Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HAF2_LEIBR

TriTrypDb:

LbrM.20.0350 , LBRM2903_200009400

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAF2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.344
CLV_NRD_NRD_1	138	140	PF00675	0.406
CLV_NRD_NRD_1	317	319	PF00675	0.463
CLV_PCSK_FUR_1	136	140	PF00082	0.298
CLV_PCSK_KEX2_1	138	140	PF00082	0.406
CLV_PCSK_KEX2_1	407	409	PF00082	0.468
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.468
CLV_PCSK_SKI1_1	132	136	PF00082	0.567
CLV_PCSK_SKI1_1	318	322	PF00082	0.518
CLV_PCSK_SKI1_1	476	480	PF00082	0.451
DEG_APCC_DBOX_1	9	17	PF00400	0.493
DEG_COP1_1	250	259	PF00400	0.516
DEG_Nend_UBRbox_1	1	4	PF02207	0.483
DEG_SPOP_SBC_1	187	191	PF00917	0.499
DOC_MAPK_DCC_7	10	18	PF00069	0.441
DOC_MAPK_DCC_7	255	265	PF00069	0.485
DOC_MAPK_gen_1	337	343	PF00069	0.428
DOC_MAPK_MEF2A_6	10	18	PF00069	0.545
DOC_PP1_RVXF_1	306	312	PF00149	0.497
DOC_PP2B_LxvP_1	11	14	PF13499	0.440
DOC_PP4_FxxP_1	228	231	PF00568	0.540
DOC_USP7_MATH_1	112	116	PF00917	0.403
DOC_USP7_MATH_1	187	191	PF00917	0.661
DOC_USP7_MATH_1	231	235	PF00917	0.531
DOC_USP7_MATH_1	294	298	PF00917	0.447
DOC_USP7_MATH_1	430	434	PF00917	0.435
DOC_WW_Pin1_4	1	6	PF00397	0.519
DOC_WW_Pin1_4	154	159	PF00397	0.453
DOC_WW_Pin1_4	193	198	PF00397	0.491
DOC_WW_Pin1_4	250	255	PF00397	0.564
DOC_WW_Pin1_4	258	263	PF00397	0.474
DOC_WW_Pin1_4	415	420	PF00397	0.636
DOC_WW_Pin1_4	47	52	PF00397	0.555
DOC_WW_Pin1_4	484	489	PF00397	0.455
LIG_14-3-3_CanoR_1	141	146	PF00244	0.370
LIG_14-3-3_CanoR_1	285	294	PF00244	0.574
LIG_14-3-3_CanoR_1	30	35	PF00244	0.510
LIG_14-3-3_CanoR_1	342	350	PF00244	0.330
LIG_BRCT_BRCA1_1	432	436	PF00533	0.412
LIG_BRCT_BRCA1_1	549	553	PF00533	0.348
LIG_CtBP_PxDLS_1	262	266	PF00389	0.411
LIG_EVH1_1	11	15	PF00568	0.439
LIG_FHA_1	117	123	PF00498	0.374
LIG_FHA_1	129	135	PF00498	0.381
LIG_FHA_1	187	193	PF00498	0.796
LIG_FHA_1	271	277	PF00498	0.464
LIG_FHA_1	281	287	PF00498	0.513
LIG_FHA_1	420	426	PF00498	0.555
LIG_FHA_1	544	550	PF00498	0.423
LIG_FHA_1	87	93	PF00498	0.431
LIG_FHA_2	326	332	PF00498	0.429
LIG_FHA_2	369	375	PF00498	0.498
LIG_FHA_2	380	386	PF00498	0.555
LIG_FHA_2	437	443	PF00498	0.579
LIG_FHA_2	82	88	PF00498	0.294
LIG_IBAR_NPY_1	521	523	PF08397	0.331
LIG_LIR_Apic_2	23	29	PF02991	0.478
LIG_LIR_Gen_1	144	151	PF02991	0.356
LIG_LIR_Gen_1	168	176	PF02991	0.474
LIG_LIR_Gen_1	527	538	PF02991	0.336
LIG_LIR_Nem_3	168	174	PF02991	0.470
LIG_LIR_Nem_3	458	463	PF02991	0.364
LIG_LIR_Nem_3	527	533	PF02991	0.425
LIG_MLH1_MIPbox_1	549	553	PF16413	0.348
LIG_NRBOX	17	23	PF00104	0.542
LIG_PDZ_Class_1	555	560	PF00595	0.313
LIG_PTB_Apo_2	518	525	PF02174	0.345
LIG_PTB_Apo_2	548	555	PF02174	0.350
LIG_REV1ctd_RIR_1	551	560	PF16727	0.394
LIG_SH2_PTP2	469	472	PF00017	0.438
LIG_SH2_SRC	469	472	PF00017	0.415
LIG_SH2_STAP1	143	147	PF00017	0.365
LIG_SH2_STAP1	24	28	PF00017	0.457
LIG_SH2_STAT5	104	107	PF00017	0.389
LIG_SH2_STAT5	124	127	PF00017	0.468
LIG_SH2_STAT5	143	146	PF00017	0.386
LIG_SH2_STAT5	150	153	PF00017	0.300
LIG_SH2_STAT5	275	278	PF00017	0.645
LIG_SH2_STAT5	310	313	PF00017	0.395
LIG_SH2_STAT5	388	391	PF00017	0.512
LIG_SH2_STAT5	460	463	PF00017	0.443
LIG_SH2_STAT5	469	472	PF00017	0.427
LIG_SH2_STAT5	516	519	PF00017	0.468
LIG_SH2_STAT5	523	526	PF00017	0.460
LIG_SH2_STAT5	552	555	PF00017	0.416
LIG_SH2_STAT5	96	99	PF00017	0.516
LIG_SH3_1	2	8	PF00018	0.476
LIG_SH3_1	327	333	PF00018	0.468
LIG_SH3_1	361	367	PF00018	0.527
LIG_SH3_2	5	10	PF14604	0.597
LIG_SH3_3	2	8	PF00018	0.604
LIG_SH3_3	251	257	PF00018	0.505
LIG_SH3_3	327	333	PF00018	0.421
LIG_SH3_3	361	367	PF00018	0.514
LIG_SH3_3	458	464	PF00018	0.379
LIG_SH3_3	9	15	PF00018	0.519
LIG_SH3_5	526	530	PF00018	0.324
LIG_SUMO_SIM_par_1	17	23	PF11976	0.473
LIG_SUMO_SIM_par_1	261	267	PF11976	0.385
LIG_TRAF2_1	176	179	PF00917	0.524
LIG_TRAF2_1	57	60	PF00917	0.381
LIG_WRC_WIRS_1	530	535	PF05994	0.312
MOD_CDK_SPK_2	250	255	PF00069	0.503
MOD_CDK_SPK_2	484	489	PF00069	0.432
MOD_CK1_1	154	160	PF00069	0.444
MOD_CK1_1	191	197	PF00069	0.494
MOD_CK1_1	258	264	PF00069	0.471
MOD_CK1_1	298	304	PF00069	0.542
MOD_CK1_1	365	371	PF00069	0.434
MOD_CK1_1	418	424	PF00069	0.444
MOD_CK1_1	47	53	PF00069	0.516
MOD_CK2_1	174	180	PF00069	0.706
MOD_CK2_1	278	284	PF00069	0.465
MOD_CK2_1	325	331	PF00069	0.415
MOD_CK2_1	342	348	PF00069	0.395
MOD_CK2_1	368	374	PF00069	0.491
MOD_CK2_1	379	385	PF00069	0.554
MOD_CK2_1	81	87	PF00069	0.290
MOD_GlcNHglycan	153	156	PF01048	0.370
MOD_GlcNHglycan	257	260	PF01048	0.636
MOD_GlcNHglycan	455	458	PF01048	0.329
MOD_GlcNHglycan	476	479	PF01048	0.554
MOD_GlcNHglycan	510	513	PF01048	0.428
MOD_GlcNHglycan	54	57	PF01048	0.697
MOD_GlcNHglycan	69	72	PF01048	0.450
MOD_GlcNHglycan	73	76	PF01048	0.530
MOD_GlcNHglycan	78	82	PF01048	0.474
MOD_GSK3_1	112	119	PF00069	0.391
MOD_GSK3_1	124	131	PF00069	0.493
MOD_GSK3_1	150	157	PF00069	0.402
MOD_GSK3_1	163	170	PF00069	0.524
MOD_GSK3_1	187	194	PF00069	0.651
MOD_GSK3_1	20	27	PF00069	0.610
MOD_GSK3_1	226	233	PF00069	0.459
MOD_GSK3_1	264	271	PF00069	0.408
MOD_GSK3_1	276	283	PF00069	0.560
MOD_GSK3_1	294	301	PF00069	0.553
MOD_GSK3_1	321	328	PF00069	0.423
MOD_GSK3_1	415	422	PF00069	0.679
MOD_GSK3_1	543	550	PF00069	0.347
MOD_GSK3_1	67	74	PF00069	0.464
MOD_GSK3_1	77	84	PF00069	0.426
MOD_GSK3_1	86	93	PF00069	0.423
MOD_N-GLC_1	166	171	PF02516	0.574
MOD_N-GLC_1	534	539	PF02516	0.440
MOD_NEK2_1	116	121	PF00069	0.357
MOD_NEK2_1	276	281	PF00069	0.522
MOD_NEK2_1	436	441	PF00069	0.411
MOD_NEK2_1	508	513	PF00069	0.458
MOD_NEK2_1	52	57	PF00069	0.464
MOD_NEK2_1	534	539	PF00069	0.356
MOD_NEK2_1	547	552	PF00069	0.322
MOD_NEK2_1	86	91	PF00069	0.467
MOD_PIKK_1	286	292	PF00454	0.555
MOD_PIKK_1	419	425	PF00454	0.535
MOD_PIKK_1	86	92	PF00454	0.400
MOD_PKA_2	286	292	PF00069	0.563
MOD_PKA_2	508	514	PF00069	0.447
MOD_PKB_1	139	147	PF00069	0.352
MOD_Plk_1	166	172	PF00069	0.577
MOD_Plk_1	179	185	PF00069	0.561
MOD_Plk_1	534	540	PF00069	0.361
MOD_Plk_4	365	371	PF00069	0.474
MOD_Plk_4	529	535	PF00069	0.418
MOD_Plk_4	543	549	PF00069	0.523
MOD_Plk_4	60	66	PF00069	0.541
MOD_ProDKin_1	1	7	PF00069	0.521
MOD_ProDKin_1	154	160	PF00069	0.461
MOD_ProDKin_1	193	199	PF00069	0.493
MOD_ProDKin_1	250	256	PF00069	0.567
MOD_ProDKin_1	258	264	PF00069	0.458
MOD_ProDKin_1	415	421	PF00069	0.631
MOD_ProDKin_1	47	53	PF00069	0.553
MOD_ProDKin_1	484	490	PF00069	0.446
MOD_SUMO_for_1	183	186	PF00179	0.564
MOD_SUMO_for_1	494	497	PF00179	0.429
MOD_SUMO_rev_2	301	309	PF00179	0.487
TRG_DiLeu_BaEn_1	78	83	PF01217	0.414
TRG_DiLeu_BaEn_2	431	437	PF01217	0.366
TRG_DiLeu_BaEn_4	178	184	PF01217	0.434
TRG_ENDOCYTIC_2	145	148	PF00928	0.380
TRG_ENDOCYTIC_2	171	174	PF00928	0.474
TRG_ENDOCYTIC_2	530	533	PF00928	0.311
TRG_ER_diArg_1	135	138	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P8	Leptomonas seymouri	52%	100%
A0A0S4ILN1	Bodo saltans	29%	100%
A0A3Q8IF83	Leishmania donovani	78%	98%
A0A3S7X7F2	Leishmania donovani	24%	100%
A4I9K8	Leishmania infantum	78%	98%
A4I9K9	Leishmania infantum	25%	100%
E9B4K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q3G9	Leishmania major	24%	97%
Q4Q3H0	Leishmania major	76%	100%