Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HAD5_LEIBR

TriTrypDb:

LbrM.20.0180 , LBRM2903_200006500

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HAD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HAD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.819
CLV_C14_Caspase3-7	183	187	PF00656	0.551
CLV_MEL_PAP_1	601	607	PF00089	0.559
CLV_NRD_NRD_1	239	241	PF00675	0.587
CLV_NRD_NRD_1	403	405	PF00675	0.785
CLV_NRD_NRD_1	416	418	PF00675	0.682
CLV_NRD_NRD_1	603	605	PF00675	0.819
CLV_NRD_NRD_1	617	619	PF00675	0.586
CLV_PCSK_FUR_1	404	408	PF00082	0.574
CLV_PCSK_KEX2_1	12	14	PF00082	0.580
CLV_PCSK_KEX2_1	403	405	PF00082	0.661
CLV_PCSK_KEX2_1	406	408	PF00082	0.689
CLV_PCSK_KEX2_1	416	418	PF00082	0.781
CLV_PCSK_KEX2_1	603	605	PF00082	0.819
CLV_PCSK_KEX2_1	616	618	PF00082	0.597
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.580
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.573
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.562
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.812
CLV_PCSK_SKI1_1	108	112	PF00082	0.565
CLV_PCSK_SKI1_1	531	535	PF00082	0.684
CLV_PCSK_SKI1_1	594	598	PF00082	0.784
DEG_COP1_1	275	284	PF00400	0.545
DEG_MDM2_SWIB_1	494	501	PF02201	0.538
DEG_SPOP_SBC_1	486	490	PF00917	0.572
DOC_CKS1_1	142	147	PF01111	0.576
DOC_CKS1_1	218	223	PF01111	0.737
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.801
DOC_CYCLIN_yCln2_LP_2	332	335	PF00134	0.656
DOC_PP2B_LxvP_1	332	335	PF13499	0.535
DOC_PP4_FxxP_1	196	199	PF00568	0.554
DOC_PP4_FxxP_1	276	279	PF00568	0.544
DOC_PP4_FxxP_1	411	414	PF00568	0.565
DOC_PP4_FxxP_1	419	422	PF00568	0.541
DOC_PP4_FxxP_1	585	588	PF00568	0.588
DOC_PP4_FxxP_1	605	608	PF00568	0.476
DOC_PP4_MxPP_1	266	269	PF00568	0.541
DOC_USP7_MATH_1	14	18	PF00917	0.581
DOC_USP7_MATH_1	157	161	PF00917	0.654
DOC_USP7_MATH_1	162	166	PF00917	0.567
DOC_USP7_MATH_1	202	206	PF00917	0.562
DOC_USP7_MATH_1	209	213	PF00917	0.641
DOC_USP7_MATH_1	247	251	PF00917	0.813
DOC_USP7_MATH_1	282	286	PF00917	0.544
DOC_USP7_MATH_1	307	311	PF00917	0.828
DOC_USP7_MATH_1	339	343	PF00917	0.567
DOC_USP7_MATH_1	396	400	PF00917	0.831
DOC_USP7_MATH_1	466	470	PF00917	0.601
DOC_USP7_MATH_1	51	55	PF00917	0.738
DOC_USP7_MATH_1	535	539	PF00917	0.646
DOC_USP7_MATH_1	72	76	PF00917	0.588
DOC_USP7_MATH_1	98	102	PF00917	0.610
DOC_USP7_MATH_2	317	323	PF00917	0.555
DOC_USP7_UBL2_3	401	405	PF12436	0.576
DOC_WW_Pin1_4	137	142	PF00397	0.829
DOC_WW_Pin1_4	195	200	PF00397	0.653
DOC_WW_Pin1_4	217	222	PF00397	0.735
DOC_WW_Pin1_4	253	258	PF00397	0.630
DOC_WW_Pin1_4	275	280	PF00397	0.672
DOC_WW_Pin1_4	286	291	PF00397	0.637
DOC_WW_Pin1_4	303	308	PF00397	0.536
DOC_WW_Pin1_4	323	328	PF00397	0.470
DOC_WW_Pin1_4	388	393	PF00397	0.825
DOC_WW_Pin1_4	410	415	PF00397	0.817
DOC_WW_Pin1_4	418	423	PF00397	0.690
DOC_WW_Pin1_4	47	52	PF00397	0.582
DOC_WW_Pin1_4	510	515	PF00397	0.578
DOC_WW_Pin1_4	56	61	PF00397	0.677
DOC_WW_Pin1_4	594	599	PF00397	0.569
DOC_WW_Pin1_4	68	73	PF00397	0.638
LIG_14-3-3_CanoR_1	13	21	PF00244	0.798
LIG_14-3-3_CanoR_1	253	257	PF00244	0.549
LIG_14-3-3_CanoR_1	362	371	PF00244	0.809
LIG_14-3-3_CanoR_1	416	420	PF00244	0.835
LIG_14-3-3_CanoR_1	579	583	PF00244	0.846
LIG_14-3-3_CanoR_1	603	608	PF00244	0.748
LIG_14-3-3_CanoR_1	617	621	PF00244	0.580
LIG_14-3-3_CanoR_1	66	71	PF00244	0.596
LIG_BIR_II_1	1	5	PF00653	0.844
LIG_BRCT_BRCA1_1	192	196	PF00533	0.602
LIG_BRCT_BRCA1_1	343	347	PF00533	0.817
LIG_BRCT_BRCA1_1	431	435	PF00533	0.803
LIG_BRCT_BRCA1_1	520	524	PF00533	0.826
LIG_EVH1_2	268	272	PF00568	0.544
LIG_FHA_1	443	449	PF00498	0.575
LIG_FHA_1	89	95	PF00498	0.561
LIG_FHA_2	111	117	PF00498	0.561
LIG_FHA_2	165	171	PF00498	0.815
LIG_FHA_2	226	232	PF00498	0.601
LIG_FHA_2	3	9	PF00498	0.584
LIG_FHA_2	486	492	PF00498	0.628
LIG_GSK3_LRP6_1	56	61	PF00069	0.578
LIG_LIR_Apic_2	193	199	PF02991	0.558
LIG_LIR_Apic_2	275	279	PF02991	0.545
LIG_LIR_Apic_2	408	414	PF02991	0.691
LIG_LIR_Apic_2	418	422	PF02991	0.785
LIG_LIR_Gen_1	491	502	PF02991	0.660
LIG_LIR_Nem_3	259	263	PF02991	0.560
LIG_LIR_Nem_3	344	350	PF02991	0.821
LIG_LIR_Nem_3	491	497	PF02991	0.664
LIG_MLH1_MIPbox_1	193	197	PF16413	0.565
LIG_MLH1_MIPbox_1	431	435	PF16413	0.803
LIG_PCNA_yPIPBox_3	206	218	PF02747	0.568
LIG_Pex14_2	197	201	PF04695	0.792
LIG_Pex14_2	272	276	PF04695	0.764
LIG_Pex14_2	494	498	PF04695	0.675
LIG_SH2_CRK	330	334	PF00017	0.678
LIG_SH2_NCK_1	330	334	PF00017	0.539
LIG_SH3_2	262	267	PF14604	0.551
LIG_SH3_3	135	141	PF00018	0.776
LIG_SH3_3	142	148	PF00018	0.762
LIG_SH3_3	196	202	PF00018	0.548
LIG_SH3_3	259	265	PF00018	0.751
LIG_SH3_3	276	282	PF00018	0.527
LIG_SH3_3	289	295	PF00018	0.502
LIG_SH3_3	311	317	PF00018	0.579
LIG_SH3_3	332	338	PF00018	0.738
LIG_SH3_3	45	51	PF00018	0.672
LIG_SH3_3	54	60	PF00018	0.749
LIG_SxIP_EBH_1	325	339	PF03271	0.542
LIG_TRAF2_1	452	455	PF00917	0.820
LIG_TRFH_1	330	334	PF08558	0.539
LIG_TYR_ITIM	328	333	PF00017	0.544
LIG_UBA3_1	374	381	PF00899	0.562
LIG_WRC_WIRS_1	431	436	PF05994	0.804
LIG_WRC_WIRS_1	99	104	PF05994	0.825
LIG_WW_3	30	34	PF00397	0.735
MOD_CDC14_SPxK_1	413	416	PF00782	0.817
MOD_CDK_SPK_2	141	146	PF00069	0.574
MOD_CDK_SPK_2	56	61	PF00069	0.831
MOD_CDK_SPxK_1	410	416	PF00069	0.819
MOD_CDK_SPxxK_3	410	417	PF00069	0.822
MOD_CK1_1	101	107	PF00069	0.822
MOD_CK1_1	121	127	PF00069	0.772
MOD_CK1_1	16	22	PF00069	0.770
MOD_CK1_1	180	186	PF00069	0.814
MOD_CK1_1	2	8	PF00069	0.649
MOD_CK1_1	212	218	PF00069	0.658
MOD_CK1_1	225	231	PF00069	0.785
MOD_CK1_1	252	258	PF00069	0.587
MOD_CK1_1	285	291	PF00069	0.763
MOD_CK1_1	342	348	PF00069	0.614
MOD_CK1_1	353	359	PF00069	0.719
MOD_CK1_1	365	371	PF00069	0.692
MOD_CK1_1	399	405	PF00069	0.742
MOD_CK1_1	418	424	PF00069	0.506
MOD_CK1_1	430	436	PF00069	0.756
MOD_CK1_1	515	521	PF00069	0.691
MOD_CK1_1	55	61	PF00069	0.670
MOD_CK1_1	555	561	PF00069	0.652
MOD_CK2_1	110	116	PF00069	0.815
MOD_CK2_1	2	8	PF00069	0.586
MOD_CK2_1	225	231	PF00069	0.596
MOD_CK2_1	449	455	PF00069	0.586
MOD_GlcNHglycan	123	126	PF01048	0.685
MOD_GlcNHglycan	164	167	PF01048	0.596
MOD_GlcNHglycan	211	214	PF01048	0.658
MOD_GlcNHglycan	245	248	PF01048	0.567
MOD_GlcNHglycan	339	342	PF01048	0.797
MOD_GlcNHglycan	364	367	PF01048	0.803
MOD_GlcNHglycan	462	465	PF01048	0.687
MOD_GlcNHglycan	468	471	PF01048	0.704
MOD_GlcNHglycan	520	523	PF01048	0.805
MOD_GlcNHglycan	573	576	PF01048	0.840
MOD_GSK3_1	116	123	PF00069	0.778
MOD_GSK3_1	12	19	PF00069	0.788
MOD_GSK3_1	137	144	PF00069	0.829
MOD_GSK3_1	178	185	PF00069	0.789
MOD_GSK3_1	186	193	PF00069	0.646
MOD_GSK3_1	209	216	PF00069	0.643
MOD_GSK3_1	235	242	PF00069	0.724
MOD_GSK3_1	243	250	PF00069	0.784
MOD_GSK3_1	282	289	PF00069	0.776
MOD_GSK3_1	303	310	PF00069	0.588
MOD_GSK3_1	319	326	PF00069	0.542
MOD_GSK3_1	333	340	PF00069	0.557
MOD_GSK3_1	358	365	PF00069	0.679
MOD_GSK3_1	423	430	PF00069	0.762
MOD_GSK3_1	47	54	PF00069	0.803
MOD_GSK3_1	481	488	PF00069	0.629
MOD_GSK3_1	508	515	PF00069	0.626
MOD_GSK3_1	531	538	PF00069	0.737
MOD_GSK3_1	590	597	PF00069	0.677
MOD_GSK3_1	64	71	PF00069	0.598
MOD_GSK3_1	72	79	PF00069	0.633
MOD_GSK3_1	82	89	PF00069	0.546
MOD_N-GLC_1	247	252	PF02516	0.811
MOD_N-GLC_1	388	393	PF02516	0.573
MOD_N-GLC_1	73	78	PF02516	0.840
MOD_NEK2_1	110	115	PF00069	0.615
MOD_NEK2_1	191	196	PF00069	0.763
MOD_NEK2_1	274	279	PF00069	0.697
MOD_NEK2_1	328	333	PF00069	0.544
MOD_NEK2_1	84	89	PF00069	0.650
MOD_OFUCOSY	117	122	PF10250	0.547
MOD_PIKK_1	103	109	PF00454	0.568
MOD_PIKK_1	353	359	PF00454	0.728
MOD_PKA_1	12	18	PF00069	0.585
MOD_PKA_1	603	609	PF00069	0.811
MOD_PKA_2	12	18	PF00069	0.767
MOD_PKA_2	239	245	PF00069	0.582
MOD_PKA_2	252	258	PF00069	0.493
MOD_PKA_2	358	364	PF00069	0.845
MOD_PKA_2	415	421	PF00069	0.809
MOD_PKA_2	459	465	PF00069	0.742
MOD_PKA_2	578	584	PF00069	0.783
MOD_PKA_2	603	609	PF00069	0.743
MOD_Plk_1	247	253	PF00069	0.784
MOD_Plk_1	282	288	PF00069	0.799
MOD_Plk_1	427	433	PF00069	0.797
MOD_Plk_1	490	496	PF00069	0.565
MOD_Plk_1	73	79	PF00069	0.840
MOD_Plk_2-3	545	551	PF00069	0.591
MOD_Plk_4	147	153	PF00069	0.811
MOD_Plk_4	191	197	PF00069	0.562
MOD_Plk_4	213	219	PF00069	0.822
MOD_Plk_4	282	288	PF00069	0.547
MOD_Plk_4	319	325	PF00069	0.807
MOD_Plk_4	328	334	PF00069	0.645
MOD_Plk_4	430	436	PF00069	0.802
MOD_ProDKin_1	137	143	PF00069	0.829
MOD_ProDKin_1	195	201	PF00069	0.649
MOD_ProDKin_1	217	223	PF00069	0.737
MOD_ProDKin_1	253	259	PF00069	0.632
MOD_ProDKin_1	275	281	PF00069	0.671
MOD_ProDKin_1	286	292	PF00069	0.637
MOD_ProDKin_1	303	309	PF00069	0.533
MOD_ProDKin_1	323	329	PF00069	0.471
MOD_ProDKin_1	388	394	PF00069	0.822
MOD_ProDKin_1	410	416	PF00069	0.819
MOD_ProDKin_1	418	424	PF00069	0.688
MOD_ProDKin_1	47	53	PF00069	0.584
MOD_ProDKin_1	510	516	PF00069	0.580
MOD_ProDKin_1	56	62	PF00069	0.680
MOD_ProDKin_1	594	600	PF00069	0.568
MOD_ProDKin_1	68	74	PF00069	0.644
MOD_SUMO_rev_2	16	25	PF00179	0.580
MOD_SUMO_rev_2	346	356	PF00179	0.570
TRG_DiLeu_BaEn_1	319	324	PF01217	0.807
TRG_DiLeu_BaEn_1	370	375	PF01217	0.566
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.548
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.568
TRG_ENDOCYTIC_2	330	333	PF00928	0.681
TRG_ER_diArg_1	382	385	PF00400	0.562
TRG_ER_diArg_1	603	605	PF00400	0.794
TRG_NLS_Bipartite_1	603	620	PF00514	0.807
TRG_NLS_MonoCore_2	402	407	PF00514	0.574
TRG_NLS_MonoExtC_3	402	407	PF00514	0.574
TRG_NLS_MonoExtN_4	401	407	PF00514	0.575
TRG_NLS_MonoExtN_4	9	15	PF00514	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IUC2	Leishmania donovani	56%	100%
A4I9I7	Leishmania infantum	56%	100%
E9AEH6	Leishmania major	54%	100%
E9B4I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%