Pyr_redox_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyridine nucleotide-disulphide oxidoreductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HAE5_LEIBR

TriTrypDb:

LbrM.20.0280 , LBRM2903_200005500

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HAE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAE5

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019418	sulfide oxidation	4	1
GO:0044237	cellular metabolic process	2	1
GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0070224	sulfide:quinone oxidoreductase activity	5	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.445
CLV_NRD_NRD_1	188	190	PF00675	0.542
CLV_NRD_NRD_1	2	4	PF00675	0.748
CLV_NRD_NRD_1	52	54	PF00675	0.418
CLV_NRD_NRD_1	558	560	PF00675	0.460
CLV_NRD_NRD_1	592	594	PF00675	0.377
CLV_NRD_NRD_1	67	69	PF00675	0.516
CLV_PCSK_KEX2_1	188	190	PF00082	0.542
CLV_PCSK_KEX2_1	2	4	PF00082	0.748
CLV_PCSK_KEX2_1	592	594	PF00082	0.391
CLV_PCSK_KEX2_1	69	71	PF00082	0.504
CLV_PCSK_KEX2_1	715	717	PF00082	0.478
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.461
CLV_PCSK_PC1ET2_1	715	717	PF00082	0.478
CLV_PCSK_SKI1_1	171	175	PF00082	0.547
CLV_PCSK_SKI1_1	297	301	PF00082	0.598
CLV_PCSK_SKI1_1	627	631	PF00082	0.298
CLV_PCSK_SKI1_1	64	68	PF00082	0.563
CLV_PCSK_SKI1_1	741	745	PF00082	0.419
CLV_Separin_Metazoa	154	158	PF03568	0.346
CLV_Separin_Metazoa	65	69	PF03568	0.747
DEG_APCC_DBOX_1	2	10	PF00400	0.553
DEG_APCC_DBOX_1	267	275	PF00400	0.445
DEG_APCC_DBOX_1	740	748	PF00400	0.619
DEG_COP1_1	769	778	PF00400	0.438
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DEG_SCF_FBW7_1	324	330	PF00400	0.548
DEG_SCF_FBW7_1	333	339	PF00400	0.531
DOC_CKS1_1	299	304	PF01111	0.375
DOC_CKS1_1	324	329	PF01111	0.612
DOC_CKS1_1	333	338	PF01111	0.552
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.411
DOC_MAPK_gen_1	105	112	PF00069	0.419
DOC_MAPK_gen_1	2	11	PF00069	0.554
DOC_MAPK_gen_1	380	389	PF00069	0.374
DOC_MAPK_gen_1	68	77	PF00069	0.623
DOC_MAPK_MEF2A_6	382	391	PF00069	0.382
DOC_MAPK_RevD_3	40	54	PF00069	0.261
DOC_PP2B_LxvP_1	345	348	PF13499	0.438
DOC_PP2B_LxvP_1	516	519	PF13499	0.411
DOC_PP2B_LxvP_1	520	523	PF13499	0.411
DOC_PP2B_LxvP_1	700	703	PF13499	0.629
DOC_PP4_FxxP_1	773	776	PF00568	0.435
DOC_USP7_MATH_1	206	210	PF00917	0.269
DOC_USP7_MATH_1	239	243	PF00917	0.419
DOC_USP7_MATH_1	306	310	PF00917	0.590
DOC_USP7_MATH_1	331	335	PF00917	0.588
DOC_USP7_MATH_1	336	340	PF00917	0.616
DOC_USP7_MATH_1	662	666	PF00917	0.542
DOC_USP7_MATH_1	82	86	PF00917	0.513
DOC_USP7_UBL2_3	663	667	PF12436	0.711
DOC_WW_Pin1_4	135	140	PF00397	0.346
DOC_WW_Pin1_4	298	303	PF00397	0.426
DOC_WW_Pin1_4	318	323	PF00397	0.473
DOC_WW_Pin1_4	332	337	PF00397	0.470
DOC_WW_Pin1_4	361	366	PF00397	0.619
DOC_WW_Pin1_4	389	394	PF00397	0.504
DOC_WW_Pin1_4	698	703	PF00397	0.775
DOC_WW_Pin1_4	766	771	PF00397	0.449
DOC_WW_Pin1_4	776	781	PF00397	0.438
LIG_14-3-3_CanoR_1	297	302	PF00244	0.469
LIG_14-3-3_CanoR_1	31	41	PF00244	0.238
LIG_14-3-3_CanoR_1	342	348	PF00244	0.512
LIG_14-3-3_CanoR_1	359	365	PF00244	0.504
LIG_14-3-3_CanoR_1	450	456	PF00244	0.317
LIG_14-3-3_CanoR_1	508	514	PF00244	0.294
LIG_14-3-3_CanoR_1	53	61	PF00244	0.699
LIG_14-3-3_CanoR_1	99	103	PF00244	0.260
LIG_Actin_WH2_2	37	55	PF00022	0.416
LIG_Actin_WH2_2	83	101	PF00022	0.513
LIG_Clathr_ClatBox_1	513	517	PF01394	0.411
LIG_EVH1_2	285	289	PF00568	0.395
LIG_FHA_1	208	214	PF00498	0.404
LIG_FHA_1	255	261	PF00498	0.516
LIG_FHA_1	298	304	PF00498	0.371
LIG_FHA_1	386	392	PF00498	0.373
LIG_FHA_1	532	538	PF00498	0.589
LIG_FHA_1	782	788	PF00498	0.523
LIG_FHA_2	129	135	PF00498	0.419
LIG_FHA_2	264	270	PF00498	0.448
LIG_FHA_2	361	367	PF00498	0.468
LIG_FHA_2	452	458	PF00498	0.304
LIG_FHA_2	495	501	PF00498	0.362
LIG_FHA_2	565	571	PF00498	0.634
LIG_FHA_2	712	718	PF00498	0.700
LIG_FHA_2	787	793	PF00498	0.525
LIG_FHA_2	99	105	PF00498	0.346
LIG_GBD_Chelix_1	42	50	PF00786	0.261
LIG_GBD_Chelix_1	622	630	PF00786	0.288
LIG_LIR_Apic_2	687	693	PF02991	0.707
LIG_LIR_Apic_2	771	776	PF02991	0.445
LIG_LIR_Gen_1	229	237	PF02991	0.346
LIG_LIR_Gen_1	476	486	PF02991	0.453
LIG_LIR_Gen_1	497	507	PF02991	0.275
LIG_LIR_Gen_1	578	589	PF02991	0.597
LIG_LIR_Gen_1	669	678	PF02991	0.594
LIG_LIR_LC3C_4	231	235	PF02991	0.419
LIG_LIR_Nem_3	229	233	PF02991	0.346
LIG_LIR_Nem_3	419	424	PF02991	0.392
LIG_LIR_Nem_3	47	52	PF02991	0.513
LIG_LIR_Nem_3	476	481	PF02991	0.461
LIG_LIR_Nem_3	497	502	PF02991	0.270
LIG_LIR_Nem_3	578	584	PF02991	0.590
LIG_LIR_Nem_3	609	615	PF02991	0.604
LIG_LIR_Nem_3	665	671	PF02991	0.606
LIG_LIR_Nem_3	672	677	PF02991	0.589
LIG_LIR_Nem_3	734	740	PF02991	0.648
LIG_LIR_Nem_3	755	761	PF02991	0.548
LIG_LIR_Nem_3	769	775	PF02991	0.446
LIG_LIR_Nem_3	777	781	PF02991	0.440
LIG_LIR_Nem_3	789	793	PF02991	0.324
LIG_MYND_3	311	315	PF01753	0.344
LIG_NRBOX	41	47	PF00104	0.261
LIG_NRBOX	86	92	PF00104	0.358
LIG_PCNA_TLS_4	568	575	PF02747	0.663
LIG_PCNA_yPIPBox_3	450	460	PF02747	0.427
LIG_PDZ_Class_3	789	794	PF00595	0.568
LIG_Pex14_1	400	404	PF04695	0.420
LIG_Pex14_2	474	478	PF04695	0.466
LIG_PTB_Apo_2	742	749	PF02174	0.411
LIG_Rb_pABgroove_1	493	501	PF01858	0.450
LIG_SH2_CRK	230	234	PF00017	0.346
LIG_SH2_CRK	427	431	PF00017	0.419
LIG_SH2_CRK	435	439	PF00017	0.378
LIG_SH2_CRK	499	503	PF00017	0.349
LIG_SH2_CRK	511	515	PF00017	0.467
LIG_SH2_CRK	612	616	PF00017	0.603
LIG_SH2_CRK	690	694	PF00017	0.633
LIG_SH2_GRB2like	426	429	PF00017	0.499
LIG_SH2_GRB2like	501	504	PF00017	0.289
LIG_SH2_NCK_1	125	129	PF00017	0.419
LIG_SH2_NCK_1	435	439	PF00017	0.270
LIG_SH2_NCK_1	594	598	PF00017	0.586
LIG_SH2_NCK_1	616	620	PF00017	0.486
LIG_SH2_NCK_1	690	694	PF00017	0.744
LIG_SH2_NCK_1	778	782	PF00017	0.517
LIG_SH2_SRC	125	128	PF00017	0.419
LIG_SH2_SRC	594	597	PF00017	0.664
LIG_SH2_STAP1	230	234	PF00017	0.346
LIG_SH2_STAP1	511	515	PF00017	0.261
LIG_SH2_STAP1	594	598	PF00017	0.586
LIG_SH2_STAP1	754	758	PF00017	0.438
LIG_SH2_STAT5	10	13	PF00017	0.563
LIG_SH2_STAT5	166	169	PF00017	0.260
LIG_SH2_STAT5	435	438	PF00017	0.392
LIG_SH2_STAT5	485	488	PF00017	0.373
LIG_SH2_STAT5	501	504	PF00017	0.397
LIG_SH2_STAT5	536	539	PF00017	0.625
LIG_SH2_STAT5	668	671	PF00017	0.592
LIG_SH2_STAT5	758	761	PF00017	0.443
LIG_SH2_STAT5	774	777	PF00017	0.433
LIG_SH3_2	12	17	PF14604	0.555
LIG_SH3_3	133	139	PF00018	0.419
LIG_SH3_3	279	285	PF00018	0.452
LIG_SH3_3	330	336	PF00018	0.564
LIG_SH3_3	441	447	PF00018	0.404
LIG_SH3_3	504	510	PF00018	0.387
LIG_SH3_3	656	662	PF00018	0.794
LIG_SH3_3	700	706	PF00018	0.697
LIG_SH3_3	717	723	PF00018	0.677
LIG_SH3_3	782	788	PF00018	0.443
LIG_SH3_3	9	15	PF00018	0.523
LIG_SUMO_SIM_anti_2	129	138	PF11976	0.419
LIG_SUMO_SIM_anti_2	512	517	PF11976	0.261
LIG_SUMO_SIM_anti_2	717	722	PF11976	0.574
LIG_SUMO_SIM_par_1	209	216	PF11976	0.336
LIG_SUMO_SIM_par_1	387	392	PF11976	0.368
LIG_SUMO_SIM_par_1	512	517	PF11976	0.411
LIG_TYR_ITIM	509	514	PF00017	0.419
LIG_TYR_ITIM	756	761	PF00017	0.543
LIG_WRC_WIRS_1	671	676	PF05994	0.588
MOD_CDK_SPxK_1	298	304	PF00069	0.371
MOD_CK1_1	209	215	PF00069	0.394
MOD_CK1_1	222	228	PF00069	0.282
MOD_CK1_1	242	248	PF00069	0.264
MOD_CK1_1	334	340	PF00069	0.573
MOD_CK1_1	364	370	PF00069	0.445
MOD_CK1_1	385	391	PF00069	0.433
MOD_CK1_1	416	422	PF00069	0.382
MOD_CK1_1	59	65	PF00069	0.706
MOD_CK1_1	608	614	PF00069	0.675
MOD_CK1_1	641	647	PF00069	0.658
MOD_CK1_1	701	707	PF00069	0.781
MOD_CK2_1	209	215	PF00069	0.260
MOD_CK2_1	360	366	PF00069	0.467
MOD_CK2_1	451	457	PF00069	0.438
MOD_CK2_1	564	570	PF00069	0.716
MOD_CK2_1	59	65	PF00069	0.706
MOD_CK2_1	644	650	PF00069	0.594
MOD_CK2_1	711	717	PF00069	0.608
MOD_CK2_1	98	104	PF00069	0.306
MOD_GlcNHglycan	215	220	PF01048	0.472
MOD_GlcNHglycan	27	30	PF01048	0.601
MOD_GlcNHglycan	275	278	PF01048	0.632
MOD_GlcNHglycan	306	309	PF01048	0.805
MOD_GlcNHglycan	338	341	PF01048	0.805
MOD_GlcNHglycan	384	387	PF01048	0.766
MOD_GlcNHglycan	46	49	PF01048	0.187
MOD_GlcNHglycan	528	531	PF01048	0.394
MOD_GlcNHglycan	640	643	PF01048	0.385
MOD_GlcNHglycan	650	654	PF01048	0.555
MOD_GlcNHglycan	664	667	PF01048	0.336
MOD_GlcNHglycan	84	87	PF01048	0.513
MOD_GlcNHglycan	93	96	PF01048	0.513
MOD_GSK3_1	215	222	PF00069	0.389
MOD_GSK3_1	263	270	PF00069	0.358
MOD_GSK3_1	306	313	PF00069	0.542
MOD_GSK3_1	323	330	PF00069	0.475
MOD_GSK3_1	331	338	PF00069	0.593
MOD_GSK3_1	360	367	PF00069	0.479
MOD_GSK3_1	385	392	PF00069	0.476
MOD_GSK3_1	408	415	PF00069	0.403
MOD_GSK3_1	52	59	PF00069	0.654
MOD_GSK3_1	644	651	PF00069	0.622
MOD_GSK3_1	662	669	PF00069	0.638
MOD_GSK3_1	698	705	PF00069	0.790
MOD_N-GLC_1	142	147	PF02516	0.546
MOD_N-GLC_1	219	224	PF02516	0.543
MOD_N-GLC_1	239	244	PF02516	0.383
MOD_NEK2_1	1	6	PF00069	0.548
MOD_NEK2_1	316	321	PF00069	0.491
MOD_NEK2_1	32	37	PF00069	0.346
MOD_NEK2_1	387	392	PF00069	0.510
MOD_NEK2_1	402	407	PF00069	0.449
MOD_NEK2_1	413	418	PF00069	0.444
MOD_NEK2_1	481	486	PF00069	0.370
MOD_NEK2_1	52	57	PF00069	0.519
MOD_NEK2_1	531	536	PF00069	0.578
MOD_NEK2_1	564	569	PF00069	0.646
MOD_NEK2_1	731	736	PF00069	0.654
MOD_NEK2_1	760	765	PF00069	0.451
MOD_NEK2_1	91	96	PF00069	0.459
MOD_NEK2_1	98	103	PF00069	0.375
MOD_NEK2_2	670	675	PF00069	0.587
MOD_PIKK_1	52	58	PF00454	0.578
MOD_PIKK_1	653	659	PF00454	0.728
MOD_PKA_1	188	194	PF00069	0.238
MOD_PKA_2	1	7	PF00069	0.547
MOD_PKA_2	167	173	PF00069	0.419
MOD_PKA_2	188	194	PF00069	0.238
MOD_PKA_2	267	273	PF00069	0.358
MOD_PKA_2	52	58	PF00069	0.681
MOD_PKA_2	526	532	PF00069	0.592
MOD_PKA_2	546	552	PF00069	0.505
MOD_PKA_2	59	65	PF00069	0.710
MOD_PKA_2	98	104	PF00069	0.260
MOD_PKB_1	380	388	PF00069	0.526
MOD_Plk_1	239	245	PF00069	0.238
MOD_Plk_1	409	415	PF00069	0.400
MOD_Plk_1	577	583	PF00069	0.595
MOD_Plk_2-3	577	583	PF00069	0.595
MOD_Plk_4	223	229	PF00069	0.339
MOD_Plk_4	242	248	PF00069	0.420
MOD_Plk_4	267	273	PF00069	0.384
MOD_Plk_4	285	291	PF00069	0.452
MOD_Plk_4	409	415	PF00069	0.400
MOD_Plk_4	416	422	PF00069	0.389
MOD_Plk_4	451	457	PF00069	0.307
MOD_Plk_4	481	487	PF00069	0.354
MOD_Plk_4	494	500	PF00069	0.292
MOD_Plk_4	509	515	PF00069	0.304
MOD_Plk_4	521	527	PF00069	0.467
MOD_Plk_4	577	583	PF00069	0.595
MOD_Plk_4	768	774	PF00069	0.450
MOD_ProDKin_1	135	141	PF00069	0.346
MOD_ProDKin_1	298	304	PF00069	0.437
MOD_ProDKin_1	318	324	PF00069	0.476
MOD_ProDKin_1	332	338	PF00069	0.471
MOD_ProDKin_1	361	367	PF00069	0.621
MOD_ProDKin_1	389	395	PF00069	0.498
MOD_ProDKin_1	698	704	PF00069	0.775
MOD_ProDKin_1	766	772	PF00069	0.451
MOD_ProDKin_1	776	782	PF00069	0.439
TRG_DiLeu_BaEn_1	476	481	PF01217	0.462
TRG_ENDOCYTIC_2	230	233	PF00928	0.346
TRG_ENDOCYTIC_2	427	430	PF00928	0.416
TRG_ENDOCYTIC_2	435	438	PF00928	0.376
TRG_ENDOCYTIC_2	499	502	PF00928	0.345
TRG_ENDOCYTIC_2	511	514	PF00928	0.467
TRG_ENDOCYTIC_2	594	597	PF00928	0.591
TRG_ENDOCYTIC_2	612	615	PF00928	0.603
TRG_ENDOCYTIC_2	616	619	PF00928	0.592
TRG_ENDOCYTIC_2	671	674	PF00928	0.586
TRG_ENDOCYTIC_2	754	757	PF00928	0.438
TRG_ENDOCYTIC_2	758	761	PF00928	0.467
TRG_ENDOCYTIC_2	778	781	PF00928	0.281
TRG_ER_diArg_1	1	3	PF00400	0.549
TRG_ER_diArg_1	188	190	PF00400	0.350
TRG_ER_diArg_1	533	536	PF00400	0.608
TRG_ER_diArg_1	58	61	PF00400	0.711
TRG_ER_diArg_1	592	594	PF00400	0.591
TRG_ER_diArg_1	67	70	PF00400	0.672
TRG_NLS_Bipartite_1	53	72	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A2	Leptomonas seymouri	57%	95%
A0A3Q8IMW0	Leishmania donovani	83%	100%
A4I9J7	Leishmania infantum	83%	100%
E9B4J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3I1	Leishmania major	81%	100%