Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAF7_LEIBR

TriTrypDb:

LbrM.20.0400 , LBRM2903_200009900

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.721
CLV_NRD_NRD_1	200	202	PF00675	0.447
CLV_NRD_NRD_1	61	63	PF00675	0.377
CLV_PCSK_KEX2_1	181	183	PF00082	0.458
CLV_PCSK_KEX2_1	208	210	PF00082	0.518
CLV_PCSK_KEX2_1	61	63	PF00082	0.411
CLV_PCSK_KEX2_1	75	77	PF00082	0.713
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.456
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.518
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.714
CLV_PCSK_PC7_1	204	210	PF00082	0.488
DEG_APCC_DBOX_1	187	195	PF00400	0.388
DEG_APCC_DBOX_1	3	11	PF00400	0.464
DEG_Nend_UBRbox_3	1	3	PF02207	0.579
DOC_CDC14_PxL_1	13	21	PF14671	0.454
DOC_CKS1_1	122	127	PF01111	0.358
DOC_CYCLIN_RxL_1	3	11	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.501
DOC_MAPK_gen_1	113	123	PF00069	0.345
DOC_MAPK_gen_1	4	12	PF00069	0.457
DOC_MAPK_JIP1_4	44	50	PF00069	0.415
DOC_MAPK_MEF2A_6	4	12	PF00069	0.457
DOC_PP1_SILK_1	40	45	PF00149	0.408
DOC_PP4_FxxP_1	22	25	PF00568	0.518
DOC_USP7_MATH_1	30	34	PF00917	0.541
DOC_WW_Pin1_4	121	126	PF00397	0.482
DOC_WW_Pin1_4	139	144	PF00397	0.602
DOC_WW_Pin1_4	174	179	PF00397	0.619
LIG_14-3-3_CanoR_1	209	213	PF00244	0.674
LIG_14-3-3_CanoR_1	49	55	PF00244	0.402
LIG_Actin_WH2_2	36	51	PF00022	0.397
LIG_Clathr_ClatBox_1	7	11	PF01394	0.452
LIG_FHA_1	63	69	PF00498	0.477
LIG_FHA_2	217	223	PF00498	0.495
LIG_FHA_2	250	256	PF00498	0.525
LIG_FHA_2	261	267	PF00498	0.519
LIG_FHA_2	84	90	PF00498	0.723
LIG_FHA_2	93	99	PF00498	0.535
LIG_LIR_Apic_2	11	17	PF02991	0.440
LIG_LIR_Gen_1	11	19	PF02991	0.441
LIG_LIR_Nem_3	11	15	PF02991	0.440
LIG_MAD2	120	128	PF02301	0.359
LIG_SH2_CRK	203	207	PF00017	0.461
LIG_SH2_GRB2like	168	171	PF00017	0.414
LIG_SH2_SRC	168	171	PF00017	0.414
LIG_SH2_STAP1	168	172	PF00017	0.411
LIG_SH2_STAT3	23	26	PF00017	0.630
LIG_SH2_STAT5	14	17	PF00017	0.444
LIG_SH2_STAT5	47	50	PF00017	0.554
LIG_SH2_STAT5	9	12	PF00017	0.443
LIG_SH3_3	122	128	PF00018	0.543
LIG_SH3_3	172	178	PF00018	0.508
LIG_Sin3_3	56	63	PF02671	0.351
LIG_SUMO_SIM_anti_2	38	44	PF11976	0.448
LIG_SUMO_SIM_par_1	95	101	PF11976	0.658
LIG_TRAF2_1	262	265	PF00917	0.550
LIG_UBA3_1	15	20	PF00899	0.536
LIG_UBA3_1	236	242	PF00899	0.421
MOD_CDK_SPxxK_3	174	181	PF00069	0.531
MOD_CK1_1	107	113	PF00069	0.362
MOD_CK1_1	211	217	PF00069	0.525
MOD_CK1_1	249	255	PF00069	0.530
MOD_CK1_1	38	44	PF00069	0.461
MOD_CK1_1	83	89	PF00069	0.536
MOD_CK2_1	214	220	PF00069	0.514
MOD_CK2_1	249	255	PF00069	0.663
MOD_GlcNHglycan	37	40	PF01048	0.648
MOD_GSK3_1	245	252	PF00069	0.544
MOD_GSK3_1	31	38	PF00069	0.555
MOD_GSK3_1	63	70	PF00069	0.543
MOD_GSK3_1	74	81	PF00069	0.554
MOD_N-GLC_1	133	138	PF02516	0.545
MOD_N-GLC_1	249	254	PF02516	0.516
MOD_N-GLC_1	31	36	PF02516	0.494
MOD_NEK2_1	237	242	PF00069	0.545
MOD_NEK2_1	82	87	PF00069	0.535
MOD_PIKK_1	211	217	PF00454	0.512
MOD_PIKK_1	260	266	PF00454	0.550
MOD_PKA_1	208	214	PF00069	0.604
MOD_PKA_1	75	81	PF00069	0.545
MOD_PKA_2	115	121	PF00069	0.385
MOD_PKA_2	208	214	PF00069	0.653
MOD_PKA_2	48	54	PF00069	0.328
MOD_PKA_2	75	81	PF00069	0.565
MOD_Plk_1	133	139	PF00069	0.600
MOD_Plk_1	31	37	PF00069	0.492
MOD_Plk_4	107	113	PF00069	0.352
MOD_Plk_4	38	44	PF00069	0.448
MOD_Plk_4	92	98	PF00069	0.501
MOD_ProDKin_1	121	127	PF00069	0.467
MOD_ProDKin_1	139	145	PF00069	0.601
MOD_ProDKin_1	174	180	PF00069	0.615
MOD_SUMO_rev_2	83	93	PF00179	0.522
TRG_DiLeu_BaEn_1	11	16	PF01217	0.435
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.468
TRG_ENDOCYTIC_2	203	206	PF00928	0.456
TRG_ENDOCYTIC_2	47	50	PF00928	0.486
TRG_ENDOCYTIC_2	9	12	PF00928	0.443
TRG_ER_diArg_1	159	162	PF00400	0.534
TRG_ER_diArg_1	186	189	PF00400	0.460
TRG_ER_diArg_1	3	6	PF00400	0.475
TRG_ER_diArg_1	60	62	PF00400	0.360
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH0	Leptomonas seymouri	52%	100%
A0A3S7X7E6	Leishmania donovani	74%	100%
E9B4L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q3G5	Leishmania major	76%	100%