CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HAD9_LEIBR

TriTrypDb:

LbrM.20.0220 , LBRM2903_200006100

Length:

207

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAD9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0031072	heat shock protein binding	3	11
GO:0051879	Hsp90 protein binding	4	11
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.455
CLV_NRD_NRD_1	83	85	PF00675	0.265
CLV_PCSK_SKI1_1	41	45	PF00082	0.154
CLV_PCSK_SKI1_1	85	89	PF00082	0.495
DOC_CYCLIN_yCln2_LP_2	7	10	PF00134	0.443
DOC_MAPK_gen_1	107	115	PF00069	0.418
DOC_MAPK_gen_1	75	83	PF00069	0.504
DOC_MAPK_MEF2A_6	107	115	PF00069	0.443
DOC_MAPK_MEF2A_6	16	24	PF00069	0.409
DOC_MAPK_MEF2A_6	75	83	PF00069	0.504
DOC_PP1_RVXF_1	39	46	PF00149	0.412
DOC_PP2B_LxvP_1	7	10	PF13499	0.474
DOC_PP2B_PxIxI_1	110	116	PF00149	0.420
DOC_USP7_MATH_1	3	7	PF00917	0.444
DOC_USP7_MATH_1	64	68	PF00917	0.407
DOC_USP7_UBL2_3	105	109	PF12436	0.542
DOC_USP7_UBL2_3	82	86	PF12436	0.440
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_deltaCOP1_diTrp_1	116	120	PF00928	0.400
LIG_FHA_1	127	133	PF00498	0.602
LIG_FHA_1	21	27	PF00498	0.465
LIG_FHA_1	31	37	PF00498	0.465
LIG_FHA_1	86	92	PF00498	0.430
LIG_FHA_2	171	177	PF00498	0.522
LIG_LIR_Gen_1	144	155	PF02991	0.552
LIG_LIR_Gen_1	18	26	PF02991	0.424
LIG_LIR_Nem_3	18	22	PF02991	0.467
LIG_LIR_Nem_3	97	103	PF02991	0.456
LIG_LYPXL_yS_3	110	113	PF13949	0.421
LIG_MYND_3	200	204	PF01753	0.529
LIG_SH2_CRK	62	66	PF00017	0.457
LIG_SH2_PTP2	19	22	PF00017	0.440
LIG_SH2_STAP1	147	151	PF00017	0.512
LIG_SH2_STAP1	55	59	PF00017	0.504
LIG_SH2_STAT5	19	22	PF00017	0.440
LIG_SH3_3	105	111	PF00018	0.436
LIG_SH3_3	19	25	PF00018	0.502
LIG_SH3_3	70	76	PF00018	0.453
LIG_SH3_3	95	101	PF00018	0.551
LIG_SUMO_SIM_par_1	32	39	PF11976	0.432
LIG_TRAF2_1	66	69	PF00917	0.440
LIG_TYR_ITIM	108	113	PF00017	0.425
MOD_CK1_1	67	73	PF00069	0.423
MOD_CK2_1	170	176	PF00069	0.553
MOD_CK2_1	63	69	PF00069	0.452
MOD_CMANNOS	117	120	PF00535	0.417
MOD_Cter_Amidation	158	161	PF01082	0.397
MOD_GlcNHglycan	1	4	PF01048	0.493
MOD_GlcNHglycan	178	181	PF01048	0.529
MOD_GlcNHglycan	189	192	PF01048	0.651
MOD_GSK3_1	111	118	PF00069	0.418
MOD_GSK3_1	145	152	PF00069	0.517
MOD_GSK3_1	183	190	PF00069	0.649
MOD_GSK3_1	26	33	PF00069	0.440
MOD_GSK3_1	63	70	PF00069	0.444
MOD_N-GLC_1	111	116	PF02516	0.488
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	154	159	PF00069	0.393
MOD_NEK2_1	26	31	PF00069	0.495
MOD_NEK2_2	55	60	PF00069	0.504
MOD_PIKK_1	149	155	PF00454	0.501
MOD_PIKK_1	67	73	PF00454	0.504
MOD_PKA_1	85	91	PF00069	0.454
MOD_PKA_2	101	107	PF00069	0.411
MOD_Plk_1	111	117	PF00069	0.497
MOD_Plk_2-3	126	132	PF00069	0.517
MOD_Plk_4	3	9	PF00069	0.420
MOD_SUMO_for_1	36	39	PF00179	0.504
TRG_DiLeu_BaEn_1	39	44	PF01217	0.354
TRG_DiLeu_BaEn_4	164	170	PF01217	0.568
TRG_ENDOCYTIC_2	110	113	PF00928	0.527
TRG_ENDOCYTIC_2	147	150	PF00928	0.470
TRG_ENDOCYTIC_2	19	22	PF00928	0.440
TRG_ENDOCYTIC_2	62	65	PF00928	0.457
TRG_ER_diArg_1	74	77	PF00400	0.481
TRG_NLS_MonoExtN_4	82	88	PF00514	0.440
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I2	Leptomonas seymouri	64%	99%
A0A0S4JQC8	Bodo saltans	32%	100%
A0A1X0P8I0	Trypanosomatidae	42%	100%
A0A3Q8II57	Leishmania donovani	86%	99%
A0A422N770	Trypanosoma rangeli	44%	100%
A4I9J1	Leishmania infantum	86%	99%
D0A1U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B4I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
G1TGF1	Oryctolagus cuniculus	27%	100%
P28707	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	96%
P83868	Rattus norvegicus	27%	100%
Q11118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q15185	Homo sapiens	27%	100%
Q3ZBF7	Bos taurus	27%	100%
Q4Q3I7	Leishmania major	85%	100%
Q5NVM4	Pongo abelii	27%	100%
Q6PWL5	Macaca fascicularis	27%	100%
Q9R0Q7	Mus musculus	27%	100%
V5B2A2	Trypanosoma cruzi	44%	100%