Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAF5_LEIBR

TriTrypDb:

LbrM.20.0380 , LBRM2903_200009700

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.323
CLV_NRD_NRD_1	113	115	PF00675	0.306
CLV_NRD_NRD_1	12	14	PF00675	0.528
CLV_NRD_NRD_1	259	261	PF00675	0.391
CLV_NRD_NRD_1	393	395	PF00675	0.511
CLV_NRD_NRD_1	84	86	PF00675	0.426
CLV_NRD_NRD_1	92	94	PF00675	0.456
CLV_PCSK_KEX2_1	193	195	PF00082	0.340
CLV_PCSK_KEX2_1	259	261	PF00082	0.391
CLV_PCSK_KEX2_1	92	94	PF00082	0.462
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.340
CLV_PCSK_SKI1_1	103	107	PF00082	0.450
CLV_PCSK_SKI1_1	244	248	PF00082	0.325
CLV_PCSK_SKI1_1	259	263	PF00082	0.398
CLV_PCSK_SKI1_1	63	67	PF00082	0.452
DEG_APCC_DBOX_1	334	342	PF00400	0.375
DEG_APCC_DBOX_1	71	79	PF00400	0.265
DEG_Nend_Nbox_1	1	3	PF02207	0.486
DOC_CDC14_PxL_1	245	253	PF14671	0.406
DOC_CKS1_1	223	228	PF01111	0.248
DOC_MAPK_MEF2A_6	72	80	PF00069	0.390
DOC_PP2B_LxvP_1	317	320	PF13499	0.435
DOC_USP7_MATH_1	116	120	PF00917	0.417
DOC_USP7_MATH_1	162	166	PF00917	0.402
DOC_USP7_MATH_1	185	189	PF00917	0.432
DOC_USP7_MATH_1	213	217	PF00917	0.408
DOC_USP7_MATH_1	305	309	PF00917	0.471
DOC_USP7_MATH_1	320	324	PF00917	0.407
DOC_USP7_MATH_2	199	205	PF00917	0.292
DOC_WW_Pin1_4	222	227	PF00397	0.368
DOC_WW_Pin1_4	399	404	PF00397	0.553
LIG_14-3-3_CanoR_1	222	226	PF00244	0.275
LIG_14-3-3_CanoR_1	259	268	PF00244	0.315
LIG_14-3-3_CanoR_1	63	68	PF00244	0.544
LIG_14-3-3_CanoR_1	72	76	PF00244	0.442
LIG_14-3-3_CanoR_1	92	100	PF00244	0.484
LIG_Actin_WH2_2	327	344	PF00022	0.470
LIG_Actin_WH2_2	98	116	PF00022	0.307
LIG_eIF4E_1	240	246	PF01652	0.375
LIG_FHA_1	149	155	PF00498	0.417
LIG_FHA_1	245	251	PF00498	0.394
LIG_FHA_1	256	262	PF00498	0.478
LIG_FHA_2	271	277	PF00498	0.497
LIG_FHA_2	351	357	PF00498	0.380
LIG_LIR_Apic_2	139	144	PF02991	0.453
LIG_LIR_Gen_1	176	185	PF02991	0.372
LIG_LIR_Nem_3	176	180	PF02991	0.373
LIG_LIR_Nem_3	49	55	PF02991	0.343
LIG_MYND_1	57	61	PF01753	0.443
LIG_PCNA_yPIPBox_3	294	307	PF02747	0.500
LIG_Pex14_2	180	184	PF04695	0.345
LIG_Rb_LxCxE_1	119	133	PF01857	0.433
LIG_REV1ctd_RIR_1	181	191	PF16727	0.357
LIG_SH2_CRK	141	145	PF00017	0.339
LIG_SH2_NCK_1	124	128	PF00017	0.413
LIG_SH2_NCK_1	141	145	PF00017	0.299
LIG_SH2_NCK_1	67	71	PF00017	0.427
LIG_SH2_PTP2	99	102	PF00017	0.319
LIG_SH2_SRC	124	127	PF00017	0.416
LIG_SH2_SRC	99	102	PF00017	0.319
LIG_SH2_STAP1	370	374	PF00017	0.499
LIG_SH2_STAT5	112	115	PF00017	0.279
LIG_SH2_STAT5	177	180	PF00017	0.357
LIG_SH2_STAT5	39	42	PF00017	0.473
LIG_SH2_STAT5	44	47	PF00017	0.446
LIG_SH2_STAT5	99	102	PF00017	0.421
LIG_SH3_3	128	134	PF00018	0.357
LIG_SH3_3	243	249	PF00018	0.333
LIG_SUMO_SIM_par_1	247	253	PF11976	0.433
LIG_SUMO_SIM_par_1	270	278	PF11976	0.554
LIG_TRAF2_1	108	111	PF00917	0.367
LIG_TRAF2_1	144	147	PF00917	0.520
LIG_TRAF2_1	17	20	PF00917	0.388
LIG_TRAF2_1	275	278	PF00917	0.413
MOD_CK1_1	216	222	PF00069	0.281
MOD_CK1_1	270	276	PF00069	0.536
MOD_CK1_1	402	408	PF00069	0.746
MOD_CK2_1	201	207	PF00069	0.501
MOD_CK2_1	270	276	PF00069	0.613
MOD_CK2_1	305	311	PF00069	0.469
MOD_CK2_1	350	356	PF00069	0.348
MOD_CK2_1	71	77	PF00069	0.276
MOD_GlcNHglycan	307	310	PF01048	0.463
MOD_GlcNHglycan	322	325	PF01048	0.336
MOD_GlcNHglycan	33	36	PF01048	0.335
MOD_GlcNHglycan	404	407	PF01048	0.567
MOD_GSK3_1	160	167	PF00069	0.543
MOD_GSK3_1	255	262	PF00069	0.345
MOD_GSK3_1	318	325	PF00069	0.535
MOD_GSK3_1	405	412	PF00069	0.618
MOD_GSK3_1	42	49	PF00069	0.579
MOD_N-GLC_1	410	415	PF02516	0.557
MOD_N-GLC_1	46	51	PF02516	0.451
MOD_NEK2_1	175	180	PF00069	0.399
MOD_NEK2_1	341	346	PF00069	0.476
MOD_PIKK_1	136	142	PF00454	0.452
MOD_PIKK_1	168	174	PF00454	0.416
MOD_PIKK_1	29	35	PF00454	0.374
MOD_PIKK_1	91	97	PF00454	0.500
MOD_PK_1	322	328	PF00069	0.354
MOD_PKA_1	259	265	PF00069	0.346
MOD_PKA_2	221	227	PF00069	0.411
MOD_PKA_2	259	265	PF00069	0.320
MOD_PKA_2	313	319	PF00069	0.483
MOD_PKA_2	341	347	PF00069	0.456
MOD_PKA_2	390	396	PF00069	0.517
MOD_PKA_2	71	77	PF00069	0.266
MOD_PKA_2	91	97	PF00069	0.492
MOD_Plk_1	350	356	PF00069	0.331
MOD_Plk_1	370	376	PF00069	0.479
MOD_Plk_1	42	48	PF00069	0.407
MOD_Plk_2-3	201	207	PF00069	0.292
MOD_Plk_4	116	122	PF00069	0.425
MOD_Plk_4	175	181	PF00069	0.403
MOD_Plk_4	187	193	PF00069	0.422
MOD_Plk_4	216	222	PF00069	0.281
MOD_Plk_4	267	273	PF00069	0.307
MOD_Plk_4	313	319	PF00069	0.454
MOD_Plk_4	370	376	PF00069	0.459
MOD_Plk_4	71	77	PF00069	0.399
MOD_ProDKin_1	222	228	PF00069	0.362
MOD_ProDKin_1	399	405	PF00069	0.558
MOD_SUMO_rev_2	101	108	PF00179	0.266
MOD_SUMO_rev_2	81	88	PF00179	0.431
TRG_DiLeu_BaEn_1	302	307	PF01217	0.632
TRG_DiLeu_BaEn_3	132	138	PF01217	0.364
TRG_ENDOCYTIC_2	124	127	PF00928	0.356
TRG_ENDOCYTIC_2	177	180	PF00928	0.427
TRG_ENDOCYTIC_2	240	243	PF00928	0.312
TRG_ENDOCYTIC_2	99	102	PF00928	0.319
TRG_ER_diArg_1	259	261	PF00400	0.396
TRG_NES_CRM1_1	147	161	PF08389	0.349
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK09	Leptomonas seymouri	58%	94%
A0A3R7KLY3	Trypanosoma rangeli	35%	100%
A0A3S7X7H5	Leishmania donovani	74%	100%
A4I9L1	Leishmania infantum	75%	100%
E9B4K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q3G7	Leishmania major	74%	100%