IFT81_CH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 81, putative

Species:

Leishmania braziliensis

UniProt:

A4HAE1_LEIBR

TriTrypDb:

LbrM.20.0240 , LBRM2903_200005900

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0030992	intraciliary transport particle B	2	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0031514	motile cilium	5	2

Expansion

Sequence features

A4HAE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAE1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0010970	transport along microtubule	4	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0030705	cytoskeleton-dependent intracellular transport	4	12
GO:0031503	protein-containing complex localization	2	12
GO:0042073	intraciliary transport	3	12
GO:0044782	cilium organization	5	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0099111	microtubule-based transport	4	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:0035721	intraciliary retrograde transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.391
CLV_C14_Caspase3-7	152	156	PF00656	0.319
CLV_C14_Caspase3-7	280	284	PF00656	0.411
CLV_NRD_NRD_1	199	201	PF00675	0.453
CLV_NRD_NRD_1	266	268	PF00675	0.479
CLV_NRD_NRD_1	278	280	PF00675	0.302
CLV_NRD_NRD_1	291	293	PF00675	0.399
CLV_NRD_NRD_1	339	341	PF00675	0.520
CLV_NRD_NRD_1	378	380	PF00675	0.407
CLV_PCSK_KEX2_1	140	142	PF00082	0.248
CLV_PCSK_KEX2_1	199	201	PF00082	0.481
CLV_PCSK_KEX2_1	266	268	PF00082	0.468
CLV_PCSK_KEX2_1	278	280	PF00082	0.302
CLV_PCSK_KEX2_1	291	293	PF00082	0.399
CLV_PCSK_KEX2_1	605	607	PF00082	0.549
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.248
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.459
CLV_PCSK_SKI1_1	165	169	PF00082	0.560
CLV_PCSK_SKI1_1	175	179	PF00082	0.217
CLV_PCSK_SKI1_1	189	193	PF00082	0.438
CLV_PCSK_SKI1_1	229	233	PF00082	0.378
CLV_PCSK_SKI1_1	291	295	PF00082	0.477
CLV_PCSK_SKI1_1	434	438	PF00082	0.445
CLV_PCSK_SKI1_1	671	675	PF00082	0.394
DEG_APCC_DBOX_1	440	448	PF00400	0.440
DEG_APCC_DBOX_1	526	534	PF00400	0.405
DEG_APCC_DBOX_1	57	65	PF00400	0.324
DEG_SCF_FBW7_2	80	87	PF00400	0.228
DOC_ANK_TNKS_1	278	285	PF00023	0.414
DOC_CKS1_1	81	86	PF01111	0.228
DOC_MAPK_gen_1	209	218	PF00069	0.293
DOC_MAPK_gen_1	338	348	PF00069	0.454
DOC_MAPK_gen_1	592	600	PF00069	0.509
DOC_MAPK_MEF2A_6	211	220	PF00069	0.279
DOC_PP1_RVXF_1	660	667	PF00149	0.468
DOC_PP1_RVXF_1	89	96	PF00149	0.308
DOC_PP2B_LxvP_1	151	154	PF13499	0.405
DOC_PP4_FxxP_1	147	150	PF00568	0.391
DOC_PP4_FxxP_1	192	195	PF00568	0.516
DOC_USP7_MATH_1	259	263	PF00917	0.475
DOC_USP7_MATH_1	617	621	PF00917	0.404
DOC_USP7_MATH_2	309	315	PF00917	0.477
DOC_WW_Pin1_4	2	7	PF00397	0.611
DOC_WW_Pin1_4	80	85	PF00397	0.270
LIG_14-3-3_CanoR_1	266	274	PF00244	0.443
LIG_14-3-3_CanoR_1	46	51	PF00244	0.248
LIG_14-3-3_CanoR_1	541	547	PF00244	0.394
LIG_14-3-3_CanoR_1	611	617	PF00244	0.362
LIG_Actin_WH2_2	160	177	PF00022	0.437
LIG_Actin_WH2_2	394	409	PF00022	0.522
LIG_Actin_WH2_2	657	673	PF00022	0.405
LIG_BIR_II_1	1	5	PF00653	0.783
LIG_BRCT_BRCA1_1	419	423	PF00533	0.554
LIG_Clathr_ClatBox_1	50	54	PF01394	0.248
LIG_CtBP_PxDLS_1	329	333	PF00389	0.535
LIG_deltaCOP1_diTrp_1	450	456	PF00928	0.406
LIG_FAT_LD_1	93	101	PF03623	0.391
LIG_FHA_1	413	419	PF00498	0.558
LIG_FHA_1	518	524	PF00498	0.395
LIG_FHA_1	564	570	PF00498	0.515
LIG_FHA_1	634	640	PF00498	0.464
LIG_FHA_2	131	137	PF00498	0.391
LIG_FHA_2	453	459	PF00498	0.384
LIG_FHA_2	506	512	PF00498	0.449
LIG_FHA_2	541	547	PF00498	0.394
LIG_FHA_2	582	588	PF00498	0.573
LIG_FHA_2	625	631	PF00498	0.506
LIG_FHA_2	81	87	PF00498	0.228
LIG_GBD_Chelix_1	64	72	PF00786	0.342
LIG_LIR_Apic_2	190	195	PF02991	0.517
LIG_LIR_Gen_1	45	56	PF02991	0.248
LIG_LIR_Gen_1	463	472	PF02991	0.485
LIG_LIR_Gen_1	587	598	PF02991	0.378
LIG_LIR_Gen_1	665	674	PF02991	0.412
LIG_LIR_Gen_1	67	76	PF02991	0.342
LIG_LIR_LC3C_4	120	124	PF02991	0.324
LIG_LIR_Nem_3	127	132	PF02991	0.283
LIG_LIR_Nem_3	166	171	PF02991	0.506
LIG_LIR_Nem_3	420	426	PF02991	0.412
LIG_LIR_Nem_3	449	454	PF02991	0.376
LIG_LIR_Nem_3	45	51	PF02991	0.248
LIG_LIR_Nem_3	463	468	PF02991	0.418
LIG_LIR_Nem_3	52	56	PF02991	0.248
LIG_LIR_Nem_3	587	593	PF02991	0.365
LIG_LIR_Nem_3	627	631	PF02991	0.442
LIG_LIR_Nem_3	665	670	PF02991	0.377
LIG_LIR_Nem_3	67	72	PF02991	0.248
LIG_LYPXL_S_1	124	128	PF13949	0.248
LIG_LYPXL_yS_3	125	128	PF13949	0.248
LIG_NRBOX	92	98	PF00104	0.391
LIG_PALB2_WD40_1	662	670	PF16756	0.385
LIG_PCNA_PIPBox_1	89	98	PF02747	0.324
LIG_Pex14_2	108	112	PF04695	0.268
LIG_PTB_Apo_2	63	70	PF02174	0.283
LIG_RPA_C_Fungi	238	250	PF08784	0.523
LIG_SH2_CRK	102	106	PF00017	0.248
LIG_SH2_CRK	171	175	PF00017	0.450
LIG_SH2_CRK	590	594	PF00017	0.379
LIG_SH2_NCK_1	48	52	PF00017	0.248
LIG_SH2_PTP2	215	218	PF00017	0.301
LIG_SH2_SRC	215	218	PF00017	0.498
LIG_SH2_SRC	560	563	PF00017	0.391
LIG_SH2_STAP1	484	488	PF00017	0.432
LIG_SH2_STAP1	628	632	PF00017	0.415
LIG_SH2_STAT3	558	561	PF00017	0.380
LIG_SH2_STAT5	143	146	PF00017	0.256
LIG_SH2_STAT5	215	218	PF00017	0.370
LIG_SH2_STAT5	631	634	PF00017	0.530
LIG_SH3_3	120	126	PF00018	0.263
LIG_SH3_3	221	227	PF00018	0.282
LIG_SH3_3	323	329	PF00018	0.540
LIG_SUMO_SIM_par_1	149	155	PF11976	0.391
LIG_SUMO_SIM_par_1	222	228	PF11976	0.285
LIG_SUMO_SIM_par_1	518	525	PF11976	0.488
LIG_SUMO_SIM_par_1	712	718	PF11976	0.554
LIG_TRAF2_1	242	245	PF00917	0.377
LIG_TRAF2_1	460	463	PF00917	0.517
LIG_TRAF2_1	500	503	PF00917	0.462
LIG_TRAF2_1	508	511	PF00917	0.413
LIG_TRAF2_1	607	610	PF00917	0.471
LIG_UBA3_1	131	140	PF00899	0.350
LIG_UBA3_1	289	294	PF00899	0.541
LIG_UBA3_1	92	98	PF00899	0.251
MOD_CK1_1	2	8	PF00069	0.565
MOD_CK1_1	25	31	PF00069	0.522
MOD_CK1_1	563	569	PF00069	0.513
MOD_CK2_1	130	136	PF00069	0.380
MOD_CK2_1	452	458	PF00069	0.385
MOD_CK2_1	46	52	PF00069	0.260
MOD_CK2_1	505	511	PF00069	0.453
MOD_CK2_1	540	546	PF00069	0.394
MOD_CK2_1	553	559	PF00069	0.393
MOD_CK2_1	581	587	PF00069	0.483
MOD_GlcNHglycan	14	17	PF01048	0.495
MOD_GlcNHglycan	189	192	PF01048	0.511
MOD_GlcNHglycan	244	248	PF01048	0.468
MOD_GlcNHglycan	27	30	PF01048	0.441
MOD_GlcNHglycan	412	415	PF01048	0.544
MOD_GlcNHglycan	667	670	PF01048	0.292
MOD_GSK3_1	108	115	PF00069	0.342
MOD_GSK3_1	265	272	PF00069	0.512
MOD_GSK3_1	406	413	PF00069	0.533
MOD_GSK3_1	446	453	PF00069	0.502
MOD_GSK3_1	581	588	PF00069	0.464
MOD_GSK3_1	665	672	PF00069	0.532
MOD_LATS_1	578	584	PF00433	0.297
MOD_LATS_1	675	681	PF00433	0.330
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	108	113	PF00069	0.305
MOD_NEK2_1	178	183	PF00069	0.376
MOD_NEK2_1	233	238	PF00069	0.464
MOD_NEK2_1	406	411	PF00069	0.488
MOD_NEK2_1	585	590	PF00069	0.353
MOD_PIKK_1	22	28	PF00454	0.565
MOD_PIKK_1	406	412	PF00454	0.481
MOD_PIKK_1	553	559	PF00454	0.412
MOD_PK_1	677	683	PF00069	0.530
MOD_PK_1	693	699	PF00069	0.610
MOD_PKA_2	265	271	PF00069	0.426
MOD_PKA_2	406	412	PF00069	0.443
MOD_PKA_2	540	546	PF00069	0.463
MOD_PKB_1	691	699	PF00069	0.601
MOD_Plk_1	22	28	PF00069	0.498
MOD_Plk_1	385	391	PF00069	0.530
MOD_Plk_1	457	463	PF00069	0.516
MOD_Plk_1	510	516	PF00069	0.416
MOD_Plk_1	517	523	PF00069	0.390
MOD_Plk_1	574	580	PF00069	0.455
MOD_Plk_1	581	587	PF00069	0.386
MOD_Plk_2-3	581	587	PF00069	0.480
MOD_Plk_4	124	130	PF00069	0.308
MOD_Plk_4	46	52	PF00069	0.248
MOD_Plk_4	560	566	PF00069	0.433
MOD_Plk_4	585	591	PF00069	0.386
MOD_ProDKin_1	2	8	PF00069	0.610
MOD_ProDKin_1	80	86	PF00069	0.270
MOD_SUMO_for_1	293	296	PF00179	0.543
MOD_SUMO_for_1	351	354	PF00179	0.323
MOD_SUMO_for_1	579	582	PF00179	0.507
MOD_SUMO_rev_2	339	349	PF00179	0.494
MOD_SUMO_rev_2	548	556	PF00179	0.314
TRG_DiLeu_BaEn_1	228	233	PF01217	0.509
TRG_DiLeu_BaEn_1	321	326	PF01217	0.412
TRG_DiLeu_BaEn_4	244	250	PF01217	0.385
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.405
TRG_ENDOCYTIC_2	125	128	PF00928	0.248
TRG_ENDOCYTIC_2	129	132	PF00928	0.248
TRG_ENDOCYTIC_2	171	174	PF00928	0.361
TRG_ENDOCYTIC_2	215	218	PF00928	0.301
TRG_ENDOCYTIC_2	465	468	PF00928	0.520
TRG_ENDOCYTIC_2	48	51	PF00928	0.248
TRG_ENDOCYTIC_2	590	593	PF00928	0.380
TRG_ER_diArg_1	277	279	PF00400	0.405
TRG_ER_diArg_1	290	292	PF00400	0.400
TRG_ER_diArg_1	440	443	PF00400	0.551
TRG_ER_diArg_1	527	530	PF00400	0.544
TRG_ER_diArg_1	592	595	PF00400	0.402
TRG_NES_CRM1_1	230	245	PF08389	0.286
TRG_NES_CRM1_1	510	525	PF08389	0.402
TRG_NES_CRM1_1	54	67	PF08389	0.391
TRG_NES_CRM1_1	94	109	PF08389	0.384
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	651	655	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W4	Leptomonas seymouri	82%	100%
A0A0S4ITV8	Bodo saltans	48%	95%
A0A1X0P8Q2	Trypanosomatidae	54%	92%
A0A3Q8IHU5	Leishmania donovani	90%	100%
A0A3R7NE32	Trypanosoma rangeli	54%	88%
A4I9J3	Leishmania infantum	90%	100%
D0A1V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	94%
E9B4J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O35594	Mus musculus	30%	100%
P83829	Rattus norvegicus	30%	100%
Q4Q3I5	Leishmania major	90%	100%
Q68RJ5	Chlamydomonas reinhardtii	26%	100%
Q8WYA0	Homo sapiens	29%	100%
V5BM72	Trypanosoma cruzi	56%	89%