GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania braziliensis

UniProt:

A4HAE0_LEIBR

TriTrypDb:

LbrM.20.0230 , LBRM2903_200006000

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HAE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAE0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.689
CLV_NRD_NRD_1	348	350	PF00675	0.526
CLV_PCSK_KEX2_1	348	350	PF00082	0.526
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.526
CLV_PCSK_SKI1_1	252	256	PF00082	0.269
CLV_PCSK_SKI1_1	264	268	PF00082	0.269
CLV_PCSK_SKI1_1	290	294	PF00082	0.251
DEG_MDM2_SWIB_1	317	325	PF02201	0.469
DEG_Nend_UBRbox_1	1	4	PF02207	0.432
DEG_SPOP_SBC_1	257	261	PF00917	0.414
DOC_CYCLIN_RxL_1	249	259	PF00134	0.516
DOC_MAPK_gen_1	2	11	PF00069	0.401
DOC_MAPK_MEF2A_6	319	328	PF00069	0.248
DOC_MAPK_MEF2A_6	85	92	PF00069	0.568
DOC_USP7_MATH_1	142	146	PF00917	0.414
DOC_USP7_MATH_1	52	56	PF00917	0.401
DOC_USP7_MATH_1	95	99	PF00917	0.644
DOC_USP7_UBL2_3	286	290	PF12436	0.411
LIG_14-3-3_CanoR_1	212	218	PF00244	0.516
LIG_14-3-3_CanoR_1	256	266	PF00244	0.516
LIG_14-3-3_CanoR_1	308	317	PF00244	0.469
LIG_14-3-3_CanoR_1	72	76	PF00244	0.625
LIG_Clathr_ClatBox_1	60	64	PF01394	0.304
LIG_FHA_1	154	160	PF00498	0.480
LIG_FHA_1	258	264	PF00498	0.455
LIG_FHA_1	340	346	PF00498	0.327
LIG_FHA_2	272	278	PF00498	0.428
LIG_LIR_Gen_1	114	125	PF02991	0.579
LIG_LIR_Gen_1	195	206	PF02991	0.516
LIG_LIR_Gen_1	244	255	PF02991	0.501
LIG_LIR_Gen_1	303	313	PF02991	0.446
LIG_LIR_Gen_1	314	325	PF02991	0.505
LIG_LIR_Gen_1	47	52	PF02991	0.494
LIG_LIR_Nem_3	114	120	PF02991	0.578
LIG_LIR_Nem_3	195	201	PF02991	0.533
LIG_LIR_Nem_3	314	320	PF02991	0.469
LIG_LIR_Nem_3	32	38	PF02991	0.485
LIG_LIR_Nem_3	334	339	PF02991	0.183
LIG_LIR_Nem_3	47	51	PF02991	0.399
LIG_NRBOX	11	17	PF00104	0.527
LIG_NRBOX	262	268	PF00104	0.469
LIG_PCNA_PIPBox_1	289	298	PF02747	0.469
LIG_PCNA_yPIPBox_3	286	296	PF02747	0.469
LIG_Pex14_2	317	321	PF04695	0.469
LIG_SH2_CRK	48	52	PF00017	0.497
LIG_SH2_STAP1	177	181	PF00017	0.504
LIG_SH2_STAP1	247	251	PF00017	0.504
LIG_SH2_STAP1	75	79	PF00017	0.636
LIG_SH2_STAT5	218	221	PF00017	0.469
LIG_SH2_STAT5	301	304	PF00017	0.500
LIG_SH2_STAT5	341	344	PF00017	0.316
LIG_SH3_3	89	95	PF00018	0.592
LIG_Sin3_3	13	20	PF02671	0.390
LIG_SUMO_SIM_par_1	204	211	PF11976	0.411
LIG_SUMO_SIM_par_1	323	329	PF11976	0.227
LIG_SUMO_SIM_par_1	59	64	PF11976	0.304
LIG_TRAF2_1	274	277	PF00917	0.469
MOD_CK1_1	152	158	PF00069	0.516
MOD_CK1_1	258	264	PF00069	0.459
MOD_CK1_1	77	83	PF00069	0.681
MOD_CK1_1	98	104	PF00069	0.652
MOD_CK2_1	271	277	PF00069	0.478
MOD_CK2_1	41	47	PF00069	0.497
MOD_GlcNHglycan	144	147	PF01048	0.230
MOD_GlcNHglycan	54	57	PF01048	0.484
MOD_GSK3_1	149	156	PF00069	0.476
MOD_GSK3_1	207	214	PF00069	0.471
MOD_GSK3_1	258	265	PF00069	0.452
MOD_GSK3_1	309	316	PF00069	0.469
MOD_GSK3_1	331	338	PF00069	0.322
MOD_N-GLC_1	142	147	PF02516	0.230
MOD_N-GLC_1	77	82	PF02516	0.479
MOD_NEK2_1	183	188	PF00069	0.531
MOD_NEK2_1	250	255	PF00069	0.499
MOD_NEK2_1	331	336	PF00069	0.331
MOD_NEK2_1	339	344	PF00069	0.311
MOD_NEK2_2	24	29	PF00069	0.438
MOD_PIKK_1	149	155	PF00454	0.414
MOD_PIKK_1	95	101	PF00454	0.598
MOD_PK_1	29	35	PF00069	0.381
MOD_PKA_2	133	139	PF00069	0.640
MOD_PKA_2	211	217	PF00069	0.551
MOD_PKA_2	255	261	PF00069	0.469
MOD_PKA_2	309	315	PF00069	0.486
MOD_PKA_2	71	77	PF00069	0.559
MOD_Plk_1	313	319	PF00069	0.469
MOD_Plk_2-3	41	47	PF00069	0.411
MOD_Plk_4	213	219	PF00069	0.469
MOD_Plk_4	326	332	PF00069	0.295
MOD_SUMO_rev_2	271	280	PF00179	0.500
MOD_SUMO_rev_2	283	288	PF00179	0.414
MOD_SUMO_rev_2	34	44	PF00179	0.476
TRG_ENDOCYTIC_2	198	201	PF00928	0.546
TRG_ENDOCYTIC_2	247	250	PF00928	0.504
TRG_ENDOCYTIC_2	296	299	PF00928	0.512
TRG_ENDOCYTIC_2	48	51	PF00928	0.498
TRG_ER_diLys_1	348	352	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV9	Leptomonas seymouri	51%	100%
A0A3S7X7B6	Leishmania donovani	69%	100%
A4I9J2	Leishmania infantum	69%	100%
E9B4J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q3I6	Leishmania major	72%	100%