LeishMANIAdb
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RIIa domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RIIa domain-containing protein
Gene product:
Regulatory subunit of type II PKA R-subunit, putative
Species:
Leishmania braziliensis
UniProt:
A4HAE4_LEIBR
TriTrypDb:
LbrM.20.0270 , LBRM2903_200005600
Length:
90

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAE4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAE4

Putative motif mimicry

Leishmania From To Domain/Motif Score
LIG_14-3-3_CanoR_1 62 68 PF00244 0.330
LIG_BIR_II_1 1 5 PF00653 0.617
LIG_BRCT_BRCA1_1 80 84 PF00533 0.444
LIG_FHA_1 4 10 PF00498 0.634
LIG_FHA_2 12 18 PF00498 0.515
LIG_PCNA_yPIPBox_3 54 64 PF02747 0.453
LIG_SH2_STAT5 45 48 PF00017 0.478
LIG_SH2_STAT5 78 81 PF00017 0.444
LIG_SH3_3 65 71 PF00018 0.351
LIG_TRAF2_1 55 58 PF00917 0.548
MOD_CK2_1 11 17 PF00069 0.503
MOD_CK2_1 63 69 PF00069 0.442
MOD_PIKK_1 63 69 PF00454 0.408
MOD_PIKK_1 73 79 PF00454 0.398
MOD_Plk_1 26 32 PF00069 0.476
MOD_Plk_4 70 76 PF00069 0.233
TRG_DiLeu_BaEn_4 26 32 PF01217 0.501
TRG_Pf-PMV_PEXEL_1 62 67 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBU2 Leptomonas seymouri 67% 95%
A0A1X0P8T9 Trypanosomatidae 46% 72%
A0A3S7X7D0 Leishmania donovani 80% 75%
A4I9J6 Leishmania infantum 80% 75%
D0A1V5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 74%
E9B4J4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 85%
Q4Q3I2 Leishmania major 82% 100%
V5BMB7 Trypanosoma cruzi 46% 73%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS