Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAF6_LEIBR

TriTrypDb:

LbrM.20.0390 , LBRM2903_200009800

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.619
CLV_MEL_PAP_1	185	191	PF00089	0.572
CLV_NRD_NRD_1	279	281	PF00675	0.546
CLV_NRD_NRD_1	397	399	PF00675	0.536
CLV_NRD_NRD_1	68	70	PF00675	0.683
CLV_PCSK_FUR_1	276	280	PF00082	0.519
CLV_PCSK_KEX2_1	278	280	PF00082	0.499
CLV_PCSK_KEX2_1	397	399	PF00082	0.536
CLV_PCSK_KEX2_1	68	70	PF00082	0.683
CLV_PCSK_PC7_1	64	70	PF00082	0.491
CLV_PCSK_SKI1_1	171	175	PF00082	0.657
CLV_PCSK_SKI1_1	215	219	PF00082	0.631
CLV_Separin_Metazoa	357	361	PF03568	0.528
DEG_APCC_DBOX_1	187	195	PF00400	0.599
DEG_SPOP_SBC_1	136	140	PF00917	0.455
DEG_SPOP_SBC_1	77	81	PF00917	0.529
DOC_MAPK_gen_1	115	123	PF00069	0.409
DOC_MAPK_gen_1	237	245	PF00069	0.578
DOC_MAPK_MEF2A_6	115	123	PF00069	0.409
DOC_MAPK_MEF2A_6	183	191	PF00069	0.579
DOC_MAPK_MEF2A_6	237	245	PF00069	0.553
DOC_PP1_RVXF_1	358	364	PF00149	0.533
DOC_PP2B_LxvP_1	247	250	PF13499	0.587
DOC_USP7_MATH_1	136	140	PF00917	0.695
DOC_USP7_MATH_1	187	191	PF00917	0.486
DOC_USP7_MATH_1	2	6	PF00917	0.660
DOC_USP7_MATH_1	201	205	PF00917	0.577
DOC_USP7_MATH_1	232	236	PF00917	0.494
DOC_USP7_MATH_1	55	59	PF00917	0.603
DOC_WW_Pin1_4	137	142	PF00397	0.477
DOC_WW_Pin1_4	161	166	PF00397	0.691
DOC_WW_Pin1_4	346	351	PF00397	0.426
DOC_WW_Pin1_4	87	92	PF00397	0.776
DOC_WW_Pin1_4	9	14	PF00397	0.621
DOC_WW_Pin1_4	98	103	PF00397	0.741
LIG_14-3-3_CanoR_1	110	115	PF00244	0.571
LIG_14-3-3_CanoR_1	188	192	PF00244	0.560
LIG_14-3-3_CanoR_1	262	267	PF00244	0.701
LIG_14-3-3_CanoR_1	402	407	PF00244	0.479
LIG_14-3-3_CanoR_1	85	90	PF00244	0.569
LIG_Actin_WH2_2	178	194	PF00022	0.584
LIG_APCC_ABBA_1	297	302	PF00400	0.363
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	264	268	PF00533	0.490
LIG_Clathr_ClatBox_1	148	152	PF01394	0.625
LIG_FHA_1	109	115	PF00498	0.738
LIG_FHA_1	141	147	PF00498	0.528
LIG_FHA_1	317	323	PF00498	0.619
LIG_FHA_1	37	43	PF00498	0.643
LIG_FHA_1	84	90	PF00498	0.731
LIG_FHA_2	174	180	PF00498	0.371
LIG_FHA_2	305	311	PF00498	0.468
LIG_HP1_1	187	191	PF01393	0.583
LIG_LIR_Gen_1	172	181	PF02991	0.606
LIG_LIR_Gen_1	36	45	PF02991	0.398
LIG_LIR_Nem_3	12	17	PF02991	0.592
LIG_LIR_Nem_3	172	177	PF02991	0.627
LIG_LIR_Nem_3	36	41	PF02991	0.394
LIG_LIR_Nem_3	5	9	PF02991	0.558
LIG_RPA_C_Fungi	232	244	PF08784	0.376
LIG_SH2_CRK	38	42	PF00017	0.392
LIG_SH2_PTP2	14	17	PF00017	0.707
LIG_SH2_STAP1	38	42	PF00017	0.362
LIG_SH2_STAT3	222	225	PF00017	0.571
LIG_SH2_STAT5	14	17	PF00017	0.723
LIG_SH2_STAT5	222	225	PF00017	0.473
LIG_SH2_STAT5	38	41	PF00017	0.513
LIG_SH3_3	10	16	PF00018	0.716
LIG_SH3_3	159	165	PF00018	0.770
LIG_SH3_3	253	259	PF00018	0.381
LIG_SH3_3	403	409	PF00018	0.453
LIG_SH3_3	86	92	PF00018	0.758
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.551
LIG_SUMO_SIM_par_1	147	152	PF11976	0.616
LIG_SUMO_SIM_par_1	240	246	PF11976	0.491
LIG_SUMO_SIM_par_1	254	260	PF11976	0.465
MOD_CDK_SPxxK_3	137	144	PF00069	0.453
MOD_CDK_SPxxK_3	87	94	PF00069	0.681
MOD_CK1_1	108	114	PF00069	0.654
MOD_CK1_1	137	143	PF00069	0.481
MOD_CK1_1	154	160	PF00069	0.618
MOD_CK1_1	227	233	PF00069	0.448
MOD_CK1_1	260	266	PF00069	0.720
MOD_CK1_1	30	36	PF00069	0.399
MOD_CK1_1	346	352	PF00069	0.634
MOD_CK1_1	381	387	PF00069	0.782
MOD_CK1_1	87	93	PF00069	0.573
MOD_CK2_1	2	8	PF00069	0.745
MOD_GlcNHglycan	158	161	PF01048	0.518
MOD_GlcNHglycan	229	232	PF01048	0.485
MOD_GlcNHglycan	234	237	PF01048	0.451
MOD_GlcNHglycan	380	383	PF01048	0.618
MOD_GSK3_1	136	143	PF00069	0.670
MOD_GSK3_1	161	168	PF00069	0.677
MOD_GSK3_1	257	264	PF00069	0.625
MOD_GSK3_1	30	37	PF00069	0.368
MOD_GSK3_1	316	323	PF00069	0.649
MOD_GSK3_1	334	341	PF00069	0.482
MOD_GSK3_1	372	379	PF00069	0.745
MOD_GSK3_1	83	90	PF00069	0.566
MOD_GSK3_1	98	105	PF00069	0.757
MOD_NEK2_1	109	114	PF00069	0.683
MOD_NEK2_1	151	156	PF00069	0.567
MOD_NEK2_1	173	178	PF00069	0.626
MOD_NEK2_1	218	223	PF00069	0.410
MOD_NEK2_1	245	250	PF00069	0.588
MOD_NEK2_1	254	259	PF00069	0.504
MOD_NEK2_1	261	266	PF00069	0.491
MOD_NEK2_2	187	192	PF00069	0.597
MOD_NEK2_2	2	7	PF00069	0.495
MOD_OFUCOSY	35	40	PF10250	0.605
MOD_PK_1	237	243	PF00069	0.489
MOD_PK_1	402	408	PF00069	0.440
MOD_PK_1	85	91	PF00069	0.569
MOD_PKA_1	68	74	PF00069	0.512
MOD_PKA_2	109	115	PF00069	0.554
MOD_PKA_2	187	193	PF00069	0.558
MOD_PKA_2	261	267	PF00069	0.681
MOD_PKA_2	68	74	PF00069	0.713
MOD_PKA_2	84	90	PF00069	0.508
MOD_Plk_1	105	111	PF00069	0.572
MOD_Plk_1	245	251	PF00069	0.521
MOD_Plk_2-3	310	316	PF00069	0.621
MOD_Plk_4	151	157	PF00069	0.683
MOD_Plk_4	2	8	PF00069	0.495
MOD_Plk_4	262	268	PF00069	0.617
MOD_Plk_4	402	408	PF00069	0.440
MOD_ProDKin_1	137	143	PF00069	0.464
MOD_ProDKin_1	161	167	PF00069	0.686
MOD_ProDKin_1	346	352	PF00069	0.427
MOD_ProDKin_1	87	93	PF00069	0.777
MOD_ProDKin_1	9	15	PF00069	0.618
MOD_ProDKin_1	98	104	PF00069	0.739
MOD_SUMO_rev_2	265	274	PF00179	0.703
TRG_DiLeu_BaEn_1	357	362	PF01217	0.525
TRG_DiLeu_BaEn_4	62	68	PF01217	0.548
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.492
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.591
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.397
TRG_DiLeu_LyEn_5	357	362	PF01217	0.525
TRG_ENDOCYTIC_2	14	17	PF00928	0.481
TRG_ENDOCYTIC_2	38	41	PF00928	0.383
TRG_ER_diArg_1	114	117	PF00400	0.502
TRG_ER_diArg_1	277	280	PF00400	0.551
TRG_ER_diArg_1	397	399	PF00400	0.536
TRG_ER_diArg_1	67	69	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW8	Leptomonas seymouri	36%	70%
A0A3S7X7D6	Leishmania donovani	70%	98%
A4I9L2	Leishmania infantum	70%	98%
E9B4L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	98%
Q4Q3G6	Leishmania major	71%	100%