AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania braziliensis

UniProt:

A4HAE8_LEIBR

TriTrypDb:

LbrM.20.0310 , LBRM2903_200008900

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HAE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAE8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.665
CLV_C14_Caspase3-7	640	644	PF00656	0.679
CLV_C14_Caspase3-7	732	736	PF00656	0.578
CLV_NRD_NRD_1	197	199	PF00675	0.440
CLV_NRD_NRD_1	220	222	PF00675	0.460
CLV_NRD_NRD_1	293	295	PF00675	0.480
CLV_NRD_NRD_1	49	51	PF00675	0.377
CLV_NRD_NRD_1	509	511	PF00675	0.269
CLV_NRD_NRD_1	581	583	PF00675	0.430
CLV_NRD_NRD_1	739	741	PF00675	0.402
CLV_PCSK_KEX2_1	197	199	PF00082	0.529
CLV_PCSK_KEX2_1	293	295	PF00082	0.479
CLV_PCSK_KEX2_1	346	348	PF00082	0.498
CLV_PCSK_KEX2_1	49	51	PF00082	0.380
CLV_PCSK_KEX2_1	509	511	PF00082	0.269
CLV_PCSK_KEX2_1	739	741	PF00082	0.402
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.498
CLV_PCSK_SKI1_1	169	173	PF00082	0.434
CLV_PCSK_SKI1_1	347	351	PF00082	0.455
CLV_PCSK_SKI1_1	368	372	PF00082	0.409
CLV_PCSK_SKI1_1	425	429	PF00082	0.465
CLV_PCSK_SKI1_1	49	53	PF00082	0.369
CLV_PCSK_SKI1_1	528	532	PF00082	0.214
CLV_PCSK_SKI1_1	645	649	PF00082	0.410
CLV_PCSK_SKI1_1	747	751	PF00082	0.350
DEG_APCC_DBOX_1	346	354	PF00400	0.662
DEG_APCC_DBOX_1	508	516	PF00400	0.469
DEG_Nend_UBRbox_2	1	3	PF02207	0.468
DEG_SCF_FBW7_1	742	748	PF00400	0.502
DOC_CKS1_1	742	747	PF01111	0.502
DOC_MAPK_gen_1	346	353	PF00069	0.646
DOC_MAPK_gen_1	447	456	PF00069	0.591
DOC_MAPK_gen_1	457	465	PF00069	0.502
DOC_MAPK_gen_1	506	515	PF00069	0.479
DOC_MAPK_gen_1	528	537	PF00069	0.688
DOC_MAPK_MEF2A_6	509	517	PF00069	0.501
DOC_MAPK_MEF2A_6	698	707	PF00069	0.501
DOC_PP1_RVXF_1	482	488	PF00149	0.517
DOC_PP4_FxxP_1	476	479	PF00568	0.591
DOC_PP4_FxxP_1	675	678	PF00568	0.511
DOC_USP7_MATH_1	12	16	PF00917	0.378
DOC_USP7_MATH_1	402	406	PF00917	0.670
DOC_USP7_MATH_1	417	421	PF00917	0.804
DOC_USP7_MATH_1	440	444	PF00917	0.665
DOC_USP7_MATH_1	555	559	PF00917	0.556
DOC_USP7_MATH_1	616	620	PF00917	0.712
DOC_USP7_MATH_1	629	633	PF00917	0.648
DOC_USP7_UBL2_3	364	368	PF12436	0.605
DOC_WW_Pin1_4	307	312	PF00397	0.626
DOC_WW_Pin1_4	551	556	PF00397	0.487
DOC_WW_Pin1_4	614	619	PF00397	0.730
DOC_WW_Pin1_4	741	746	PF00397	0.508
LIG_14-3-3_CanoR_1	130	135	PF00244	0.614
LIG_14-3-3_CanoR_1	137	147	PF00244	0.588
LIG_14-3-3_CanoR_1	269	276	PF00244	0.658
LIG_14-3-3_CanoR_1	414	424	PF00244	0.627
LIG_14-3-3_CanoR_1	425	431	PF00244	0.649
LIG_14-3-3_CanoR_1	447	452	PF00244	0.620
LIG_14-3-3_CanoR_1	484	488	PF00244	0.556
LIG_14-3-3_CanoR_1	49	59	PF00244	0.608
LIG_14-3-3_CanoR_1	698	703	PF00244	0.517
LIG_14-3-3_CanoR_1	739	745	PF00244	0.588
LIG_14-3-3_CanoR_1	785	790	PF00244	0.593
LIG_Actin_WH2_2	423	440	PF00022	0.619
LIG_AP2alpha_1	668	672	PF02296	0.524
LIG_APCC_ABBA_1	559	564	PF00400	0.508
LIG_APCC_ABBAyCdc20_2	116	122	PF00400	0.656
LIG_BIR_III_4	566	570	PF00653	0.534
LIG_BRCT_BRCA1_1	116	120	PF00533	0.633
LIG_BRCT_BRCA1_1	127	131	PF00533	0.568
LIG_BRCT_BRCA1_1	272	276	PF00533	0.746
LIG_BRCT_BRCA1_1	452	456	PF00533	0.523
LIG_deltaCOP1_diTrp_1	121	131	PF00928	0.667
LIG_eIF4E_1	108	114	PF01652	0.639
LIG_FHA_1	399	405	PF00498	0.628
LIG_FHA_1	484	490	PF00498	0.566
LIG_FHA_1	496	502	PF00498	0.427
LIG_FHA_1	521	527	PF00498	0.414
LIG_FHA_1	532	538	PF00498	0.539
LIG_FHA_1	546	552	PF00498	0.624
LIG_FHA_1	592	598	PF00498	0.585
LIG_FHA_1	716	722	PF00498	0.508
LIG_FHA_1	746	752	PF00498	0.534
LIG_FHA_1	781	787	PF00498	0.522
LIG_FHA_2	170	176	PF00498	0.621
LIG_FHA_2	241	247	PF00498	0.642
LIG_FHA_2	414	420	PF00498	0.630
LIG_FHA_2	520	526	PF00498	0.469
LIG_FHA_2	601	607	PF00498	0.680
LIG_FHA_2	699	705	PF00498	0.502
LIG_FXI_DFP_1	562	566	PF00024	0.314
LIG_FXI_DFP_1	633	637	PF00024	0.432
LIG_GBD_Chelix_1	504	512	PF00786	0.269
LIG_HCF-1_HBM_1	722	725	PF13415	0.573
LIG_LIR_Apic_2	291	295	PF02991	0.629
LIG_LIR_Gen_1	107	114	PF02991	0.593
LIG_LIR_Gen_1	128	139	PF02991	0.536
LIG_LIR_Gen_1	21	31	PF02991	0.227
LIG_LIR_Gen_1	450	456	PF02991	0.673
LIG_LIR_Gen_1	548	555	PF02991	0.571
LIG_LIR_Gen_1	563	571	PF02991	0.537
LIG_LIR_Gen_1	653	663	PF02991	0.593
LIG_LIR_Gen_1	666	675	PF02991	0.539
LIG_LIR_Gen_1	679	685	PF02991	0.520
LIG_LIR_Gen_1	86	93	PF02991	0.518
LIG_LIR_Nem_3	107	113	PF02991	0.593
LIG_LIR_Nem_3	121	127	PF02991	0.629
LIG_LIR_Nem_3	128	134	PF02991	0.578
LIG_LIR_Nem_3	21	26	PF02991	0.433
LIG_LIR_Nem_3	382	388	PF02991	0.642
LIG_LIR_Nem_3	42	46	PF02991	0.539
LIG_LIR_Nem_3	450	454	PF02991	0.542
LIG_LIR_Nem_3	548	553	PF02991	0.589
LIG_LIR_Nem_3	563	568	PF02991	0.523
LIG_LIR_Nem_3	570	575	PF02991	0.612
LIG_LIR_Nem_3	653	658	PF02991	0.605
LIG_LIR_Nem_3	666	671	PF02991	0.531
LIG_LIR_Nem_3	679	684	PF02991	0.522
LIG_LIR_Nem_3	722	727	PF02991	0.487
LIG_LIR_Nem_3	86	90	PF02991	0.515
LIG_MLH1_MIPbox_1	452	456	PF16413	0.523
LIG_PDZ_Class_3	793	798	PF00595	0.684
LIG_Pex14_2	120	124	PF04695	0.633
LIG_Pex14_2	131	135	PF04695	0.583
LIG_Pex14_2	451	455	PF04695	0.526
LIG_Pex14_2	668	672	PF04695	0.524
LIG_Pex14_2	681	685	PF04695	0.507
LIG_PTB_Apo_2	649	656	PF02174	0.544
LIG_PTB_Phospho_1	649	655	PF10480	0.546
LIG_REV1ctd_RIR_1	453	463	PF16727	0.464
LIG_SH2_CRK	110	114	PF00017	0.592
LIG_SH2_CRK	292	296	PF00017	0.677
LIG_SH2_CRK	48	52	PF00017	0.554
LIG_SH2_CRK	87	91	PF00017	0.517
LIG_SH2_STAP1	108	112	PF00017	0.590
LIG_SH2_STAP1	127	131	PF00017	0.612
LIG_SH2_STAP1	223	227	PF00017	0.650
LIG_SH2_STAP1	655	659	PF00017	0.520
LIG_SH2_STAP1	725	729	PF00017	0.585
LIG_SH2_STAT3	267	270	PF00017	0.646
LIG_SH2_STAT5	110	113	PF00017	0.545
LIG_SH2_STAT5	170	173	PF00017	0.675
LIG_SH2_STAT5	215	218	PF00017	0.644
LIG_SH2_STAT5	223	226	PF00017	0.674
LIG_SH2_STAT5	338	341	PF00017	0.631
LIG_SH2_STAT5	386	389	PF00017	0.581
LIG_SH2_STAT5	560	563	PF00017	0.537
LIG_SH2_STAT5	84	87	PF00017	0.576
LIG_SH2_STAT5	89	92	PF00017	0.579
LIG_SH3_3	23	29	PF00018	0.233
LIG_SH3_3	245	251	PF00018	0.751
LIG_SH3_3	4	10	PF00018	0.435
LIG_SH3_3	612	618	PF00018	0.646
LIG_SUMO_SIM_anti_2	144	151	PF11976	0.648
LIG_SUMO_SIM_anti_2	284	291	PF11976	0.727
LIG_SUMO_SIM_par_1	284	291	PF11976	0.727
LIG_SUMO_SIM_par_1	461	468	PF11976	0.454
LIG_SUMO_SIM_par_1	511	516	PF11976	0.469
LIG_TRAF2_1	243	246	PF00917	0.642
LIG_TRAF2_1	282	285	PF00917	0.648
LIG_TRAF2_1	394	397	PF00917	0.632
LIG_TYR_ITIM	46	51	PF00017	0.557
LIG_TYR_ITIM	85	90	PF00017	0.511
LIG_UBA3_1	216	222	PF00899	0.607
MOD_CDK_SPxK_1	741	747	PF00069	0.507
MOD_CK1_1	15	21	PF00069	0.271
MOD_CK1_1	151	157	PF00069	0.608
MOD_CK1_1	271	277	PF00069	0.679
MOD_CK1_1	307	313	PF00069	0.728
MOD_CK1_1	405	411	PF00069	0.693
MOD_CK1_1	443	449	PF00069	0.672
MOD_CK1_1	545	551	PF00069	0.636
MOD_CK1_1	605	611	PF00069	0.673
MOD_CK1_1	617	623	PF00069	0.713
MOD_CK2_1	138	144	PF00069	0.575
MOD_CK2_1	240	246	PF00069	0.639
MOD_CK2_1	406	412	PF00069	0.627
MOD_CK2_1	413	419	PF00069	0.619
MOD_CK2_1	513	519	PF00069	0.469
MOD_CK2_1	595	601	PF00069	0.621
MOD_CK2_1	605	611	PF00069	0.747
MOD_Cter_Amidation	195	198	PF01082	0.535
MOD_GlcNHglycan	150	153	PF01048	0.503
MOD_GlcNHglycan	194	197	PF01048	0.458
MOD_GlcNHglycan	199	202	PF01048	0.425
MOD_GlcNHglycan	321	324	PF01048	0.553
MOD_GlcNHglycan	380	384	PF01048	0.419
MOD_GlcNHglycan	389	392	PF01048	0.427
MOD_GlcNHglycan	405	408	PF01048	0.467
MOD_GlcNHglycan	419	422	PF01048	0.461
MOD_GlcNHglycan	438	441	PF01048	0.472
MOD_GlcNHglycan	443	446	PF01048	0.450
MOD_GlcNHglycan	597	600	PF01048	0.492
MOD_GlcNHglycan	620	623	PF01048	0.537
MOD_GlcNHglycan	637	642	PF01048	0.404
MOD_GlcNHglycan	764	767	PF01048	0.313
MOD_GlcNHglycan	95	98	PF01048	0.408
MOD_GSK3_1	10	17	PF00069	0.412
MOD_GSK3_1	126	133	PF00069	0.603
MOD_GSK3_1	143	150	PF00069	0.706
MOD_GSK3_1	169	176	PF00069	0.716
MOD_GSK3_1	392	399	PF00069	0.687
MOD_GSK3_1	402	409	PF00069	0.728
MOD_GSK3_1	413	420	PF00069	0.760
MOD_GSK3_1	436	443	PF00069	0.731
MOD_GSK3_1	492	499	PF00069	0.469
MOD_GSK3_1	515	522	PF00069	0.516
MOD_GSK3_1	545	552	PF00069	0.630
MOD_GSK3_1	587	594	PF00069	0.705
MOD_GSK3_1	610	617	PF00069	0.708
MOD_GSK3_1	741	748	PF00069	0.613
MOD_GSK3_1	758	765	PF00069	0.537
MOD_GSK3_1	780	787	PF00069	0.562
MOD_N-GLC_1	261	266	PF02516	0.472
MOD_N-GLC_1	276	281	PF02516	0.416
MOD_N-GLC_1	307	312	PF02516	0.473
MOD_N-GLC_1	372	377	PF02516	0.409
MOD_NEK2_1	143	148	PF00069	0.640
MOD_NEK2_1	162	167	PF00069	0.612
MOD_NEK2_1	216	221	PF00069	0.722
MOD_NEK2_1	276	281	PF00069	0.627
MOD_NEK2_1	304	309	PF00069	0.693
MOD_NEK2_1	342	347	PF00069	0.615
MOD_NEK2_1	39	44	PF00069	0.414
MOD_NEK2_1	426	431	PF00069	0.662
MOD_NEK2_1	696	701	PF00069	0.728
MOD_NEK2_1	77	82	PF00069	0.571
MOD_NEK2_2	483	488	PF00069	0.558
MOD_NEK2_2	555	560	PF00069	0.518
MOD_PIKK_1	276	282	PF00454	0.667
MOD_PIKK_1	610	616	PF00454	0.731
MOD_PIKK_1	715	721	PF00454	0.562
MOD_PK_1	461	467	PF00069	0.457
MOD_PK_1	785	791	PF00069	0.603
MOD_PKA_1	197	203	PF00069	0.638
MOD_PKA_1	221	227	PF00069	0.645
MOD_PKA_1	49	55	PF00069	0.571
MOD_PKA_2	197	203	PF00069	0.651
MOD_PKA_2	268	274	PF00069	0.643
MOD_PKA_2	413	419	PF00069	0.637
MOD_PKA_2	483	489	PF00069	0.568
MOD_PKA_2	49	55	PF00069	0.571
MOD_PKA_2	545	551	PF00069	0.633
MOD_PKA_2	697	703	PF00069	0.513
MOD_PKA_2	784	790	PF00069	0.554
MOD_Plk_1	143	149	PF00069	0.627
MOD_Plk_1	271	277	PF00069	0.689
MOD_Plk_1	587	593	PF00069	0.637
MOD_Plk_1	610	616	PF00069	0.647
MOD_Plk_1	703	709	PF00069	0.534
MOD_Plk_1	730	736	PF00069	0.672
MOD_Plk_2-3	241	247	PF00069	0.642
MOD_Plk_2-3	661	667	PF00069	0.593
MOD_Plk_4	130	136	PF00069	0.620
MOD_Plk_4	143	149	PF00069	0.732
MOD_Plk_4	18	24	PF00069	0.313
MOD_Plk_4	450	456	PF00069	0.525
MOD_Plk_4	461	467	PF00069	0.512
MOD_Plk_4	483	489	PF00069	0.574
MOD_Plk_4	496	502	PF00069	0.422
MOD_Plk_4	555	561	PF00069	0.516
MOD_Plk_4	587	593	PF00069	0.555
MOD_Plk_4	677	683	PF00069	0.527
MOD_Plk_4	698	704	PF00069	0.617
MOD_ProDKin_1	307	313	PF00069	0.626
MOD_ProDKin_1	551	557	PF00069	0.489
MOD_ProDKin_1	614	620	PF00069	0.728
MOD_ProDKin_1	741	747	PF00069	0.507
MOD_SUMO_for_1	592	595	PF00179	0.575
MOD_SUMO_rev_2	605	613	PF00179	0.749
TRG_DiLeu_BaEn_1	587	592	PF01217	0.552
TRG_DiLeu_BaEn_2	157	163	PF01217	0.666
TRG_DiLeu_BaEn_4	587	593	PF01217	0.555
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.556
TRG_ENDOCYTIC_2	110	113	PF00928	0.592
TRG_ENDOCYTIC_2	385	388	PF00928	0.629
TRG_ENDOCYTIC_2	48	51	PF00928	0.608
TRG_ENDOCYTIC_2	655	658	PF00928	0.522
TRG_ENDOCYTIC_2	724	727	PF00928	0.495
TRG_ENDOCYTIC_2	87	90	PF00928	0.513
TRG_ER_diArg_1	197	199	PF00400	0.640
TRG_ER_diArg_1	292	294	PF00400	0.686
TRG_ER_diArg_1	48	50	PF00400	0.583
TRG_ER_diArg_1	508	510	PF00400	0.469
TRG_NLS_MonoExtC_3	581	587	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ4	Leptomonas seymouri	50%	97%
A0A3Q8IUC9	Leishmania donovani	69%	99%
A4I9K4	Leishmania infantum	69%	100%
E9B4K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q3H4	Leishmania major	67%	100%