Calx-beta domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Antimony resistance marker of 58 kDa

Species:

Leishmania braziliensis

UniProt:

A4HAD8_LEIBR

TriTrypDb:

LbrM.20.0210 , LBRM2903_200006200

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAD8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	443	445	PF00675	0.356
CLV_PCSK_KEX2_1	443	445	PF00082	0.356
CLV_PCSK_SKI1_1	144	148	PF00082	0.352
CLV_PCSK_SKI1_1	163	167	PF00082	0.256
CLV_PCSK_SKI1_1	271	275	PF00082	0.361
CLV_PCSK_SKI1_1	31	35	PF00082	0.395
CLV_PCSK_SKI1_1	424	428	PF00082	0.307
CLV_PCSK_SKI1_1	444	448	PF00082	0.166
CLV_PCSK_SKI1_1	59	63	PF00082	0.371
DEG_APCC_DBOX_1	30	38	PF00400	0.412
DEG_SCF_FBW7_1	367	372	PF00400	0.621
DEG_SCF_FBW7_2	243	248	PF00400	0.566
DOC_CDC14_PxL_1	342	350	PF14671	0.331
DOC_MAPK_gen_1	144	154	PF00069	0.322
DOC_MAPK_MEF2A_6	171	179	PF00069	0.296
DOC_MAPK_MEF2A_6	316	323	PF00069	0.380
DOC_PP1_RVXF_1	124	131	PF00149	0.489
DOC_PP1_RVXF_1	29	36	PF00149	0.331
DOC_PP1_RVXF_1	457	463	PF00149	0.372
DOC_PP2B_LxvP_1	213	216	PF13499	0.314
DOC_PP2B_LxvP_1	397	400	PF13499	0.541
DOC_USP7_MATH_1	310	314	PF00917	0.412
DOC_WW_Pin1_4	241	246	PF00397	0.705
DOC_WW_Pin1_4	254	259	PF00397	0.390
DOC_WW_Pin1_4	295	300	PF00397	0.477
DOC_WW_Pin1_4	359	364	PF00397	0.617
DOC_WW_Pin1_4	365	370	PF00397	0.764
DOC_WW_Pin1_4	377	382	PF00397	0.471
LIG_14-3-3_CanoR_1	308	317	PF00244	0.436
LIG_APCC_ABBA_1	415	420	PF00400	0.242
LIG_BIR_III_4	385	389	PF00653	0.518
LIG_Clathr_ClatBox_1	37	41	PF01394	0.331
LIG_Clathr_ClatBox_1	457	461	PF01394	0.205
LIG_FHA_1	209	215	PF00498	0.427
LIG_FHA_1	227	233	PF00498	0.211
LIG_FHA_1	310	316	PF00498	0.336
LIG_FHA_1	366	372	PF00498	0.675
LIG_FHA_1	449	455	PF00498	0.357
LIG_FHA_1	480	486	PF00498	0.403
LIG_FHA_1	49	55	PF00498	0.382
LIG_FHA_1	507	513	PF00498	0.343
LIG_FHA_1	87	93	PF00498	0.377
LIG_FHA_2	18	24	PF00498	0.205
LIG_FHA_2	244	250	PF00498	0.458
LIG_FHA_2	323	329	PF00498	0.309
LIG_FHA_2	371	377	PF00498	0.729
LIG_LIR_Apic_2	252	258	PF02991	0.349
LIG_LIR_Gen_1	136	146	PF02991	0.291
LIG_LIR_Gen_1	207	216	PF02991	0.331
LIG_LIR_Nem_3	136	142	PF02991	0.330
LIG_LIR_Nem_3	207	213	PF02991	0.331
LIG_LIR_Nem_3	23	28	PF02991	0.343
LIG_LIR_Nem_3	290	295	PF02991	0.323
LIG_LIR_Nem_3	32	38	PF02991	0.335
LIG_LIR_Nem_3	420	426	PF02991	0.342
LIG_PCNA_yPIPBox_3	144	157	PF02747	0.313
LIG_PCNA_yPIPBox_3	271	285	PF02747	0.497
LIG_PCNA_yPIPBox_3	424	438	PF02747	0.296
LIG_Pex14_2	102	106	PF04695	0.384
LIG_Pex14_2	114	118	PF04695	0.305
LIG_Pex14_2	507	511	PF04695	0.356
LIG_SH2_CRK	139	143	PF00017	0.328
LIG_SH2_CRK	210	214	PF00017	0.412
LIG_SH2_NCK_1	139	143	PF00017	0.356
LIG_SH2_PTP2	467	470	PF00017	0.205
LIG_SH2_SRC	253	256	PF00017	0.608
LIG_SH2_STAP1	139	143	PF00017	0.336
LIG_SH2_STAP1	210	214	PF00017	0.331
LIG_SH2_STAP1	230	234	PF00017	0.166
LIG_SH2_STAP1	355	359	PF00017	0.412
LIG_SH2_STAP1	487	491	PF00017	0.291
LIG_SH2_STAT5	210	213	PF00017	0.331
LIG_SH2_STAT5	230	233	PF00017	0.166
LIG_SH2_STAT5	253	256	PF00017	0.608
LIG_SH2_STAT5	301	304	PF00017	0.412
LIG_SH2_STAT5	406	409	PF00017	0.620
LIG_SH2_STAT5	467	470	PF00017	0.205
LIG_SH3_3	191	197	PF00018	0.330
LIG_SH3_3	346	352	PF00018	0.476
LIG_SH3_3	389	395	PF00018	0.612
LIG_SH3_3	457	463	PF00018	0.205
LIG_SH3_3	58	64	PF00018	0.409
LIG_SUMO_SIM_anti_2	412	417	PF11976	0.437
LIG_SUMO_SIM_anti_2	450	459	PF11976	0.331
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.205
LIG_SUMO_SIM_par_1	93	99	PF11976	0.336
LIG_TRAF2_1	20	23	PF00917	0.385
LIG_TRAF2_1	246	249	PF00917	0.536
LIG_TRAF2_2	70	75	PF00917	0.312
LIG_TYR_ITIM	137	142	PF00017	0.356
LIG_TYR_ITIM	208	213	PF00017	0.331
LIG_UBA3_1	33	42	PF00899	0.319
MOD_CDC14_SPxK_1	257	260	PF00782	0.334
MOD_CDK_SPxK_1	254	260	PF00069	0.349
MOD_CK1_1	370	376	PF00069	0.689
MOD_CK2_1	102	108	PF00069	0.408
MOD_CK2_1	17	23	PF00069	0.205
MOD_CK2_1	243	249	PF00069	0.464
MOD_CK2_1	322	328	PF00069	0.392
MOD_CK2_1	370	376	PF00069	0.740
MOD_GlcNHglycan	233	237	PF01048	0.195
MOD_GSK3_1	204	211	PF00069	0.477
MOD_GSK3_1	228	235	PF00069	0.313
MOD_GSK3_1	239	246	PF00069	0.716
MOD_GSK3_1	355	362	PF00069	0.374
MOD_GSK3_1	363	370	PF00069	0.626
MOD_N-GLC_1	167	172	PF02516	0.336
MOD_N-GLC_1	239	244	PF02516	0.593
MOD_N-GLC_1	295	300	PF02516	0.336
MOD_N-GLC_1	448	453	PF02516	0.336
MOD_N-GLC_1	48	53	PF02516	0.333
MOD_NEK2_1	102	107	PF00069	0.477
MOD_NEK2_1	175	180	PF00069	0.394
MOD_NEK2_1	190	195	PF00069	0.265
MOD_NEK2_1	357	362	PF00069	0.242
MOD_NEK2_1	471	476	PF00069	0.349
MOD_PIKK_1	370	376	PF00454	0.640
MOD_PIKK_1	438	444	PF00454	0.205
MOD_PKA_2	133	139	PF00069	0.325
MOD_Plk_1	190	196	PF00069	0.393
MOD_Plk_1	239	245	PF00069	0.605
MOD_Plk_1	355	361	PF00069	0.427
MOD_Plk_2-3	88	94	PF00069	0.412
MOD_Plk_4	102	108	PF00069	0.366
MOD_Plk_4	204	210	PF00069	0.445
MOD_Plk_4	287	293	PF00069	0.331
MOD_Plk_4	471	477	PF00069	0.331
MOD_Plk_4	481	487	PF00069	0.427
MOD_Plk_4	63	69	PF00069	0.423
MOD_ProDKin_1	241	247	PF00069	0.707
MOD_ProDKin_1	254	260	PF00069	0.393
MOD_ProDKin_1	295	301	PF00069	0.477
MOD_ProDKin_1	359	365	PF00069	0.626
MOD_ProDKin_1	377	383	PF00069	0.471
MOD_SUMO_rev_2	104	114	PF00179	0.422
TRG_DiLeu_BaEn_2	494	500	PF01217	0.444
TRG_ENDOCYTIC_2	139	142	PF00928	0.336
TRG_ENDOCYTIC_2	143	146	PF00928	0.336
TRG_ENDOCYTIC_2	210	213	PF00928	0.412
TRG_ENDOCYTIC_2	25	28	PF00928	0.367
TRG_ENDOCYTIC_2	423	426	PF00928	0.360
TRG_ER_diArg_1	443	445	PF00400	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I505	Leptomonas seymouri	62%	96%
A0A0N1PDX2	Leptomonas seymouri	37%	100%
A0A1X0P8U8	Trypanosomatidae	42%	100%
A0A3Q8IE32	Leishmania donovani	81%	100%
A0A3S7X7C8	Leishmania donovani	38%	100%
A4HAD7	Leishmania braziliensis	38%	94%
A4I9I9	Leishmania infantum	38%	100%
A4I9J0	Leishmania infantum	81%	100%
D0A1U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B4I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q3I8	Leishmania major	81%	100%
Q4Q3I9	Leishmania major	38%	94%
V5B262	Trypanosoma cruzi	37%	100%