Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAE3_LEIBR

TriTrypDb:

LbrM.20.0260 , LBRM2903_200005700

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.503
CLV_C14_Caspase3-7	179	183	PF00656	0.512
CLV_C14_Caspase3-7	308	312	PF00656	0.581
CLV_NRD_NRD_1	137	139	PF00675	0.483
CLV_NRD_NRD_1	173	175	PF00675	0.407
CLV_NRD_NRD_1	286	288	PF00675	0.460
CLV_NRD_NRD_1	301	303	PF00675	0.713
CLV_NRD_NRD_1	366	368	PF00675	0.511
CLV_NRD_NRD_1	38	40	PF00675	0.772
CLV_PCSK_KEX2_1	173	175	PF00082	0.430
CLV_PCSK_KEX2_1	286	288	PF00082	0.460
CLV_PCSK_KEX2_1	301	303	PF00082	0.697
CLV_PCSK_KEX2_1	316	318	PF00082	0.448
CLV_PCSK_KEX2_1	366	368	PF00082	0.492
CLV_PCSK_KEX2_1	38	40	PF00082	0.772
CLV_PCSK_KEX2_1	54	56	PF00082	0.522
CLV_PCSK_KEX2_1	72	74	PF00082	0.503
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.610
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.515
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.503
CLV_PCSK_SKI1_1	138	142	PF00082	0.597
CLV_Separin_Metazoa	150	154	PF03568	0.501
DOC_CKS1_1	101	106	PF01111	0.654
DOC_CKS1_1	203	208	PF01111	0.511
DOC_CKS1_1	249	254	PF01111	0.546
DOC_USP7_MATH_1	181	185	PF00917	0.347
DOC_USP7_MATH_1	266	270	PF00917	0.523
DOC_USP7_MATH_1	29	33	PF00917	0.781
DOC_USP7_MATH_2	2	8	PF00917	0.667
DOC_WW_Pin1_4	100	105	PF00397	0.634
DOC_WW_Pin1_4	107	112	PF00397	0.628
DOC_WW_Pin1_4	197	202	PF00397	0.596
DOC_WW_Pin1_4	204	209	PF00397	0.506
DOC_WW_Pin1_4	244	249	PF00397	0.686
DOC_WW_Pin1_4	276	281	PF00397	0.625
LIG_14-3-3_CanoR_1	138	147	PF00244	0.516
LIG_14-3-3_CanoR_1	15	24	PF00244	0.649
LIG_14-3-3_CanoR_1	242	248	PF00244	0.719
LIG_14-3-3_CanoR_1	349	356	PF00244	0.472
LIG_Clathr_ClatBox_1	295	299	PF01394	0.625
LIG_eIF4E_1	290	296	PF01652	0.627
LIG_EVH1_1	277	281	PF00568	0.543
LIG_FHA_1	198	204	PF00498	0.617
LIG_FHA_2	64	70	PF00498	0.636
LIG_HCF-1_HBM_1	19	22	PF13415	0.504
LIG_LIR_Apic_2	99	104	PF02991	0.644
LIG_LIR_Gen_1	161	168	PF02991	0.487
LIG_LIR_Nem_3	161	165	PF02991	0.536
LIG_LIR_Nem_3	99	105	PF02991	0.648
LIG_SH2_CRK	102	106	PF00017	0.655
LIG_SH2_CRK	162	166	PF00017	0.494
LIG_SH2_CRK	290	294	PF00017	0.666
LIG_SH2_NCK_1	162	166	PF00017	0.587
LIG_SH2_NCK_1	290	294	PF00017	0.626
LIG_SH2_SRC	180	183	PF00017	0.642
LIG_SH2_STAP1	22	26	PF00017	0.546
LIG_SH2_STAP1	267	271	PF00017	0.634
LIG_SH2_STAT5	102	105	PF00017	0.658
LIG_SH3_2	249	254	PF14604	0.635
LIG_SH3_3	246	252	PF00018	0.553
LIG_SH3_3	275	281	PF00018	0.568
LIG_SH3_3	82	88	PF00018	0.662
LIG_SH3_CIN85_PxpxPR_1	111	116	PF14604	0.653
LIG_TRAF2_1	176	179	PF00917	0.609
LIG_TRAF2_1	326	329	PF00917	0.614
LIG_TRAF2_1	362	365	PF00917	0.545
LIG_WW_3	222	226	PF00397	0.575
MOD_CDK_SPxK_1	248	254	PF00069	0.545
MOD_CDK_SPxxK_3	100	107	PF00069	0.656
MOD_CDK_SPxxK_3	109	116	PF00069	0.690
MOD_CK1_1	163	169	PF00069	0.534
MOD_CK1_1	231	237	PF00069	0.734
MOD_CK1_1	322	328	PF00069	0.510
MOD_CK1_1	376	382	PF00069	0.556
MOD_CK2_1	244	250	PF00069	0.591
MOD_CK2_1	359	365	PF00069	0.665
MOD_CK2_1	63	69	PF00069	0.550
MOD_Cter_Amidation	36	39	PF01082	0.624
MOD_DYRK1A_RPxSP_1	244	248	PF00069	0.593
MOD_GlcNHglycan	262	266	PF01048	0.655
MOD_GlcNHglycan	272	275	PF01048	0.743
MOD_GlcNHglycan	321	324	PF01048	0.558
MOD_GlcNHglycan	4	9	PF01048	0.752
MOD_GSK3_1	126	133	PF00069	0.573
MOD_GSK3_1	160	167	PF00069	0.497
MOD_GSK3_1	244	251	PF00069	0.709
MOD_GSK3_1	266	273	PF00069	0.659
MOD_GSK3_1	324	331	PF00069	0.713
MOD_GSK3_1	373	380	PF00069	0.511
MOD_GSK3_1	77	84	PF00069	0.655
MOD_GSK3_1	96	103	PF00069	0.628
MOD_N-GLC_1	126	131	PF02516	0.629
MOD_N-GLC_1	29	34	PF02516	0.735
MOD_N-GLC_1	47	52	PF02516	0.574
MOD_NEK2_1	377	382	PF00069	0.423
MOD_NEK2_1	96	101	PF00069	0.454
MOD_PIKK_1	225	231	PF00454	0.624
MOD_PIKK_1	324	330	PF00454	0.663
MOD_PK_1	81	87	PF00069	0.541
MOD_PKA_2	14	20	PF00069	0.722
MOD_PKA_2	243	249	PF00069	0.681
MOD_PKA_2	365	371	PF00069	0.527
MOD_PKB_1	317	325	PF00069	0.635
MOD_Plk_1	126	132	PF00069	0.375
MOD_Plk_1	160	166	PF00069	0.541
MOD_Plk_1	267	273	PF00069	0.675
MOD_Plk_1	359	365	PF00069	0.376
MOD_Plk_4	160	166	PF00069	0.485
MOD_Plk_4	291	297	PF00069	0.627
MOD_Plk_4	96	102	PF00069	0.652
MOD_ProDKin_1	100	106	PF00069	0.636
MOD_ProDKin_1	107	113	PF00069	0.629
MOD_ProDKin_1	197	203	PF00069	0.595
MOD_ProDKin_1	204	210	PF00069	0.504
MOD_ProDKin_1	244	250	PF00069	0.686
MOD_ProDKin_1	276	282	PF00069	0.621
MOD_SUMO_for_1	140	143	PF00179	0.488
MOD_SUMO_rev_2	163	172	PF00179	0.446
MOD_SUMO_rev_2	50	56	PF00179	0.586
TRG_DiLeu_BaEn_2	328	334	PF01217	0.619
TRG_DiLeu_BaEn_2	91	97	PF01217	0.455
TRG_ENDOCYTIC_2	102	105	PF00928	0.651
TRG_ENDOCYTIC_2	162	165	PF00928	0.530
TRG_ER_diArg_1	115	118	PF00400	0.547
TRG_ER_diArg_1	173	175	PF00400	0.430
TRG_ER_diArg_1	301	304	PF00400	0.710
TRG_NLS_Bipartite_1	301	320	PF00514	0.585
TRG_NLS_MonoExtC_3	137	143	PF00514	0.486
TRG_NLS_MonoExtN_4	136	142	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK05	Leptomonas seymouri	58%	92%
A0A1X0P9W7	Trypanosomatidae	37%	100%
A0A3R7K419	Trypanosoma rangeli	33%	98%
A0A3S5H7V7	Leishmania donovani	82%	100%
A4I9J5	Leishmania infantum	82%	100%
E9B4J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3I3	Leishmania major	80%	100%
V5B266	Trypanosoma cruzi	33%	100%