS_1	935	940	PF05994	0.636
MOD_CDK_SPK_2	24	29	PF00069	0.753
MOD_CDK_SPK_2	624	629	PF00069	0.601
MOD_CK1_1	149	155	PF00069	0.747
MOD_CK1_1	174	180	PF00069	0.702
MOD_CK1_1	182	188	PF00069	0.597
MOD_CK1_1	198	204	PF00069	0.674
MOD_CK1_1	213	219	PF00069	0.699
MOD_CK1_1	224	230	PF00069	0.678
MOD_CK1_1	231	237	PF00069	0.664
MOD_CK1_1	24	30	PF00069	0.537
MOD_CK1_1	259	265	PF00069	0.779
MOD_CK1_1	298	304	PF00069	0.757
MOD_CK1_1	311	317	PF00069	0.668
MOD_CK1_1	328	334	PF00069	0.792
MOD_CK1_1	34	40	PF00069	0.681
MOD_CK1_1	341	347	PF00069	0.628
MOD_CK1_1	428	434	PF00069	0.723
MOD_CK1_1	445	451	PF00069	0.535
MOD_CK1_1	49	55	PF00069	0.717
MOD_CK1_1	5	11	PF00069	0.774
MOD_CK1_1	591	597	PF00069	0.738
MOD_CK1_1	615	621	PF00069	0.581
MOD_CK1_1	627	633	PF00069	0.514
MOD_CK1_1	63	69	PF00069	0.682
MOD_CK1_1	688	694	PF00069	0.800
MOD_CK1_1	70	76	PF00069	0.701
MOD_CK1_1	704	710	PF00069	0.749
MOD_CK1_1	719	725	PF00069	0.728
MOD_CK1_1	756	762	PF00069	0.779
MOD_CK1_1	817	823	PF00069	0.734
MOD_CK1_1	826	832	PF00069	0.690
MOD_CK1_1	859	865	PF00069	0.763
MOD_CK1_1	934	940	PF00069	0.635
MOD_CK1_1	95	101	PF00069	0.728
MOD_CK2_1	596	602	PF00069	0.690
MOD_CK2_1	627	633	PF00069	0.592
MOD_CK2_1	677	683	PF00069	0.736
MOD_CK2_1	688	694	PF00069	0.693
MOD_CK2_1	70	76	PF00069	0.758
MOD_CK2_1	754	760	PF00069	0.718
MOD_CK2_1	817	823	PF00069	0.760
MOD_GlcNHglycan	136	139	PF01048	0.743
MOD_GlcNHglycan	162	165	PF01048	0.774
MOD_GlcNHglycan	181	184	PF01048	0.725
MOD_GlcNHglycan	202	205	PF01048	0.672
MOD_GlcNHglycan	215	218	PF01048	0.681
MOD_GlcNHglycan	223	226	PF01048	0.698
MOD_GlcNHglycan	231	234	PF01048	0.683
MOD_GlcNHglycan	240	243	PF01048	0.678
MOD_GlcNHglycan	262	265	PF01048	0.634
MOD_GlcNHglycan	267	270	PF01048	0.634
MOD_GlcNHglycan	310	313	PF01048	0.756
MOD_GlcNHglycan	327	330	PF01048	0.745
MOD_GlcNHglycan	344	347	PF01048	0.635
MOD_GlcNHglycan	359	362	PF01048	0.797
MOD_GlcNHglycan	425	428	PF01048	0.731
MOD_GlcNHglycan	452	455	PF01048	0.720
MOD_GlcNHglycan	461	464	PF01048	0.670
MOD_GlcNHglycan	503	506	PF01048	0.604
MOD_GlcNHglycan	582	585	PF01048	0.782
MOD_GlcNHglycan	686	690	PF01048	0.595
MOD_GlcNHglycan	706	709	PF01048	0.787
MOD_GlcNHglycan	756	759	PF01048	0.676
MOD_GlcNHglycan	772	775	PF01048	0.803
MOD_GlcNHglycan	796	799	PF01048	0.661
MOD_GlcNHglycan	816	819	PF01048	0.520
MOD_GlcNHglycan	82	85	PF01048	0.717
MOD_GlcNHglycan	894	897	PF01048	0.596
MOD_GSK3_1	121	128	PF00069	0.652
MOD_GSK3_1	146	153	PF00069	0.734
MOD_GSK3_1	154	161	PF00069	0.719
MOD_GSK3_1	16	23	PF00069	0.637
MOD_GSK3_1	171	178	PF00069	0.720
MOD_GSK3_1	196	203	PF00069	0.773
MOD_GSK3_1	2	9	PF00069	0.759
MOD_GSK3_1	224	231	PF00069	0.770
MOD_GSK3_1	238	245	PF00069	0.681
MOD_GSK3_1	24	31	PF00069	0.579
MOD_GSK3_1	252	259	PF00069	0.600
MOD_GSK3_1	286	293	PF00069	0.639
MOD_GSK3_1	295	302	PF00069	0.776
MOD_GSK3_1	321	328	PF00069	0.814
MOD_GSK3_1	334	341	PF00069	0.640
MOD_GSK3_1	342	349	PF00069	0.750
MOD_GSK3_1	352	359	PF00069	0.560
MOD_GSK3_1	362	369	PF00069	0.507
MOD_GSK3_1	419	426	PF00069	0.754
MOD_GSK3_1	430	437	PF00069	0.774
MOD_GSK3_1	445	452	PF00069	0.555
MOD_GSK3_1	49	56	PF00069	0.753
MOD_GSK3_1	576	583	PF00069	0.701
MOD_GSK3_1	588	595	PF00069	0.619
MOD_GSK3_1	607	614	PF00069	0.790
MOD_GSK3_1	63	70	PF00069	0.676
MOD_GSK3_1	685	692	PF00069	0.769
MOD_GSK3_1	697	704	PF00069	0.741
MOD_GSK3_1	776	783	PF00069	0.697
MOD_GSK3_1	787	794	PF00069	0.675
MOD_GSK3_1	804	811	PF00069	0.737
MOD_GSK3_1	902	909	PF00069	0.806
MOD_GSK3_1	910	917	PF00069	0.651
MOD_GSK3_1	934	941	PF00069	0.515
MOD_GSK3_1	95	102	PF00069	0.691
MOD_LATS_1	509	515	PF00433	0.665
MOD_N-GLC_1	149	154	PF02516	0.588
MOD_N-GLC_1	229	234	PF02516	0.725
MOD_N-GLC_1	341	346	PF02516	0.802
MOD_N-GLC_1	428	433	PF02516	0.826
MOD_N-GLC_1	67	72	PF02516	0.658
MOD_NEK2_1	223	228	PF00069	0.772
MOD_NEK2_1	260	265	PF00069	0.661
MOD_NEK2_1	356	361	PF00069	0.799
MOD_NEK2_1	405	410	PF00069	0.794
MOD_NEK2_1	423	428	PF00069	0.696
MOD_NEK2_1	53	58	PF00069	0.615
MOD_NEK2_1	559	564	PF00069	0.600
MOD_NEK2_1	580	585	PF00069	0.666
MOD_NEK2_1	67	72	PF00069	0.602
MOD_NEK2_1	780	785	PF00069	0.608
MOD_NEK2_1	792	797	PF00069	0.771
MOD_NEK2_1	938	943	PF00069	0.503
MOD_NEK2_2	522	527	PF00069	0.473
MOD_PIKK_1	362	368	PF00454	0.591
MOD_PIKK_1	730	736	PF00454	0.731
MOD_PIKK_1	780	786	PF00454	0.678
MOD_PIKK_1	856	862	PF00454	0.769
MOD_PK_1	697	703	PF00069	0.579
MOD_PKA_1	419	425	PF00069	0.730
MOD_PKA_1	511	517	PF00069	0.653
MOD_PKA_1	696	702	PF00069	0.578
MOD_PKA_1	770	776	PF00069	0.563
MOD_PKA_2	245	251	PF00069	0.706
MOD_PKA_2	285	291	PF00069	0.590
MOD_PKA_2	346	352	PF00069	0.710
MOD_PKA_2	357	363	PF00069	0.705
MOD_PKA_2	418	424	PF00069	0.740
MOD_PKA_2	511	517	PF00069	0.653
MOD_PKA_2	576	582	PF00069	0.657
MOD_PKA_2	696	702	PF00069	0.825
MOD_PKA_2	754	760	PF00069	0.586
MOD_PKA_2	769	775	PF00069	0.717
MOD_PKA_2	938	944	PF00069	0.508
MOD_PKB_1	46	54	PF00069	0.609
MOD_Plk_1	592	598	PF00069	0.592
MOD_Plk_1	67	73	PF00069	0.658
MOD_Plk_1	759	765	PF00069	0.568
MOD_Plk_4	313	319	PF00069	0.606
MOD_Plk_4	346	352	PF00069	0.723
MOD_Plk_4	472	478	PF00069	0.653
MOD_Plk_4	559	565	PF00069	0.744
MOD_Plk_4	592	598	PF00069	0.798
MOD_Plk_4	6	12	PF00069	0.576
MOD_Plk_4	776	782	PF00069	0.562
MOD_Plk_4	817	823	PF00069	0.628
MOD_Plk_4	861	867	PF00069	0.689
MOD_Plk_4	903	909	PF00069	0.557
MOD_Plk_4	914	920	PF00069	0.486
MOD_Plk_4	95	101	PF00069	0.545
MOD_ProDKin_1	196	202	PF00069	0.615
MOD_ProDKin_1	21	27	PF00069	0.616
MOD_ProDKin_1	28	34	PF00069	0.682
MOD_ProDKin_1	295	301	PF00069	0.831
MOD_ProDKin_1	321	327	PF00069	0.728
MOD_ProDKin_1	334	340	PF00069	0.803
MOD_ProDKin_1	428	434	PF00069	0.641
MOD_ProDKin_1	596	602	PF00069	0.616
MOD_ProDKin_1	624	630	PF00069	0.647
MOD_ProDKin_1	708	714	PF00069	0.735
MOD_ProDKin_1	787	793	PF00069	0.723
MOD_ProDKin_1	823	829	PF00069	0.821
MOD_SUMO_for_1	667	670	PF00179	0.690
MOD_SUMO_rev_2	553	562	PF00179	0.501
TRG_DiLeu_BaEn_1	881	886	PF01217	0.559
TRG_DiLeu_BaEn_2	471	477	PF01217	0.603
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.693
TRG_ENDOCYTIC_2	481	484	PF00928	0.526
TRG_ER_diArg_1	45	48	PF00400	0.621
TRG_ER_diArg_1	532	535	PF00400	0.588
TRG_ER_diArg_1	572	575	PF00400	0.630
TRG_ER_diArg_1	696	698	PF00400	0.825
TRG_ER_diArg_1	737	739	PF00400	0.824
TRG_ER_diArg_1	938	940	PF00400	0.630
TRG_ER_diArg_1	943	945	PF00400	0.642
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC30	Leptomonas seymouri	34%	95%
A0A3Q8IGY8	Leishmania donovani	58%	100%
A4I9L5	Leishmania infantum	59%	100%
E9B4L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4Q3G3	Leishmania major	57%	97%