Putative deoxyhypusine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyhypusine synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAE7_LEIBR

TriTrypDb:

LbrM.20.0300 , LBRM2903_200008800

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HAE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAE7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	3	11
GO:0009058	biosynthetic process	2	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018205	peptidyl-lysine modification	6	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	5
GO:0034038	deoxyhypusine synthase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.347
CLV_C14_Caspase3-7	517	521	PF00656	0.266
CLV_NRD_NRD_1	130	132	PF00675	0.322
CLV_NRD_NRD_1	193	195	PF00675	0.336
CLV_NRD_NRD_1	416	418	PF00675	0.704
CLV_NRD_NRD_1	566	568	PF00675	0.508
CLV_NRD_NRD_1	574	576	PF00675	0.619
CLV_NRD_NRD_1	585	587	PF00675	0.590
CLV_NRD_NRD_1	61	63	PF00675	0.401
CLV_NRD_NRD_1	64	66	PF00675	0.419
CLV_PCSK_FUR_1	564	568	PF00082	0.436
CLV_PCSK_KEX2_1	130	132	PF00082	0.379
CLV_PCSK_KEX2_1	193	195	PF00082	0.336
CLV_PCSK_KEX2_1	566	568	PF00082	0.512
CLV_PCSK_KEX2_1	584	586	PF00082	0.649
CLV_PCSK_KEX2_1	61	63	PF00082	0.388
CLV_PCSK_SKI1_1	79	83	PF00082	0.486
DOC_CYCLIN_yCln2_LP_2	404	407	PF00134	0.489
DOC_MAPK_gen_1	417	423	PF00069	0.553
DOC_MAPK_gen_1	478	484	PF00069	0.291
DOC_MAPK_RevD_3	553	567	PF00069	0.385
DOC_PP2B_LxvP_1	404	407	PF13499	0.355
DOC_PP4_FxxP_1	224	227	PF00568	0.642
DOC_SPAK_OSR1_1	121	125	PF12202	0.404
DOC_USP7_MATH_1	133	137	PF00917	0.572
DOC_USP7_MATH_1	227	231	PF00917	0.602
DOC_USP7_MATH_1	285	289	PF00917	0.319
DOC_USP7_MATH_1	326	330	PF00917	0.462
DOC_USP7_MATH_1	438	442	PF00917	0.539
DOC_USP7_MATH_1	588	592	PF00917	0.503
DOC_USP7_MATH_2	525	531	PF00917	0.266
DOC_USP7_UBL2_3	225	229	PF12436	0.706
DOC_WW_Pin1_4	129	134	PF00397	0.558
DOC_WW_Pin1_4	223	228	PF00397	0.680
DOC_WW_Pin1_4	255	260	PF00397	0.531
DOC_WW_Pin1_4	301	306	PF00397	0.331
DOC_WW_Pin1_4	342	347	PF00397	0.522
DOC_WW_Pin1_4	389	394	PF00397	0.302
LIG_14-3-3_CanoR_1	209	216	PF00244	0.588
LIG_14-3-3_CanoR_1	22	29	PF00244	0.347
LIG_14-3-3_CanoR_1	357	366	PF00244	0.599
LIG_14-3-3_CanoR_1	374	380	PF00244	0.404
LIG_14-3-3_CanoR_1	436	446	PF00244	0.542
LIG_14-3-3_CanoR_1	589	594	PF00244	0.491
LIG_Actin_WH2_2	268	285	PF00022	0.470
LIG_APCC_ABBA_1	541	546	PF00400	0.291
LIG_BIR_II_1	1	5	PF00653	0.399
LIG_BRCT_BRCA1_1	260	264	PF00533	0.380
LIG_BRCT_BRCA1_1	391	395	PF00533	0.327
LIG_deltaCOP1_diTrp_1	307	315	PF00928	0.377
LIG_FHA_1	106	112	PF00498	0.303
LIG_FHA_1	234	240	PF00498	0.486
LIG_FHA_1	319	325	PF00498	0.285
LIG_FHA_1	375	381	PF00498	0.433
LIG_FHA_1	441	447	PF00498	0.708
LIG_FHA_1	478	484	PF00498	0.352
LIG_FHA_1	505	511	PF00498	0.308
LIG_FHA_1	592	598	PF00498	0.532
LIG_FHA_2	302	308	PF00498	0.371
LIG_FHA_2	357	363	PF00498	0.486
LIG_FHA_2	442	448	PF00498	0.525
LIG_GBD_Chelix_1	316	324	PF00786	0.427
LIG_GBD_Chelix_1	55	63	PF00786	0.335
LIG_LIR_Apic_2	159	164	PF02991	0.475
LIG_LIR_Apic_2	222	227	PF02991	0.643
LIG_LIR_Apic_2	402	406	PF02991	0.518
LIG_LIR_Apic_2	429	435	PF02991	0.512
LIG_LIR_Gen_1	155	165	PF02991	0.311
LIG_LIR_Gen_1	261	272	PF02991	0.334
LIG_LIR_Gen_1	293	303	PF02991	0.451
LIG_LIR_Gen_1	505	510	PF02991	0.303
LIG_LIR_Gen_1	537	547	PF02991	0.308
LIG_LIR_Gen_1	591	600	PF02991	0.485
LIG_LIR_Gen_1	77	87	PF02991	0.404
LIG_LIR_Nem_3	261	267	PF02991	0.336
LIG_LIR_Nem_3	293	298	PF02991	0.461
LIG_LIR_Nem_3	505	509	PF02991	0.303
LIG_LIR_Nem_3	530	534	PF02991	0.266
LIG_LIR_Nem_3	537	543	PF02991	0.266
LIG_LIR_Nem_3	548	553	PF02991	0.266
LIG_LIR_Nem_3	591	596	PF02991	0.485
LIG_LIR_Nem_3	77	83	PF02991	0.404
LIG_LIR_Nem_3	97	103	PF02991	0.307
LIG_LYPXL_S_1	99	103	PF13949	0.404
LIG_LYPXL_yS_3	100	103	PF13949	0.404
LIG_LYPXL_yS_3	43	46	PF13949	0.284
LIG_Pex14_2	391	395	PF04695	0.351
LIG_PTB_Apo_2	247	254	PF02174	0.392
LIG_PTB_Phospho_1	247	253	PF10480	0.396
LIG_SH2_CRK	161	165	PF00017	0.465
LIG_SH2_PTP2	80	83	PF00017	0.335
LIG_SH2_STAT3	199	202	PF00017	0.294
LIG_SH2_STAT3	253	256	PF00017	0.477
LIG_SH2_STAT5	157	160	PF00017	0.449
LIG_SH2_STAT5	199	202	PF00017	0.497
LIG_SH2_STAT5	358	361	PF00017	0.493
LIG_SH2_STAT5	403	406	PF00017	0.524
LIG_SH2_STAT5	550	553	PF00017	0.374
LIG_SH2_STAT5	80	83	PF00017	0.404
LIG_SH3_1	161	167	PF00018	0.462
LIG_SH3_3	161	167	PF00018	0.517
LIG_SH3_3	23	29	PF00018	0.404
LIG_SH3_3	387	393	PF00018	0.226
LIG_SH3_3	447	453	PF00018	0.671
LIG_SH3_3	555	561	PF00018	0.354
LIG_SH3_3	78	84	PF00018	0.438
LIG_SUMO_SIM_par_1	452	457	PF11976	0.426
LIG_SUMO_SIM_par_1	551	557	PF11976	0.431
LIG_TRFH_1	403	407	PF08558	0.334
LIG_TRFH_1	80	84	PF08558	0.335
LIG_UBA3_1	149	154	PF00899	0.466
LIG_UBA3_1	469	478	PF00899	0.193
MOD_CDC14_SPxK_1	226	229	PF00782	0.480
MOD_CDK_SPK_2	223	228	PF00069	0.482
MOD_CDK_SPxK_1	223	229	PF00069	0.481
MOD_CDK_SPxxK_3	255	262	PF00069	0.290
MOD_CK1_1	13	19	PF00069	0.515
MOD_CK1_1	176	182	PF00069	0.355
MOD_CK1_1	214	220	PF00069	0.726
MOD_CK1_1	258	264	PF00069	0.491
MOD_CK1_1	336	342	PF00069	0.481
MOD_CK1_1	361	367	PF00069	0.528
MOD_CK1_1	42	48	PF00069	0.455
MOD_CK1_1	440	446	PF00069	0.617
MOD_CK1_1	477	483	PF00069	0.266
MOD_CK1_1	591	597	PF00069	0.607
MOD_CK2_1	301	307	PF00069	0.413
MOD_CK2_1	356	362	PF00069	0.605
MOD_CK2_1	425	431	PF00069	0.506
MOD_GlcNHglycan	12	15	PF01048	0.518
MOD_GlcNHglycan	134	138	PF01048	0.661
MOD_GlcNHglycan	139	142	PF01048	0.498
MOD_GlcNHglycan	178	181	PF01048	0.353
MOD_GlcNHglycan	183	186	PF01048	0.355
MOD_GlcNHglycan	213	216	PF01048	0.603
MOD_GlcNHglycan	217	220	PF01048	0.603
MOD_GlcNHglycan	335	338	PF01048	0.593
MOD_GlcNHglycan	362	366	PF01048	0.534
MOD_GlcNHglycan	409	412	PF01048	0.480
MOD_GlcNHglycan	6	9	PF01048	0.445
MOD_GSK3_1	129	136	PF00069	0.517
MOD_GSK3_1	205	212	PF00069	0.605
MOD_GSK3_1	215	222	PF00069	0.770
MOD_GSK3_1	223	230	PF00069	0.695
MOD_GSK3_1	299	306	PF00069	0.391
MOD_GSK3_1	328	335	PF00069	0.556
MOD_GSK3_1	352	359	PF00069	0.635
MOD_GSK3_1	436	443	PF00069	0.684
MOD_GSK3_1	588	595	PF00069	0.675
MOD_GSK3_1	9	16	PF00069	0.502
MOD_N-GLC_1	425	430	PF02516	0.506
MOD_N-GLC_1	436	441	PF02516	0.649
MOD_NEK2_1	10	15	PF00069	0.500
MOD_NEK2_1	105	110	PF00069	0.281
MOD_NEK2_1	111	116	PF00069	0.259
MOD_NEK2_1	263	268	PF00069	0.416
MOD_NEK2_1	48	53	PF00069	0.321
MOD_NEK2_1	55	60	PF00069	0.325
MOD_PIKK_1	352	358	PF00454	0.523
MOD_PIKK_1	577	583	PF00454	0.473
MOD_PKA_1	228	234	PF00069	0.612
MOD_PKA_2	21	27	PF00069	0.412
MOD_PKA_2	333	339	PF00069	0.516
MOD_PKA_2	356	362	PF00069	0.800
MOD_PKA_2	375	381	PF00069	0.432
MOD_PKA_2	588	594	PF00069	0.582
MOD_Plk_1	504	510	PF00069	0.308
MOD_Plk_1	545	551	PF00069	0.302
MOD_Plk_4	173	179	PF00069	0.456
MOD_Plk_4	219	225	PF00069	0.708
MOD_Plk_4	263	269	PF00069	0.281
MOD_Plk_4	375	381	PF00069	0.314
MOD_Plk_4	391	397	PF00069	0.333
MOD_Plk_4	399	405	PF00069	0.415
MOD_Plk_4	546	552	PF00069	0.269
MOD_Plk_4	592	598	PF00069	0.482
MOD_ProDKin_1	129	135	PF00069	0.569
MOD_ProDKin_1	223	229	PF00069	0.680
MOD_ProDKin_1	255	261	PF00069	0.522
MOD_ProDKin_1	301	307	PF00069	0.329
MOD_ProDKin_1	342	348	PF00069	0.519
MOD_ProDKin_1	389	395	PF00069	0.303
MOD_SUMO_for_1	153	156	PF00179	0.480
MOD_SUMO_for_1	523	526	PF00179	0.399
MOD_SUMO_rev_2	425	435	PF00179	0.575
TRG_DiLeu_BaEn_1	6	11	PF01217	0.536
TRG_DiLeu_BaEn_2	117	123	PF01217	0.289
TRG_DiLeu_BaLyEn_6	549	554	PF01217	0.266
TRG_ENDOCYTIC_2	100	103	PF00928	0.404
TRG_ENDOCYTIC_2	157	160	PF00928	0.307
TRG_ENDOCYTIC_2	295	298	PF00928	0.436
TRG_ENDOCYTIC_2	43	46	PF00928	0.289
TRG_ENDOCYTIC_2	544	547	PF00928	0.269
TRG_ENDOCYTIC_2	550	553	PF00928	0.284
TRG_ENDOCYTIC_2	80	83	PF00928	0.404
TRG_ER_diArg_1	129	131	PF00400	0.193
TRG_ER_diArg_1	192	194	PF00400	0.330
TRG_ER_diArg_1	563	566	PF00400	0.484
TRG_ER_diArg_1	583	586	PF00400	0.652
TRG_ER_diArg_1	61	63	PF00400	0.193
TRG_NES_CRM1_1	265	279	PF08389	0.239
TRG_NLS_Bipartite_1	575	590	PF00514	0.516
TRG_NLS_MonoCore_2	585	590	PF00514	0.620
TRG_NLS_MonoExtN_4	583	590	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXU4	Leptomonas seymouri	54%	100%
A0A1X0P8R7	Trypanosomatidae	38%	100%
A0A3Q8IH77	Leishmania donovani	76%	100%
A0A422NFI0	Trypanosoma rangeli	37%	100%
A4I9K3	Leishmania infantum	75%	100%
B5APK2	Leishmania donovani	76%	100%
D0A1W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q38BX0	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	38%	100%
Q4Q3H5	Leishmania major	75%	100%
V5BRS6	Trypanosoma cruzi	36%	100%