Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HAF3_LEIBR

TriTrypDb:

LbrM.20.0360 , LBRM2903_200009500

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 6
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HAF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.575
CLV_NRD_NRD_1	190	192	PF00675	0.619
CLV_PCSK_KEX2_1	190	192	PF00082	0.527
CLV_PCSK_SKI1_1	288	292	PF00082	0.304
CLV_PCSK_SKI1_1	511	515	PF00082	0.474
DEG_Nend_UBRbox_1	1	4	PF02207	0.422
DOC_CDC14_PxL_1	201	209	PF14671	0.313
DOC_CKS1_1	421	426	PF01111	0.444
DOC_MAPK_DCC_7	199	209	PF00069	0.438
DOC_MAPK_gen_1	199	209	PF00069	0.336
DOC_MAPK_MEF2A_6	202	209	PF00069	0.301
DOC_PP4_FxxP_1	337	340	PF00568	0.464
DOC_PP4_FxxP_1	357	360	PF00568	0.283
DOC_USP7_MATH_1	193	197	PF00917	0.704
DOC_USP7_MATH_1	290	294	PF00917	0.394
DOC_USP7_MATH_1	340	344	PF00917	0.613
DOC_USP7_MATH_1	407	411	PF00917	0.583
DOC_USP7_MATH_1	430	434	PF00917	0.373
DOC_WW_Pin1_4	242	247	PF00397	0.420
DOC_WW_Pin1_4	356	361	PF00397	0.470
DOC_WW_Pin1_4	420	425	PF00397	0.384
LIG_14-3-3_CanoR_1	156	163	PF00244	0.423
LIG_14-3-3_CanoR_1	190	198	PF00244	0.500
LIG_14-3-3_CanoR_1	2	7	PF00244	0.398
LIG_14-3-3_CanoR_1	324	332	PF00244	0.493
LIG_14-3-3_CanoR_1	338	348	PF00244	0.386
LIG_14-3-3_CanoR_1	397	406	PF00244	0.518
LIG_14-3-3_CanoR_1	448	455	PF00244	0.458
LIG_14-3-3_CanoR_1	508	514	PF00244	0.470
LIG_14-3-3_CanoR_1	544	548	PF00244	0.337
LIG_BRCT_BRCA1_1	167	171	PF00533	0.414
LIG_BRCT_BRCA1_1	333	337	PF00533	0.396
LIG_deltaCOP1_diTrp_1	522	527	PF00928	0.517
LIG_FHA_1	208	214	PF00498	0.390
LIG_FHA_1	220	226	PF00498	0.402
LIG_FHA_1	239	245	PF00498	0.355
LIG_FHA_1	377	383	PF00498	0.500
LIG_FHA_1	42	48	PF00498	0.567
LIG_FHA_1	421	427	PF00498	0.413
LIG_FHA_1	432	438	PF00498	0.432
LIG_FHA_1	449	455	PF00498	0.550
LIG_FHA_1	71	77	PF00498	0.385
LIG_FHA_2	190	196	PF00498	0.567
LIG_FHA_2	21	27	PF00498	0.565
LIG_LIR_Apic_2	334	340	PF02991	0.431
LIG_LIR_Gen_1	297	304	PF02991	0.422
LIG_LIR_Gen_1	35	43	PF02991	0.480
LIG_LIR_Gen_1	415	424	PF02991	0.497
LIG_LIR_Gen_1	495	502	PF02991	0.425
LIG_LIR_Nem_3	168	174	PF02991	0.339
LIG_LIR_Nem_3	297	301	PF02991	0.404
LIG_LIR_Nem_3	35	40	PF02991	0.586
LIG_LIR_Nem_3	415	419	PF02991	0.533
LIG_LIR_Nem_3	452	458	PF02991	0.492
LIG_LIR_Nem_3	480	486	PF02991	0.390
LIG_LIR_Nem_3	495	500	PF02991	0.500
LIG_LIR_Nem_3	536	542	PF02991	0.407
LIG_LYPXL_yS_3	483	486	PF13949	0.387
LIG_PCNA_yPIPBox_3	373	382	PF02747	0.435
LIG_PTB_Apo_2	347	354	PF02174	0.355
LIG_PTB_Phospho_1	347	353	PF10480	0.345
LIG_SH2_CRK	101	105	PF00017	0.452
LIG_SH2_CRK	298	302	PF00017	0.408
LIG_SH2_CRK	353	357	PF00017	0.382
LIG_SH2_CRK	37	41	PF00017	0.484
LIG_SH2_CRK	416	420	PF00017	0.508
LIG_SH2_NCK_1	542	546	PF00017	0.429
LIG_SH2_SRC	547	550	PF00017	0.290
LIG_SH2_STAP1	157	161	PF00017	0.416
LIG_SH2_STAP1	450	454	PF00017	0.406
LIG_SH2_STAT3	97	100	PF00017	0.414
LIG_SH2_STAT5	150	153	PF00017	0.385
LIG_SH2_STAT5	17	20	PF00017	0.522
LIG_SH2_STAT5	214	217	PF00017	0.440
LIG_SH2_STAT5	22	25	PF00017	0.559
LIG_SH2_STAT5	381	384	PF00017	0.609
LIG_SH2_STAT5	39	42	PF00017	0.602
LIG_SH2_STAT5	450	453	PF00017	0.501
LIG_SH2_STAT5	524	527	PF00017	0.547
LIG_SH2_STAT5	533	536	PF00017	0.433
LIG_SH2_STAT5	542	545	PF00017	0.316
LIG_SH2_STAT5	561	564	PF00017	0.411
LIG_SH2_STAT5	97	100	PF00017	0.350
LIG_SH3_1	418	424	PF00018	0.463
LIG_SH3_3	175	181	PF00018	0.529
LIG_SH3_3	252	258	PF00018	0.591
LIG_SH3_3	418	424	PF00018	0.457
LIG_SH3_3	481	487	PF00018	0.392
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.340
LIG_SUMO_SIM_par_1	205	211	PF11976	0.384
LIG_TYR_ITIM	296	301	PF00017	0.402
LIG_TYR_ITIM	414	419	PF00017	0.476
LIG_WRC_WIRS_1	341	346	PF05994	0.474
MOD_CK1_1	217	223	PF00069	0.328
MOD_CK1_1	232	238	PF00069	0.558
MOD_CK1_1	316	322	PF00069	0.521
MOD_CK1_1	550	556	PF00069	0.393
MOD_CK2_1	189	195	PF00069	0.711
MOD_CK2_1	405	411	PF00069	0.628
MOD_CK2_1	532	538	PF00069	0.502
MOD_GlcNHglycan	142	145	PF01048	0.435
MOD_GlcNHglycan	167	170	PF01048	0.422
MOD_GlcNHglycan	216	219	PF01048	0.372
MOD_GlcNHglycan	407	410	PF01048	0.538
MOD_GlcNHglycan	554	557	PF01048	0.399
MOD_GSK3_1	185	192	PF00069	0.766
MOD_GSK3_1	213	220	PF00069	0.443
MOD_GSK3_1	234	241	PF00069	0.387
MOD_GSK3_1	263	270	PF00069	0.680
MOD_GSK3_1	290	297	PF00069	0.385
MOD_GSK3_1	327	334	PF00069	0.525
MOD_GSK3_1	356	363	PF00069	0.614
MOD_GSK3_1	392	399	PF00069	0.715
MOD_GSK3_1	543	550	PF00069	0.539
MOD_N-GLC_1	138	143	PF02516	0.480
MOD_N-GLC_1	193	198	PF02516	0.628
MOD_N-GLC_1	326	331	PF02516	0.448
MOD_N-GLC_1	41	46	PF02516	0.579
MOD_N-GLC_1	509	514	PF02516	0.597
MOD_NEK2_1	20	25	PF00069	0.686
MOD_NEK2_1	207	212	PF00069	0.375
MOD_NEK2_1	238	243	PF00069	0.453
MOD_NEK2_1	325	330	PF00069	0.470
MOD_NEK2_1	331	336	PF00069	0.457
MOD_NEK2_1	392	397	PF00069	0.516
MOD_NEK2_1	509	514	PF00069	0.492
MOD_PIKK_1	185	191	PF00454	0.514
MOD_PIKK_1	41	47	PF00454	0.577
MOD_PIKK_1	432	438	PF00454	0.468
MOD_PKA_2	155	161	PF00069	0.418
MOD_PKA_2	189	195	PF00069	0.510
MOD_PKA_2	396	402	PF00069	0.527
MOD_PKA_2	540	546	PF00069	0.410
MOD_Plk_1	193	199	PF00069	0.547
MOD_Plk_1	326	332	PF00069	0.543
MOD_Plk_1	462	468	PF00069	0.402
MOD_Plk_1	509	515	PF00069	0.466
MOD_Plk_4	193	199	PF00069	0.563
MOD_Plk_4	2	8	PF00069	0.481
MOD_Plk_4	234	240	PF00069	0.339
MOD_Plk_4	327	333	PF00069	0.413
MOD_Plk_4	360	366	PF00069	0.536
MOD_Plk_4	564	570	PF00069	0.515
MOD_ProDKin_1	242	248	PF00069	0.426
MOD_ProDKin_1	356	362	PF00069	0.473
MOD_ProDKin_1	420	426	PF00069	0.437
MOD_SUMO_rev_2	386	390	PF00179	0.594
TRG_DiLeu_BaEn_1	43	48	PF01217	0.562
TRG_ENDOCYTIC_2	101	104	PF00928	0.437
TRG_ENDOCYTIC_2	142	145	PF00928	0.462
TRG_ENDOCYTIC_2	17	20	PF00928	0.580
TRG_ENDOCYTIC_2	298	301	PF00928	0.406
TRG_ENDOCYTIC_2	37	40	PF00928	0.439
TRG_ENDOCYTIC_2	416	419	PF00928	0.522
TRG_ENDOCYTIC_2	483	486	PF00928	0.387
TRG_ENDOCYTIC_2	497	500	PF00928	0.375
TRG_ER_diArg_1	321	324	PF00400	0.523
TRG_NES_CRM1_1	468	482	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW70	Leptomonas seymouri	62%	98%
A0A1X0PA87	Trypanosomatidae	42%	100%
A0A3Q8IF83	Leishmania donovani	26%	100%
A0A3S7X7F2	Leishmania donovani	77%	100%
A4I9K8	Leishmania infantum	25%	100%
A4I9K9	Leishmania infantum	77%	100%
Q4Q3G9	Leishmania major	77%	99%