Peptidase S59 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Antimony resistance marker of 56 kDa, putative

Species:

Leishmania braziliensis

UniProt:

A4HAD7_LEIBR

TriTrypDb:

LbrM.20.0200 , LBRM2903_200006300

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HAD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAD7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.511
CLV_C14_Caspase3-7	397	401	PF00656	0.201
CLV_MEL_PAP_1	61	67	PF00089	0.327
CLV_NRD_NRD_1	382	384	PF00675	0.327
CLV_NRD_NRD_1	482	484	PF00675	0.486
CLV_PCSK_KEX2_1	482	484	PF00082	0.596
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.596
CLV_PCSK_SKI1_1	148	152	PF00082	0.365
CLV_PCSK_SKI1_1	269	273	PF00082	0.374
CLV_PCSK_SKI1_1	27	31	PF00082	0.413
CLV_PCSK_SKI1_1	292	296	PF00082	0.219
CLV_PCSK_SKI1_1	352	356	PF00082	0.327
CLV_PCSK_SKI1_1	47	51	PF00082	0.358
CLV_PCSK_SKI1_1	473	477	PF00082	0.327
DEG_APCC_KENBOX_2	274	278	PF00400	0.327
DOC_MAPK_gen_1	176	186	PF00069	0.403
DOC_MAPK_gen_1	30	38	PF00069	0.327
DOC_MAPK_gen_1	352	360	PF00069	0.327
DOC_MAPK_gen_1	76	84	PF00069	0.430
DOC_PP1_RVXF_1	305	311	PF00149	0.359
DOC_PP2B_LxvP_1	315	318	PF13499	0.201
DOC_USP7_MATH_1	258	262	PF00917	0.466
DOC_WW_Pin1_4	370	375	PF00397	0.506
DOC_WW_Pin1_4	63	68	PF00397	0.365
LIG_14-3-3_CanoR_1	179	185	PF00244	0.474
LIG_14-3-3_CanoR_1	228	233	PF00244	0.303
LIG_14-3-3_CanoR_1	39	48	PF00244	0.220
LIG_14-3-3_CanoR_1	428	432	PF00244	0.437
LIG_14-3-3_CanoR_1	483	488	PF00244	0.547
LIG_APCC_ABBA_1	139	144	PF00400	0.289
LIG_BIR_III_4	432	436	PF00653	0.430
LIG_BRCT_BRCA1_1	372	376	PF00533	0.610
LIG_CaM_IQ_9	465	480	PF13499	0.430
LIG_FHA_1	121	127	PF00498	0.552
LIG_FHA_1	179	185	PF00498	0.383
LIG_FHA_1	196	202	PF00498	0.330
LIG_FHA_1	331	337	PF00498	0.319
LIG_FHA_1	418	424	PF00498	0.374
LIG_FHA_1	451	457	PF00498	0.418
LIG_FHA_1	96	102	PF00498	0.390
LIG_FHA_2	437	443	PF00498	0.332
LIG_FHA_2	461	467	PF00498	0.455
LIG_LIR_Gen_1	19	29	PF02991	0.380
LIG_LIR_Gen_1	389	399	PF02991	0.382
LIG_LIR_Nem_3	100	105	PF02991	0.270
LIG_LIR_Nem_3	144	150	PF02991	0.350
LIG_LIR_Nem_3	166	172	PF02991	0.331
LIG_LIR_Nem_3	19	25	PF02991	0.370
LIG_LIR_Nem_3	389	395	PF02991	0.356
LIG_LYPXL_S_1	101	105	PF13949	0.201
LIG_LYPXL_yS_3	102	105	PF13949	0.201
LIG_PCNA_yPIPBox_3	148	162	PF02747	0.334
LIG_PCNA_yPIPBox_3	27	41	PF02747	0.327
LIG_PCNA_yPIPBox_3	272	286	PF02747	0.492
LIG_Pex14_2	117	121	PF04695	0.330
LIG_Pex14_2	425	429	PF04695	0.430
LIG_Pex14_2	475	479	PF04695	0.361
LIG_REV1ctd_RIR_1	422	432	PF16727	0.327
LIG_SH2_CRK	143	147	PF00017	0.342
LIG_SH2_CRK	388	392	PF00017	0.380
LIG_SH2_GRB2like	171	174	PF00017	0.380
LIG_SH2_GRB2like	253	256	PF00017	0.559
LIG_SH2_NCK_1	143	147	PF00017	0.361
LIG_SH2_NCK_1	22	26	PF00017	0.380
LIG_SH2_NCK_1	388	392	PF00017	0.356
LIG_SH2_SRC	22	25	PF00017	0.405
LIG_SH2_SRC	253	256	PF00017	0.559
LIG_SH2_STAP1	143	147	PF00017	0.345
LIG_SH2_STAP1	22	26	PF00017	0.380
LIG_SH2_STAP1	356	360	PF00017	0.430
LIG_SH2_STAP1	388	392	PF00017	0.345
LIG_SH2_STAT5	253	256	PF00017	0.576
LIG_SH2_STAT5	302	305	PF00017	0.430
LIG_SH2_STAT5	455	458	PF00017	0.378
LIG_SH3_3	102	108	PF00018	0.252
LIG_SH3_3	181	187	PF00018	0.422
LIG_SH3_3	300	306	PF00018	0.318
LIG_SH3_3	314	320	PF00018	0.436
LIG_SH3_3	454	460	PF00018	0.434
LIG_SH3_3	5	11	PF00018	0.605
LIG_SUMO_SIM_anti_2	357	364	PF11976	0.430
LIG_SUMO_SIM_par_1	259	266	PF11976	0.417
LIG_SUMO_SIM_par_1	329	339	PF11976	0.308
LIG_SUMO_SIM_par_1	94	100	PF11976	0.369
LIG_TRAF2_1	328	331	PF00917	0.327
LIG_TRAF2_2	202	207	PF00917	0.249
LIG_UBA3_1	157	165	PF00899	0.380
LIG_UBA3_1	281	289	PF00899	0.434
MOD_CDK_SPxxK_3	63	70	PF00069	0.327
MOD_CK1_1	477	483	PF00069	0.388
MOD_CK2_1	365	371	PF00069	0.587
MOD_CK2_1	440	446	PF00069	0.327
MOD_CK2_1	460	466	PF00069	0.455
MOD_Cter_Amidation	480	483	PF01082	0.483
MOD_GlcNHglycan	205	210	PF01048	0.367
MOD_GSK3_1	253	260	PF00069	0.395
MOD_GSK3_1	330	337	PF00069	0.401
MOD_GSK3_1	361	368	PF00069	0.564
MOD_GSK3_1	423	430	PF00069	0.255
MOD_GSK3_1	436	443	PF00069	0.316
MOD_GSK3_1	446	453	PF00069	0.340
MOD_GSK3_1	483	490	PF00069	0.637
MOD_N-GLC_1	172	177	PF02516	0.361
MOD_N-GLC_1	296	301	PF02516	0.345
MOD_N-GLC_1	417	422	PF02516	0.361
MOD_N-GLC_1	450	455	PF02516	0.376
MOD_N-GLC_1	51	56	PF02516	0.343
MOD_NEK2_1	178	183	PF00069	0.404
MOD_NEK2_1	40	45	PF00069	0.466
MOD_NEK2_1	92	97	PF00069	0.407
MOD_PIKK_1	263	269	PF00454	0.327
MOD_PIKK_1	296	302	PF00454	0.201
MOD_PIKK_1	40	46	PF00454	0.219
MOD_PIKK_1	450	456	PF00454	0.367
MOD_PIKK_1	474	480	PF00454	0.327
MOD_PKA_1	483	489	PF00069	0.546
MOD_PKA_2	178	184	PF00069	0.327
MOD_PKA_2	227	233	PF00069	0.257
MOD_PKA_2	427	433	PF00069	0.405
MOD_PKA_2	77	83	PF00069	0.437
MOD_Plk_1	205	211	PF00069	0.359
MOD_Plk_1	241	247	PF00069	0.505
MOD_Plk_1	258	264	PF00069	0.424
MOD_Plk_1	330	336	PF00069	0.458
MOD_Plk_1	356	362	PF00069	0.422
MOD_Plk_1	450	456	PF00069	0.279
MOD_Plk_2-3	446	452	PF00069	0.327
MOD_Plk_4	258	264	PF00069	0.418
MOD_Plk_4	331	337	PF00069	0.247
MOD_Plk_4	356	362	PF00069	0.353
MOD_Plk_4	54	60	PF00069	0.374
MOD_Plk_4	92	98	PF00069	0.394
MOD_ProDKin_1	370	376	PF00069	0.499
MOD_ProDKin_1	63	69	PF00069	0.365
MOD_SUMO_for_1	150	153	PF00179	0.421
MOD_SUMO_for_1	354	357	PF00179	0.327
MOD_SUMO_rev_2	124	134	PF00179	0.626
MOD_SUMO_rev_2	189	195	PF00179	0.500
MOD_SUMO_rev_2	380	386	PF00179	0.327
MOD_SUMO_rev_2	432	437	PF00179	0.430
MOD_SUMO_rev_2	66	71	PF00179	0.440
TRG_DiLeu_BaEn_1	153	158	PF01217	0.201
TRG_DiLeu_BaEn_2	343	349	PF01217	0.327
TRG_DiLeu_BaEn_4	87	93	PF01217	0.201
TRG_ENDOCYTIC_2	102	105	PF00928	0.201
TRG_ENDOCYTIC_2	143	146	PF00928	0.340
TRG_ENDOCYTIC_2	147	150	PF00928	0.336
TRG_ENDOCYTIC_2	22	25	PF00928	0.383
TRG_ENDOCYTIC_2	388	391	PF00928	0.358
TRG_ENDOCYTIC_2	392	395	PF00928	0.365
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I505	Leptomonas seymouri	38%	91%
A0A0N1PDX2	Leptomonas seymouri	57%	100%
A0A1X0P8U8	Trypanosomatidae	41%	100%
A0A3Q8IE32	Leishmania donovani	40%	95%
A0A3S7X7C8	Leishmania donovani	84%	100%
A4HAD8	Leishmania braziliensis	38%	95%
A4I9I9	Leishmania infantum	84%	100%
A4I9J0	Leishmania infantum	40%	95%
C9ZT01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A1U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B4I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	95%
Q4Q3I8	Leishmania major	40%	100%
Q4Q3I9	Leishmania major	85%	100%
V5B262	Trypanosoma cruzi	40%	100%