Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HAE2_LEIBR

TriTrypDb:

LbrM.20.0250 , LBRM2903_200005800

Length:

1322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	2
GO:0042981	regulation of apoptotic process	6	2
GO:0043067	regulation of programmed cell death	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.635
CLV_C14_Caspase3-7	470	474	PF00656	0.679
CLV_C14_Caspase3-7	572	576	PF00656	0.452
CLV_NRD_NRD_1	1195	1197	PF00675	0.433
CLV_NRD_NRD_1	1239	1241	PF00675	0.609
CLV_NRD_NRD_1	1289	1291	PF00675	0.585
CLV_NRD_NRD_1	284	286	PF00675	0.691
CLV_NRD_NRD_1	301	303	PF00675	0.700
CLV_NRD_NRD_1	331	333	PF00675	0.647
CLV_NRD_NRD_1	367	369	PF00675	0.734
CLV_NRD_NRD_1	52	54	PF00675	0.407
CLV_NRD_NRD_1	639	641	PF00675	0.662
CLV_NRD_NRD_1	649	651	PF00675	0.534
CLV_NRD_NRD_1	655	657	PF00675	0.460
CLV_PCSK_KEX2_1	1060	1062	PF00082	0.702
CLV_PCSK_KEX2_1	114	116	PF00082	0.460
CLV_PCSK_KEX2_1	1195	1197	PF00082	0.433
CLV_PCSK_KEX2_1	1239	1241	PF00082	0.612
CLV_PCSK_KEX2_1	146	148	PF00082	0.657
CLV_PCSK_KEX2_1	284	286	PF00082	0.691
CLV_PCSK_KEX2_1	301	303	PF00082	0.488
CLV_PCSK_KEX2_1	331	333	PF00082	0.647
CLV_PCSK_KEX2_1	367	369	PF00082	0.734
CLV_PCSK_KEX2_1	52	54	PF00082	0.520
CLV_PCSK_KEX2_1	639	641	PF00082	0.716
CLV_PCSK_KEX2_1	657	659	PF00082	0.397
CLV_PCSK_PC1ET2_1	1060	1062	PF00082	0.702
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.419
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.657
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.457
CLV_PCSK_PC7_1	635	641	PF00082	0.720
CLV_PCSK_SKI1_1	1028	1032	PF00082	0.494
CLV_PCSK_SKI1_1	115	119	PF00082	0.397
CLV_PCSK_SKI1_1	1195	1199	PF00082	0.475
CLV_PCSK_SKI1_1	1252	1256	PF00082	0.663
CLV_PCSK_SKI1_1	180	184	PF00082	0.537
CLV_PCSK_SKI1_1	193	197	PF00082	0.641
CLV_PCSK_SKI1_1	38	42	PF00082	0.639
CLV_PCSK_SKI1_1	545	549	PF00082	0.541
CLV_PCSK_SKI1_1	560	564	PF00082	0.578
CLV_PCSK_SKI1_1	593	597	PF00082	0.403
DEG_APCC_DBOX_1	1023	1031	PF00400	0.431
DEG_APCC_DBOX_1	1310	1318	PF00400	0.572
DEG_APCC_DBOX_1	358	366	PF00400	0.608
DEG_APCC_DBOX_1	697	705	PF00400	0.653
DEG_Nend_UBRbox_3	1	3	PF02207	0.401
DEG_SPOP_SBC_1	104	108	PF00917	0.742
DEG_SPOP_SBC_1	294	298	PF00917	0.764
DOC_CYCLIN_RxL_1	1024	1036	PF00134	0.423
DOC_CYCLIN_RxL_1	144	154	PF00134	0.664
DOC_MAPK_gen_1	1216	1224	PF00069	0.444
DOC_MAPK_gen_1	146	153	PF00069	0.675
DOC_MAPK_gen_1	231	239	PF00069	0.410
DOC_MAPK_gen_1	79	88	PF00069	0.386
DOC_MAPK_MEF2A_6	1218	1226	PF00069	0.437
DOC_MAPK_MEF2A_6	146	153	PF00069	0.627
DOC_MAPK_MEF2A_6	809	817	PF00069	0.356
DOC_MAPK_NFAT4_5	146	154	PF00069	0.628
DOC_USP7_MATH_1	10	14	PF00917	0.511
DOC_USP7_MATH_1	102	106	PF00917	0.452
DOC_USP7_MATH_1	1064	1068	PF00917	0.703
DOC_USP7_MATH_1	1140	1144	PF00917	0.668
DOC_USP7_MATH_1	1225	1229	PF00917	0.669
DOC_USP7_MATH_1	294	298	PF00917	0.763
DOC_USP7_MATH_1	526	530	PF00917	0.733
DOC_USP7_MATH_1	537	541	PF00917	0.489
DOC_USP7_MATH_1	692	696	PF00917	0.425
DOC_USP7_MATH_1	827	831	PF00917	0.557
DOC_USP7_MATH_1	89	93	PF00917	0.611
DOC_USP7_MATH_1	974	978	PF00917	0.496
DOC_USP7_UBL2_3	43	47	PF12436	0.543
DOC_WW_Pin1_4	305	310	PF00397	0.551
DOC_WW_Pin1_4	790	795	PF00397	0.763
DOC_WW_Pin1_4	891	896	PF00397	0.551
LIG_14-3-3_CanoR_1	1195	1201	PF00244	0.625
LIG_14-3-3_CanoR_1	1207	1215	PF00244	0.570
LIG_14-3-3_CanoR_1	1252	1261	PF00244	0.660
LIG_14-3-3_CanoR_1	1290	1300	PF00244	0.433
LIG_14-3-3_CanoR_1	180	189	PF00244	0.488
LIG_14-3-3_CanoR_1	266	272	PF00244	0.473
LIG_14-3-3_CanoR_1	380	384	PF00244	0.566
LIG_14-3-3_CanoR_1	52	58	PF00244	0.615
LIG_14-3-3_CanoR_1	582	589	PF00244	0.641
LIG_14-3-3_CanoR_1	601	605	PF00244	0.528
LIG_14-3-3_CanoR_1	613	620	PF00244	0.504
LIG_14-3-3_CanoR_1	629	637	PF00244	0.656
LIG_14-3-3_CanoR_1	874	881	PF00244	0.675
LIG_14-3-3_CanoR_1	9	19	PF00244	0.562
LIG_14-3-3_CanoR_1	938	946	PF00244	0.440
LIG_14-3-3_CanoR_1	997	1003	PF00244	0.393
LIG_Actin_WH2_2	1219	1235	PF00022	0.678
LIG_Actin_WH2_2	146	163	PF00022	0.424
LIG_Actin_WH2_2	906	924	PF00022	0.353
LIG_Actin_WH2_2	982	999	PF00022	0.607
LIG_BIR_III_4	846	850	PF00653	0.568
LIG_CaM_IQ_9	344	359	PF13499	0.403
LIG_Clathr_ClatBox_1	842	846	PF01394	0.558
LIG_deltaCOP1_diTrp_1	1103	1108	PF00928	0.663
LIG_FHA_1	1253	1259	PF00498	0.654
LIG_FHA_1	287	293	PF00498	0.457
LIG_FHA_1	397	403	PF00498	0.498
LIG_FHA_1	435	441	PF00498	0.571
LIG_FHA_1	446	452	PF00498	0.621
LIG_FHA_1	456	462	PF00498	0.648
LIG_FHA_1	791	797	PF00498	0.734
LIG_FHA_1	83	89	PF00498	0.440
LIG_FHA_1	853	859	PF00498	0.367
LIG_FHA_1	922	928	PF00498	0.328
LIG_FHA_2	1034	1040	PF00498	0.643
LIG_FHA_2	1251	1257	PF00498	0.636
LIG_FHA_2	1292	1298	PF00498	0.428
LIG_FHA_2	167	173	PF00498	0.625
LIG_FHA_2	181	187	PF00498	0.391
LIG_FHA_2	23	29	PF00498	0.351
LIG_FHA_2	230	236	PF00498	0.651
LIG_FHA_2	268	274	PF00498	0.673
LIG_FHA_2	444	450	PF00498	0.681
LIG_FHA_2	859	865	PF00498	0.637
LIG_GBD_Chelix_1	1200	1208	PF00786	0.656
LIG_GBD_Chelix_1	401	409	PF00786	0.655
LIG_LIR_Gen_1	1052	1062	PF02991	0.425
LIG_LIR_Gen_1	25	33	PF02991	0.354
LIG_LIR_Gen_1	459	468	PF02991	0.445
LIG_LIR_Gen_1	856	866	PF02991	0.633
LIG_LIR_Nem_3	1052	1058	PF02991	0.412
LIG_LIR_Nem_3	1106	1111	PF02991	0.429
LIG_LIR_Nem_3	22	26	PF02991	0.445
LIG_LIR_Nem_3	459	465	PF02991	0.488
LIG_LIR_Nem_3	856	862	PF02991	0.627
LIG_LYPXL_yS_3	23	26	PF13949	0.440
LIG_MYND_1	794	798	PF01753	0.760
LIG_NRBOX	1161	1167	PF00104	0.433
LIG_NRBOX	1313	1319	PF00104	0.567
LIG_NRBOX	861	867	PF00104	0.641
LIG_PCNA_yPIPBox_3	938	951	PF02747	0.309
LIG_Pex14_1	687	691	PF04695	0.579
LIG_RPA_C_Fungi	193	205	PF08784	0.429
LIG_SH2_STAP1	1055	1059	PF00017	0.586
LIG_SH2_STAT5	930	933	PF00017	0.317
LIG_Sin3_3	948	955	PF02671	0.358
LIG_SUMO_SIM_anti_2	860	867	PF11976	0.640
LIG_SUMO_SIM_par_1	217	223	PF11976	0.540
LIG_SUMO_SIM_par_1	699	706	PF11976	0.656
LIG_SUMO_SIM_par_1	860	867	PF11976	0.387
LIG_TRAF2_1	1036	1039	PF00917	0.637
LIG_TRAF2_1	1047	1050	PF00917	0.454
LIG_TRAF2_1	1135	1138	PF00917	0.713
LIG_TRAF2_1	1147	1150	PF00917	0.696
LIG_TRAF2_1	1210	1213	PF00917	0.533
LIG_TRAF2_1	1228	1231	PF00917	0.557
LIG_TRAF2_1	270	273	PF00917	0.422
LIG_TRAF2_1	439	442	PF00917	0.548
LIG_TRAF2_1	467	470	PF00917	0.645
LIG_TRAF2_1	485	488	PF00917	0.396
LIG_TRAF2_1	760	763	PF00917	0.559
LIG_TRAF2_1	956	959	PF00917	0.431
LIG_UBA3_1	61	69	PF00899	0.500
LIG_UBA3_1	701	705	PF00899	0.656
LIG_WRC_WIRS_1	1317	1322	PF05994	0.645
LIG_WRC_WIRS_1	507	512	PF05994	0.495
MOD_CK1_1	105	111	PF00069	0.732
MOD_CK1_1	1217	1223	PF00069	0.444
MOD_CK1_1	1295	1301	PF00069	0.439
MOD_CK1_1	1316	1322	PF00069	0.649
MOD_CK1_1	296	302	PF00069	0.782
MOD_CK1_1	305	311	PF00069	0.725
MOD_CK1_1	529	535	PF00069	0.735
MOD_CK1_1	747	753	PF00069	0.669
MOD_CK1_1	790	796	PF00069	0.762
MOD_CK1_1	875	881	PF00069	0.702
MOD_CK1_1	894	900	PF00069	0.408
MOD_CK1_1	957	963	PF00069	0.515
MOD_CK2_1	1033	1039	PF00069	0.647
MOD_CK2_1	106	112	PF00069	0.391
MOD_CK2_1	1064	1070	PF00069	0.705
MOD_CK2_1	1167	1173	PF00069	0.534
MOD_CK2_1	1206	1212	PF00069	0.626
MOD_CK2_1	1225	1231	PF00069	0.445
MOD_CK2_1	1250	1256	PF00069	0.644
MOD_CK2_1	1291	1297	PF00069	0.426
MOD_CK2_1	1316	1322	PF00069	0.548
MOD_CK2_1	180	186	PF00069	0.593
MOD_CK2_1	22	28	PF00069	0.437
MOD_CK2_1	229	235	PF00069	0.646
MOD_CK2_1	267	273	PF00069	0.648
MOD_CK2_1	53	59	PF00069	0.624
MOD_CK2_1	646	652	PF00069	0.692
MOD_CK2_1	679	685	PF00069	0.613
MOD_CK2_1	691	697	PF00069	0.595
MOD_CK2_1	719	725	PF00069	0.691
MOD_CK2_1	864	870	PF00069	0.392
MOD_CK2_1	886	892	PF00069	0.520
MOD_CK2_1	89	95	PF00069	0.606
MOD_GlcNHglycan	1150	1153	PF01048	0.757
MOD_GlcNHglycan	1169	1172	PF01048	0.340
MOD_GlcNHglycan	242	245	PF01048	0.667
MOD_GlcNHglycan	298	301	PF01048	0.642
MOD_GlcNHglycan	310	313	PF01048	0.533
MOD_GlcNHglycan	320	323	PF01048	0.535
MOD_GlcNHglycan	5	8	PF01048	0.649
MOD_GlcNHglycan	615	618	PF01048	0.607
MOD_GlcNHglycan	789	793	PF01048	0.657
MOD_GlcNHglycan	798	801	PF01048	0.595
MOD_GlcNHglycan	803	807	PF01048	0.515
MOD_GlcNHglycan	846	850	PF01048	0.529
MOD_GlcNHglycan	878	881	PF01048	0.701
MOD_GlcNHglycan	961	964	PF01048	0.573
MOD_GlcNHglycan	986	989	PF01048	0.580
MOD_GSK3_1	10	17	PF00069	0.380
MOD_GSK3_1	100	107	PF00069	0.474
MOD_GSK3_1	1049	1056	PF00069	0.636
MOD_GSK3_1	113	120	PF00069	0.476
MOD_GSK3_1	1207	1214	PF00069	0.590
MOD_GSK3_1	1291	1298	PF00069	0.466
MOD_GSK3_1	166	173	PF00069	0.616
MOD_GSK3_1	498	505	PF00069	0.573
MOD_GSK3_1	516	523	PF00069	0.620
MOD_GSK3_1	872	879	PF00069	0.696
MOD_GSK3_1	90	97	PF00069	0.623
MOD_GSK3_1	950	957	PF00069	0.466
MOD_N-GLC_1	1292	1297	PF02516	0.577
MOD_NEK2_1	1165	1170	PF00069	0.564
MOD_NEK2_1	1265	1270	PF00069	0.619
MOD_NEK2_1	153	158	PF00069	0.590
MOD_NEK2_1	229	234	PF00069	0.556
MOD_NEK2_1	253	258	PF00069	0.693
MOD_NEK2_1	323	328	PF00069	0.642
MOD_NEK2_1	719	724	PF00069	0.580
MOD_NEK2_1	744	749	PF00069	0.678
MOD_NEK2_1	921	926	PF00069	0.325
MOD_PIKK_1	1022	1028	PF00454	0.576
MOD_PIKK_1	1141	1147	PF00454	0.781
MOD_PIKK_1	1157	1163	PF00454	0.430
MOD_PIKK_1	1178	1184	PF00454	0.625
MOD_PIKK_1	1265	1271	PF00454	0.448
MOD_PIKK_1	180	186	PF00454	0.447
MOD_PIKK_1	229	235	PF00454	0.646
MOD_PIKK_1	286	292	PF00454	0.472
MOD_PIKK_1	302	308	PF00454	0.741
MOD_PIKK_1	416	422	PF00454	0.452
MOD_PIKK_1	498	504	PF00454	0.548
MOD_PIKK_1	581	587	PF00454	0.635
MOD_PIKK_1	629	635	PF00454	0.647
MOD_PIKK_1	886	892	PF00454	0.449
MOD_PIKK_1	996	1002	PF00454	0.487
MOD_PK_1	1196	1202	PF00069	0.637
MOD_PK_1	53	59	PF00069	0.624
MOD_PKA_1	331	337	PF00069	0.497
MOD_PKA_2	1206	1212	PF00069	0.707
MOD_PKA_2	1217	1223	PF00069	0.515
MOD_PKA_2	160	166	PF00069	0.672
MOD_PKA_2	210	216	PF00069	0.670
MOD_PKA_2	331	337	PF00069	0.497
MOD_PKA_2	379	385	PF00069	0.636
MOD_PKA_2	581	587	PF00069	0.635
MOD_PKA_2	600	606	PF00069	0.527
MOD_PKA_2	612	618	PF00069	0.404
MOD_PKA_2	787	793	PF00069	0.680
MOD_PKA_2	875	881	PF00069	0.702
MOD_PKA_2	921	927	PF00069	0.376
MOD_PKA_2	937	943	PF00069	0.455
MOD_PKA_2	996	1002	PF00069	0.487
MOD_PKB_1	786	794	PF00069	0.723
MOD_PKB_1	874	882	PF00069	0.447
MOD_Plk_1	1211	1217	PF00069	0.719
MOD_Plk_1	1292	1298	PF00069	0.579
MOD_Plk_1	498	504	PF00069	0.364
MOD_Plk_1	535	541	PF00069	0.503
MOD_Plk_1	679	685	PF00069	0.697
MOD_Plk_2-3	1250	1256	PF00069	0.672
MOD_Plk_2-3	22	28	PF00069	0.350
MOD_Plk_2-3	443	449	PF00069	0.705
MOD_Plk_2-3	954	960	PF00069	0.582
MOD_Plk_4	1196	1202	PF00069	0.578
MOD_Plk_4	1313	1319	PF00069	0.669
MOD_Plk_4	210	216	PF00069	0.670
MOD_Plk_4	22	28	PF00069	0.383
MOD_Plk_4	323	329	PF00069	0.668
MOD_Plk_4	834	840	PF00069	0.298
MOD_Plk_4	858	864	PF00069	0.634
MOD_ProDKin_1	305	311	PF00069	0.547
MOD_ProDKin_1	790	796	PF00069	0.762
MOD_ProDKin_1	891	897	PF00069	0.553
MOD_SUMO_rev_2	106	116	PF00179	0.452
MOD_SUMO_rev_2	1116	1122	PF00179	0.756
MOD_SUMO_rev_2	1217	1225	PF00179	0.595
MOD_SUMO_rev_2	1228	1235	PF00179	0.566
MOD_SUMO_rev_2	42	49	PF00179	0.388
MOD_SUMO_rev_2	459	468	PF00179	0.681
MOD_SUMO_rev_2	892	902	PF00179	0.710
TRG_DiLeu_BaEn_1	113	118	PF01217	0.538
TRG_DiLeu_BaEn_1	488	493	PF01217	0.450
TRG_DiLeu_BaEn_1	499	504	PF01217	0.337
TRG_DiLeu_BaEn_1	697	702	PF01217	0.650
TRG_DiLeu_BaEn_4	353	359	PF01217	0.560
TRG_DiLeu_BaEn_4	442	448	PF01217	0.696
TRG_DiLeu_LyEn_5	697	702	PF01217	0.397
TRG_ENDOCYTIC_2	1055	1058	PF00928	0.432
TRG_ENDOCYTIC_2	23	26	PF00928	0.440
TRG_ENDOCYTIC_2	27	30	PF00928	0.449
TRG_ER_diArg_1	1194	1196	PF00400	0.436
TRG_ER_diArg_1	1215	1218	PF00400	0.708
TRG_ER_diArg_1	330	332	PF00400	0.466
TRG_ER_diArg_1	349	352	PF00400	0.500
TRG_ER_diArg_1	51	53	PF00400	0.382
TRG_ER_diArg_1	639	641	PF00400	0.646
TRG_ER_diArg_1	655	658	PF00400	0.401
TRG_ER_diArg_1	873	876	PF00400	0.443
TRG_NES_CRM1_1	979	994	PF08389	0.350
TRG_Pf-PMV_PEXEL_1	1252	1256	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	831	835	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	929	933	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H4	Leptomonas seymouri	42%	93%
A0A3Q8IF73	Leishmania donovani	76%	99%
A4I9J4	Leishmania infantum	76%	99%
E9B4J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q3I4	Leishmania major	74%	100%